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Artikel: Psychotic Episode and Schizophrenia in Slovakian Narcolepsy Database.

Feketeová, Eva / Dragašek, Jozef / Klobučníková, Katarína / Ďurdík, Peter / Čarnakovič, Simona / Slavkovská, Miriam / Chylová, Martina

Brain sciences

2022  Band 13, Heft 1

Abstract: Narcolepsy type 1 (NT1), a central disorder of hypersomnolence, is associated with mood, anxiety or hyperactivity mental disorders. Association with psychotic episode or schizophrenia is rare and could be the source of diagnostic and therapeutic ... ...

Abstract Narcolepsy type 1 (NT1), a central disorder of hypersomnolence, is associated with mood, anxiety or hyperactivity mental disorders. Association with psychotic episode or schizophrenia is rare and could be the source of diagnostic and therapeutic difficulties. Their frequency in the national narcolepsy database has not been systematically studied. The aim of the presented study was to calculate the frequency of NT1 patients diagnosed with psychosis and/or schizophrenia, to identify clinical characteristics of these cases, and to look for narcoleptic and psychotic symptoms during re-evaluation years later. We identified three (4%) cases diagnosed with a psychotic episode in the course of NT1. They were diagnosed with NT1 by age ≤18 years. In the re-evaluation (mean follow-up 9.8 years), we identified one case with a dual diagnosis of NT1 and schizophrenia; two cases were diagnosed with a solitary psychotic episode in the course of NT1. NT1 patients diagnosed in the age ≤18 years are at higher risk of psychotic episode, and this may be related to higher vulnerability during the ongoing neurodevelopmental period. Comorbid schizophrenia with NT1 in the Slovakian Narcolepsy Database was within the prevalence expected in the general population. The solitary psychotic episode in the course of NT1 did not reduce the possibility of subsequent symptomatic treatment afterwards.
Sprache Englisch
Erscheinungsdatum 2022-12-24
Erscheinungsland Switzerland
Dokumenttyp Journal Article
ZDB-ID 2651993-8
ISSN 2076-3425
ISSN 2076-3425
DOI 10.3390/brainsci13010043
Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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