Artikel: Evolution of dependoparvoviruses across geological timescales-implications for design of AAV-based gene therapy vectors.
2020 Band 6, Heft 2, Seite(n) veaa043
Abstract: Endogenous viral elements (EVEs) are genetic remnants of viruses that have integrated into host genomes millions of years ago and retained as heritable elements passed on to offspring until present-day. As a result, EVEs provide an opportunity to analyse ...
Abstract | Endogenous viral elements (EVEs) are genetic remnants of viruses that have integrated into host genomes millions of years ago and retained as heritable elements passed on to offspring until present-day. As a result, EVEs provide an opportunity to analyse the genomes of extinct viruses utilizing these genomic viral fossils to study evolution of viruses over large timescales. Analysis of sequences from near full-length EVEs of dependoparvoviral origin identified within three mammalian taxa, Whippomorpha (whales and hippos), Vespertilionidae (smooth-nosed bats), and Lagomorpha (rabbits, hares, and pikas), indicates that distinct ancestral dependoparvovirus species integrated into these host genomes approximately 77 to 23 million years ago. These ancestral viruses are unique relative to modern adeno-associated viruses (AAVs), and distinct from extant species of genus |
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Sprache | Englisch |
Erscheinungsdatum | 2020-05-22 |
Erscheinungsland | England |
Dokumenttyp | Journal Article |
ZDB-ID | 2818949-8 |
ISSN | 2057-1577 |
ISSN | 2057-1577 |
DOI | 10.1093/ve/veaa043 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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