Article: Phosphate-binding pocket on cyclin B governs CDK substrate phosphorylation and mitotic timing.
bioRxiv : the preprint server for biology
2024
Abstract: Cell cycle progression is governed by complexes of the cyclin-dependent kinases (CDKs) and their regulatory subunits cyclin and Cks1. CDKs phosphorylate hundreds of substrates, often at multiple sites. Multisite phosphorylation depends on Cks1, which ... ...
Abstract | Cell cycle progression is governed by complexes of the cyclin-dependent kinases (CDKs) and their regulatory subunits cyclin and Cks1. CDKs phosphorylate hundreds of substrates, often at multiple sites. Multisite phosphorylation depends on Cks1, which binds initial priming phosphorylation sites to promote secondary phosphorylation at other sites. Here, we describe a similar role for a recently discovered phosphate-binding pocket (PP) on B-type cyclins. Mutation of the PP in Clb2, the major mitotic cyclin of budding yeast, alters bud morphology and delays the onset of anaphase. Using phosphoproteomics |
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Language | English |
Publishing date | 2024-02-29 |
Publishing country | United States |
Document type | Preprint |
DOI | 10.1101/2024.02.28.582599 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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