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  1. Artikel ; Online: Two Gracilioethers Containing a [2(5H)-Furanylidene]ethanoate Moiety and 9,10-Dihydroplakortone G

    Luis A. Amador / Abimael D. Rodríguez / Lesly Carmona-Sarabia / Emilee E. Colón-Lorenzo / Adelfa E. Serrano

    Applied Sciences, Vol 14, Iss 1, p

    New Polyketides from the Caribbean Marine Sponge Plakortis halichondrioides

    2023  Band 281

    Abstract: Gracilioether M ( 6 ) and 11,12-dihydrogracilioether M ( 7 ), two polyketides with a [2(5H)-furanylidene]ethanoate moiety, along with known plakortone G ( 9 ) and its new naturally occurring derivative 9,10-dihydroplakortone G ( 8 ), were isolated from ... ...

    Abstract Gracilioether M ( 6 ) and 11,12-dihydrogracilioether M ( 7 ), two polyketides with a [2(5H)-furanylidene]ethanoate moiety, along with known plakortone G ( 9 ) and its new naturally occurring derivative 9,10-dihydroplakortone G ( 8 ), were isolated from the Caribbean marine sponge Plakortis halichondrioides . The structures and absolute configuration of 6 , 7 , and 8 were characterized by analysis of HRESIMS and NMR spectroscopic data, chemical derivatization, and side-by-side comparisons with published NMR data of related analogs. Compounds 6 and 7 and a mixture of 8 and 9 were evaluated for cytotoxicity against MCF-7 human breast cancer cells. In addition, the in vitro antiplasmodial activity against Plasmodium berghei of these compounds was scrutinized using a drug luminescence assay.
    Schlagwörter Plakortis halichondrioides ; polyketide ; gracilioether ; marine sponges ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 540
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Marine Pharmacology in 2016–2017

    Alejandro M. S. Mayer / Aimee J. Guerrero / Abimael D. Rodríguez / Orazio Taglialatela-Scafati / Fumiaki Nakamura / Nobuhiro Fusetani

    Marine Drugs, Vol 19, Iss 2, p

    Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

    2021  Band 49

    Abstract: The review of the 2016–2017 marine pharmacology literature was prepared in a manner similar as the 10 prior reviews of this series. Preclinical marine pharmacology research during 2016–2017 assessed 313 marine compounds with novel pharmacology reported ... ...

    Abstract The review of the 2016–2017 marine pharmacology literature was prepared in a manner similar as the 10 prior reviews of this series. Preclinical marine pharmacology research during 2016–2017 assessed 313 marine compounds with novel pharmacology reported by a growing number of investigators from 54 countries. The peer-reviewed literature reported antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities for 123 marine natural products, 111 marine compounds with antidiabetic and anti-inflammatory activities as well as affecting the immune and nervous system, while in contrast 79 marine compounds displayed miscellaneous mechanisms of action which upon further investigation may contribute to several pharmacological classes. Therefore, in 2016–2017, the preclinical marine natural product pharmacology pipeline generated both novel pharmacology as well as potentially new lead compounds for the growing clinical marine pharmaceutical pipeline, and thus sustained with its contributions the global research for novel and effective therapeutic strategies for multiple disease categories.
    Schlagwörter drug ; marine ; sea ; chemical ; natural product ; pharmacology ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Marine Pharmacology in 2012–2013

    Alejandro M. S. Mayer / Abimael D. Rodríguez / Orazio Taglialatela-Scafati / Nobuhiro Fusetani

    Marine Drugs, Vol 15, Iss 9, p

    Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

    2017  Band 273

    Abstract: The peer-reviewed marine pharmacology literature from 2012 to 2013 was systematically reviewed, consistent with the 1998–2011 reviews of this series. Marine pharmacology research from 2012 to 2013, conducted by scientists from 42 countries in addition to ...

    Abstract The peer-reviewed marine pharmacology literature from 2012 to 2013 was systematically reviewed, consistent with the 1998–2011 reviews of this series. Marine pharmacology research from 2012 to 2013, conducted by scientists from 42 countries in addition to the United States, reported findings on the preclinical pharmacology of 257 marine compounds. The preclinical pharmacology of compounds isolated from marine organisms revealed antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral and anthelmitic pharmacological activities for 113 marine natural products. In addition, 75 marine compounds were reported to have antidiabetic and anti-inflammatory activities and affect the immune and nervous system. Finally, 69 marine compounds were shown to display miscellaneous mechanisms of action which could contribute to novel pharmacological classes. Thus, in 2012–2013, the preclinical marine natural product pharmacology pipeline provided novel pharmacology and lead compounds to the clinical marine pharmaceutical pipeline, and contributed significantly to potentially novel therapeutic approaches to several global disease categories.
    Schlagwörter drug ; marine ; chemical ; metabolite ; natural product ; pharmacology ; pharmaceutical ; review ; toxicology ; pipeline ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2017-08-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Kallolide A acetate pyrazoline

    Idaliz Rodríguez-Escudero / Jeffrey Marrero / Abimael D. Rodríguez

    Acta Crystallographica Section E, Vol 68, Iss 1, Pp o41-o

    2012  Band 42

    Abstract: In the crystal structure of kallolide A acetate pyrazoline [systematic name: 7-methyl-16-oxo-4,10-bis(prop-1-en-2-yl)-17,18-dioxa-14,15-diazatetracyclo[9.4.2.16,9.01,12]octadeca-6,8,14-trien-5-yl acetate], C23H28N2O5, there is a 12-membered carbon ... ...

    Abstract In the crystal structure of kallolide A acetate pyrazoline [systematic name: 7-methyl-16-oxo-4,10-bis(prop-1-en-2-yl)-17,18-dioxa-14,15-diazatetracyclo[9.4.2.16,9.01,12]octadeca-6,8,14-trien-5-yl acetate], C23H28N2O5, there is a 12-membered carbon macrocyclic structure. In addition, there is a trisubstituted furan ring, an approximately planar γ-lactone ring [maximum deviation of 0.057 (3) Å] and a pyrazoline ring, the latter in an envelope conformation. The pyrazoline and the γ-lactone rings are fused in a cis configuration. In the crystal, molecules are linked by weak C—H.O interactions, forming a two-dimensional network parallel to (001). An intramolecular C—H.O hydrogen bond is also present.
    Schlagwörter Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2012-01-01T00:00:00Z
    Verlag International Union of Crystallography
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: 3β-Chloro-N-methoxy-N-methylcholest-5-ene-24-carboxamide

    Karilys González / Karinel Nieves / Abimael D. Rodríguez

    Acta Crystallographica Section E, Vol 68, Iss 12, Pp o3471-o

    2012  Band 3471

    Abstract: The title compound, C26H42ClNO2, is a 3β-chloro steroid with a Weinreb amide at the C-24 position. The two cyclohexane and the cyclohexene rings adopt chair and boat conformations, respectively. The cyclopentane ring has an envelope conformation. ...

    Abstract The title compound, C26H42ClNO2, is a 3β-chloro steroid with a Weinreb amide at the C-24 position. The two cyclohexane and the cyclohexene rings adopt chair and boat conformations, respectively. The cyclopentane ring has an envelope conformation.
    Schlagwörter Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2012-12-01T00:00:00Z
    Verlag International Union of Crystallography
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Marine Pharmacology in 2009–2011

    Nobuhiro Fusetani / Orazio Taglialatela-Scafati / Alejandro M. S. Mayer / Abimael D. Rodríguez

    Marine Drugs, Vol 11, Iss 7, Pp 2510-

    Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and other Miscellaneous Mechanisms of Action

    2013  Band 2573

    Abstract: The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this review, following the format used in the 1998–2008 reviews of this series. The pharmacology of structurally-characterized compounds isolated from marine animals, ... ...

    Abstract The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this review, following the format used in the 1998–2008 reviews of this series. The pharmacology of structurally-characterized compounds isolated from marine animals, algae, fungi and bacteria is discussed in a comprehensive manner. Antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral pharmacological activities were reported for 102 marine natural products. Additionally, 60 marine compounds were observed to affect the immune and nervous system as well as possess antidiabetic and anti-inflammatory effects. Finally, 68 marine metabolites were shown to interact with a variety of receptors and molecular targets, and thus will probably contribute to multiple pharmacological classes upon further mechanism of action studies. Marine pharmacology during 2009–2011 remained a global enterprise, with researchers from 35 countries, and the United States, contributing to the preclinical pharmacology of 262 marine compounds which are part of the preclinical pharmaceutical pipeline. Continued pharmacological research with marine natural products will contribute to enhance the marine pharmaceutical clinical pipeline, which in 2013 consisted of 17 marine natural products, analogs or derivatives targeting a limited number of disease categories.
    Schlagwörter drug ; marine ; chemical ; metabolite ; natural ; product ; pharmacology ; pharmaceutical ; review ; toxicology ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2013-07-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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