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  1. AU="Şengül, Sevim Süreyya"
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  1. Artikel ; Online: Prognostic value of computed tomography associated body composition measurement changes in metastatic colorectal cancer patients.

    Sevgilioglu, Zekai Emre / Evrimler, Sehnaz / Iscan, Gokce / Kayikcioglu, Erkan / Sengul, Sevim Sureyya / Cetin, Bulent

    Acta radiologica (Stockholm, Sweden : 1987)

    2023  Band 64, Heft 11, Seite(n) 2849–2857

    Abstract: Background: Sarcopenia is associated with poor prognosis in metastatic colorectal cancer (mCRC) patients.: Purpose: To investigate the prognostic value of body composition measurement changes measured by computed tomography (CT) in mCRC patients.: ... ...

    Abstract Background: Sarcopenia is associated with poor prognosis in metastatic colorectal cancer (mCRC) patients.
    Purpose: To investigate the prognostic value of body composition measurement changes measured by computed tomography (CT) in mCRC patients.
    Material and methods: The abdominal skeletal muscle density (SMD) and skeletal muscle (SMI) indices, as well as the visceral (VATI) and subcutaneous fat tissue (SATI) indices, were calculated by automatic segmentation method on the abdominal CT images obtained before (n = 71) and after chemotherapy (n = 52). Skeletal muscle gauge (SMG = SMD × SMI) was calculated. We calculated the percentage change of body composition measurements with respect to the first measurements. The cutoff value for the change in SMG was calculated by receiver operating characteristic analysis. Kaplan-Meier and Cox regression analyses were performed to calculate the prognostic value of age, gender, tumor location, metastasis site and carcinoembriogenic antigen (CEA) elevation, hypoalbuminemia, body mass index classification, presence of sarcopenia and SMG changes in terms of overall survival.
    Results: There was a significant association between SMG change and mortality (
    Conclusion: In mCRC patients, hypoalbuminemia and highly decreased SMG are significant prognostic factors for overall survival. Therefore, we suggest that the change in SMG calculated in follow-up images should also be evaluated in the prognosis estimation of this patient group.
    Mesh-Begriff(e) Humans ; Prognosis ; Sarcopenia/diagnostic imaging ; Sarcopenia/pathology ; Hypoalbuminemia/pathology ; Tomography, X-Ray Computed/methods ; Muscle, Skeletal/diagnostic imaging ; Muscle, Skeletal/pathology ; Body Composition ; Rectal Neoplasms/pathology ; Retrospective Studies
    Sprache Englisch
    Erscheinungsdatum 2023-09-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 105-3
    ISSN 1600-0455 ; 0284-1851 ; 0349-652X
    ISSN (online) 1600-0455
    ISSN 0284-1851 ; 0349-652X
    DOI 10.1177/02841851231198345
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Adipose tissue indices predict prognosis in hodgkin lymphoma.

    Özbalcı, Demircan / Erdoğan, Mehmet / Alanoğlu, Emine Güçhan / Şengül, Sevim Süreyya / Yüceer, Kamuran / Eroğlu, Hande Nur / Yağcı, Samet

    Leukemia research

    2024  Band 138, Seite(n) 107457

    Abstract: Introduction background: This study evaluated the impact of adipose tissue indices on prognosis of HL.: Methods: Fifty-five patients with newly diagnosed Hodgkin Lymphoma were evaluated retrospectively for association with adipose tissue indices ( ... ...

    Abstract Introduction background: This study evaluated the impact of adipose tissue indices on prognosis of HL.
    Methods: Fifty-five patients with newly diagnosed Hodgkin Lymphoma were evaluated retrospectively for association with adipose tissue indices (total abdominal tissue volume, radiodensity, subcutaneous and visceral adipose tissue SUVmax value and prognostic factors for Hodgkin Lymphoma such as IPS-3, IPS-7, stage, sedimentation, progression free and overall survival.
    Results: For IPS-3, SAT SUVmax and TAAT radiodensity were significantly increased in high-risk patients (2and 3) compared to group 0 and 1. For IPS-7, total abdominal adipose volume was significantly decreased in high-risk patients, SAT SUVmax significantly increased in high-risk patients and decreased in low-risk patients. In addition, SAT SUVmax was significantly increased in patients with high sedimentation rate, with B symptoms and who passed away during follow-up. SAT SUVmax showed moderate positive correlation with sedimentation, IPS-3, IPS-7, and stage. In addition, it was observed that TAAT radiodensity and SAT SUVmax were significantly better for determining prognosis than other adipose tissue indices. Roc analysis showed that the diagnostic value of all adipose tissue indices in predicting IPS-3 and IPS-7 prognoses were statistically significant.
    Conclusion: SAT SUVmax and TAAT radiodensity were two new and independent markers with diagnostic value in predicting prognosis.
    Mesh-Begriff(e) Humans ; Hodgkin Disease/diagnostic imaging ; Retrospective Studies ; Disease-Free Survival ; Prognosis ; Adipose Tissue/diagnostic imaging
    Sprache Englisch
    Erscheinungsdatum 2024-02-15
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2024.107457
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Correlation of

    Kaymak, Zümrüt Arda / Karahan, Nermin / Erdoğan, Mehmet / Erdemoğlu, Evrim / Zihni, İsmail / Şengül, Sevim Süreyya

    Molecular imaging and radionuclide therapy

    2021  Band 30, Heft 2, Seite(n) 93–100

    Abstract: Objectives: Post-hypoxia hypoxia-inducible factor (HIF)-1α activation plays a vital role in colorectal cancer (CRC) angiogenesis. Although glucose metabolism is induced in some cancer types via HIF-1α, the prognostic significance of HIF-1α in CRC and ... ...

    Abstract Objectives: Post-hypoxia hypoxia-inducible factor (HIF)-1α activation plays a vital role in colorectal cancer (CRC) angiogenesis. Although glucose metabolism is induced in some cancer types via HIF-1α, the prognostic significance of HIF-1α in CRC and its correlation with
    Methods: Thirty-six histopathologically confirmed patients with CRC who had
    Results: The tumor location, tumor diameter, perineural invasion, lymphovascular invasion, T and N stage were not significantly correlated with HIF-1α overexpression. In contrast, the tumor differentiation was negatively correlated with HIF-1α expression (r=-0.332, p=0.048). None of the
    Conclusion: The expected association between HIF-1α overexpression and
    Sprache Englisch
    Erscheinungsdatum 2021-05-28
    Erscheinungsland Turkey
    Dokumenttyp Journal Article
    ISSN 2146-1414
    ISSN 2146-1414
    DOI 10.4274/mirt.galenos.2021.04934
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: The Role of Ga-68 PSMA PET/CT Scan on Differentiating of Oligometastatic and High Risk Prostate Cancer

    Erdoğan, Mehmet / Özkan, Emine Elif / Öztürk, Sefa Alperen / Yıldız, Mustafa / Şengül, Sevim Süreyya

    Molecular imaging and radionuclide therapy

    2020  Band 29, Heft 3, Seite(n) 98–104

    Abstract: Objectives: In this study, we aimed to investigate whether Ga-68 prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) scanning is adequate to predict intermediate risk, high risk, or oligometastatic prostate ... ...

    Titelübersetzung Oligometastatik ve Yüksek Riskli Prostat Kanserinin Ayrımında Ga-68 PSMA PET/BT Taramasının Rolü.
    Abstract Objectives: In this study, we aimed to investigate whether Ga-68 prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) scanning is adequate to predict intermediate risk, high risk, or oligometastatic prostate cancer (PCa) as an initial staging modality.
    Methods: The Ga-68 PSMA PET/CT scan images of 50 PCa patients pathologically proven by transrectal ultrasound guided biopsy were evaluated retrospectively. The association of standard uptake value maximum (SUV
    Results: The SUV
    Conclusion: In this paper, we demonstrated the association between SUV
    Sprache Englisch
    Erscheinungsdatum 2020-10-23
    Erscheinungsland Turkey
    Dokumenttyp Journal Article
    ISSN 2146-1414
    ISSN 2146-1414
    DOI 10.4274/mirt.galenos.2020.89421
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: The Role of Metabolic Volumetric Parameters in Predicting Malignancy in Incidental Thyroid Nodules Detected in

    Erdoğan, Mehmet / Korkmaz, Hakan / Torus, Bora / Avcı, Mustafa / Boylubay, Şerife Mehtap / Çiriş, Metin / Yıldız, Mustafa / Şengül, Sevim Süreyya

    Molecular imaging and radionuclide therapy

    2021  Band 30, Heft 2, Seite(n) 86–92

    Abstract: Objectives: The metabolic activities of tumors can be calculated volumetrically during positron emission tomography/computed tomography (PET/CT) imaging using metabolic tumor volume (MTV) and total lesion glycolysis (TLG). This study aimed to evaluate ... ...

    Abstract Objectives: The metabolic activities of tumors can be calculated volumetrically during positron emission tomography/computed tomography (PET/CT) imaging using metabolic tumor volume (MTV) and total lesion glycolysis (TLG). This study aimed to evaluate the roles of MTV and TLG in predicting the malignancy risk of incidental thyroid nodules detected by PET/CT imaging.
    Methods: Active metabolic areas of each section were manually drawn by region of interest to calculate the MTV of nodules, and all obtained values were then summed. TLG, the product of mean standardized uptake value and MTV, was calculated by multiplying two values. All participants underwent thyroid ultrasonography imaging. All nodules were divided into risk classes according to the European Thyroid Image Reporting and Data System (EU-TIRADS) that was developed by the European Thyroid Association. The American Thyroid Association Guidelines were used to determine which thyroid nodules would undergo thyroid fine-needle biopsy (FNAB). Results were classified according to the Bethesda scoring system.
    Results: TLG levels were significantly higher in malignant or malignant-suspicious nodules than in benign nodules (p=0.013). Although MTV levels were high in malignant or malignant-suspicious nodules than in benign and non-diagnostic nodules, it was statistically insignificant at limit values (p=0.079). Areas under curve (AUC) were 0.726 (p=0.005) and AUC: 0.668 (p=0.039) for TLG and MTV, respectively. The 2.3 g cut-off value of TLG has a sensitivity of 85.7% and specificity of 59.0%. The 1.7 mL cut-off value of MTV has a sensitivity of 78.6% and specificity of 60.4%.
    Conclusion: We believe that TLG evaluation will be useful in predicting high-risk malignancy or malignancy suspicion based on EU-TIRADS risk classification of incidental thyroid nodules detected in PET/CT images. We believe that unnecessary thyroid FNABs can be avoided for thyroid incidental nodules if such relation and cut-off values are determined and that it will be useful in hastening the operation of the necessary patients.
    Sprache Englisch
    Erscheinungsdatum 2021-05-28
    Erscheinungsland Turkey
    Dokumenttyp Journal Article
    ISSN 2146-1414
    ISSN 2146-1414
    DOI 10.4274/mirt.galenos.2021.75983
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Solitary Pulmonary Nodule: Morphological Effects on Metabolic Activity Assessment

    Erdoğan, Mehmet / Evrimler, Şehnaz / Aydın, Hüseyin / Karaibrahimoğlu, Adnan / Şengül, Sevim Süreyya

    Molecular imaging and radionuclide therapy

    2019  Band 28, Heft 3, Seite(n) 112–119

    Abstract: Objectives: We aimed to evaluate the effects of morphological characteristics of the solitary pulmonary nodules (SPN) on metabolic activity assessment. To the best of our knowledge, this is the first study to compare the volumetric metabolic activity ... ...

    Abstract Objectives: We aimed to evaluate the effects of morphological characteristics of the solitary pulmonary nodules (SPN) on metabolic activity assessment. To the best of our knowledge, this is the first study to compare the volumetric metabolic activity parameters according to the morphologic parameters of the nodules.
    Methods: In this retrospective study,
    Results: SPN diameter, SUV
    Conclusion: SUV
    Sprache Englisch
    Erscheinungsdatum 2019-09-10
    Erscheinungsland Turkey
    Dokumenttyp Journal Article
    ISSN 2146-1414
    ISSN 2146-1414
    DOI 10.4274/mirt.galenos.2019.65707
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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