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  1. Artikel ; Online: Effect of a national guideline on postoperative troponin surveillance: a retrospective cohort study.

    Alvarez Torres, Eva / Bartoszko, Justyna / Martinez Perez, Selene / Tait, Gordon / Santema, Michael / Beattie, W Scott / McCluskey, Stuart A / van Klei, Wilton A

    Canadian journal of anaesthesia = Journal canadien d'anesthesie

    2023  Band 71, Heft 3, Seite(n) 322–329

    Abstract: Purpose: We aimed to evaluate the effect of the 2017 Canadian Cardiovascular Society (CCS) guidelines on troponin surveillance after noncardiac surgery.: Methods: This was a single-centre, retrospective, observational study. Patients aged 40 yr or ... ...

    Titelübersetzung Effet d’une ligne directrice nationale sur le monitorage postopératoire de la troponine : une étude de cohorte rétrospective.
    Abstract Purpose: We aimed to evaluate the effect of the 2017 Canadian Cardiovascular Society (CCS) guidelines on troponin surveillance after noncardiac surgery.
    Methods: This was a single-centre, retrospective, observational study. Patients aged 40 yr or older undergoing intermediate- to high-risk elective noncardiac surgery between 2016 and 2021 were included. We compared the number and percentage of troponin tests ordered before and after the guidelines were published and compared patient characteristics, specifically cardiovascular comorbidity, using odds ratio's (OR) with 95% confidence intervals (CIs). Outcomes were myocardial injury, myocardial infarction (MI), and in-hospital mortality.
    Results: The cohort included 36,386 patients and the median age was 63 yr. Between 2016 and 2018, troponin surveillance was done in 2,461 (13%) of the 19,046 patients, compared with 2,398 (14%) of the 17,340 patients who had surgery between 2019 and 2021 (OR, 1.08; 95% CI, 1.02 to 1.15). Patients who had surgery in the second period had less cardiovascular comorbidity; the adjusted OR for troponin surveillance was 1.14 (95% CI, 1.07 to 1.21). In the two periods, troponin was elevated in 561 (2.9%) and 470 (2.7%) patients, an MI was documented in 54 (0.3%) and 36 (0.2%) patients, and 95 (0.5%) and 73 (0.4%) patients died, respectively. After adjustment for baseline differences in the two periods, the ORs for MI and mortality were 0.83 (95% CI, 0.54 to 1.27) and 0.88 (95% CI, 0.64 to 1.19), respectively.
    Conclusion: Although the odds of troponin ordering were slightly but significantly higher after publication of the CCS guidelines, the odds for detecting an MI and for mortality did not change.
    Mesh-Begriff(e) Humans ; Middle Aged ; Troponin ; Retrospective Studies ; Postoperative Complications/epidemiology ; Postoperative Complications/diagnosis ; Canada ; Myocardial Infarction/diagnosis ; Myocardial Infarction/epidemiology
    Chemische Substanzen Troponin
    Sprache Englisch
    Erscheinungsdatum 2023-11-16
    Erscheinungsland United States
    Dokumenttyp Observational Study ; Journal Article
    ZDB-ID 91002-8
    ISSN 1496-8975 ; 0832-610X
    ISSN (online) 1496-8975
    ISSN 0832-610X
    DOI 10.1007/s12630-023-02647-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Acute hypokinetic-rigid syndrome following SARS-CoV-2 infection.

    Méndez-Guerrero, Antonio / Laespada-García, María Isabel / Gómez-Grande, Adolfo / Ruiz-Ortiz, Mariano / Blanco-Palmero, Víctor Antonio / Azcarate-Diaz, Francisco Javier / Rábano-Suárez, Pablo / Álvarez-Torres, Eva / de Fuenmayor-Fernández de la Hoz, Carlos Pablo / Vega Pérez, Diana / Rodríguez-Montalbán, Raquel / Pérez-Rivilla, Alfredo / Sayas Catalán, Javier / Ramos-González, Ana / González de la Aleja, Jesús

    Neurology

    2020  Band 95, Heft 15, Seite(n) e2109–e2118

    Abstract: Objective: To report a case of a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who acutely developed a hypokinetic-rigid syndrome.: Methods: Patient data were obtained from medical records from the Hospital ... ...

    Abstract Objective: To report a case of a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who acutely developed a hypokinetic-rigid syndrome.
    Methods: Patient data were obtained from medical records from the Hospital Universitario 12 de Octubre in Madrid, Spain. [
    Results: We report a previously healthy 58-year-old man who developed hyposmia, generalized myoclonus, fluctuating and transient changes in level of consciousness, opsoclonus, and an asymmetric hypokinetic-rigid syndrome with ocular abnormalities after a severe SARS-CoV-2 infection. DaT-SPECT confirmed a bilateral decrease in presynaptic dopamine uptake asymmetrically involving both putamina. Significant improvement in the parkinsonian symptoms was observed without any specific treatment.
    Conclusion: This case study provides clinical and functional neuroimaging evidence to support that SARS-CoV-2 can gain access to the CNS, affecting midbrain structures and leading to neurologic signs and symptoms.
    Mesh-Begriff(e) Betacoronavirus ; Brain/diagnostic imaging ; Brain/metabolism ; COVID-19 ; Consciousness Disorders ; Coronavirus Infections/complications ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/physiopathology ; Disease Progression ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Electroencephalography ; Humans ; Hypokinesia/diagnostic imaging ; Hypokinesia/etiology ; Hypokinesia/physiopathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Muscle Rigidity/diagnostic imaging ; Muscle Rigidity/etiology ; Muscle Rigidity/physiopathology ; Nortropanes ; Ocular Motility Disorders ; Pandemics ; Parkinson Disease, Postencephalitic/diagnostic imaging ; Parkinson Disease, Postencephalitic/etiology ; Parkinson Disease, Postencephalitic/physiopathology ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/physiopathology ; Putamen/diagnostic imaging ; Putamen/metabolism ; SARS-CoV-2 ; Tomography, Emission-Computed, Single-Photon
    Chemische Substanzen Dopamine Plasma Membrane Transport Proteins ; Nortropanes ; ioflupane (VF232WE742)
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-07-08
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000010282
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Acute hypokinetic-rigid syndrome following SARS-CoV-2 infection

    Méndez-Guerrero, Antonio / Laespada-García, María Isabel / Gómez-Grande, Adolfo / Ruiz-Ortiz, Mariano / Blanco-Palmero, Víctor Antonio / Azcarate-Diaz, Francisco Javier / Rábano-Suárez, Pablo / Álvarez-Torres, Eva / de Fuenmayor-Fernández de la Hoz, Carlos Pablo / Vega Pérez, Diana / Rodríguez-Montalbán, Raquel / Pérez-Rivilla, Alfredo / Sayas Catalán, Javier / Ramos-González, Ana / González de la Aleja, Jesús

    Neurology

    Abstract: OBJECTIVE: To report a case of a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who acutely developed a hypokinetic-rigid syndrome. METHODS: Patient data were obtained from medical records from the Hospital ... ...

    Abstract OBJECTIVE: To report a case of a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who acutely developed a hypokinetic-rigid syndrome. METHODS: Patient data were obtained from medical records from the Hospital Universitario 12 de Octubre in Madrid, Spain. [123I]-ioflupane dopamine transporter (DaT) SPECT images were acquired 4 hours after a single dose of 185 MBq of 123I-FP-CIT. Quantitative analysis was performed with DaTQUANT software providing the specific binding ratio and z score values of the striatum. RESULTS: We report a previously healthy 58-year-old man who developed hyposmia, generalized myoclonus, fluctuating and transient changes in level of consciousness, opsoclonus, and an asymmetric hypokinetic-rigid syndrome with ocular abnormalities after a severe SARS-CoV-2 infection. DaT-SPECT confirmed a bilateral decrease in presynaptic dopamine uptake asymmetrically involving both putamina. Significant improvement in the parkinsonian symptoms was observed without any specific treatment. CONCLUSION: This case study provides clinical and functional neuroimaging evidence to support that SARS-CoV-2 can gain access to the CNS, affecting midbrain structures and leading to neurologic signs and symptoms.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #638341
    Datenquelle COVID19

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  4. Artikel ; Online: Acute hypokinetic-rigid syndrome following SARS-CoV-2 infection

    Méndez-Guerrero, Antonio / Laespada-García, María Isabel / Gómez-Grande, Adolfo / Ruiz-Ortiz, Mariano / Blanco-Palmero, Víctor Antonio / Azcarate-Diaz, Francisco Javier / Rábano-Suárez, Pablo / Álvarez-Torres, Eva / de Fuenmayor-Fernández de la Hoz, Carlos Pablo / Pérez, Diana Vega / Rodríguez-Montalbán, Raquel / Pérez-Rivilla, Alfredo / Catalán, Javier Sayas / González, Ana Ramos- / González de la Aleja, Jesús

    Neurology

    2020  , Seite(n) 10.1212/WNL.0000000000010282

    Abstract: OBJECTIVE: To report a case of a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who acutely developed a hypokinetic-rigid syndrome. METHODS: Patient data were obtained from medical records from the “Hospital ... ...

    Abstract OBJECTIVE: To report a case of a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who acutely developed a hypokinetic-rigid syndrome. METHODS: Patient data were obtained from medical records from the “Hospital Universitario 12 de Octubre” in Madrid, Spain. [ 123 I]-ioflupane dopamine transporter single-photon emission CT (DaT-SPECT) images were acquired 4 hours after a single dose of 185 MBq of 123 I-FP-CIT. Quantitative analysis was performed using DaTQUANT TM software providing the specific binding ratio (SBR) and z-score values of the striatum. RESULTS: We report a previously healthy 58-year-old man who developed hyposmia, generalized myoclonus, fluctuating and transient changes in level of consciousness, opsoclonus and an asymmetric hypokinetic-rigid syndrome with ocular abnormalities after a severe SARS-CoV-2 infection. DaT-SPECT confirmed a bilateral decrease in presynaptic dopamine uptake asymmetrically involving both putamina. Significant improvement in the parkinsonian symptoms was observed without any specific treatment. CONCLUSION: This case study provides clinical and functional neuroimaging evidence to support that SARS-CoV-2 can gain access to the central nervous system, affecting midbrain structures and leading to neurological signs and symptoms.
    Schlagwörter Clinical Neurology ; covid19
    Sprache Englisch
    Verlag Ovid Technologies (Wolters Kluwer Health)
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/wnl.0000000000010282
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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