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  1. Artikel ; Online: Silver nanoparticles synthesized with a fraction from the bark of Eysenhardtia polystachya with high chalcone and dihydrochalcone content effectively inhibit oxidative stress in the zebrafish embryo model

    Abraham Heriberto Garcia Campoy / Fernando Felipe Martinez Jeronimo / Rosa Martha Perez Gutierrez / Alethia Martinez Ramirez

    Nanomedicine Journal, Vol 5, Iss 3, Pp 152-

    2018  Band 162

    Abstract: Objective(s): In this study, we desvcribe a simple eco-friendly approach for the synthesis of a potent, stable and benign silver nanoparticles to carry and deliver chalcones and dihydrochalcones present in a methanol extract of Eysenhardtia polystachya ( ... ...

    Abstract Objective(s): In this study, we desvcribe a simple eco-friendly approach for the synthesis of a potent, stable and benign silver nanoparticles to carry and deliver chalcones and dihydrochalcones present in a methanol extract of Eysenhardtia polystachya (EP). Materials and Methods: In this process silver nanoparticles carring EP compounds (EP/AgNPs) are synthesized in a single step by eliminating the additional handling associated with incorporating EP compounds. The resulting nanoparticles (EP/AgNPs) were characterized using several physicochemical techniques. Cell viability was measured in vitro with RAW264.7 murine macrophage cells. In addition, we evaluated the ability of EP and EP/AgNPs to protect against glucose-induced oxidative in vivo stress using zebrafish embryos. Results: The synthesized EP/AgNPs showed an absorption peak at 413 nm on ultraviolet-visible spectroscopy (UV-vis), revealing the surface plasmon resonance of the nanoparticles. Transmission electron microscopy (TEM) indicated that most of the particles were spherical with a diameter of 10 to 12 nm, a polydispersity index (PDI) of 0.197 and a zeta potential of –32.25 mV, suggesting high stability of these nanoparticles. This study also demonstrated the biocompatibility of the nanoparticles when tested in RAW264.7 cells and its protective efficacy against oxidative stress induced by the exposure of zebrafish embryos to high glucose concentrations. Treatment with EP/AgNPs increased the activity of anti-stress biomarkers such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and total soluble protein. Exposure of the embryos to EP/AgNPs significantly (P
    Schlagwörter Eysenhardtia polystachya ; chalcones ; dihydrochalcones ; silver nanoparticles ; Oxidative Stress ; zebrafish ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 500
    Sprache Englisch
    Erscheinungsdatum 2018-07-01T00:00:00Z
    Verlag Mashhad University of Medical Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: 3′- O -β- d -glucopyranosyl-α,4,2′,4′,6′-pentahydroxy-dihydrochalcone, from Bark of Eysenhardtia polystachya Prevents Diabetic Nephropathy via Inhibiting Protein Glycation in STZ-Nicotinamide Induced Diabetic Mice

    Rosa Martha Pérez Gutierrez / Abraham Heriberto García Campoy / Silvia Patricia Paredes Carrera / Alethia Muñiz Ramirez / José Maria Mota Flores / Sergio Odin Flores Valle

    Molecules, Vol 24, Iss 7, p

    2019  Band 1214

    Abstract: Previous studies have shown that accumulation of advanced glycation end products (AGEs) can be the cause of diabetic nephropathy (DN) in diabetic patients. Dihydrochalcone 3′- O -β- d -glucopyranosyl α,4,2′,4′,6′-pentahydroxy–dihydrochalcone ( 1 ) is a ... ...

    Abstract Previous studies have shown that accumulation of advanced glycation end products (AGEs) can be the cause of diabetic nephropathy (DN) in diabetic patients. Dihydrochalcone 3′- O -β- d -glucopyranosyl α,4,2′,4′,6′-pentahydroxy–dihydrochalcone ( 1 ) is a powerful antiglycation compound previously isolated from Eysenhardtia polystachya . The aim was to investigate whether ( 1 ) was able to protect against diabetic nephropathy in streptozotocin (STZ)-induced diabetic mice, which displayed renal dysfunction markers such as body weight, creatinine, uric acid, serum urea, total urinary protein, and urea nitrogen in the blood (BUN). In addition, pathological changes were evaluated including glycated hemoglobin (HbA1c), advanced glycation end products (AGEs) in the kidney, as well as in circulation level and pro-inflammatory markers ICAM-1 levels in diabetic mice. After 5 weeks, these elevated markers of dihydrochalcone treatment (25, 50 and 100 mg/kg) were significantly ( p < 0.05) attenuated. In addition, they ameliorate the indices of renal inflammation as indicated by ICAM-1 markers. The kidney and circulatory AGEs levels in diabetic mice were significantly ( p < 0.05) attenuated by ( 1 ) treatment. Histological analysis of kidney tissues showed an important recovery in its structure compared with the diabetic group. It was found that the compound ( 1 ) attenuated the renal damage in diabetic mice by inhibiting AGEs formation.
    Schlagwörter dihydrochalcone ; advanced glycation end-product ; Eysenhardtia polystachya ; diabetic mice ; renoprotective ; Organic chemistry ; QD241-441
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2019-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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