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  1. Artikel: Immunomodulatory effect of chinese herbal medicine formula sheng-fei-yu-chuan-tang in lipopolysaccharide-induced acute lung injury mice.

    Lin, Chia-Hung / Yeh, Ching-Hua / Lin, Li-Jen / Wang, Shulhn-Der / Wang, Jen-Shu / Kao, Shung-Te

    Evidence-based complementary and alternative medicine : eCAM

    2013  Band 2013, Seite(n) 976342

    Abstract: Traditional Chinese medicine formula Sheng-Fei-Yu-Chuan-Tang (SFYCT), consisting of 13 ...

    Abstract Traditional Chinese medicine formula Sheng-Fei-Yu-Chuan-Tang (SFYCT), consisting of 13 medicinal plants, was used to treat patients with lung diseases. This study investigated the immunoregulatory effect of SFYCT on intratracheal lipopolysaccharides- (LPS-) challenged acute lung injury (ALI) mice. SFYCT attenuated pulmonary edema, macrophages, and neutrophils infiltration in the airways. SFYCT decreased inflammatory cytokines, including tumor necrosis factor- α (TNF α ), interleukin-1 β , and interleukin-6 and inhibited nitric oxide (NO) production but increased anti-inflammatory cytokines, interleukin-4, and interleukin-10, in the bronchoalveolar lavage fluid of LPS-challenged mice. TNF α and monocyte chemotactic protein-1 mRNA expression in the lung of LPS-challenged mice as well as LPS-stimulated lung epithelial cell and macrophage were decreased by SFYCT treatment. SFYCT treatment also decreased the inducible nitric oxide synthase expression and phosphorylation of nuclear factor- κ B (NF- κ B) in the lung of mice and macrophage with LPS stimulation. SFYCT treatment dose dependently decreased the LPS-induced NO and reactive oxygen species generation in LPS-stimulated macrophage. In conclusion, SFYCT attenuated lung inflammation during LPS-induced ALI through decreasing inflammatory cytokines production while increasing anti-inflammatory cytokines production. The immunoregulatory effect of SFYCT is related to inhibiting NF- κ B phosphorylation.
    Sprache Englisch
    Erscheinungsdatum 2013-08-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2013/976342
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: The Chinese Herbal Medicine Formula Sheng-Fei-Yu-Chuan-Tang Suppresses Th2 Responses and Increases IFN γ in Dermatophagoides pteronyssinus Induced Chronic Asthmatic Mice.

    Lin, Chia-Hung / Yeh, Ching-Hua / Lin, Li-Jen / Wang, Jen-Shu / Wang, Shulhn-Der / Kao, Shung-Te

    Evidence-based complementary and alternative medicine : eCAM

    2013  Band 2013, Seite(n) 984121

    Abstract: Sheng-Fei-Yu-Chuan-Tang (SFYCT), a traditional Chinese medicine formula consisting of 13 ...

    Abstract Sheng-Fei-Yu-Chuan-Tang (SFYCT), a traditional Chinese medicine formula consisting of 13 medicinal plants, has been used in the treatment of asthma. This study demonstrated the immunoregulatory effect of SFYCT on chronic allergic asthma using the Dermatophagoides-pteronyssinus- (Der p-) challenged chronic asthmatic murine model. SFYCT decreased the airway hyperresponseness (AHR), pulmonary inflammatory cell infiltration, and airway remodeling in Der p mice. SFYCT treatment decreased Der p-induced total IgE and Der-p-specific IgG1 but not IgG2a/2b Ab titer in serum of Der p mice. SFYCT also decreased Th2 cytokines, IL-4, IL-5, and IL-13, but increased IFN- γ and IL-12 in the BALF of Der p mice. TGF- β 1 and collagen production in the lung of mice were decreased by SFYCT. The mRNA expression of chemokine including Eotaxin, RANTES, and MCP-1 in the lung of Der p mice was decreased by SFYCT. In conclusion, the suppressed Der-p-induced airway inflammation, remodeling, and hyperresponseness in chronic asthma murine model are related to SFYCT inhibits Th2 responses, decreases chemokine expression and promotes IFN- γ and IL-12 production. SFYCT could show Der-p-induced Th2 responses to Th1 responses by increasing IFN- γ which is merit for clinical application on asthma patients.
    Sprache Englisch
    Erscheinungsdatum 2013-03-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2013/984121
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

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  3. Artikel ; Online: Immunomodulatory Effect of Chinese Herbal Medicine Formula Sheng-Fei-Yu-Chuan-Tang in Lipopolysaccharide-Induced Acute Lung Injury Mice

    Chia-Hung Lin / Ching-Hua Yeh / Li-Jen Lin / Shulhn-Der Wang / Jen-Shu Wang / Shung-Te Kao

    Evidence-Based Complementary and Alternative Medicine, Vol

    2013  Band 2013

    Abstract: Traditional Chinese medicine formula Sheng-Fei-Yu-Chuan-Tang (SFYCT), consisting of 13 ...

    Abstract Traditional Chinese medicine formula Sheng-Fei-Yu-Chuan-Tang (SFYCT), consisting of 13 medicinal plants, was used to treat patients with lung diseases. This study investigated the immunoregulatory effect of SFYCT on intratracheal lipopolysaccharides- (LPS-) challenged acute lung injury (ALI) mice. SFYCT attenuated pulmonary edema, macrophages, and neutrophils infiltration in the airways. SFYCT decreased inflammatory cytokines, including tumor necrosis factor-α (TNFα), interleukin-1β, and interleukin-6 and inhibited nitric oxide (NO) production but increased anti-inflammatory cytokines, interleukin-4, and interleukin-10, in the bronchoalveolar lavage fluid of LPS-challenged mice. TNFα and monocyte chemotactic protein-1 mRNA expression in the lung of LPS-challenged mice as well as LPS-stimulated lung epithelial cell and macrophage were decreased by SFYCT treatment. SFYCT treatment also decreased the inducible nitric oxide synthase expression and phosphorylation of nuclear factor-κB (NF-κB) in the lung of mice and macrophage with LPS stimulation. SFYCT treatment dose dependently decreased the LPS-induced NO and reactive oxygen species generation in LPS-stimulated macrophage. In conclusion, SFYCT attenuated lung inflammation during LPS-induced ALI through decreasing inflammatory cytokines production while increasing anti-inflammatory cytokines production. The immunoregulatory effect of SFYCT is related to inhibiting NF-κB phosphorylation.
    Schlagwörter Other systems of medicine ; RZ201-999
    Sprache Englisch
    Erscheinungsdatum 2013-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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  4. Artikel ; Online: The Chinese Herbal Medicine Formula Sheng-Fei-Yu-Chuan-Tang Suppresses Th2 Responses and Increases IFNγ in Dermatophagoides pteronyssinus Induced Chronic Asthmatic Mice

    Chia-Hung Lin / Ching-Hua Yeh / Li-Jen Lin / Jen-Shu Wang / Shulhn-Der Wang / Shung-Te Kao

    Evidence-Based Complementary and Alternative Medicine, Vol

    2013  Band 2013

    Abstract: Sheng-Fei-Yu-Chuan-Tang (SFYCT), a traditional Chinese medicine formula consisting of 13 ...

    Abstract Sheng-Fei-Yu-Chuan-Tang (SFYCT), a traditional Chinese medicine formula consisting of 13 medicinal plants, has been used in the treatment of asthma. This study demonstrated the immunoregulatory effect of SFYCT on chronic allergic asthma using the Dermatophagoides-pteronyssinus- (Der p-) challenged chronic asthmatic murine model. SFYCT decreased the airway hyperresponseness (AHR), pulmonary inflammatory cell infiltration, and airway remodeling in Der p mice. SFYCT treatment decreased Der p-induced total IgE and Der-p-specific IgG1 but not IgG2a/2b Ab titer in serum of Der p mice. SFYCT also decreased Th2 cytokines, IL-4, IL-5, and IL-13, but increased IFN-γ and IL-12 in the BALF of Der p mice. TGF-β1 and collagen production in the lung of mice were decreased by SFYCT. The mRNA expression of chemokine including Eotaxin, RANTES, and MCP-1 in the lung of Der p mice was decreased by SFYCT. In conclusion, the suppressed Der-p-induced airway inflammation, remodeling, and hyperresponseness in chronic asthma murine model are related to SFYCT inhibits Th2 responses, decreases chemokine expression and promotes IFN-γ and IL-12 production. SFYCT could show Der-p-induced Th2 responses to Th1 responses by increasing IFN-γ which is merit for clinical application on asthma patients.
    Schlagwörter Other systems of medicine ; RZ201-999
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2013-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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  5. Buch: Lin mu yi chuan yu zhong xue

    Wang, Mingma

    2001  

    Verfasserangabe Wang Minma zhu bian
    Schlagwörter Forest genetics. ; Trees/Breeding.
    Sprache Chinesisch
    Umfang 422 p., [4] p. of plates :, ill. (some col.) ;, 26 cm.
    Ausgabenhinweis Di 1 ban.
    Verlag Zhongguo nong ye chu ban she
    Erscheinungsort Beijing
    Dokumenttyp Buch
    Anmerkung "Guo jia ke xue ji shu xue shu zhu zuo chu ban ji jin zi zhu chu ban."
    ISBN 7503827599 ; 9787503827594
    Datenquelle NAL Katalog (AGRICOLA)

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  6. Buch: Zhongguo yi chuan lun li de zheng ming yu tan suo

    Wang, Yanguang

    The ethical disputes and exploration on ethics of genetics in China

    (Sheng ming ke xue jiao cha yan jiu cong shu)

    2006  

    Titelvarianten Ethical disputes and exploration on ethics of genetics in China
    Verfasserangabe Wang Yanguang zhu bian
    Serientitel Sheng ming ke xue jiao cha yan jiu cong shu
    Mesh-Begriff(e) Bioethical Issues ; Genetic Engineering/ethics ; Genetic Techniques/ethics
    Schlagwörter China
    Sprache Chinesisch
    Umfang v, 206 p. :, ill. ;, 24 cm.
    Ausgabenhinweis Di 1 ban.
    Verlag Ke xue chu ban she
    Erscheinungsort Beijing
    Dokumenttyp Buch
    ISBN 9787030161642 ; 7030161645
    Datenquelle Katalog der US National Library of Medicine (NLM)

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  7. Artikel: Fungal communities associated with early immature tubers of wild

    Li, Dong / Jin, Xiao-Han / Li, Yu / Wang, Yu-Chuan / He, Hai-Yan / Zhang, Han-Bo

    Ecology and evolution

    2024  Band 14, Heft 2, Seite(n) e11004

    Abstract: Full myco-heterotrophic ... ...

    Abstract Full myco-heterotrophic orchid
    Sprache Englisch
    Erscheinungsdatum 2024-02-21
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2635675-2
    ISSN 2045-7758
    ISSN 2045-7758
    DOI 10.1002/ece3.11004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: CHARGE syndrome with de novo frameshift mutation in a patient with total retinal detachment and large choroidal coloboma.

    Yu-Chuan Kang, Eugene / Wang, Nan-Kai / Wu, Wei-Chi

    American journal of ophthalmology case reports

    2022  Band 25, Seite(n) 101352

    Sprache Englisch
    Erscheinungsdatum 2022-02-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2451-9936
    ISSN (online) 2451-9936
    DOI 10.1016/j.ajoc.2022.101352
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  9. Artikel ; Online: Simultaneous improvement of thermostability and maltotriose-forming ability of a fungal α-amylase for bread making by directed evolution.

    Wang, Yu-Chuan / Ma, Jun-Wen / Liu, Hai-Jie / Jiang, Zheng-Qiang / Li, Yan-Xiao

    International journal of biological macromolecules

    2024  Band 264, Heft Pt 1, Seite(n) 130481

    Abstract: For applications in food industries, a fungal α-amylase from Malbranchea cinnamomea was engineered by directed evolution. Through two rounds of screening, a mutant α-amylase (mMcAmyA) was obtained with higher optimal temperature (70 °C, 5 °C increase) ... ...

    Abstract For applications in food industries, a fungal α-amylase from Malbranchea cinnamomea was engineered by directed evolution. Through two rounds of screening, a mutant α-amylase (mMcAmyA) was obtained with higher optimal temperature (70 °C, 5 °C increase) and better hydrolysis properties (18.6 % maltotriose yield, 2.5-fold increase) compared to the wild-type α-amylase (McAmyA). Site-directed mutations revealed that Threonine (Thr) 226 Serine (Ser) substitution was the main reason for the property evolution of mMcAmyA. Through high cell density fermentation, the highest expression level of Thr226Ser was 3951 U/mL. Thr226Ser was further used for bread baking with a dosage of 1000 U/kg flour, resulting in a 17.8 % increase in specific volume and a 35.6 % decrease in hardness compared to the control. The results were a significant improvement on those of McAmyA. Moreover, the mutant showed better anti-staling properties compared to McAmyA, as indicated by the improved sensory evaluation after 4 days of storage at 4 and 25 °C. These findings provide insights into the structure-function relationship of fungal α-amylase and introduce a potential candidate for bread-making industry.
    Mesh-Begriff(e) alpha-Amylases/genetics ; alpha-Amylases/metabolism ; Bread ; Hydrolysis ; Trisaccharides
    Chemische Substanzen alpha-Amylases (EC 3.2.1.1) ; maltotriose (639K0T34IK) ; Trisaccharides
    Sprache Englisch
    Erscheinungsdatum 2024-02-29
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.130481
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: NR1H4 disease: rapidly progressing neonatal intrahepatic cholestasis and early death.

    Li, Zhong-Die / Li, Yu-Chuan / Jing-Zhao / Wang, Jian-She / Xie, Xin-Bao

    Orphanet journal of rare diseases

    2024  Band 19, Heft 1, Seite(n) 171

    Abstract: Background: Clinical studies on progressive familial intrahepatic cholestasis (PFIC) type 5 caused by mutations in NR1H4 are limited.: Methods: New patients with biallelic NR1H4 variants from our center and all patients from literature were ... ...

    Abstract Background: Clinical studies on progressive familial intrahepatic cholestasis (PFIC) type 5 caused by mutations in NR1H4 are limited.
    Methods: New patients with biallelic NR1H4 variants from our center and all patients from literature were retrospectively analyzed.
    Results: Three new patients were identified to be carrying five new variants. Liver phenotypes of our patients manifests as low-γ-glutamyl transferase cholestasis, liver failure and related complications. One patient underwent liver transplantation (LT) and survived, and two other patients died without LT. Nine other patients were collected through literature review. Twelve out of 13 patients showed neonatal jaundice, with the median age of onset being 7 days after birth. Reported clinical manifestations included cholestasis (13/13, 100%), elevated AFP (11/11, 100%), coagulopathy (11/11, 100%), hypoglycemia (9/13, 69%), failure to thrive (8/13, 62%), splenomegaly (7/13, 54%), hyperammonemia (7/13, 54%), and hepatomegaly (6/13, 46%). Six of 13 patients received LT at a median age of 6.2 months, and only one patient died of acute infection at one year after LT. Other 7 patients had no LT and died with a median age of 5 months (range 1.2-8). There were 8 patients with homozygous genotype and 5 patients with compound heterozygous genotype. In total, 13 different variants were detected, and 5 out of 12 single or multiple nucleotides variants were located in exon 5.
    Conclusions: We identified three newly-diagnosed patients and five novel mutations. NR1H4-related PFIC typically cause progressive disease and early death. LT may be the only lifesaving therapy leading to cure.
    Mesh-Begriff(e) Humans ; Infant, Newborn ; Infant ; Retrospective Studies ; Cholestasis, Intrahepatic/genetics ; Cholestasis, Intrahepatic/diagnosis ; Cholestasis, Intrahepatic/therapy ; Cholestasis/genetics
    Sprache Englisch
    Erscheinungsdatum 2024-04-19
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2225857-7
    ISSN 1750-1172 ; 1750-1172
    ISSN (online) 1750-1172
    ISSN 1750-1172
    DOI 10.1186/s13023-024-03166-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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