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  1. Buch: Molecular probes for biomedical applications / 2

    Achilefu, Samuel

    (Proceedings of SPIE ; 6867 ; Progress in biomedical optics and imaging ; 9,26)

    2008  

    Verfasserangabe SPIE
    Serientitel Proceedings of SPIE ; 6867
    Progress in biomedical optics and imaging ; 9,26
    Molecular probes for biomedical applications
    Überordnung Molecular probes for biomedical applications
    Sprache Englisch
    Umfang Getr. Zählung : Ill., graph. Darst.
    Verlag SPIE
    Erscheinungsort Bellingham, Wash
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch
    HBZ-ID HT015698321
    ISBN 978-0-8194-7042-3 ; 0-8194-7042-2
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  2. Buch: Optical molecular probes for biomedical applications

    Achilefu, Samuel

    22 - 24 January 2006, San Jose, California, USA

    (SPIE ; 6097 ; Progress in biomedical optics and imaging ; 7,20)

    2006  

    Verfasserangabe SPIE, the International Society for Optical Engineering. Samuel I. Achilefu ..., chairs/ed
    Serientitel SPIE ; 6097
    Progress in biomedical optics and imaging ; 7,20
    Proceedings / SPIE, The International Society for Optical Engineering
    Überordnung Proceedings / SPIE, The International Society for Optical Engineering
    Schlagwörter Molecular Probe Techniques ; Diagnostic Imaging ; Spectrometry, Fluorescence ; Nanostructures ; Biosensing Techniques
    Sprache Englisch
    Umfang Getr. Zählung : ill., graph. Darst.
    Verlag SPIE
    Erscheinungsort Bellingham, Wash
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch
    HBZ-ID HT015307554
    ISBN 0-8194-6139-3 ; 978-0-8194-6139-1
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  3. Buch: Optical, ultrasound, X-Ray and radiopharmaceutical imaging

    Achilefu, Samuel / Krause, Werner

    (Contrast agents ; 2 ; Topics in current chemistry ; 222)

    2002  

    Verfasserangabe with contributions by S. Achilefu ... Vol. ed.: Werner Krause
    Serientitel Contrast agents ; 2
    Topics in current chemistry ; 222
    Überordnung
    Sprache Englisch
    Umfang VIII, 291 S. : Ill., graph. Darst.
    Verlag Springer
    Erscheinungsort Berlin u.a.
    Erscheinungsland Deutschland
    Dokumenttyp Buch
    HBZ-ID HT013419676
    ISBN 3-540-43451-8 ; 978-3-540-43451-1
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  4. Artikel: Low-cost augmented reality goggles enable precision fluorescence-guided cancer surgery.

    Shmuylovich, Leonid / O'Brien, Christine M / Nwosu, Karen / Achilefu, Samuel

    Research square

    2023  

    Abstract: Disparities in surgical outcomes often result from subjective than objective decisions dictated by surgical training, experience, and available resources. To improve outcomes, surgeons have adopted advancements in robotics, endoscopy, and intra-operative ...

    Abstract Disparities in surgical outcomes often result from subjective than objective decisions dictated by surgical training, experience, and available resources. To improve outcomes, surgeons have adopted advancements in robotics, endoscopy, and intra-operative imaging including fluorescence-guided surgery (FGS), which highlight tumors in real-time without using ionizing radiation. However, like many medical innovations, technical, economic, and logistic challenges have hindered widespread adoption of FGS beyond high-resource centers. To overcome these impediments, we developed the fully-wearable and battery-powered fluorescence imaging augmented reality Raspberry Pi-based goggle system (FAR-Pi). Novel device design ensures distance-independent coalignment between real and augmented FAR-Pi views and offers higher spatial resolution, depth of focus, and fluorescence detection sensitivity than existing bulkier, pricier, and wall-powered technologies. When paired with pan-tumor targeting fluorescent agents such as LS301, FAR-Pi objectively identifies tumors in vivo. As an open-source, affordable, and adaptable system, FAR-Pi is poised to democratize access to FGS and improve health outcomes worldwide.
    Sprache Englisch
    Erscheinungsdatum 2023-07-12
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.21203/rs.3.rs-3084024/v1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Rapid response activatable molecular probes for intraoperative optical image-guided tumor resection.

    Achilefu, Samuel

    Hepatology (Baltimore, Md.)

    2012  Band 56, Heft 3, Seite(n) 1170–1173

    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2012-09
    Erscheinungsland United States
    Dokumenttyp Comment ; Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.25807
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: The insatiable quest for near-infrared fluorescent probes for molecular imaging.

    Achilefu, Samuel

    Angewandte Chemie (International ed. in English)

    2011  Band 49, Heft 51, Seite(n) 9816–9818

    Mesh-Begriff(e) Fluorescence Resonance Energy Transfer ; Fluorescent Dyes ; Humans ; Infrared Rays ; Luminescence ; Molecular Imaging/methods
    Chemische Substanzen Fluorescent Dyes
    Sprache Englisch
    Erscheinungsdatum 2011-01-25
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.201005684
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Buch ; Konferenzbeitrag: Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VI

    Achilefu, Samuel / Raghavachari, Ramesh

    2-5 February 2014, San Francisco, California, United States

    (Progress in biomedical optics and imaging, ; vol. 15, no. 31 ; Proceedings of SPIE, ; volume 8956)

    2014  

    Titelvarianten Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications 6 ; Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications Six
    Körperschaft SPIE (Society),
    Veranstaltung/Kongress Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications (Conference) (6th, 2014, SanFranciscoCalif.) ; SPIE Photonics West (Conference) (2014, SanFranciscoCalif.)
    Verfasserangabe Samuel Achilefu, Ramesh Raghavachari, editors ; sponsored and published by SPIE
    Serientitel Progress in biomedical optics and imaging, ; vol. 15, no. 31
    Proceedings of SPIE, ; volume 8956
    Mesh-Begriff(e) Nanoparticles/therapeutic use ; Molecular Probe Techniques ; Molecular Probes ; Nanoparticles ; Spectroscopy, Near-Infrared
    Sprache Englisch
    Umfang 1 volume (various pagings) :, illustrations.
    Dokumenttyp Buch ; Konferenzbeitrag
    Anmerkung "SPIE Photonics West"--cover.
    ISBN 9780819498694 ; 0819498696
    Datenquelle Katalog der US National Library of Medicine (NLM)

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  8. Buch ; Konferenzbeitrag: Reporters, markers, dyes, nanoparticles, and molecular probes for biomedical applications II

    Achilefu, Samuel

    25 - 27 January 2010, San Francisco, California, United States ; [SPIE Photonics West]

    (Proceedings of SPIE ; 7576 ; Progress in biomedical optics and imaging ; Vol. 11, No. 29)

    2010  

    Veranstaltung/Kongress Conference (2010.01.25-27, SanFranciscoCalif.) ; SPIE Photonics West (2010.01.25-27, SanFranciscoCalif.)
    Verfasserangabe sponsored and publ. by SPIE. Samual Achilefu .̤, ed
    Serientitel Proceedings of SPIE ; 7576
    Progress in biomedical optics and imaging ; Vol. 11, No. 29
    Mesh-Begriff(e) Biosensing Techniques ; Diagnostic Imaging ; Molecular Probe Techniques ; Molecular Probes/diagnostic use ; Nanoparticles ; Spectrometry, Fluorescence
    Schlagwörter Diagnostic imaging ; Dyes in medical diagnosis ; Imaging systems in biology ; Imaging systems in medicine ; Molecular probes/Diagnostic use ; Nanoparticles
    Sprache Englisch
    Umfang Getr. Zählung [ca. 350 S.], Ill., graph. Darst.
    Verlag SPIE
    Erscheinungsort Bellingham, Wash
    Dokumenttyp Buch ; Konferenzbeitrag
    ISBN 9780819479723 ; 0819479721
    Datenquelle Katalog der Technische Informationsbibliothek Hannover

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  9. Artikel: Early Expression of MMP-9 Predicts Recovery of Tibialis Anterior after Sciatic Nerve Crush Injury.

    Brogan, David M / Dy, Christopher J / Wever, Jason / Lee, Tony / Achilefu, Samuel

    Plastic and reconstructive surgery. Global open

    2022  Band 10, Heft 4, Seite(n) e4260

    Abstract: Background: The purpose of this study was to assess the expression of molecular markers and epineural blood flow after differing degrees of nerve injury to identify potential tools to predict nerve recovery in a rat sciatic nerve model.: Methods: A ... ...

    Abstract Background: The purpose of this study was to assess the expression of molecular markers and epineural blood flow after differing degrees of nerve injury to identify potential tools to predict nerve recovery in a rat sciatic nerve model.
    Methods: A total of 72 rats were divided into nine groups. Each group was subjected to one of three crush injuries, created by applying one of three vascular clamps for 30 seconds. Vascularity was assessed with laser Doppler flowmetry before and after crush, and at nonsurvival surgery. Nonsurvival surgeries were performed 6 hours, 2 weeks, or 6 weeks later with nerve conduction studies and muscle strength testing. Expression of matrix metalloproteinase 9 (MMP-9) and matrix metalloproteinase 2 (MMP-2) in each nerve was quantified using with enzyme linked immunosorbent analysis.
    Results: Persistent hyperemia was noted in the zone of injury compared with baseline at 2 weeks and 6 weeks in the groups that displayed incomplete recovery. Expression of MMP-9 at 6 hours increased with increasing severity of crush and was inversely related to tibialis anterior muscle force recovery. The ratio of MMP-9:MMP-2 expression correlated well with recovery of compound nerve action potential amplitude at 6 weeks.
    Conclusions: Resolution of nerve hyperemia may correlate with nerve recovery from trauma, but early measures of nerve blood flow after injury are not prognostic of recovery. Ratio of MMP-9:MMP-2 expression 6 hours after injury correlates with recovery of compound nerve action potential at 6 weeks, while MMP-9 expression alone predicts tibialis anterior recovery. These findings together suggest that increased MMP-9 expression is a potentially useful marker of more severe nerve injury.
    Sprache Englisch
    Erscheinungsdatum 2022-04-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000004260
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Introduction to concepts and strategies for molecular imaging.

    Achilefu, Samuel

    Chemical reviews

    2010  Band 110, Heft 5, Seite(n) 2575–2578

    Mesh-Begriff(e) Animals ; Humans ; Molecular Imaging/methods
    Sprache Englisch
    Erscheinungsdatum 2010-05-12
    Erscheinungsland United States
    Dokumenttyp Editorial ; Introductory Journal Article
    ZDB-ID 207949-5
    ISSN 1520-6890 ; 0009-2665
    ISSN (online) 1520-6890
    ISSN 0009-2665
    DOI 10.1021/cr1001113
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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