Article ; Online: Rhodiola Rosea Extract Counteracts Stress in an Adaptogenic Response Curve Manner via Elimination of ROS and Induction of Neurite Outgrowth.
Oxidative medicine and cellular longevity
2022 Volume 2022, Page(s) 5647599
Abstract: Background: Sustained stress with the overproduction of corticosteroids has been shown to increase reactive oxygen species (ROS) leading to an oxidative stress state. Mitochondria are the main generators of ROS and are directly and detrimentally ... ...
Abstract | Background: Sustained stress with the overproduction of corticosteroids has been shown to increase reactive oxygen species (ROS) leading to an oxidative stress state. Mitochondria are the main generators of ROS and are directly and detrimentally affected by their overproduction. Neurons depend almost solely on ATP produced by mitochondria in order to satisfy their energy needs and to form synapses, while stress has been proven to alter synaptic plasticity. Emerging evidence underpins that Methods: In this study, the effect of Results: RRE increased bioenergetics as well as cell viability and scavenged ROS with a similar efficacy in both cells lines and counteracted the respective corticosteroid-induced dysregulation. The effect of RRE, both under dexamethasone-stress and under normal conditions, resulted in biphasic U-shape and inverted U-shape dose response curves, a characteristic feature of adaptogenic plant extracts. Additionally, RRE treatment promoted neurite outgrowth and induced an increase in BDNF levels. Conclusion: These findings indicate that RRE may constitute a candidate for the prevention of stress-induced pathophysiological processes as well as oxidative stress. Therefore, it could be employed against stress-associated mental disorders potentially leading to the development of a condition-specific supplementation. |
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MeSH term(s) | Animals ; Brain-Derived Neurotrophic Factor ; Dexamethasone ; Humans ; Mice ; Neuronal Outgrowth ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Reactive Oxygen Species ; Rhodiola |
Chemical Substances | Brain-Derived Neurotrophic Factor ; Plant Extracts ; Reactive Oxygen Species ; Dexamethasone (7S5I7G3JQL) |
Language | English |
Publishing date | 2022-05-13 |
Publishing country | United States |
Document type | Journal Article ; Retracted Publication |
ZDB-ID | 2455981-7 |
ISSN | 1942-0994 ; 1942-0994 |
ISSN (online) | 1942-0994 |
ISSN | 1942-0994 |
DOI | 10.1155/2022/5647599 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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