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  1. Artikel ; Online: Diminished LAG3

    Hu, Suiyuan / Tao, Yuting / Hu, Fanlei / Liu, Xu

    Annals of medicine

    2023  Band 55, Heft 1, Seite(n) 2208373

    Abstract: Background: Lymphocyte activation gene-3 (LAG3) positive B cells have been identified as a novel regulatory B cell subset, while the role of LAG3: Materials and methods: Peripheral blood mononuclear cells (PBMCs) from RA, osteoarthritis (OA) patients ...

    Abstract Background: Lymphocyte activation gene-3 (LAG3) positive B cells have been identified as a novel regulatory B cell subset, while the role of LAG3
    Materials and methods: Peripheral blood mononuclear cells (PBMCs) from RA, osteoarthritis (OA) patients and healthy volunteers were collected for flow cytometry staining of LAG3
    Results: A significant decrease of LAG3
    Conclusions: Impairment of LAG3
    Mesh-Begriff(e) Animals ; Humans ; Mice ; Arthritis, Experimental/pathology ; Arthritis, Rheumatoid ; Leukocytes, Mononuclear
    Chemische Substanzen Lag3 protein, human ; Lag3 protein, mouse
    Sprache Englisch
    Erscheinungsdatum 2023-05-04
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2023.2208373
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Diminished LAG3+ B cells correlate with exacerbated rheumatoid arthritis

    Suiyuan Hu / Yuting Tao / Fanlei Hu / Xu Liu

    Annals of Medicine, Vol 55, Iss

    2023  Band 1

    Abstract: AbstractBackground Lymphocyte activation gene-3 (LAG3) positive B cells have been identified as a novel regulatory B cell subset, while the role of LAG3+ B cells in the pathogenesis of rheumatoid arthritis (RA) remains elusive.Materials and methods ... ...

    Abstract AbstractBackground Lymphocyte activation gene-3 (LAG3) positive B cells have been identified as a novel regulatory B cell subset, while the role of LAG3+ B cells in the pathogenesis of rheumatoid arthritis (RA) remains elusive.Materials and methods Peripheral blood mononuclear cells (PBMCs) from RA, osteoarthritis (OA) patients and healthy volunteers were collected for flow cytometry staining of LAG3+ B cells. Their correlation with RA patient clinical and immunological features were analyzed. Moreover, the frequencies of LAG3+ B cells in collagen-induced arthritis (CIA) mice and naive mice were also detected.Results A significant decrease of LAG3+ B cells was observed in RA patients as compared with healthy individuals and OA patients. Notably, the frequencies of LAG3+ B cells were negatively correlated with tender joint count (r = −0.4301, p = .0157) and DAS28-ESR (r = −0.4018, p = .025) in RA patients. In CIA mice, LAG3+ B cell frequencies were also decreased and negatively correlated with the CIA arthritis score.Conclusions Impairment of LAG3+ B cells potentially contributes to RA development. Reconstituting LAG3+ B cells might provide novel therapeutic strategies for the persistent disease.Key messagesLAG3+ B cells have been identified as a novel regulatory B cell subset. However, its role in the pathogenesis of RA remains unknown.This study revealed the decreased frequency of LAG3+ B cells in RA patients. Notably, LAG3+ B cells were negatively correlated with RA disease activity including the tender joint count and DAS28-ESR.In CIA mice, LAG3+ B cell frequencies were also decreased and negatively correlated with the CIA arthritis score.Reconstitution of LAG3+ B cells might provide novel therapeutic strategies for disease perpetuation.
    Schlagwörter Immunotherapy ; LAG3 ; rheumatoid arthritis ; regulatory B cells ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag Taylor & Francis Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Immunological role of Gas6/TAM signaling in hemostasis and thrombosis.

    Li, Fanshu / Xu, Liling / Li, Chun / Hu, Fanlei / Su, Yin

    Thrombosis research

    2024  Band 238, Seite(n) 161–171

    Abstract: The immune system is an emerging regulator of hemostasis and thrombosis. The concept of immunothrombosis redefines the relationship between coagulation and immunomodulation, and the Gas6/Tyro3-Axl-MerTK (TAM) signaling pathway builds the bridge across ... ...

    Abstract The immune system is an emerging regulator of hemostasis and thrombosis. The concept of immunothrombosis redefines the relationship between coagulation and immunomodulation, and the Gas6/Tyro3-Axl-MerTK (TAM) signaling pathway builds the bridge across them. During coagulation, Gas6/TAM signaling pathway not only activates platelets, but also promotes thrombosis through endothelial cells and vascular smooth muscle cells involved in inflammatory responses. Thrombosis appears to be a common result of a Gas6/TAM signaling pathway-mediated immune dysregulation. TAM TK and its ligands have been found to be involved in coagulation through the PI3K/AKT or JAK/STAT pathway in various systemic diseases, providing new perspectives in the understanding of immunothrombosis. Gas6/TAM signaling pathway serves as a breakthrough target for novel therapeutic strategies to improve disease management. Many preclinical and clinical studies of TAM receptor inhibitors are in process, confirming the pivotal role of Gas6/TAM signaling pathway in immunothrombosis. Therapeutics targeting the TAM receptor show potential both in anticoagulation management and immunotherapy. Here, we review the immunological functions of the Gas6/TAM signaling pathway in coagulation and its multiple mechanisms in diseases identified to date, and discuss the new clinical strategies that may generated by these roles.
    Sprache Englisch
    Erscheinungsdatum 2024-05-03
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2024.05.002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Raman spectroscopy as a promising diagnostic method for rheumatoid arthritis.

    Cao, Lulu / Zheng, Xi / Han, Peng / Ren, Limin / Jing Wang / Hu, Fanlei / Li, Zhanguo

    Analytical methods : advancing methods and applications

    2023  Band 15, Heft 6, Seite(n) 709–718

    Abstract: ... ...

    Abstract Background
    Mesh-Begriff(e) Humans ; Spectrum Analysis, Raman ; Arthritis, Rheumatoid/diagnosis ; Rheumatoid Factor ; Autoantibodies ; Anti-Citrullinated Protein Antibodies
    Chemische Substanzen Rheumatoid Factor (9009-79-4) ; Autoantibodies ; Anti-Citrullinated Protein Antibodies
    Sprache Englisch
    Erscheinungsdatum 2023-02-09
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d2ay01904c
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Effect of polydimethylsiloxane surface morphology on osteogenic differentiation of mesenchymal stem cells through SIRT1 signalling pathway.

    Hu, Zezun / Yang, Fanlei / Xiang, Pan / Luo, Zongping / Liang, Ting / Xu, Hao

    Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine

    2024  Band 238, Heft 5, Seite(n) 537–549

    Abstract: Constructing surface topography with a certain roughness is a widely used, non-toxic, cost-effective and effective method for improving the microenvironment of cells, promoting the proliferation and osteogenic differentiation of mesenchymal stem cells ( ... ...

    Abstract Constructing surface topography with a certain roughness is a widely used, non-toxic, cost-effective and effective method for improving the microenvironment of cells, promoting the proliferation and osteogenic differentiation of mesenchymal stem cells (MSCs), and promoting the osseointegration of grafts and further improving their biocompatibility under clinical environmental conditions. SIRT1 plays an important regulatory role in the osteogenic differentiation of bone marrow-derived MSCs (BM-MSCs). However, it remains unknown whether SIRT1 plays an important regulatory role in the osteogenic differentiation of BM-MSCs with regard to surface morphology. Polydimethylsiloxane (PDMS) with different surface morphologies were prepared using different grits of sandpaper. The value for BMSCs added on different surfaces was detected by cell proliferation assays. RT-qPCR and Western blotting were performed to detect SIRT1 activation and osteogenic differentiation of MSCs. Osteogenesis of MSCs was detected by alkaline phosphatase (ALP) and alizarin red S staining. SIRT1 inhibition experiments were performed to investigate the role of SIRT1 in the osteogenic differentiation of MSCs induced by surface morphology. We found that BM-MSCs have better value and osteogenic differentiation ability on a surface with roughness of PDMS-1000M. SIRT1 showed higher gene and protein expression on a PDMS-1000M surface with a roughness of 13.741 ± 1.388 µm. The promotion of the osteogenic differentiation of MSCs on the PDMS-1000M surface was significantly decreased after inhibiting SIRT1 expression. Our study demonstrated that a surface morphology with certain roughness can activate the SIRT1 pathway of MSCs and promote the osteogenic differentiation of BMSCs via the SIRT1 pathway.
    Mesh-Begriff(e) Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Mesenchymal Stem Cells/drug effects ; Sirtuin 1/metabolism ; Sirtuin 1/genetics ; Osteogenesis/drug effects ; Cell Differentiation/drug effects ; Dimethylpolysiloxanes/chemistry ; Dimethylpolysiloxanes/pharmacology ; Surface Properties ; Signal Transduction/drug effects ; Animals ; Cell Proliferation/drug effects
    Chemische Substanzen Sirtuin 1 (EC 3.5.1.-) ; Dimethylpolysiloxanes ; baysilon (63148-62-9)
    Sprache Englisch
    Erscheinungsdatum 2024-04-01
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1065942-0
    ISSN 2041-3033 ; 0046-2039 ; 0954-4119
    ISSN (online) 2041-3033
    ISSN 0046-2039 ; 0954-4119
    DOI 10.1177/09544119241242964
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Double-negative (DN) B cells: an under-recognized effector memory B cell subset in autoimmunity.

    Li, Yuzi / Li, Zhanguo / Hu, Fanlei

    Clinical and experimental immunology

    2021  Band 205, Heft 2, Seite(n) 119–127

    Abstract: Human B cells could be divided into four classical subsets based on CD27 and immunoglobulin (Ig)D expression. Distinct from the other three well-studied subsets, ... ...

    Abstract Human B cells could be divided into four classical subsets based on CD27 and immunoglobulin (Ig)D expression. Distinct from the other three well-studied subsets, CD27
    Mesh-Begriff(e) Animals ; Autoimmune Diseases/immunology ; B-Lymphocyte Subsets/immunology ; Humans ; Immunoglobulin D/immunology ; Immunologic Memory/immunology
    Chemische Substanzen Immunoglobulin D
    Sprache Englisch
    Erscheinungsdatum 2021-06-06
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 218531-3
    ISSN 1365-2249 ; 0009-9104 ; 0964-2536
    ISSN (online) 1365-2249
    ISSN 0009-9104 ; 0964-2536
    DOI 10.1111/cei.13615
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  7. Artikel ; Online: Scavenger receptor A in immunity and autoimmune diseases: Compelling evidence for targeted therapy.

    Xie, Yang / Jia, Yuan / Li, Zhanguo / Hu, Fanlei

    Expert opinion on therapeutic targets

    2022  Band 26, Heft 5, Seite(n) 461–477

    Abstract: Introduction: Scavenger receptor A (SR-A) is reported to be involved in innate and adaptive immunity and in recent years, the soluble form of SR-A has also been identified. Intriguingly, SR-A displays double-edged sword features in different diseases. ... ...

    Abstract Introduction: Scavenger receptor A (SR-A) is reported to be involved in innate and adaptive immunity and in recent years, the soluble form of SR-A has also been identified. Intriguingly, SR-A displays double-edged sword features in different diseases. Moreover, targeted therapy on SR-A, including genetic modulation, small molecule inhibitor, inhibitory peptides, fucoidan, and blocking antibodies, provides potential strategies for treatment. Currently, therapeutics targeting SR-A are in preclinical studies and clinical trials, revealing great perspectives in future immunotherapy.
    Areas covered: Through searching PubMed (January 1979-March 2022) and clinicaltrials.gov, we review most of the research and clinical trials involving SR-A. This review briefly summarizes recent study advances on SR-A, with particular concern on its role in immunity and autoimmune diseases.
    Expert opinion: Given the emerging evidence of SR-A in immunity, its targeted therapy has been studied in various diseases, especially autoimmune diseases. However, many challenges still remain to be overcome, such as the double-sworded effects and the specific isoform targeting. For further clinical success of SR-A targeted therapy, the crystal structure illustration and the dual function discrimination of SR-A should be further investigated. Nevertheless, although challenging, targeting SR-A would be a potential effective strategy in the treatment of autoimmune diseases and other immune-related diseases.
    Mesh-Begriff(e) Adaptive Immunity ; Autoimmune Diseases/drug therapy ; Humans ; Immunotherapy ; Receptors, Scavenger
    Chemische Substanzen Receptors, Scavenger
    Sprache Englisch
    Erscheinungsdatum 2022-05-12
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1080/14728222.2022.2072729
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  8. Artikel: Research hotspots and trends on acupuncture treatment for headache: a bibliometric analysis from 2003 to 2023.

    Zhao, Shun / Hu, Songfeng / Luo, Yujing / Li, Wangjun / Zhao, Fenfen / Wang, Changkang / Meng, Fanlei / He, Xingwei

    Frontiers in neuroscience

    2024  Band 18, Seite(n) 1338323

    Abstract: Background: While acupuncture treatment has gained extensive usage in addressing headaches, there remains a notable gap in the literature analysis for this field. Therefore, this study aims to conduct a literature review using Citespace, VOSviewer, and ... ...

    Abstract Background: While acupuncture treatment has gained extensive usage in addressing headaches, there remains a notable gap in the literature analysis for this field. Therefore, this study aims to conduct a literature review using Citespace, VOSviewer, and Bibliometrix, aiming to examine the current status, strengths, and potential future directions in the utilization of acupuncture for headache treatment.
    Methods: Relevant literature on acupuncture treatment for headaches between 2003 and 2023 was retrieved from the Web of Science (WoS) core database. Utilizing CiteSpace 6.1.R6, VOSviewer 1.6.18, and Bibliometrix 4.1.4, we conducted bibliometric analyses across various categories, including countries/regions, institutions, authors, journals, references, and keywords.
    Results: A total of 808 research reports were included. China and the United States have significantly contributed to this field. Chengdu University of Chinese Medicine holds the record for the highest number of published papers. Liu Lu has the highest publication output, while Linde K has the highest citation rate.
    Conclusion: Acupuncture treatment for headaches has established a stable trend with a promising developmental trajectory. Research in this field mainly focuses on different acupuncture prevention and treatment for various types of headaches, the safety and efficacy of acupuncture, etc. Research on the mechanism of action mainly focuses on interpreting bidirectional and holistic regulation between pain and emotion by acupuncture and the regulation of brain function connection and neuroimaging technology by acupuncture. Future research should expand on the advantages and indications of acupuncture treatment for different headaches and their modern mechanisms.
    Sprache Englisch
    Erscheinungsdatum 2024-03-21
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2024.1338323
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  9. Artikel ; Online: Soluble CD24 is an inflammatory biomarker in early and seronegative rheumatoid arthritis.

    Zheng, Xi / Wang, Ping / Song, Jing / Tang, Yundi / Xie, Yang / Jin, Xu / Zhu, Danxue / Fang, Xiangyu / Wei, Chaonan / Li, Ru / Hu, Fanlei / Li, Zhanguo

    Annals of medicine

    2023  Band 55, Heft 2, Seite(n) 2246370

    Abstract: Introduction: ...

    Abstract Introduction:
    Mesh-Begriff(e) Humans ; Arthritis, Rheumatoid/diagnosis ; Rheumatic Diseases ; Biomarkers ; Clinical Relevance ; Enzyme-Linked Immunosorbent Assay ; CD24 Antigen
    Chemische Substanzen Biomarkers ; CD24 protein, human ; CD24 Antigen
    Sprache Englisch
    Erscheinungsdatum 2023-08-17
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2023.2246370
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  10. Artikel ; Online: Elevated expression of hsa_circ_0000479 in neutrophils correlates with features of systemic lupus erythematosus.

    Yao, Ranran / Xu, Liling / Cheng, Gong / Wang, Ziye / Liang, Ruyu / Pei, Wenwen / Cao, Lulu / Jia, Yuan / Ye, Hua / Hu, Fanlei / Su, Yin

    Annals of medicine

    2024  Band 56, Heft 1, Seite(n) 2309607

    Abstract: Objective: Accumulating evidence suggests that differentially expressed circular RNAs (circRNAs) play critical roles in immune cells of systemic lupus erythematosus (SLE) patients. Hsa_circ_0000479 has been studied in the field of cancer and infection, ... ...

    Abstract Objective: Accumulating evidence suggests that differentially expressed circular RNAs (circRNAs) play critical roles in immune cells of systemic lupus erythematosus (SLE) patients. Hsa_circ_0000479 has been studied in the field of cancer and infection, whereas seldom studied in autoimmune diseases. The aim of this study was to investigate the role and clinical value of neutrophil hsa_circ_0000479 in SLE.
    Methods: The expression levels of hsa_circ_0000479 in both healthy individuals and SLE patients' neutrophils were detected by qPCR and compared with those in peripheral blood mononuclear cells (PBMCs) . In addition, the correlation of hsa_circ_0000479 levels in neutrophils with the clinical and immunological features of SLE patients was also analysed.
    Results: The expression levels of hsa_circ_0000479 in the patients with SLE were significantly higher in neutrophils than that of PBMCs, and also significantly higher than that in healthy controls (HCs). Moreover, the expression levels of hsa_circ_0000479 in neutrophils were negatively associated with absolute neutrophil count and complement 3 (C3), whereas positively correlated with anti-dsDNA and anti-nucleosome antibodies in SLE. In addition, SLE patients with higher levels of hsa_circ_0000479 demonstrated more several clinical manifestations, including Raynaud's phenomenon, alopecia and leucopenia.
    Conclusions: Hsa_circ_0000479 is up-regulated in neutrophils of SLE patients, and is also associated with several important laboratory indicators and clinical manifestations, suggesting that hsa_circ_0000479 in neutrophils was one of probable factors involved in the pathogenesis of SLE with potential clinical value.
    Mesh-Begriff(e) Humans ; Neutrophils/metabolism ; Leukocytes, Mononuclear/metabolism ; RNA, Circular/metabolism ; Lupus Erythematosus, Systemic/genetics ; Leukocyte Count
    Chemische Substanzen RNA, Circular
    Sprache Englisch
    Erscheinungsdatum 2024-02-01
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2024.2309607
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