Artikel ; Online: Generalized pustular psoriasis in a toddler with IL36RN mutation: a case report.
2024 Band 15, Seite(n) 1337799
Abstract: Generalized Pustular Psoriasis (GPP) is a dermatological autoinflammatory disease that rarely occurs in children and is associated with complex genetic factors. GPP pathogenesis has been associated with mutations in IL36RN gene, which encodes an ... ...
Abstract | Generalized Pustular Psoriasis (GPP) is a dermatological autoinflammatory disease that rarely occurs in children and is associated with complex genetic factors. GPP pathogenesis has been associated with mutations in IL36RN gene, which encodes an interleukin-36 receptor antagonist. GPP usually occurs without a history of psoriasis in the patients or their family members. This case report describes the clinical course of a 3-year-old toddler with GPP. The diagnosis of GPP was confirmed through a comprehensive series of examinations, and genetic testing revealed an IL36RN mutation, providing further insight into the genetic basis of the condition. This case highlights the importance of a genetic perspective for diagnosing GPP, particularly in children. |
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Mesh-Begriff(e) | Humans ; Child, Preschool ; Interleukins/genetics ; Psoriasis/diagnosis ; Psoriasis/genetics ; Psoriasis/pathology ; Mutation ; Genetic Testing ; Acute Disease ; Chronic Disease ; Skin Diseases, Vesiculobullous/genetics |
Chemische Substanzen | Interleukins ; IL36RN protein, human |
Sprache | Englisch |
Erscheinungsdatum | 2024-03-20 |
Erscheinungsland | Switzerland |
Dokumenttyp | Case Reports |
ZDB-ID | 2606827-8 |
ISSN | 1664-3224 ; 1664-3224 |
ISSN (online) | 1664-3224 |
ISSN | 1664-3224 |
DOI | 10.3389/fimmu.2024.1337799 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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