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  1. Artikel ; Online: The role of the ER stress sensor IRE1 in cardiovascular diseases.

    Zhou, Lu / Zhu, Xizi / Lei, Shaoqing / Wang, Yafeng / Xia, Zhongyuan

    Molecular and cellular biochemistry

    2024  

    Abstract: Despite enormous advances in the treatment of cardiovascular diseases, including I/R injury and heart failure, heart diseases remain a leading cause of mortality worldwide. Inositol-requiring enzyme 1 (IRE1) is an evolutionarily conserved sensor ... ...

    Abstract Despite enormous advances in the treatment of cardiovascular diseases, including I/R injury and heart failure, heart diseases remain a leading cause of mortality worldwide. Inositol-requiring enzyme 1 (IRE1) is an evolutionarily conserved sensor endoplasmic reticulum (ER) transmembrane protein that senses ER stress. It manages ER stress induced by the accumulation of unfolded/misfolded proteins via the unfolded protein response (UPR). However, if the stress still persists, the UPR pathways are activated and induce cell death. Emerging evidence shows that, beyond the UPR, IRE1 participates in the progression of cardiovascular diseases by regulating inflammation levels, immunity, and lipid metabolism. Here, we summarize the recent findings and discuss the potential therapeutic effects of IRE1 in the treatment of cardiovascular diseases.
    Sprache Englisch
    Erscheinungsdatum 2024-05-08
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 184833-1
    ISSN 1573-4919 ; 0300-8177
    ISSN (online) 1573-4919
    ISSN 0300-8177
    DOI 10.1007/s11010-024-05014-z
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  2. Artikel ; Online: Author's reply.

    Lei, Shaoqing / Xia, Zhong-Yuan / Xia, Zhengyuan

    EClinicalMedicine

    2020  Band 23, Seite(n) 100386

    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-05-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2020.100386
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  3. Artikel ; Online: Exploring adsorption capacity and mechanisms involved in cadmium removal from aqueous solutions by biochar derived from euhalophyte

    Shaoqing Ge / Shuai Zhao / Lei Wang / Zhenyong Zhao / Shoule Wang / Changyan Tian

    Scientific Reports, Vol 14, Iss 1, Pp 1-

    2024  Band 11

    Abstract: Abstract Biochar has shown potential as a sorbent for reducing Cd levels in water. Euhalophytes, which thrive in saline-alkali soils containing high concentrations of metal ions and anions, present an intriguing opportunity for producing biochar with ... ...

    Abstract Abstract Biochar has shown potential as a sorbent for reducing Cd levels in water. Euhalophytes, which thrive in saline-alkali soils containing high concentrations of metal ions and anions, present an intriguing opportunity for producing biochar with inherent metal adsorption properties. This study focused on biochar derived from the euhalophyte Salicornia europaea and aimed to investigate its Cd adsorption capacity through adsorption kinetics and isotherm experiments. The results demonstrated that S. europaea biochar exhibited a high specific surface area, substantial base cation content, and a low negative surface charge, making it a highly effective adsorbent for Cd. The adsorption data fit well with the Langmuir isotherm model, revealing a maximum adsorption capacity of 108.54 mg g−1 at 25 °C. The adsorption process involved both surface adsorption and intraparticle diffusion. The Cd adsorption mechanism on the biochar encompassed precipitation, ion exchange, functional group complexation, and cation-π interactions. Notably, the precipitation of Cd2+ with CO3 2− in the biochar played a dominant role, accounting for 73.7% of the overall removal mechanism. These findings underscore the potential of euhalophytes such as S. europaea as a promising solution for remediating Cd contamination in aquatic environments.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 541
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Exploring adsorption capacity and mechanisms involved in cadmium removal from aqueous solutions by biochar derived from euhalophyte.

    Ge, Shaoqing / Zhao, Shuai / Wang, Lei / Zhao, Zhenyong / Wang, Shoule / Tian, Changyan

    Scientific reports

    2024  Band 14, Heft 1, Seite(n) 450

    Abstract: Biochar has shown potential as a sorbent for reducing Cd levels in water. Euhalophytes, which thrive in saline-alkali soils containing high concentrations of metal ions and anions, present an intriguing opportunity for producing biochar with inherent ... ...

    Abstract Biochar has shown potential as a sorbent for reducing Cd levels in water. Euhalophytes, which thrive in saline-alkali soils containing high concentrations of metal ions and anions, present an intriguing opportunity for producing biochar with inherent metal adsorption properties. This study focused on biochar derived from the euhalophyte Salicornia europaea and aimed to investigate its Cd adsorption capacity through adsorption kinetics and isotherm experiments. The results demonstrated that S. europaea biochar exhibited a high specific surface area, substantial base cation content, and a low negative surface charge, making it a highly effective adsorbent for Cd. The adsorption data fit well with the Langmuir isotherm model, revealing a maximum adsorption capacity of 108.54 mg g
    Mesh-Begriff(e) Cadmium/analysis ; Adsorption ; Water Purification/methods ; Water ; Charcoal ; Cations ; Kinetics ; Water Pollutants, Chemical/analysis
    Chemische Substanzen Cadmium (00BH33GNGH) ; biochar ; Water (059QF0KO0R) ; Charcoal (16291-96-6) ; Cations ; Water Pollutants, Chemical
    Sprache Englisch
    Erscheinungsdatum 2024-01-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-50525-2
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  5. Artikel: The complete mitochondrial genome of

    Fang, Jingping / Xu, Xiuming / Chen, Qinchang / Lin, Aiting / Lin, Shaoqing / Lei, Wen / Zhong, Cairong / Huang, Yongji / He, Yongjin

    Frontiers in microbiology

    2022  Band 13, Seite(n) 966219

    Abstract: ... The ... ...

    Abstract The haptophyte
    Sprache Englisch
    Erscheinungsdatum 2022-09-27
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.966219
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  6. Artikel ; Online: Stem cell-derived and circulating exosomal microRNAs as new potential tools for diabetic nephropathy management

    Lei Peng / Yu Chen / Shaoqing Shi / Heling Wen

    Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-

    2022  Band 19

    Abstract: Abstract Background Despite major advances in the treatment of diabetic nephropathy (DN) in recent years, it remains the most common cause of end-stage renal disease. An early diagnosis and therapy may slow down the DN progression. Numerous potential ... ...

    Abstract Abstract Background Despite major advances in the treatment of diabetic nephropathy (DN) in recent years, it remains the most common cause of end-stage renal disease. An early diagnosis and therapy may slow down the DN progression. Numerous potential biomarkers are currently being researched. Circulating levels of the kidney-released exosomes and biological molecules, which reflect the DN pathology including glomerular and tubular dysfunction as well as mesangial expansion and fibrosis, have shown the potential for predicting the occurrence and progression of DN. Moreover, many experimental therapies are currently being investigated, including stem cell therapy and medications targeting inflammatory, oxidant, or pro-fibrotic pathways activated during the DN progression. The therapeutic potential of stem cells is partly depending on their secretory capacity, particularly exosomal microRNAs (Exo-miRs). In recent years, a growing line of research has shown the participation of Exo-miRs in the pathophysiological processes of DN, which may provide effective therapeutic and biomarker tools for DN treatment. Methods A systematic literature search was performed in MEDLINE, Scopus, and Google Scholar to collect published findings regarding therapeutic stem cell-derived Exo-miRs for DN treatment as well as circulating Exo-miRs as potential DN-associated biomarkers. Findings Glomerular mesangial cells and podocytes are the most important culprits in the pathogenesis of DN and, thus, can be considered valuable therapeutic targets. Preclinical investigations have shown that stem cell-derived exosomes can exert beneficial effects in DN by transferring renoprotective miRs to the injured mesangial cells and podocytes. Of note, renoprotective Exo-miR-125a secreted by adipose-derived mesenchymal stem cells can improve the injured mesangial cells, while renoprotective Exo-miRs secreted by adipose-derived stem cells (Exo-miR-486 and Exo-miR-215-5p), human urine‐derived stem cells (Exo-miR-16-5p), and bone marrow-derived mesenchymal ...
    Schlagwörter Biomarker ; Exosome ; Diabetic nephropathy ; microRNA ; Serum ; Stem cell ; Medicine (General) ; R5-920 ; Biochemistry ; QD415-436
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel: Release characteristics of elemental mercury during low calorific value coal combustion.

    Gao, Libing / Liu, Kai / Guo, Shaoqing / Liang, Lei / Li, Hongyan

    Royal Society open science

    2022  Band 9, Heft 5, Seite(n) 211961

    Abstract: The dynamic release characteristics of ... ...

    Abstract The dynamic release characteristics of Hg
    Sprache Englisch
    Erscheinungsdatum 2022-05-24
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2787755-3
    ISSN 2054-5703
    ISSN 2054-5703
    DOI 10.1098/rsos.211961
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  8. Artikel ; Online: Author's reply - Clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID-19 infection.

    Lei, Shaoqing / Jiang, Fang / Xia, Zhong-Yuan / Xia, Zhengyuan

    EClinicalMedicine

    2020  Band 22, Seite(n) 100363

    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-04-29
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2020.100363
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  9. Artikel ; Online: FOXO1 reduces STAT3 activation and causes impaired mitochondrial quality control in diabetic cardiomyopathy.

    Zhou, Lu / Su, Wating / Wang, Yafeng / Zhang, Yuefu / Xia, Zhongyuan / Lei, Shaoqing

    Diabetes, obesity & metabolism

    2023  Band 26, Heft 2, Seite(n) 732–744

    Abstract: Aims: To investigate the role of FOXO1 in STAT3 activation and mitochondrial quality control in the diabetic heart.: Methods: Type 1 diabetes mellitus (T1DM) was induced in rats by a single intraperitoneal injection of 60 mg · kg: Results: Rats ... ...

    Abstract Aims: To investigate the role of FOXO1 in STAT3 activation and mitochondrial quality control in the diabetic heart.
    Methods: Type 1 diabetes mellitus (T1DM) was induced in rats by a single intraperitoneal injection of 60 mg · kg
    Results: Rats with T1DM or T2DM had excessive cardiac FOXO1 activation, accompanied by decreased STAT3 activation. Immunofluorescence and immunoprecipitation analysis showed colocalization and association of FOXO1 and STAT3 under basal conditions in isolated cardiomyocytes. Selective inhibition of FOXO1 activation by AS1842856 or FOXO1 siRNA transfection improved STAT3 activation, mitophagy and mitochondrial fusion, and decreased mitochondrial fission in isolated cardiomyocytes exposed to HG. Transfection with STAT3 siRNA further reduced mitophagy, mitochondrial fusion and increased mitochondrial fission in HG-treated cardiomyocytes. AS1842856 alleviated cardiac dysfunction, pathological damage and improved STAT3 activation, mitophagy and mitochondrial dynamics in diabetic db/db mice. Additionally, AS1842856 improved mitochondrial function indicated by increased mitochondrial membrane potential and adenosine triphosphate production and decreased mitochondrial reactive oxygen species production in isolated cardiomyocytes exposed to HG.
    Conclusions: Excessive FOXO1 activation during diabetes reduces STAT3 activation, with subsequent impairment of mitochondrial quality, ultimately promoting the development of diabetic cardiomyopathy.
    Mesh-Begriff(e) Animals ; Mice ; Rats ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/metabolism ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/metabolism ; Diabetic Cardiomyopathies ; Glucose/metabolism ; Mitochondria ; Myocytes, Cardiac/metabolism ; RNA, Small Interfering/therapeutic use
    Chemische Substanzen Glucose (IY9XDZ35W2) ; RNA, Small Interfering ; Foxo1 protein, rat ; Foxo1 protein, mouse ; Stat3 protein, rat ; Stat3 protein, mouse
    Sprache Englisch
    Erscheinungsdatum 2023-11-14
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.15369
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  10. Artikel ; Online: DJ-1 preserves ischemic postconditioning-induced cardioprotection in STZ-induced type 1 diabetic rats: role of PTEN and DJ-1 subcellular translocation.

    Li, Wei / Leng, Yan / Xiong, Yonghong / Li, Wenyuan / Cai, Yin / Xue, Rui / Chen, Rong / Lei, Shaoqing / Xia, Zhengyuan / Xia, Zhongyuan

    Cell communication and signaling : CCS

    2024  Band 22, Heft 1, Seite(n) 252

    Abstract: Background: Ischemic postconditioning (IPostC) has been reported as a promising method for protecting against myocardial ischemia-reperfusion (MI/R) injury. Our previous study found that the infarct-limiting effect of IPostC is abolished in the heart of ...

    Abstract Background: Ischemic postconditioning (IPostC) has been reported as a promising method for protecting against myocardial ischemia-reperfusion (MI/R) injury. Our previous study found that the infarct-limiting effect of IPostC is abolished in the heart of diabetes whose cardiac expression of DJ-1 (also called PARK7, Parkinsonism associated deglycase) is reduced. However, the role and in particular the underlying mechanism of DJ-1 in the loss of sensitivity to IPostC-induced cardioprotection in diabetic hearts remains unclear.
    Methods: Streptozotocin-induced type 1 diabetic rats were subjected to MI/R injury by occluding the left anterior descending artery (LAD) and followed by reperfusion. IPostC was induced by three cycles of 10s of reperfusion and ischemia at the onset of reperfusion. AAV9-CMV-DJ-1, AAV9-CMV-C106S-DJ-1 or AAV9-DJ-1 siRNA were injected via tail vein to either over-express or knock-down DJ-1 three weeks before inducing MI/R.
    Results: Diabetic rats subjected to MI/R exhibited larger infarct area, more severe oxidative injury concomitant with significantly reduced cardiac DJ-1 expression and increased PTEN expression as compared to non-diabetic rats. AAV9-mediated cardiac DJ-1 overexpression, but not the cardiac overexpression of DJ-1 mutant C106S, restored IPostC-induced cardioprotection and this effect was accompanied by increased cytoplasmic DJ-1 translocation toward nuclear and mitochondrial, reduced PTEN expression, and increased Nrf-2/HO-1 transcription. Our further study showed that AAV9-mediated targeted DJ-1 gene knockdown aggravated MI/R injury in diabetic hearts, and this exacerbation of MI/R injury was partially reversed by IPostC in the presence of PTEN inhibition or Nrf-2 activation.
    Conclusions: These findings suggest that DJ-1 preserves the cardioprotective effect of IPostC against MI/R injury in diabetic rats through nuclear and mitochondrial DJ-1 translocation and that inhibition of cardiac PTEN and activation of Nrf-2/HO-1 may represent the major downstream mechanisms whereby DJ-1 preserves the cardioprotective effect of IPostC in diabetes.
    Mesh-Begriff(e) Animals ; Protein Deglycase DJ-1/metabolism ; Protein Deglycase DJ-1/genetics ; PTEN Phosphohydrolase/metabolism ; PTEN Phosphohydrolase/genetics ; Ischemic Postconditioning ; Diabetes Mellitus, Experimental/metabolism ; Male ; Rats ; Rats, Sprague-Dawley ; Myocardial Reperfusion Injury/metabolism ; Myocardial Reperfusion Injury/pathology ; Myocardial Reperfusion Injury/genetics ; NF-E2-Related Factor 2/metabolism ; NF-E2-Related Factor 2/genetics ; Diabetes Mellitus, Type 1/metabolism ; Diabetes Mellitus, Type 1/complications ; Protein Transport ; Streptozocin ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology
    Chemische Substanzen Protein Deglycase DJ-1 (EC 3.1.2.-) ; PTEN Phosphohydrolase (EC 3.1.3.67) ; PARK7 protein, rat (EC 3.1.2.-) ; NF-E2-Related Factor 2 ; Streptozocin (5W494URQ81) ; Pten protein, rat (EC 3.1.3.67)
    Sprache Englisch
    Erscheinungsdatum 2024-05-02
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126315-2
    ISSN 1478-811X ; 1478-811X
    ISSN (online) 1478-811X
    ISSN 1478-811X
    DOI 10.1186/s12964-024-01638-2
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