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Artikel: Bio-Fabrication of Bio-Inspired Silica Nanomaterials from Orange Peels in Combating Oxidative Stress.

Abomughaid, Mosleh Mohammad

2022 Band 12, Heft 18

Abstract: Silica nanoparticles were synthesized using the aqueous extract of orange peels by the green chemistry approach and simple method. The physicochemical properties such as optical and chemical banding of as-synthesized silica nanoparticles were analyzed ... ...

Abstract	Silica nanoparticles were synthesized using the aqueous extract of orange peels by the green chemistry approach and simple method. The physicochemical properties such as optical and chemical banding of as-synthesized silica nanoparticles were analyzed with UV-visible spectroscopy and Fourier transform infrared spectroscopy. Scanning Electron Microscopy with Energy Dispersive X-Ray Analysis and X-ray diffraction analysis were employed to confirm the shape, size and elemental purities of the silica nanoparticles. The thermal stability and mass loss of the silica nanoparticles was examined using thermogravimetric analysis and zeta potential analysis. The surface plasmon resonance band of the silica nanoparticle was obtained in the wavelength of 292 nm. Silica nanoparticles with a spherical and amorphous nature and an average size of 20 nm were produced and confirmed by X-ray diffraction and Scanning Electron Microscopy. The zeta potential of the silica nanoparticles was -25.00 mV. The strong and broad bands were located at 457, 642 and 796 cm
Sprache	Englisch
Erscheinungsdatum	2022-09-18
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12183236
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Long-Term Survival and Cancer Risk in the Hepatitis C Virus-Infected Patients After Antiviral Treatment: A Nationwide Cohort Study.

Chen, Yi-Ju / Huang, Jing-Yang / Baskaran, Rathinasamy / Abomughaid, Mosleh Mohammad / Hsieh, Chang-Chi / Lin, Wan-Teng

Journal of Cancer

2024 Band 15, Heft 1, Seite(n) 113–125

Abstract: Background: ...

Abstract	Background:
Sprache	Englisch
Erscheinungsdatum	2024-01-01
Erscheinungsland	Australia
Dokumenttyp	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.87259
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Potato protein hydrolysate inhibits RANKL-induced osteoclast development by inhibiting osteoclastogenic genes via the NF-κB/MAPKs signaling pathways.

Chen, Yi-Ju / He, Yen-Hua / Lo, Yun-Hsin / Yang, Hong-Siang / Abomughaid, Mosleh Mohammad / Kumar, K J Senthil / Lin, Wan-Teng

Environmental toxicology

2024

Abstract: In recent times, there has been growing attention towards exploring the nutritional and functional aspects of potato protein, along with its diverse applications. In the present study, we examined the anti-osteoclast properties of potato protein ... ...

Abstract	In recent times, there has been growing attention towards exploring the nutritional and functional aspects of potato protein, along with its diverse applications. In the present study, we examined the anti-osteoclast properties of potato protein hydrolysate (PP902) in vitro. Murine macrophages (RAW264.7) were differentiated into osteoclasts by receptor activator of nuclear factor-κB ligand (RANKL), and PP902 was examined for its inhibitory effect. Initially, treatment with PP902 was found to significantly prevent RANKL-induced morphological changes in macrophage cells, as determined by tartrate-resistant acid phosphatase (TRAP) staining analysis. This notion was further supported by F-actin analysis using a confocal microscope. Furthermore, PP902 treatment effectively and dose-dependently down-regulated the expression of RANKL-induced osteoclastogenic marker genes, including TRAP, CTR, RANK, NFATc1, OC-STAMP, and c-Fos. These inhibitory effects were associated with suppressing NF-κB transcriptional activation and subsequent reduced nuclear translocation. The decrease in NF-κB activity resulted from reduced activation of its upstream kinases, including I-κBα and IKKα. Moreover, PP902 significantly inhibited RANKL-induced p38MAPK and ERK1/2 activities. Nevertheless, PP902 treatment prevents RANKL-induced intracellular reactive oxygen species generation via increased HO-1 activity. The combined antioxidant and anti-inflammatory effects of PP902 resulted in significant suppression of osteoclastogenesis, suggesting its potential as an adjuvant therapy for osteoclast-related diseases.
Sprache	Englisch
Erscheinungsdatum	2024-04-12
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.24251
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Bio-fabrication of Bio-inspired Silica Nanomaterials from Bryophyllum pinnatum Leaf for Agricultural Applications

Sankareswaran, M. / Periakaruppan, Rajiv / Sasivarnam, M. / Danaraj, Jeyapragash / Dhanasekaran, Sugapriya / Abomughaid, Mosleh Mohammad

Applied biochemistry and biotechnology. 2022 Sept., v. 194, no. 9

2022

Abstract: A green chemistry approach was employed to synthesize silica nanoparticles (SiNPs) using aqueous extract of Bryophyllum pinnatum leaf as capping agents. The novelty of this study was to produce silica nanoparticles using the biological method. An ... ...

Abstract	A green chemistry approach was employed to synthesize silica nanoparticles (SiNPs) using aqueous extract of Bryophyllum pinnatum leaf as capping agents. The novelty of this study was to produce silica nanoparticles using the biological method. An analysis of the physicochemical properties of formed nanoparticles was successfully completed through sophisticated characterization methods, such as UV–Visible absorbance spectroscopy, Fourier transform infra-red spectroscopy, X-ray diffraction, scanning electron microscope, energy dispersive X-ray, zeta potential analysis, and thermo-gravimetric analysis. All the characterization results indicated their spherical morphology and amorphous nature with an average size of 24 nm. FT-IR results highlighted the key bioactive compounds that could be responsible for capping and reducing the formation of SiNPs. Synthesized SiNPs show excellent stability with a negative zeta potential value of − 32 mV. The biomolecules from B. pinnatum were successfully working for the formation of Si NPs with spherical shapes. Moreover, to assess the agricultural application, green-synthesized SiNPs were carried out by seed germination assay on Vigna radiata. The seed germination assay confirms that a low concentration of SiNPs enhances seed germination. Meanwhile, a higher concentration of the SiNPs inhibits seed germination and shoot, and root formation. SiNPs at optimum concentration could be used in the agriculture field as nano growth promoters.
Schlagwörter	Fourier transform infrared spectroscopy ; Kalanchoe pinnata ; Vigna radiata ; X-ray diffraction ; absorbance ; biochemical compounds ; biofabrication ; energy-dispersive X-ray analysis ; green chemistry ; leaves ; nanoparticles ; seed germination ; silica ; thermogravimetry ; zeta potential
Sprache	Englisch
Erscheinungsverlauf	2022-09
Umfang	p. 4266-4277.
Erscheinungsort	Springer US
Dokumenttyp	Artikel
ZDB-ID	392344-7
ISSN	0273-2289
ISSN	0273-2289
DOI	10.1007/s12010-022-03996-4
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Bio-fabrication of Bio-inspired Silica Nanomaterials from Bryophyllum pinnatum Leaf for Agricultural Applications.

Sankareswaran, M / Periakaruppan, Rajiv / Sasivarnam, M / Danaraj, Jeyapragash / Dhanasekaran, Sugapriya / Abomughaid, Mosleh Mohammad

Applied biochemistry and biotechnology

2022 Band 194, Heft 9, Seite(n) 4266–4277

Abstract	A green chemistry approach was employed to synthesize silica nanoparticles (SiNPs) using aqueous extract of Bryophyllum pinnatum leaf as capping agents. The novelty of this study was to produce silica nanoparticles using the biological method. An analysis of the physicochemical properties of formed nanoparticles was successfully completed through sophisticated characterization methods, such as UV-Visible absorbance spectroscopy, Fourier transform infra-red spectroscopy, X-ray diffraction, scanning electron microscope, energy dispersive X-ray, zeta potential analysis, and thermo-gravimetric analysis. All the characterization results indicated their spherical morphology and amorphous nature with an average size of 24 nm. FT-IR results highlighted the key bioactive compounds that could be responsible for capping and reducing the formation of SiNPs. Synthesized SiNPs show excellent stability with a negative zeta potential value of - 32 mV. The biomolecules from B. pinnatum were successfully working for the formation of Si NPs with spherical shapes. Moreover, to assess the agricultural application, green-synthesized SiNPs were carried out by seed germination assay on Vigna radiata. The seed germination assay confirms that a low concentration of SiNPs enhances seed germination. Meanwhile, a higher concentration of the SiNPs inhibits seed germination and shoot, and root formation. SiNPs at optimum concentration could be used in the agriculture field as nano growth promoters.
Mesh-Begriff(e)	Agriculture ; Green Chemistry Technology ; Kalanchoe ; Metal Nanoparticles/chemistry ; Plant Extracts/chemistry ; Plant Leaves/chemistry ; Silicon Dioxide ; Spectroscopy, Fourier Transform Infrared ; X-Ray Diffraction
Chemische Substanzen	Plant Extracts ; Silicon Dioxide (7631-86-9)
Sprache	Englisch
Erscheinungsdatum	2022-06-06
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	392344-7
ISSN	1559-0291 ; 0273-2289
ISSN (online)	1559-0291
ISSN	0273-2289
DOI	10.1007/s12010-022-03996-4
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Semilicoisoflavone B Induces Apoptosis of Oral Cancer Cells by Inducing ROS Production and Downregulating MAPK and Ras/Raf/MEK Signaling.

Hsieh, Ming-Ju / Ho, Hsin-Yu / Lo, Yu-Sheng / Lin, Chia-Chieh / Chuang, Yi-Ching / Abomughaid, Mosleh Mohammad / Hsieh, Ming-Chang / Chen, Mu-Kuan

International journal of molecular sciences

2023 Band 24, Heft 5

Abstract: Oral squamous cell carcinoma (OSCC) is the sixth most common type of cancer worldwide. Despite advancement in treatment, advanced-stage OSCC is associated with poor prognosis and high mortality. The present study aimed to investigate the anticancer ... ...

Abstract	Oral squamous cell carcinoma (OSCC) is the sixth most common type of cancer worldwide. Despite advancement in treatment, advanced-stage OSCC is associated with poor prognosis and high mortality. The present study aimed to investigate the anticancer activities of semilicoisoflavone B (SFB), which is a natural phenolic compound isolated from
Mesh-Begriff(e)	Humans ; Apoptosis/drug effects ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Mitogen-Activated Protein Kinase Kinases ; Mouth Neoplasms/drug therapy ; Mouth Neoplasms/metabolism ; Reactive Oxygen Species/metabolism ; Mitogen-Activated Protein Kinases/drug effects ; Mitogen-Activated Protein Kinases/metabolism ; ras Proteins/drug effects ; ras Proteins/metabolism ; Proto-Oncogene Proteins c-raf/drug effects ; Proto-Oncogene Proteins c-raf/metabolism
Chemische Substanzen	Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2) ; Reactive Oxygen Species ; semilicoisoflavone B (T9TP371NFX) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; ras Proteins (EC 3.6.5.2) ; Proto-Oncogene Proteins c-raf (EC 2.7.11.1)
Sprache	Englisch
Erscheinungsdatum	2023-02-24
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24054505
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Picrasidine J, a Dimeric β-Carboline-Type Alkaloid from

Ho, Hsin-Yu / Lin, Chia-Chieh / Lo, Yu-Sheng / Chuang, Yi-Ching / Abomughaid, Mosleh Mohammad / Hsieh, Ming-Ju

International journal of molecular sciences

2023 Band 24, Heft 17

Abstract: Head and neck squamous cell carcinoma (HNSCC) are associated with recurrence, distant metastasis, and poor overall survival. This highlights the need for identifying potential therapeutics with minimal side-effects. The present study was designed to ... ...

Abstract	Head and neck squamous cell carcinoma (HNSCC) are associated with recurrence, distant metastasis, and poor overall survival. This highlights the need for identifying potential therapeutics with minimal side-effects. The present study was designed to investigate the anticancer effects of picrasidine J, a dimeric β-carboline-type alkaloid isolated from the southern Asian plant
Mesh-Begriff(e)	Picrasma ; Squamous Cell Carcinoma of Head and Neck ; Alkaloids/pharmacology ; Carbolines ; Antineoplastic Agents/pharmacology ; Polymers ; Head and Neck Neoplasms/drug therapy
Chemische Substanzen	Alkaloids ; Carbolines ; Antineoplastic Agents ; Polymers
Sprache	Englisch
Erscheinungsdatum	2023-08-25
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241713230
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: VH-4-A Bioactive Peptide from Soybean and Exercise Training Constrict Hypertension in Rats through Activating Cell Survival and AMPKα1, Sirt1, PGC1α, and FoX3α.

Baskaran, Rathinasamy / Balasubramanian, Balamuralikrishnan / Ho, Jou-Hsuan / Wang, Ming-Fu / Abomughaid, Mosleh Mohammad / Yang, Hong-Siang / Lin, Wan-Teng

Molecules (Basel, Switzerland)

2022 Band 27, Heft 22

Abstract: Hypertension is a chronic disease related to age, which affects tens of millions of people around the world. It is an important risk factor that causes myocardial infarction, heart failure, stroke, and kidney damage. Bioactive peptide VHVV (VH-4) from ... ...

Abstract	Hypertension is a chronic disease related to age, which affects tens of millions of people around the world. It is an important risk factor that causes myocardial infarction, heart failure, stroke, and kidney damage. Bioactive peptide VHVV (VH-4) from soybean has shown several biological activities. Physical exercise is a cornerstone of non-pharmacologic treatment for hypertension and has established itself as an effective and complementary strategy for managing hypertension. The present study evaluates the efficacy of VH-4 supplement and swimming exercise training in preventing hypertension in spontaneously hypertensive rats (SHR). SHR animals were treated with VH-4 (25 mg/kg by intraperitoneal administration) and swimming exercise (1 h daily) for eight weeks, and the hemodynamic parameters, histology, and cell survival pathway protein expression were examined. In SHR rats, increased heart weight, blood pressure, and histological aberrations were observed. Cell survival protein p-PI3K and p-AKT and antiapoptosis proteins Bcl2 and Bcl-XL expression decreased in SHR animals. SIRT1 and FOXO3 were decreased in hypertensive rats. Both bioactive peptide VH-4 treatment and swimming exercise training in hypertensive rats increased the cell survival proteins p-PI3K and p-AKT and AMPKα1, Sirt1, PGC1α, and FoX3α proteins. Soy peptide VH-4, along with exercise, acts synergistically and prevents hypertension by activating cell survival and AMPKα1, Sirt1, PGC1α, and FoX3α proteins.
Mesh-Begriff(e)	Rats ; Animals ; Sirtuin 1/metabolism ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Glycine max/metabolism ; Cell Survival ; Proto-Oncogene Proteins c-akt/metabolism ; Physical Conditioning, Animal ; Hypertension ; Rats, Inbred SHR ; Peptides/pharmacology ; Peptides/metabolism ; Fabaceae/metabolism ; Phosphatidylinositol 3-Kinases/metabolism
Chemische Substanzen	Sirtuin 1 (EC 3.5.1.-) ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Peptides ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Sirt1 protein, rat (EC 3.5.1.-)
Sprache	Englisch
Erscheinungsdatum	2022-11-09
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27227705
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Psychedelics for alzheimer's disease-related dementia: Unveiling therapeutic possibilities and pathways.

Sinha, Jitendra Kumar / Trisal, Anchal / Ghosh, Shampa / Gupta, Saurabh / Singh, Krishna Kumar / Han, Sung Soo / Mahapatra, Madhumita / Abomughaid, Mosleh Mohammad / Abomughayedh, Ali M / Almutary, Abdulmajeed G / Iqbal, Danish / Bhaskar, Rakesh / Mishra, Prabhu Chandra / Jha, Saurabh Kumar / Jha, Niraj Kumar / Singh, Abhishek Kumar

Ageing research reviews

2024 Band 96, Seite(n) 102211

Abstract: Psychedelics have traditionally been used for spiritual and recreational purposes, but recent developments in psychotherapy have highlighted their potential as therapeutic agents. These compounds, which act as potent 5-hydroxytryptamine (5HT) agonists, ... ...

Abstract	Psychedelics have traditionally been used for spiritual and recreational purposes, but recent developments in psychotherapy have highlighted their potential as therapeutic agents. These compounds, which act as potent 5-hydroxytryptamine (5HT) agonists, have been recognized for their ability to enhance neural plasticity through the activation of the serotoninergic and glutamatergic systems. However, the implications of these findings for the treatment of neurodegenerative disorders, particularly dementia, have not been fully explored. In recent years, studies have revealed the modulatory and beneficial effects of psychedelics in the context of dementia, specifically Alzheimer's disease (AD)-related dementia, which lacks a definitive cure. Psychedelics such as N,N-dimethyltryptamine (DMT), lysergic acid diethylamide (LSD), and Psilocybin have shown potential in mitigating the effects of this debilitating disease. These compounds not only target neurotransmitter imbalances but also act at the molecular level to modulate signalling pathways in AD, including the brain-derived neurotrophic factor signalling pathway and the subsequent activation of mammalian target of rapamycin and other autophagy regulators. Therefore, the controlled and dose-dependent administration of psychedelics represents a novel therapeutic intervention worth exploring and considering for the development of drugs for the treatment of AD-related dementia. In this article, we critically examined the literature that sheds light on the therapeutic possibilities and pathways of psychedelics for AD-related dementia. While this emerging field of research holds great promise, further studies are necessary to elucidate the long-term safety, efficacy, and optimal treatment protocols. Ultimately, the integration of psychedelics into the current treatment paradigm may provide a transformative approach for addressing the unmet needs of individuals living with AD-related dementia and their caregivers.
Mesh-Begriff(e)	Humans ; Hallucinogens/pharmacology ; Hallucinogens/therapeutic use ; Alzheimer Disease/drug therapy ; Lysergic Acid Diethylamide/pharmacology ; Lysergic Acid Diethylamide/therapeutic use ; Psilocybin/pharmacology ; Psilocybin/therapeutic use ; N,N-Dimethyltryptamine
Chemische Substanzen	Hallucinogens ; Lysergic Acid Diethylamide (8NA5SWF92O) ; Psilocybin (2RV7212BP0) ; N,N-Dimethyltryptamine (WUB601BHAA)
Sprache	Englisch
Erscheinungsdatum	2024-02-01
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review
ZDB-ID	2075672-0
ISSN	1872-9649 ; 1568-1637
ISSN (online)	1872-9649
ISSN	1568-1637
DOI	10.1016/j.arr.2024.102211
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Investigating the Potential Therapeutic Mechanisms of Puerarin in Neurological Diseases.

Chauhan, Payal / Wadhwa, Karan / Mishra, Richa / Gupta, Saurabh / Ahmad, Fuzail / Kamal, Mehnaz / Iqbal, Danish / Alsaweed, Mohammed / Nuli, Mohana Vamsi / Abomughaid, Mosleh Mohammad / Almutary, Abdulmajeed G / Mishra, Prabhu Chandra / Jha, Saurabh Kumar / Ojha, Shreesh / Nelson, Vinod Kumar / Dargar, Abha / Singh, Govind / Jha, Niraj Kumar

Molecular neurobiology

2024

Abstract: Plants and their derived phytochemicals have a long history of treating a wide range of illnesses for several decades. They are believed to be the origin of a diverse array of medicinal compounds. One of the compounds found in kudzu root is puerarin, a ... ...

Abstract	Plants and their derived phytochemicals have a long history of treating a wide range of illnesses for several decades. They are believed to be the origin of a diverse array of medicinal compounds. One of the compounds found in kudzu root is puerarin, a isoflavone glycoside commonly used as an alternative medicine to treat various diseases. From a biological perspective, puerarin can be described as a white needle crystal with the chemical name of 7-hydroxy-3-(4-hydroxyphenyl)-1-benzopyran-4-one-8-D-glucopyranoside. Besides, puerarin is sparingly soluble in water and produces no color or light yellow solution. Multiple experimental and clinical studies have confirmed the significant therapeutic effects of puerarin. These effects span a wide range of pharmacological effects, including neuroprotection, hepatoprotection, cardioprotection, immunomodulation, anticancer properties, anti-diabetic properties, anti-osteoporosis properties, and more. Puerarin achieves these effects by interacting with various cellular and molecular pathways, such as MAPK, AMPK, NF-κB, mTOR, β-catenin, and PKB/Akt, as well as different receptors, enzymes, and growth factors. The current review highlights the molecular mechanism of puerarin as a neuroprotective agent in the treatment of various neurodegenerative and neurological diseases. Extensive cellular, animal, and clinical research has provided valuable insights into its effectiveness in conditions such as Alzheimer's disease, Parkinson's disease, epilepsy, cerebral stroke, depression, and more.
Sprache	Englisch
Erscheinungsdatum	2024-05-23
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-024-04222-4
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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