Artikel ; Online: Impaired Glymphatic Flow on Diffusion Tensor MRI as a Marker of Neurodegeneration in Alzheimer's Disease: Correlation with Gray Matter Volume Loss and Cognitive Decline Independent of Cerebral Amyloid Deposition.
Journal of Alzheimer's disease : JAD
2024 Band 99, Heft 1, Seite(n) 279–290
Abstract: Background: Impaired glymphatic flow on the Alzheimer's disease (AD) spectrum may be evaluated using diffusion tensor image analysis along the perivascular space (DTI-ALPS).: Objective: We aimed to validate impaired glymphatic flow and explore its ... ...
Abstract | Background: Impaired glymphatic flow on the Alzheimer's disease (AD) spectrum may be evaluated using diffusion tensor image analysis along the perivascular space (DTI-ALPS). Objective: We aimed to validate impaired glymphatic flow and explore its association with gray matter volume, cognitive status, and cerebral amyloid deposition on the AD spectrum. Methods: 80 participants (mean age, 76.9±8.5 years; 57 women) with AD (n = 65) and cognitively normal (CN) (n = 15) who underwent 3T brain MRI including DTI and/or amyloid PET were included. After adjusting for age, sex, apolipoprotein E status, and burden of white matter hyperintensities, the ALPS-index was compared according to the AD spectrum. The association between the ALPS-index and gray matter volume, cognitive status, and quantitative amyloid from PET was assessed. Results: The ALPS-index in the AD was significantly lower (mean, 1.476; 95% CI, 1.395-1.556) than in the CN (1.784;1.615-1.952; p = 0.026). Volumes of the entorhinal cortex, hippocampus, temporal pole, and primary motor cortex showed significant associations with the ALPS-index (all, p < 0.05). There was a positive correlation between the ALPS-index and MMSE score (partial r = 0.435; p < 0.001), but there was no significant correlation between the ALPS-index and amyloid SUVRs (all, p > 0.05). Conclusions: Decreased glymphatic flow measured by DTI-ALPS in AD may serve as a marker of neurodegeneration correlating with structural atrophy and cognitive decline. |
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Mesh-Begriff(e) | Humans ; Female ; Male ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/pathology ; Alzheimer Disease/metabolism ; Aged ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/metabolism ; Cognitive Dysfunction/pathology ; Gray Matter/diagnostic imaging ; Gray Matter/pathology ; Gray Matter/metabolism ; Diffusion Tensor Imaging ; Glymphatic System/diagnostic imaging ; Glymphatic System/pathology ; Glymphatic System/metabolism ; Positron-Emission Tomography ; Aged, 80 and over ; Brain/diagnostic imaging ; Brain/pathology ; Brain/metabolism |
Sprache | Englisch |
Erscheinungsdatum | 2024-04-26 |
Erscheinungsland | Netherlands |
Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 1440127-7 |
ISSN | 1875-8908 ; 1387-2877 |
ISSN (online) | 1875-8908 |
ISSN | 1387-2877 |
DOI | 10.3233/JAD-231131 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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