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  1. Artikel ; Online: Yu-Ping-Feng-San alleviates inflammation in atopic dermatitis mice by TLR4/MyD88/NF-κB pathway.

    Nie, Jing / Jiang, Xiaoyuan / Wang, Guomi / Xu, Yanan / Pan, Rui / Yu, Wantao / Li, Yuanwen / Wang, Jingxiao

    Journal of ethnopharmacology

    2024  Band 329, Seite(n) 118092

    Abstract: Ethnopharmacological relevance: Yu-Ping-Feng-San (YPF) is a traditional Chinese medicine formula ...

    Abstract Ethnopharmacological relevance: Yu-Ping-Feng-San (YPF) is a traditional Chinese medicine formula that has therapeutic effects on allergic diseases such as allergic rhinitis and asthma. However, its potential efficacy and mechanism in the treatment of atopic dermatitis (AD) has not been extensively illustrated.
    Aim of the study: The purpose of this study was to investigate the efficacy and possible mechanisms of YPF in AD pathogenesis.
    Methods: Network pharmacology and GEO data mining were adopted to firstly identify the potential mechanisms of YPF on AD. Then DNCB induced-AD murine model was established to test the efficacy of YPF and verify its effects on inflammatory cytokines and NF-κB pathway. In addition, molecular docking was performed to detect the binding affinity of YPF's active components with NF-κB pathway related molecules.
    Results: Network pharmacology and human data mining suggested that YPF may act on the NF-κB pathway in AD pathogenesis. With DNCB mice model, we found that YPF significantly improved AD symptoms, reduced SCORAD scores, and alleviated skin tissue inflammation in mice. At the same time, the expression of inflammatory cytokines, TNF-α, sPLA2-IIA and IL-6, was down-regulated. Moreover, YPF suppressed TLR4/MyD88/NF-κB pathway in situ in a dose-dependent manner. Molecular docking further confirmed that seven compounds in YPF had exceptional binding properties with TNF-α, IL-6 and TLR4.
    Conclusion: YPF may help the recovery of AD by inhibiting the TLR4/MyD88/NF-κB pathway, which provides novel insights for the treatment of AD by YPF.
    Sprache Englisch
    Erscheinungsdatum 2024-04-09
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.118092
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Yu-Ping-Feng Formula Ameliorates Alveolar-Capillary Barrier Injury Induced by Exhausted-Exercise

    Wang, Di / Li, Quan / Pan, Chun-Shui / Yan, Li / Sun, Kai / Wang, Xiao-Yi / Anwaier, Gulinigaer / Liao, Qian-Zan / Xie, Ting-Ting / Fan, Jing-Yu / Huo, Xin-Mei / Wang, Yuan / Han, Jing-Yan

    Frontiers in pharmacology

    2022  Band 13, Seite(n) 891802

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2022-06-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.891802
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Yu-Ping-Feng Formula Ameliorates Alveolar-Capillary Barrier Injury Induced by Exhausted-Exercise via Regulation of Cytoskeleton

    Di Wang / Quan Li / Chun-Shui Pan / Li Yan / Kai Sun / Xiao-Yi Wang / Gulinigaer Anwaier / Qian-Zan Liao / Ting-Ting Xie / Jing-Yu Fan / Xin-Mei Huo / Yuan Wang / Jing-Yan Han

    Frontiers in Pharmacology, Vol

    2022  Band 13

    Abstract: Background: Yu-ping-feng powder (YPF) is a compound traditional Chinese medicine extensively used ...

    Abstract Background: Yu-ping-feng powder (YPF) is a compound traditional Chinese medicine extensively used in China for respiratory diseases. However, the role of YPF in alveolar-capillary barrier dysfunction remains unknown. This study aimed to explore the effect and potential mechanism of YPF on alveolar-capillary barrier injury induced by exhausted exercise.Methods: Male Sprague–Dawley rats were used to establish an exhausted-exercise model by using a motorized rodent treadmill. YPF at doses of 2.18 g/kg was administrated by gavage before exercise training for 10 consecutive days. Food intake-weight/body weight, blood gas analysis, lung water percent content, BALF protein concentration, morphological observation, quantitative proteomics, real-time PCR, and Western blot were performed. A rat pulmonary microvascular endothelial cell line (PMVEC) subjected to hypoxia was applied for assessing the related mechanism.Results: YPF attenuated the decrease of food intake weight/body weight, improved lung swelling and hemorrhage, alleviated the increase of lung water percent content and BALF protein concentration, and inhibited the impairment of lung morphology. In addition, YPF increased the expression of claudin 3, claudin 18, occludin, VE-cadherin, and β-catenin, attenuated the epithelial and endothelial hyperpermeability in vivo and/or in vitro, and the stress fiber formation in PMVECs after hypoxia. Quantitative proteomics discovered that the effect of YPF implicated the Siah2-ubiquitin-proteasomal pathway, Gng12-PAK1-MLCK, and RhoA/ROCK, which was further confirmed by Western blot. Data are available via ProteomeXchange with identifier PXD032737.Conclusion: YPF ameliorated alveolar-capillary barrier injury induced by exhausted exercise, which is accounted for at least partly by the regulation of cytoskeleton.
    Schlagwörter traditional Chinese medicine ; lung injury ; proteomics ; cell junctions ; stress fiber ; Therapeutics. Pharmacology ; RM1-950
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Chemical profiling and mechanistic studies of Zhi-Shang-Feng granules against influenza virus by high-performance liquid chromatography coupled with Q exactive focus hybrid quadrupole orbitrap high-resolution mass spectrometry in combination with network pharmacology analysis.

    Xie, Yuan-Yuan / Luo, Jia-Yi / Hu, Hong / Pan, Juan / Jiang, Meng / Wang, Shu-Mei

    Journal of separation science

    2023  Band 46, Heft 20, Seite(n) e2200839

    Abstract: Zhi-Shang-Feng Granules are used in the clinical treatment of influenza to relieve headaches ... responsible for therapeutic effects of Zhi-Shang-Feng g ranules against influenza virus, an analytical method ... high resolution mass spectrometry was developed and the chemical profile of Zhi-Shang-Feng granules was ...

    Abstract Zhi-Shang-Feng Granules are used in the clinical treatment of influenza to relieve headaches, chills and fever, bronchitis, nasal congestion, neuralgia and other symptoms. To decipher the components responsible for therapeutic effects of Zhi-Shang-Feng g ranules against influenza virus, an analytical method based on high-performance liquid chromatography coupled with Q exactive focus hybrid quadrupole orbitrap high resolution mass spectrometry was developed and the chemical profile of Zhi-Shang-Feng granules was characterized. Then, the identified components were used to conduct network pharmacological analysis and determine the potential mechanism of Zhi-Shang-Feng Granules. As a result, 177 compounds were putatively identified through comprehensive analysis by liquid chromatography coupled with high-resolution mass spectrometry, of which 23 compounds were unambiguously confirmed with reference standards. Components in Zhi-Shang-Feng Granules were found to specifically act on different enzymes, G-protein-coupled receptors, ion channels and transporters in the immune, endocrine, nervous, and circulatory systems. The potential mechanism was related to several biological processes, including cell growth and death, pattern recognition receptor signalling, signalling by interleukins, and lipid metabolism. The combination of chemical profile characterization and network construction provided useful insight into the overall chemical composition of Zhi-Shang-Feng granules and revealed their potential anti-infection, anti-inflammatory and immunoregulatory mechanisms against influenza virus infected disease.
    Mesh-Begriff(e) Chromatography, High Pressure Liquid ; Network Pharmacology ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/chemistry ; Mass Spectrometry/methods ; Orthomyxoviridae
    Chemische Substanzen Drugs, Chinese Herbal
    Sprache Englisch
    Erscheinungsdatum 2023-08-13
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2047990-6
    ISSN 1615-9314 ; 1615-9306
    ISSN (online) 1615-9314
    ISSN 1615-9306
    DOI 10.1002/jssc.202200839
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Effects of Yu-Ping-Feng polysaccharides (YPS) on the immune response, intestinal microbiota, disease resistance and growth performance of Litopenaeus vannamei.

    Su, Chen / Fan, Depeng / Pan, Luqing / Lu, Yusong / Wang, Yuxuan / Zhang, Mengyu

    Fish & shellfish immunology

    2020  Band 105, Seite(n) 104–116

    Abstract: A 28-day feeding trial was conducted to investigate the effects of Yu-Ping-Feng polysaccharides ...

    Abstract A 28-day feeding trial was conducted to investigate the effects of Yu-Ping-Feng polysaccharides (YPS) containing Astragalus polysaccharides (APS), Atractylodes macrocephala polysaccharides (AMP) and Saposhnikoviae polysaccharides (SPS) on the immune response, intestinal microbiota, disease resistance and growth performance of Litopenaeus vannamei. Seven hundred and twenty shrimp (3.04 ± 0.33 g) were fed the following diets: Control, YPS1 (0.13% APS + 0.0325% AMP + 0.0325% SPS), YPS2 (0.13% APS + 0.0325% AMP + 0.065% SPS) and YPS3 (0.13% APS + 0.0325% AMP+0.0975% SPS). After 14 and 28 days of feeding, the immune responses of hemocytes and intestine were measured. Intestinal microbiota and growth performance were measured after 28 days of feeding, after that, a 7-day challenge test against Vibrio harveyi was conducted. A significant (P < 0.05) increase of the total haemocyte count (THC), phagocytic activity, antibacterial activity and phenoloxidase (PO) activity was observed in shrimp fed YPS diets compared to the control. Also, dietary YPS supplementation particularly YPS3 group significantly increased the expressions of immune-related genes in the hemocytes and intestine. Regarding the intestinal microbiota, the microbial diversity and richness decreased and functional genes associated with short-chain fatty acids metabolism increased in YPS groups. After Vibrio harveyi challenge, the cumulative mortality in YPS groups was significantly lower than that of the control. Besides, dietary YPS had no significant effect on growth performance of shrimp (P > 0.05). The present results suggested that YPS could be considered as potential prebiotics for aquaculture farmed shrimp.
    Mesh-Begriff(e) Animals ; Gastrointestinal Microbiome/drug effects ; Hemocytes/immunology ; Immunity, Innate/drug effects ; Intestines/immunology ; Penaeidae/growth & development ; Penaeidae/immunology ; Penaeidae/microbiology ; Polysaccharides/administration & dosage ; Random Allocation ; Vibrio/physiology
    Chemische Substanzen Polysaccharides
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-07-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1067738-0
    ISSN 1095-9947 ; 1050-4648
    ISSN (online) 1095-9947
    ISSN 1050-4648
    DOI 10.1016/j.fsi.2020.07.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Analysis of immunostimulatory activity of polysaccharide extracted from Yu-Ping-Feng in vitro and in vivo.

    Fan, Wentao / Zheng, Pimiao / Wang, Yang / Hao, Pan / Liu, Jianzhu / Zhao, Xiaona

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2017  Band 93, Seite(n) 146–155

    Abstract: As a traditional Chinese multiherbal formula, Yu-Ping-Feng (YPF) is frequently used to treat cold ...

    Abstract As a traditional Chinese multiherbal formula, Yu-Ping-Feng (YPF) is frequently used to treat cold, flu and inflammation-associated diseases. We aimed to evaluate the immunostimulatory effects of polysaccharide isolated from YPF (YPF-PS) in vitro and in vivo. In in vitro experiment, macrophage cell proliferation, phagocytosis rate, cytokine and costimulatory molecule release, T lymphocyte proliferation, cell cycle distribution, CD4
    Sprache Englisch
    Erscheinungsdatum 2017-09
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2017.05.138
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.198: Hefte anzeigen Standort:
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  7. Artikel ; Online: Feng-liao-chang-wei-kang is synergistic with 5-fluorouracil in inhibiting proliferation of colorectal cancer

    Pan-Li Ni / Shu-Hong Tian / Zhao-Xin Yang / Jun-Qing Zhang / Fan Yang / Li-Fan Zhong / Lian-Fang Gan / Mian-Qing Huang / Ling Huang

    Asian Pacific Journal of Tropical Medicine, Vol 12, Iss 14, Pp 41-

    2019  Band 53

    Abstract: Objective: To explore the effect of Feng-liao-chang-wei-kang (FLCWK) on acute and chronic ...

    Abstract Objective: To explore the effect of Feng-liao-chang-wei-kang (FLCWK) on acute and chronic gastroenteritis, synergistic effect on the growth inhibitory effect with 5-fluorouracil (5-FU) on colorectal cancer and its underlying mechanisms. Methods: In the in vitro study, HT-29 cells were divided into 5-FU alone, FLCWK alone and coadministration groups. The MTT assay was used to analyze the proliferation of HT-29 cells at 24 h. Flow cytometry was used to observe the apoptosis, cycle of colorectal cancer HT-29 cells at 24 h. In the in vivo experiment, The subcutaneous transplantation tumor model of colorectal cancer HT-29-Luc was established with nude mice. All mice were randomly divided into 5-FU alone, FLCWK alone and coadministration groups according to body weight. During administration, the Interactive Video Information System small animal live imaging system was used to monitor the growth of subcutaneous transplantation in nude mice. The model of colitis-associated colorectal cancer (CACC) was established with BALB/c mice. BALB/c mice were randomly divided into the normal control group, the model control group, and the FLCWK group. At the end of the administration, the pathological status was detected by HE staining. Cell apoptosis of tumor tissue tumor and colon tissues were observed by TUNEL staining and TUNEL green fluorescence. The protein expression of Caspase 3, p-STAT3, Bcl-2, Bax and P-gp in tumor tissues tumor and colon tissues were tested by using immunohistochemical assay. Results: FLCWK and 5-FU coadministration suppressed HT-29 cell viability and induced S phase arrest and apoptosis compared to treatment with 5-FU alone. Furthermore, compared to treatment with 5-FU alone, coadministration of FLCWK and 5-FU obviously reduced tumor volume and weight and induced apoptosis through decreasing p-STAT3 and P-gp and increasing Caspase 3 protein expression in a murine xenograft tumor model. Moreover, the result revealed decreased number and size of tumors following FLCWK protective administration, downregulated p-STAT3 and Bcl-2 levels and upregulated Bax and Caspase 3 expression in mice with CACC. Conclusions: FLCWK has synergistic effects with 5-FU on colorectal cancer by suppressing the STAT3 pathway and downregulating P-gp expression. Furthermore, FLCWK administration suppresses CACC tumorigenesis by inhibiting the STAT3 pathway.
    Schlagwörter colorectal cancer ; flcwk ; 5-fluorouracil ; synergistic effect ; colitis-associated colorectal cancer ; Arctic medicine. Tropical medicine ; RC955-962
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2019-01-01T00:00:00Z
    Verlag Wolters Kluwer Medknow Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel: Effects of Yu-Ping-Feng polysaccharides (YPS) on the immune response, intestinal microbiota, disease resistance and growth performance of Litopenaeus vannamei

    Su, Chen / Fan, Depeng / Pan, Luqing / Lu, Yusong / Wang, Yuxuan / Zhang, Mengyu

    Fish & shellfish immunology. 2020 Oct., v. 105

    2020  

    Abstract: A 28-day feeding trial was conducted to investigate the effects of Yu-Ping-Feng polysaccharides ...

    Abstract A 28-day feeding trial was conducted to investigate the effects of Yu-Ping-Feng polysaccharides (YPS) containing Astragalus polysaccharides (APS), Atractylodes macrocephala polysaccharides (AMP) and Saposhnikoviae polysaccharides (SPS) on the immune response, intestinal microbiota, disease resistance and growth performance of Litopenaeus vannamei. Seven hundred and twenty shrimp (3.04 ± 0.33 g) were fed the following diets: Control, YPS1 (0.13% APS + 0.0325% AMP + 0.0325% SPS), YPS2 (0.13% APS + 0.0325% AMP + 0.065% SPS) and YPS3 (0.13% APS + 0.0325% AMP+0.0975% SPS). After 14 and 28 days of feeding, the immune responses of hemocytes and intestine were measured. Intestinal microbiota and growth performance were measured after 28 days of feeding, after that, a 7-day challenge test against Vibrio harveyi was conducted. A significant (P < 0.05) increase of the total haemocyte count (THC), phagocytic activity, antibacterial activity and phenoloxidase (PO) activity was observed in shrimp fed YPS diets compared to the control. Also, dietary YPS supplementation particularly YPS3 group significantly increased the expressions of immune-related genes in the hemocytes and intestine. Regarding the intestinal microbiota, the microbial diversity and richness decreased and functional genes associated with short-chain fatty acids metabolism increased in YPS groups. After Vibrio harveyi challenge, the cumulative mortality in YPS groups was significantly lower than that of the control. Besides, dietary YPS had no significant effect on growth performance of shrimp (P > 0.05). The present results suggested that YPS could be considered as potential prebiotics for aquaculture farmed shrimp.
    Schlagwörter Astragalus ; Atractylodes macrocephala ; Litopenaeus vannamei ; Vibrio harveyi ; antibacterial properties ; aquaculture ; disease resistance ; fish ; growth performance ; hemocytes ; immune response ; intestinal microorganisms ; intestines ; monophenol monooxygenase ; mortality ; phagocytosis ; polysaccharides ; prebiotics ; shellfish ; shrimp
    Sprache Englisch
    Erscheinungsverlauf 2020-10
    Umfang p. 104-116.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 1067738-0
    ISSN 1095-9947 ; 1050-4648
    ISSN (online) 1095-9947
    ISSN 1050-4648
    DOI 10.1016/j.fsi.2020.07.003
    Datenquelle NAL Katalog (AGRICOLA)

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  9. Buch ; Online ; E-Book: Multi-modal EEG monitoring of severely neurologically ill patients

    Wang, Xuefeng / Li, Feng / Pan, Suyue

    2022  

    Titelvarianten Multi-modal EEG-monitoring of severely neurologically ill patients ; Multi modal EEG monitoring of severely neurologically ill patients
    Verfasserangabe Xuefeng Wang, Feng Li, Suyue Pan editors
    Schlagwörter Neurology
    Thema/Rubrik (Code) 616.8
    Sprache Englisch
    Umfang 1 Online-Ressource (xiii, 360 Seiten), Illustrationen, Diagramme
    Verlag Springer
    Erscheinungsort Singapore
    Erscheinungsland Singapur
    Dokumenttyp Buch ; Online ; E-Book
    Bemerkung Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021142413
    ISBN 978-981-16-4493-1 ; 9789811644924 ; 9789811644948 ; 9789811644955 ; 981-16-4493-4 ; 9811644926 ; 9811644942 ; 9811644950
    DOI 10.1007/978-981-16-4493-1
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  10. Buch ; Dissertation / Habilitation: Enhancement of irreversible electroporation by transarterial injection of lidocaine as a cell sensitizer

    Pan, Feng / Sommer, Christof-Matthias

    an experimental in vivo liver study

    2019  

    Körperschaft Universität Heidelberg
    Verfasserangabe vorgelegt von Feng Pan ; Doktorvater: Priv.-Doz. Dr. med. Christof-Matthias Sommer
    Sprache Englisch
    Umfang VI, 61 Seiten, Illustrationen, Diagramme
    Erscheinungsort Heidelberg
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dissertation, Ruprecht-Karls-Universität Heidelberg, 2021
    Anmerkung Text auf Englisch, Zusammenfassung auf Englisch und Deutsch
    HBZ-ID HT021379315
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    SignaturLeihstatusStandort
    2022 E 613 bestellbar zur Ausleihe Magazin

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