Artikel ; Online: Association of sex with major bleeding risks in sub-Saharian anticoagulated patients with mechanical heart valves: A cohort study from the Khartoum Emergency Salam Centre.
International journal of cardiology
2023 Band 394, Seite(n) 131398
Abstract: Background: Rheumatic heart disease (RHD) with mechanical heart valve (MHV) replacement is common in Africa. However, MHV requires lifelong anticoagulation that could have a particular impact in women in reproductive age.: Methods: We report data of ... ...
| Abstract | Background: Rheumatic heart disease (RHD) with mechanical heart valve (MHV) replacement is common in Africa. However, MHV requires lifelong anticoagulation that could have a particular impact in women in reproductive age. Methods: We report data of a prospective observational cohort study conducted between August 2018 and September 2019 in MHV patients in the Salam Centre for Cardiac Surgery built in Khartoum by Emergency, an Italian Non-Governmental Organization, to evaluate bleeding risk, its associated determinants, and the impact of lifelong anticoagulation in fertile women. Results: We studied 3647 patients (median age 25.1 years; 53.9% female). During follow-up [median time 1.1 (0.1-1.2) years], we recorded 85 major bleedings (rate 2.16 × 100 pt-years), Major bleedings occurred more frequently among women (64/85 cases, 75.3%; rate 3.0 × 100 pt-years), compared to men (21/85 cases, 24.7%; rate 1.16 × 100 pt-years) (RR 2.6; 95% CI 1.6-4.5; p = 0.0001). Multivariate analysis was performed to identify variables associated with major bleeding, and female sex was the only risk factor significantly associated, whereas aspirin treatment and higher INR target showed a non-significant trend for higher bleeding risk. Thirty-two/85 (37.6%) of major bleedings were metrorrhagias. When we calculate the incidence of major bleedings after the exclusion of gynecological events, no sex differences in the bleeding risk were found (HR 1.3, 95% CI 0.8-2.3; p = 0.3). Conclusions: Bleeding risk of young MHV patients on oral anticoagulant therapy is higher among women, mainly due to metrorrhagia. Women in the reproductive life are at high risk for gynecological bleeding when treated with anticoagulants. |
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| Mesh-Begriff(e) | Male ; Humans ; Female ; Adult ; Warfarin/adverse effects ; Cohort Studies ; Prospective Studies ; Thromboembolism/epidemiology ; Anticoagulants/adverse effects ; Hemorrhage/chemically induced ; Hemorrhage/diagnosis ; Hemorrhage/epidemiology ; Heart Valve Prosthesis/adverse effects ; Risk Factors ; Heart Valves |
| Chemische Substanzen | Warfarin (5Q7ZVV76EI) ; Anticoagulants |
| Sprache | Englisch |
| Erscheinungsdatum | 2023-09-27 |
| Erscheinungsland | Netherlands |
| Dokumenttyp | Observational Study ; Journal Article |
| ZDB-ID | 779519-1 |
| ISSN | 1874-1754 ; 0167-5273 |
| ISSN (online) | 1874-1754 |
| ISSN | 0167-5273 |
| DOI | 10.1016/j.ijcard.2023.131398 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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