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  1. Artikel: Microstructure and Dielectric Properties of Gradient Composite Ba

    Jili, Xiaobing / Gao, Libin / Chen, Hongwei / Zhang, Jihua

    Micromachines

    2024  Band 15, Heft 4

    Abstract: Multilayer ceramic capacitors (MLCCs) prepared using ... ...

    Abstract Multilayer ceramic capacitors (MLCCs) prepared using Ba
    Sprache Englisch
    Erscheinungsdatum 2024-03-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi15040470
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Anti-inflammatory or anti-SARS-CoV-2 ingredients in Huashi Baidu Decoction and their corresponding targets

    Zixuan Wang / Hongwei Gao

    Arabian Journal of Chemistry, Vol 16, Iss 5, Pp 104663- (2023)

    Target screening and molecular docking study

    2023  

    Abstract: Coronavirus disease 2019 (COVID-19) is a rapidly emerging infectious disease caused by SARS-CoV-2. Inflammatory factors may play essential roles in COVID-19 progression. Huashi Baidu Decoction (HSBD) is a traditional Chinese medicine (TCM) formula that ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is a rapidly emerging infectious disease caused by SARS-CoV-2. Inflammatory factors may play essential roles in COVID-19 progression. Huashi Baidu Decoction (HSBD) is a traditional Chinese medicine (TCM) formula that can expel cold, dispel dampness, and reduce inflammation. HSBD has been widely used for the treatment of COVID-19. However, the active ingredients and potential targets for HSBD to exert anti-inflammatory or anti-SARS-CoV-2 effects remain unclear. In this paper, the active ingredients with anti-inflammatory or anti-viral effects in HSBD and their potential targets were screened using the Discovery Studio 2020 software. By overlapping the targets of HSBD and COVID-19, 8 common targets (FYN, SFTPD, P53, RBP4, IL1RN, TTR, SRPK1, and AKT1) were identified. We determined 2 key targets (P53 and AKT1) by network pharmacology. The main active ingredients in HSBD were evaluated using the key targets as receptor proteins for molecular docking. The results suggested that the best active ingredients Kaempferol2 and Kaempferol3 have the potential as supplements for the treatment of COVID-19.
    Schlagwörter COVID-19 ; Anti-SARS-CoV-2 ; Anti-inflammatory ; Traditional Chinese medicine formula ; Target ; Active ingredient ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 540
    Sprache Englisch
    Erscheinungsdatum 2023-05-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel: A Theoretical Study on the Medicinal Properties and Eletronic Structures of Platinum(IV) Anticancer Agents With Cl Substituents.

    Yan, Xiaoyang / Gao, Hongwei

    Frontiers in oncology

    2022  Band 12, Seite(n) 860159

    Abstract: In this paper, we selected Pt(en) ... ...

    Abstract In this paper, we selected Pt(en)Cl
    Sprache Englisch
    Erscheinungsdatum 2022-05-19
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.860159
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  4. Artikel: Computer-aided drug design for virtual-screening and active-predicting of main protease (M

    Dai, Renhui / Gao, Hongwei / Su, Ruiling

    Frontiers in pharmacology

    2023  Band 14, Seite(n) 1288363

    Abstract: Introduction: ...

    Abstract Introduction:
    Sprache Englisch
    Erscheinungsdatum 2023-11-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1288363
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  5. Artikel ; Online: Anti-inflammatory or anti-SARS-CoV-2 ingredients in Huashi Baidu Decoction and their corresponding targets: Target screening and molecular docking study.

    Wang, Zixuan / Gao, Hongwei

    Arabian journal of chemistry

    2023  Band 16, Heft 5, Seite(n) 104663

    Abstract: Coronavirus disease 2019 (COVID-19) is a rapidly emerging infectious disease caused by SARS-CoV-2. Inflammatory factors may play essential roles in COVID-19 progression. Huashi Baidu Decoction (HSBD) is a traditional Chinese medicine (TCM) formula that ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is a rapidly emerging infectious disease caused by SARS-CoV-2. Inflammatory factors may play essential roles in COVID-19 progression. Huashi Baidu Decoction (HSBD) is a traditional Chinese medicine (TCM) formula that can expel cold, dispel dampness, and reduce inflammation. HSBD has been widely used for the treatment of COVID-19. However, the active ingredients and potential targets for HSBD to exert anti-inflammatory or anti-SARS-CoV-2 effects remain unclear. In this paper, the active ingredients with anti-inflammatory or anti-viral effects in HSBD and their potential targets were screened using the Discovery Studio 2020 software. By overlapping the targets of HSBD and COVID-19, 8 common targets (FYN, SFTPD, P53, RBP4, IL1RN, TTR, SRPK1, and AKT1) were identified. We determined 2 key targets (P53 and AKT1) by network pharmacology. The main active ingredients in HSBD were evaluated using the key targets as receptor proteins for molecular docking. The results suggested that the best active ingredients Kaempferol2 and Kaempferol3 have the potential as supplements for the treatment of COVID-19.
    Sprache Englisch
    Erscheinungsdatum 2023-02-15
    Erscheinungsland Saudi Arabia
    Dokumenttyp Journal Article
    ISSN 1878-5379
    ISSN (online) 1878-5379
    DOI 10.1016/j.arabjc.2023.104663
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: CircRNAs in cancer therapy tolerance.

    He, Miao / Pan, Yunyan / You, Chongge / Gao, Hongwei

    Clinica chimica acta; international journal of clinical chemistry

    2024  Band 558, Seite(n) 119684

    Abstract: The rapidly expanding field of circular RNA (circ-RNA) research has opened new avenues in cancer diagnostics and treatment, highlighting the role of serum circRNAs as potential biomarkers for assessing tumor therapy resistance. This review ... ...

    Abstract The rapidly expanding field of circular RNA (circ-RNA) research has opened new avenues in cancer diagnostics and treatment, highlighting the role of serum circRNAs as potential biomarkers for assessing tumor therapy resistance. This review comprehensively compiles existing knowledge regarding the biogenesis, function, and clinical relevance of circRNAs, emphasizing their stability, abundance, and cell type-specific expression profiles, which make them ideal candidates for noninvasive early biomarkers in cancer treatment. We explored the roles of circRNAs in oncogenesis and tumor progression and their complex interactions with patient responses to various cancer treatments, such as chemotherapy, radiotherapy, targeted therapy, and immunotherapy. Through the analysis of data from recent studies and clinical trials, we underscore the prognostic significance of serum circRNAs in predicting therapeutic outcomes, their involvement in resistance mechanisms, and their capacity to inform personalized treatment approaches. Additionally, this review addresses the obstacles inherent in circRNA research, including the need for standardized protocols for circRNA extraction and quantification and the elucidation of the clinical significance of circRNAs. Furthermore, our investigation extends to future prospects, including embedding circRNA profiling into regular clinical workflows and pioneering circRNA-based therapeutic approaches. We underscore the transformative potential of serum circRNAs in enhancing cancer diagnosis, improving the accuracy of therapy tolerance predictions, and ultimately fostering the advent of precision oncology.
    Mesh-Begriff(e) Humans ; RNA, Circular/genetics ; RNA, Circular/blood ; Neoplasms/genetics ; Neoplasms/diagnosis ; Neoplasms/therapy ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/blood ; Drug Resistance, Neoplasm/genetics
    Chemische Substanzen RNA, Circular ; Biomarkers, Tumor
    Sprache Englisch
    Erscheinungsdatum 2024-04-20
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2024.119684
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Case report: Giant coronary artery aneurysms with severe stenosis and multiple abdominal artery aneurysms.

    Gao, Hongli / Li, Hongwei

    Frontiers in medicine

    2023  Band 10, Seite(n) 1187690

    Abstract: Background: Giant coronary artery aneurysms (GCAAs) were relatively rare. Little was known about its characteristics, its etiology and its therapy. GCAAs with multiple abdominal artery aneurysms (AAAs) were more unusual and rarer.: Case presentation: ...

    Abstract Background: Giant coronary artery aneurysms (GCAAs) were relatively rare. Little was known about its characteristics, its etiology and its therapy. GCAAs with multiple abdominal artery aneurysms (AAAs) were more unusual and rarer.
    Case presentation: A 29-year-old female presented to our hospital with abrupt-onset abdominal pain in the left upper quadrant and then she died in 2018. In 2016, prior to this visit, she came to our department for intermittent retrosternal compression pain during rest or sports activities. Medical history showed she had a coronary artery aneurysm (CAA) in 2004. We found evidence of multiple coronary aneurysms with severe stenosis and multiple AAAs and coronary artery bypass grafting (CABG) was carried out. In combination with laboratory analysis, imaging studies, and pathological examination, CAA may result from the long-term effects of Kawasaki disease (KD). Finally, the patient died of a ruptured abdominal aneurysm.
    Conclusions: We report a rare case of GCAAs with severe stenosis and multiple AAAs in a young woman with a history of KD-induced coronary aneurysm. Although the understanding of the optimal treatment strategy for GCAAs combined with multiple aneurysms was limited, we found that CABG was effective in the treatment of GCAAs in this patient. In the clinical treatment of patients with GCAAs, attention should be paid to the examination of systemic blood vessels.
    Sprache Englisch
    Erscheinungsdatum 2023-05-25
    Erscheinungsland Switzerland
    Dokumenttyp Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1187690
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: A Review on Material Selection Benchmarking in GeTe-Based RF Phase-Change Switches for Each Layer.

    Qu, Sheng / Gao, Libin / Wang, Jiamei / Chen, Hongwei / Zhang, Jihua

    Micromachines

    2024  Band 15, Heft 3

    Abstract: The global demand for radio frequency (RF) modules and components has grown exponentially in recent decades. RF switches are the essential unit in RF front-end and reconfigurable systems leading to the rapid development of novel and advanced switch ... ...

    Abstract The global demand for radio frequency (RF) modules and components has grown exponentially in recent decades. RF switches are the essential unit in RF front-end and reconfigurable systems leading to the rapid development of novel and advanced switch technology. Germanium telluride (GeTe), as one of the Chalcogenide phase-change materials, has been applied as an RF switch due to its low insertion loss, high isolation, fast switching speed, and low power consumption in recent years. In this review, an in-depth exploration of GeTe film characterization is presented, followed by a comparison of the device structure of directly heated and indirectly heated RF phase-change switches (RFPCSs). Focusing on the prototypical structure of indirectly heated RFPCSs as the reference, the intrinsic properties of each material layer and the rationale behind the material selection is analyzed. Furthermore, the design size of each material layer of the device and its subsequent RF performance are summarized. Finally, we cast our gaze toward the promising future prospects of RFPCS technology.
    Sprache Englisch
    Erscheinungsdatum 2024-03-13
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi15030380
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: DFT Study on the Substituent Effect of Anticancer Picoline-Diazido-Pt(IV) Compounds.

    Mu, Meilin / Gao, Hongwei

    Frontiers in oncology

    2022  Band 11, Seite(n) 749178

    Abstract: The geometric structure of azido Pt(IV) compounds containing picoline was calculated by using density functional theory(DFT) at the LSDA/SDD level. The ESP distribution shows the possible reaction sites of the compounds. In addition, the frequency ... ...

    Abstract The geometric structure of azido Pt(IV) compounds containing picoline was calculated by using density functional theory(DFT) at the LSDA/SDD level. The ESP distribution shows the possible reaction sites of the compounds. In addition, the frequency calculation results assigned the infrared spectra of these compounds, and specified important stretching and bending vibrations. The HOMO-LUMO energy gaps of these compounds are also calculated to explain the charge transfer of the molecules. The distribution of Mulliken charges and natural atomic charges of these atoms is also calculated. Natural bond orbital(NBO) analysis explains the intramolecular interactions and their electron density.
    Sprache Englisch
    Erscheinungsdatum 2022-01-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.749178
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  10. Artikel ; Online: Value of cystatin C in predicting recurrence in patients with severe diabetic foot and diabetic foot ulcer.

    An, Jingsi / Yu, Hongwei / Gao, Zhenyu / Hu, Xiangka / Wang, Xueying

    Biomarkers in medicine

    2023  Band 17, Heft 5, Seite(n) 287–296

    Abstract: Objective: ...

    Abstract Objective:
    Mesh-Begriff(e) Humans ; Cystatin C/blood ; Diabetic Foot/diagnosis ; Risk Factors ; Recurrence
    Chemische Substanzen Cystatin C
    Sprache Englisch
    Erscheinungsdatum 2023-06-07
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2481014-9
    ISSN 1752-0371 ; 1752-0363
    ISSN (online) 1752-0371
    ISSN 1752-0363
    DOI 10.2217/bmm-2022-0837
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