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  1. AU=Zhao Limei AU=Zhao Limei
  2. AU="Feng, Sheau-Line"
  3. AU="Goldman, Nick"
  4. AU="Oumezzine, Ma"
  5. AU="Elena D. Nosyreva"
  6. AU="Birara, Sunita"
  7. AU=Banegas Matthew P. AU=Banegas Matthew P.
  8. AU="Mendelow, Alexander David"
  9. AU="Pereira, Taci"
  10. AU="Natalie Taylor"
  11. AU="Moradi, Tayebeh"
  12. AU="Ramesh C. Santra"
  13. AU="Selvarajah, Aravinda"
  14. AU="Vaisman, Adva"
  15. AU="Rádiková, Žofia"
  16. AU=Poulin Stphane P.

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  1. Artikel ; Online: The Realization of Common Prosperity through Relative Poverty Alleviation

    Zhao Limei

    Contemporary Social Sciences (2022)

    Gradient Development and Optimization

    2022  

    Abstract: Relative poverty alleviation is explicitly consistent with common prosperity. Relative poverty alleviation, which is part of the modernization of national governance capacity, is both an objective requirement of effective poverty alleviation and an ... ...

    Abstract Relative poverty alleviation is explicitly consistent with common prosperity. Relative poverty alleviation, which is part of the modernization of national governance capacity, is both an objective requirement of effective poverty alleviation and an inevitable approach to the realization of common prosperity. The alleviation of relative poverty and the realization of common prosperity are intrinsically coupled because they feature overlapping time sequences, monistic values, superimposed fields, similar systems, and homogeneous elements. The relationship between the two is essentially symbiotic, coexistent, and synergistic. Consequently, how to effectively alleviate relative poverty and build a dynamic longterm mechanism for relative poverty alleviation will be one of the major challenges for China to tackle before it can make more obvious and substantial progress toward common prosperity for all by 2035. This paper proposes relevant countermeasures and suggestions, which mainly concern the building of a dynamic, multi-dimensional mechanism for relative poverty alleviation and a coordinated mode for the two missions. The aim is to achieve a balanced integration of the academic logic, social logic, and policy logic
    Schlagwörter relative poverty alleviation ; common prosperity ; coordinated advancement ; Social Sciences ; H
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2022-09-01T00:00:00Z
    Verlag Editorial Department of Contemporary Social Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel: Investigation of Crystallization Growth Characteristics of Mg(OH)

    Lv, Yunqing / Bai, Limei / Ma, Yuxin / Zhao, Liucheng

    Materials (Basel, Switzerland)

    2024  Band 17, Heft 9

    Abstract: Utilizing MgO as the precursor and deionized water as the solvent, this study synthesized nanoparticles of Mg(OH) ...

    Abstract Utilizing MgO as the precursor and deionized water as the solvent, this study synthesized nanoparticles of Mg(OH)
    Sprache Englisch
    Erscheinungsdatum 2024-04-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17091956
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Regarding the prognostic factors in patients with ALK-positive non-small cell lung cancer treated with crizotinib.

    Hu, Limei / Xie, Youjun / Zhao, Hongying

    Pulmonology

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-02-23
    Erscheinungsland Spain
    Dokumenttyp Letter
    ZDB-ID 3009651-0
    ISSN 2531-0437 ; 2531-0429
    ISSN (online) 2531-0437
    ISSN 2531-0429
    DOI 10.1016/j.pulmoe.2024.02.007
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Editorial: Application of data mining in pharmaceutical research.

    Bu, Qingting / Lyu, Jun / Zhao, Limei / Cao, Shiyi / Jia, Deyong / Pan, Zhenyu

    Frontiers in pharmacology

    2024  Band 15, Seite(n) 1388738

    Sprache Englisch
    Erscheinungsdatum 2024-03-01
    Erscheinungsland Switzerland
    Dokumenttyp Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1388738
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  5. Artikel ; Online: Boosting Electrochemical CO

    Deng, Jun / Qiu, Limei / Xin, Mudi / He, Wenhui / Zhao, Wenhui / Dong, Juncai / Xu, Guangtong

    Small (Weinheim an der Bergstrasse, Germany)

    2024  , Seite(n) e2311060

    Abstract: Cu-based metal-organic frameworks (MOFs) have attracted much attention for electrocatalytic ... ...

    Abstract Cu-based metal-organic frameworks (MOFs) have attracted much attention for electrocatalytic CO
    Sprache Englisch
    Erscheinungsdatum 2024-01-29
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202311060
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Collision Energy Analysis within the Vertical Shaft Impact Crusher Based on the Computational Fluid Dynamics-Discrete Element Method.

    Wu, Canhui / Zhao, Limei / Cao, Zhen

    ACS omega

    2024  Band 9, Heft 7, Seite(n) 7967–7975

    Abstract: Particles in the vertical shaft impact crusher absorb and dissipate collision energy in the impact breakage. The distribution of the collision energy determines the breakage rate of materials and breakage energy consumption of the entire system. In this ... ...

    Abstract Particles in the vertical shaft impact crusher absorb and dissipate collision energy in the impact breakage. The distribution of the collision energy determines the breakage rate of materials and breakage energy consumption of the entire system. In this paper, the gas-solid coupling method is used to explore the regional distribution of collision energy, collision frequency, and collision energy spectrum of the material particle groups. Hence, a theoretical basis is provided for the efficient and energy-saving design of the crusher. First, a coupling mathematical model of the computational fluid dynamics and discrete element method is established to describe the interaction between material and fluid in the crushing chamber. Moreover, the experiment is carried out using a PL8500 VSI crusher and compared with the simulation results to verify the model's reliability. Finally, the effects of different working conditions on the energy dissipation distribution and energy spectrum are explored. The results show that the collision energy within the crushing chamber can be accurately predicted by using the fluid-solid coupling model. Moreover, increasing the rotational speed can effectively transform low-energy collision events into high-energy collisions and increase the collision frequency with energy dissipation above the threshold energy. Thus, the probability of material breakage is increased. Last, increasing the feed rate minorly affects the material breakage rate, while the specific energy of the entire system is reduced.
    Sprache Englisch
    Erscheinungsdatum 2024-02-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c08017
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: An overview of the regulatory role of annexin A1 in the tumor microenvironment and its prospective clinical application (Review).

    Gao, Kuan / Li, Xinyang / Luo, Shuya / Zhao, Limei

    International journal of oncology

    2024  Band 64, Heft 5

    Abstract: Although annexin A1 (ANXA1), a 37 kDa phospholipid‑binding anti‑inflammatory protein expressed in various tissues and cell types, has been investigated extensively for its regulatory role in cancer biology, studies have mainly focused on its ... ...

    Abstract Although annexin A1 (ANXA1), a 37 kDa phospholipid‑binding anti‑inflammatory protein expressed in various tissues and cell types, has been investigated extensively for its regulatory role in cancer biology, studies have mainly focused on its intracellular role. However, cancer cells and stromal cells expressing ANXA1 have the ability to transmit signals within the tumor microenvironment (TME) through autocrine, juxtacrine, or paracrine signaling. This bidirectional crosstalk between cancer cells and their environment is also crucial for cancer progression, contributing to uncontrolled tumor proliferation, invasion, metastasis and resistance to therapy. The present review explored the important role of ANXA1 in regulating the cell‑specific crosstalk between various compartments of the TME and analyzed the guiding significance of the crosstalk effects in promotion or suppressing cancer progression in the development of cancer treatments. The literature shows that ANXA1 is critical for the regulation of the TME, indicating that ANXA1 signaling between cancer cells and the TME is a potential therapeutic target for the development of novel therapeutic approaches for impeding cancer development.
    Mesh-Begriff(e) Humans ; Annexin A1/genetics ; Annexin A1/metabolism ; Neoplasms/drug therapy ; Neoplasms/genetics ; Signal Transduction ; Tumor Microenvironment/genetics
    Chemische Substanzen Annexin A1
    Sprache Englisch
    Erscheinungsdatum 2024-03-22
    Erscheinungsland Greece
    Dokumenttyp Review ; Journal Article
    ZDB-ID 1154403-x
    ISSN 1791-2423 ; 1019-6439
    ISSN (online) 1791-2423
    ISSN 1019-6439
    DOI 10.3892/ijo.2024.5639
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  8. Artikel ; Online: Population pharmacokinetic analyses of methotrexate in pediatric patients: a systematic review.

    Cheng, Yu / Zhang, Yujia / Zhang, Ying / Liu, Maobai / Zhao, Limei

    European journal of clinical pharmacology

    2024  

    Abstract: Background and objectives: Methotrexate is widely utilized in the chemotherapy of malignant tumors and autoimmune diseases in the pediatric population, but dosing can be challenging. Several population pharmacokinetic models were developed to ... ...

    Abstract Background and objectives: Methotrexate is widely utilized in the chemotherapy of malignant tumors and autoimmune diseases in the pediatric population, but dosing can be challenging. Several population pharmacokinetic models were developed to characterize factors influencing variability and improve individualization of dosing regimens. However, significant covariates included varied across studies. The primary objective of this review was to summarize and discuss population pharmacokinetic models of methotrexate and covariates that influence pharmacokinetic variability in pediatric patients.
    Methods: Systematic searches were conducted in the PubMed and EMBASE databases from inception to 7 July 2023. Reporting Quality was evaluated based on a checklist with 31 items. The characteristics of studies and information for model construction and validation were extracted, summarized, and discussed.
    Results: Eighteen studies (four prospective studies and fourteen retrospective studies with sample sizes of 14 to 772 patients and 2.7 to 93.1 samples per patient) were included in this study. Two-compartment models were the commonly used structural models for methotrexate, and the clearance range of methotrexate ranged from 2.32 to 19.03 L/h (median: 6.86 L/h). Body size and renal function were found to significantly affect the clearance of methotrexate for pediatric patients. There were limited reports on the role of other covariates, such as gene polymorphisms and co-medications, in the pharmacokinetic parameters of methotrexate pediatric patients. Internal and external evaluations were used to assess the performance of the population pharmacokinetic models.
    Conclusion: A more rigorous external evaluation needs to be performed before routine clinical use to select the appropriate PopPK model. Further research is necessary to incorporate larger cohorts or pool analyses in specific susceptible pediatric populations to improve the understanding of predicted exposure profiles and covariate identification.
    Sprache Englisch
    Erscheinungsdatum 2024-03-18
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 121960-1
    ISSN 1432-1041 ; 0031-6970
    ISSN (online) 1432-1041
    ISSN 0031-6970
    DOI 10.1007/s00228-024-03665-x
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    Zs.A 672: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Artikel ; Online: Farmers’ adoption intentions of water-saving agriculture under the risks of frequent irrigation-induced landslides

    Jue Wang / Limei Liu / Kuanyao Zhao / Qi Wen

    Climate Risk Management, Vol 39, Iss , Pp 100484- (2023)

    2023  

    Abstract: Water-saving agriculture (WSA) is often introduced as an effective strategy to reduce water infiltration and mitigate irrigation-induced landslide risks. The effects highly rely on smallholder farmers, who often would rather suffer from landslides than ... ...

    Abstract Water-saving agriculture (WSA) is often introduced as an effective strategy to reduce water infiltration and mitigate irrigation-induced landslide risks. The effects highly rely on smallholder farmers, who often would rather suffer from landslides than adapt. This study focused on farmers’ adoption intention of WSA in general and drip irrigation and drought-tolerant crop in specific, representing changes in technology and farming systems. An integrative theoretical model was developed based on the extended theory of planned behavior (TPB) with elements from the norm activation model and technology acceptance model. Hypotheses were tested using data from a questionnaire survey with 363 farmers in Loess Plateau, Northwest China. The results of structural equation modeling showed that the most crucial factor bolstering farmers’ adoption intention was subjective norm, regardless of different measures. Attitude was more influential than perceived behavior control in drip irrigation and vice versa in drought-tolerant crop adoption, indicating that attitude was more important in technology change and capacity played a crucial role in farming system shift. In addition, awareness of environmental consequences contributed positively to subjective norm and attitude, and perceived ease-of-use improved perceived behavior control. Most notably, the extended TPB model has more explanatory power than the classical one. By considering the moral and technical aspects, the extended model enhanced the comprehensiveness of explaining drivers of farmers’ WSA adoption intention under the irrigation-induced landslide risks. The findings shed light on future disaster risk management for China and other countries under the landslide risk.
    Schlagwörter Irrigation-induced landslide ; Water-saving agriculture ; Smallholder farmer ; Adoption intention ; Extended theory of planned behavior ; Landslide mitigation ; Meteorology. Climatology ; QC851-999
    Thema/Rubrik (Code) 650
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel: Development of a UPLC-MS/MS method for simultaneous therapeutic drug monitoring of anti-hepatocellular carcinoma drugs and analgesics in human plasma.

    Lu, Shijia / Zhao, Mingming / Zhao, Limei / Li, Guofei

    Frontiers in pharmacology

    2023  Band 14, Seite(n) 1136735

    Abstract: In hepatocellular carcinoma treatment, sorafenib, oxaliplatin, 5-fluorouracil, capecitabine, lenvatinib, and donafenib are first-line drugs; regorafenib, apatinib, and cabozantinib are second-line drugs; and oxycodone, morphine, and fentanyl are commonly ...

    Abstract In hepatocellular carcinoma treatment, sorafenib, oxaliplatin, 5-fluorouracil, capecitabine, lenvatinib, and donafenib are first-line drugs; regorafenib, apatinib, and cabozantinib are second-line drugs; and oxycodone, morphine, and fentanyl are commonly used analgesics. However, the high degree of inter- and intra-individual variability in the efficacy and toxicity of these drugs remains an urgent issue. Therapeutic drug monitoring (TDM) is the most reliable technical means for evaluating drug safety and efficacy. Therefore, we developed an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for simultaneous TDM of three chemotherapy drugs (5-fluorouracil, oxaliplatin, and capecitabin), six targeted drugs (sorafenib, donafenib, apatinib, cabozantinib, regorafenib, and lenvatinib), and three analgesics (morphine, fentanyl, and oxycodone). We extracted 12 analytes and isotope internal standards (ISs) from plasma samples by magnetic solid phase extraction (mSPE) and separated them using a ZORBAX Eclipse Plus C18 column with water containing 0.1% formic acid and methanol containing 0.1% formic acid as the mobile phase. The analytical performance of our method in terms of sensitivity, linearity, specificity, carryover, precision, limit of quantification, matrix effect, accuracy, dilution integrity, extraction recovery, stability, and crosstalk of all the analytes under different conditions met all the criteria stipulated by the guidelines of the Chinese Pharmacopoeia and U.S. Food and Drug Administration. The response function was estimated at 10.0-10 000.0 ng/mL for sorafenib, donafenib, apatinib, cabozantinib, regorafenib, and lenvatinib, and 20.0-20 000.0 ng/mL for 5-fluorouracil, oxaliplatin, capecitabin, morphine, fentanyl, and oxycodone, with a correlation of > 0.9956 for all compounds. The precision and accuracy of all analytes were < 7.21% and 5.62%, respectively. Our study provides empirical support for a simple, reliable, specific, and suitable technique for clinical TDM and pharmacokinetics.
    Sprache Englisch
    Erscheinungsdatum 2023-05-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1136735
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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