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  1. Buch ; Online: Por una Asamblea Constituyente Constitución

    Quiero Aguirre, Francisco / Gajardo Falcón, Jaime

    mecanismos, procesos y contenidos para una nueva

    2016  

    Schlagwörter Constitution: government & the state ; History of the Americas ; Political Science ; History ; Latin American Studies
    Sprache Spanisch
    Umfang 1 Online-Ressource
    Verlag CLACSO
    Dokumenttyp Buch ; Online
    Anmerkung Spanish
    HBZ-ID HT030609634
    ISBN 9789567074150 ; 9567074151
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Artikel ; Online: Optimizing opioid prescribing practices after minimally invasive lung resection through a quality-improvement intervention.

    Barber, Evan / Whidden, Melissa / Aguirre, Francisco / Graham, Andrew

    Canadian journal of surgery. Journal canadien de chirurgie

    2023  Band 66, Heft 3, Seite(n) E228–E235

    Abstract: Background: In their 2019 guideline on the prescribing and management of opioids after elective ambulatory thoracic surgery, the Canadian Association of Thoracic Surgeons (CATS) recommended 120 morphine milligram equivalents (MME) after minimally ... ...

    Abstract Background: In their 2019 guideline on the prescribing and management of opioids after elective ambulatory thoracic surgery, the Canadian Association of Thoracic Surgeons (CATS) recommended 120 morphine milligram equivalents (MME) after minimally invasive (video-assisted thoracoscopic surgery [VATS]) lung resection. We conducted a quality-improvement project to optimize opioid prescribing after VATS lung resection.
    Methods: We assessed baseline prescribing practices for opioid-naive patients. Using a mixed-methods approach, we selected 2 quality-improvement interventions: formal incorporation of the CATS guideline into our postoperative care pathway, and development of a patient information handout regarding opioids. The intervention was initiated on Oct. 1, 2020, and was formally implemented on Dec. 1, 2020. The outcome measure was average MME of discharge opioid prescriptions, the process measure was proportion of discharge prescriptions exceeding the recommended dosage, and the balancing measure was opioid prescription refills. We analyzed the data using control charts, and compared all measures between the pre-intervention (12 mo before) and postintervention (12 mo after) groups.
    Results: A total of 348 patients who underwent VATS lung resection were identified, 173 before the intervention and 175 after the intervention. Significantly less MME was prescribed after the intervention (100 v. 158,
    Conclusion: After implementation of the CATS opioid guideline, there was a significant reduction in opioids prescribed at discharge and no increase in opioid prescription refills. Control charts are a valuable resource for monitoring outcomes on an ongoing basis and for assessing the effects of an intervention.
    Mesh-Begriff(e) Humans ; Analgesics, Opioid/therapeutic use ; Pain, Postoperative/drug therapy ; Pain, Postoperative/etiology ; Practice Patterns, Physicians' ; Canada ; Lung
    Chemische Substanzen Analgesics, Opioid ; MME (78185-58-7)
    Sprache Englisch
    Erscheinungsdatum 2023-05-02
    Erscheinungsland Canada
    Dokumenttyp Journal Article
    ZDB-ID 410651-9
    ISSN 1488-2310 ; 0008-428X
    ISSN (online) 1488-2310
    ISSN 0008-428X
    DOI 10.1503/cjs.008122
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Role of the ubiquitin-proteasome system in the sarcopenic-like phenotype induced by CCL5/RANTES.

    Conejeros-Lillo, Sabrina / Aguirre, Francisco / Cabrera, Daniel / Simon, Felipe / Peñailillo, Luis / Cabello-Verrugio, Claudio

    European journal of translational myology

    2024  Band 34, Heft 1

    Abstract: Sarcopenia is characterized by reduced muscle strength and mass and a decline in muscle fiber diameter and amount of sarcomeric proteins. Sarcopenia involves the activation of the ubiquitin-proteasome system (UPS). MuRF-1 and atrogin-1 are E3 ubiquitin ... ...

    Abstract Sarcopenia is characterized by reduced muscle strength and mass and a decline in muscle fiber diameter and amount of sarcomeric proteins. Sarcopenia involves the activation of the ubiquitin-proteasome system (UPS). MuRF-1 and atrogin-1 are E3 ubiquitin ligases belonging to UPS, leading to proteolysis mediated by the PSMB 5, 6, and 7 subunits of 20S proteasome. CCL5/RANTES induces a sarcopenic-like effect in muscle cells. The present work explored the impact of CCL5 on UPS components and the influence of UPS on its sarcopenic-like effect. We demonstrated that CCL5 increased MuRF-1 and atrogin-1 protein levels and mRNA levels of subunits PSMB 5, 6, and 7. We used the MG132 inhibitor to elucidate the role of the 20S proteasome in the CCL5-induced sarcopenic-like effect. This inhibitor prevented the decrease in troponin and MHC protein levels and partially prevented the reduction in the diameter of single-isolated FDB muscle fibers induced by CCL5. These findings indicate that CCL5 actively modulates the UPS. Moreover, our results show the direct participation of UPS in the sarcopenic-like phenotype induced by CCL5.
    Sprache Englisch
    Erscheinungsdatum 2024-02-15
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 2545577-1
    ISSN 2037-7460 ; 2037-7452
    ISSN (online) 2037-7460
    ISSN 2037-7452
    DOI 10.4081/ejtm.2024.12249
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Environmental prospective of valorizing corn processing effluent to produce ferulic acid grafted chitosan polymer.

    Arias, Ana / Torres, Eduardo / García-Zamora, José Luis / Pacheco-Aguirre, Francisco M / Feijoo, Gumersindo / Moreira, Maria Teresa

    Journal of environmental management

    2024  Band 360, Seite(n) 121210

    Abstract: The food industry requires new production models that include more environmentally friendly waste management practices, considering that the environmental loads of solid waste and wastewater associated with this sector cause damage to the receiving ... ...

    Abstract The food industry requires new production models that include more environmentally friendly waste management practices, considering that the environmental loads of solid waste and wastewater associated with this sector cause damage to the receiving ecosystems. The approach considered in this study focuses on the design and environmental assessment of an enzymatic process for the valorization of ferulic acid present in the effluent of a corn tortilla plant. The ferulic acid can be immobilized on chitosan so that the ferulic acid grafted chitosan can be used as a bioactive film with enhanced antioxidant properties with potential applications in the biotechnology sector. Its real projection approach requires the evaluation of its environmental and economic performance, trying to identify its benefits and potential in the value chain, using the Techno-Economic Analysis (TEA) as a phase for the conceptual design of the process and the Life Cycle Assessment (LCA) methodology for the environmental evaluation. It should be noted that the TEA indicators are promising, since the values of the financial indicators obtained are representative of the economic profitability, which makes the ferulic acid valorization a viable process. In terms of the environmental impact of the process, the buffer dose and the chitosan production process are identified as the main critical points. This double benefit in environmental and economic terms shows that the valorization of ferulic acid for chitosan functionalization is a promising alternative to improve the sustainability performance of corn processing.
    Sprache Englisch
    Erscheinungsdatum 2024-05-22
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2024.121210
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Bonn

    Z 7556: Hefte anzeigen

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  5. Artikel ; Online: Exercise Programs Combined with Diet Supplementation Improve Body Composition and Physical Function in Older Adults with Sarcopenia: A Systematic Review.

    Hernández-Lepe, Marco Antonio / Miranda-Gil, Michelle Itzel / Valbuena-Gregorio, Edith / Olivas-Aguirre, Francisco Javier

    Nutrients

    2023  Band 15, Heft 8

    Abstract: Sarcopenia is a progressive and frequent syndrome among older adults highly related to physical inactivity and malnutrition. Nowadays, it is considered a pathology that triggers multiple health complications associated with the loss of muscle mass, ... ...

    Abstract Sarcopenia is a progressive and frequent syndrome among older adults highly related to physical inactivity and malnutrition. Nowadays, it is considered a pathology that triggers multiple health complications associated with the loss of muscle mass, strength, autonomy, and quality of life. The objective of the present systematic review was to evaluate the effect of exercise programs combined with dietary supplementation on body composition as the primary outcome. This systematic review was carried out in accordance with the elements considered for planning a systematic review by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), and the search was performed in the Scopus, EBSCO, and PubMed databases for the last 10 years. A total of 16 studies met the inclusion criteria and were included in this systematic review. Regular resistance exercise together with daily essential amino acids or whey protein and vitamin D supplementation improve the maintenance or gains in appendiceal/skeletal muscle mass and total lean mass in sarcopenic older adults. The data suggest a synergistic effect not only on the primary outcome, but also on other variables such as strength, speed, stability, and other indicators of quality of life. This systematic review was registered in PROSPERO, ID: CRD42022344284.
    Mesh-Begriff(e) Humans ; Aged ; Sarcopenia ; Muscle Strength ; Quality of Life ; Dietary Supplements ; Body Composition ; Resistance Training ; Diet ; Muscle, Skeletal/metabolism
    Sprache Englisch
    Erscheinungsdatum 2023-04-21
    Erscheinungsland Switzerland
    Dokumenttyp Systematic Review ; Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15081998
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Buch: Complementarities and tensions in NGO-state relations in agricultural development

    Aguirre, Francisco / Namdar-Irani, Mina

    the trajectory of AGRARIA (Chile)

    (Network paper / Agricultural Administration Network ; 32)

    1992  

    Verfasserangabe Francisco Aguirre ; Mina Namdar-Irani
    Serientitel Network paper / Agricultural Administration Network ; 32
    Network paper / Overseas Development Institute, Agricultural Administration Unit, Agricultural Administration Network
    Überordnung Network paper / Overseas Development Institute, Agricultural Administration Unit, Agricultural Administration Network
    Umfang III, 32 S. : Kt.
    Verlag ODI
    Erscheinungsort London
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch
    HBZ-ID HT009723696
    Datenquelle Katalog ZB MED Ernährung, Umwelt, Agrar

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    Verfügbar in ZB MED Bonn

    SignaturLeihstatusStandort
    998/121 ausleihbar (Lesesaal) Freihandmagazin (U1)

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  7. Artikel: Is There an Adequate Therapeutic Approach to Thyroid Pathology in Patients with Down Syndrome?

    Murillo-Llorente, Maria Teresa / Pérez-Bermejo, Marcelino / Llacer-Heredia, Verónica / Tomás-Aguirre, Beatriz / Valls-Arévalo, Angel / Tomás-Aguirre, Francisco

    Diagnostics (Basel, Switzerland)

    2023  Band 13, Heft 23

    Abstract: Thyroid dysfunction stands as the most prevalent endocrine disorder in individuals with Down syndrome, particularly showcasing both clinical and subclinical hypothyroidism. TSH and FT4 blood values serve as common diagnostic and treatment adjustment ... ...

    Abstract Thyroid dysfunction stands as the most prevalent endocrine disorder in individuals with Down syndrome, particularly showcasing both clinical and subclinical hypothyroidism. TSH and FT4 blood values serve as common diagnostic and treatment adjustment markers. In Down syndrome (DS), hormone values may deviate from those observed in the general population, which may lead to overdiagnosis and consequent iatrogenesis of subclinical hypothyroidism. The objective of this study was to analyze the appropriateness of the replacement therapeutic approach by identifying the TSH and FT4 values that can be considered normal in these patients.
    Methods: A cross-sectional study was conducted in 503 subjects with DS of both sexes and without age limit drawn from the Health Program for individuals with DS in Valencia (Spain) from February 1993 to November 2021. The exclusion criteria included hyperthyroidism, nodules, tumors, or individuals under treatment with drugs influencing iodine metabolism. The normality of data distribution was assessed using the Shapiro-Wilk test. Outliers were detected using the Reed's criterion. Hormone values were estimated using quantile regression models for the 2.5th and 97.5th percentiles.
    Results: The normal values identified were 0.88-11.25 mIU/L for TSH and 0.71-1.63 ng/dL for FT4. The Wald test indicated no significant differences in the reference intervals based on age or sex.
    Conclusion: The establishment of these values, which, in people with DS, can be considered unique, is of great importance, allowing a watchful waiting attitude to be maintained before starting replacement therapy that is unnecessarily or adjusting medication in diagnosed cases.
    Sprache Englisch
    Erscheinungsdatum 2023-11-21
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13233499
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: [Titelangabe fehlt]

    García, Abad / Valero-Morales, Isabel / Valbuena-Gregorio, Edith / Olivas-Aguirre, Francisco Javier / Tolentino-Mayo, Lizbeth / Barquera, Simón / Nieto, Claudia

    Salud publica de Mexico

    2023  Band 65, Heft 4, jul-ago, Seite(n) 377–386

    Abstract: Objetivo: Identificar los mensajes persuasivos usados por la industria de alimentos y bebidas no saludables en las redes sociales más visitadas por niñas, niños y adolescentes mexicanos y determinar a qué grupo de edad estaban dirigidos. Material y ... ...

    Titelübersetzung Mensajes persuasivos en redes sociales de la industria de alimentos y bebidas no saludables.
    Abstract Objetivo: Identificar los mensajes persuasivos usados por la industria de alimentos y bebidas no saludables en las redes sociales más visitadas por niñas, niños y adolescentes mexicanos y determinar a qué grupo de edad estaban dirigidos. Material y métodos. Se analizaron 892 anuncios de los 20 productos y marcas de alimentos y bebidas no saludables más consumidas en México publicados en las cuentas oficiales de dichos productos y marcas en YouTube, Facebook e Instagram. Se determinó el mensaje primario y el público objetivo (niños, adolescentes o ambos) y se clasificó como emocional o racional.
    Resultados: En Facebook, la proporción de anuncios con mensajes emocionales (50.7%) y mensajes racionales (49.3%) fue similar. En YouTube hubo mayor proporción de mensajes racionales (60.2%). Se encontraron 2.9 más posibilidades de que un mensaje persuasivo emocional se dirija a niños o adolescentes en comparación con mensajes que no tienen publicidad dirigida. Conclusión. La naturaleza de los mensajes persuasivos analizados depende de la red social en la que se presentaron. La industria alimentaria dirige sus mensajes a niños o adolescentes, razón por la que es importante regular la publicidad de alimentos y bebidas no saludables en redes sociales que busca influir en el comportamiento y las decisiones de compra de niñas, niños y adolescentes.
    Sprache Spanisch
    Erscheinungsdatum 2023-07-15
    Erscheinungsland Mexico
    Dokumenttyp English Abstract ; Journal Article
    ZDB-ID 954220-6
    ISSN 1606-7916 ; 0036-3634
    ISSN (online) 1606-7916
    ISSN 0036-3634
    DOI 10.21149/14308
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 1309: Hefte anzeigen Standort:
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  9. Artikel ; Online: Ursodeoxycholic acid induces sarcopenia associated with decreased protein synthesis and autophagic flux.

    Orozco-Aguilar, Josué / Tacchi, Franco / Aguirre, Francisco / Valero-Breton, Mayalen / Castro-Sepulveda, Mauricio / Simon, Felipe / Cabello-Verrugio, Claudio

    Biological research

    2023  Band 56, Heft 1, Seite(n) 28

    Abstract: Background: Skeletal muscle generates force and movements and maintains posture. Under pathological conditions, muscle fibers suffer an imbalance in protein synthesis/degradation. This event causes muscle mass loss and decreased strength and muscle ... ...

    Abstract Background: Skeletal muscle generates force and movements and maintains posture. Under pathological conditions, muscle fibers suffer an imbalance in protein synthesis/degradation. This event causes muscle mass loss and decreased strength and muscle function, a syndrome known as sarcopenia. Recently, our laboratory described secondary sarcopenia in a chronic cholestatic liver disease (CCLD) mouse model. Interestingly, the administration of ursodeoxycholic acid (UDCA), a hydrophilic bile acid, is an effective therapy for cholestatic hepatic alterations. However, the effect of UDCA on skeletal muscle mass and functionality has never been evaluated, nor the possible involved mechanisms.
    Methods: We assessed the ability of UDCA to generate sarcopenia in C57BL6 mice and develop a sarcopenic-like phenotype in C
    Results: UDCA induced sarcopenia in healthy mice, evidenced by decreased strength, muscle mass, and physical function, with a decline in the fiber's diameter and the troponin I protein levels. In the C
    Conclusions: Our results indicate that UDCA induces sarcopenia in mice and sarcopenic-like features in C
    Mesh-Begriff(e) Mice ; Animals ; Sarcopenia/chemically induced ; Sarcopenia/pathology ; Ursodeoxycholic Acid/pharmacology ; Ursodeoxycholic Acid/metabolism ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; Troponin I/metabolism ; Mice, Inbred C57BL ; Muscle, Skeletal/metabolism
    Chemische Substanzen Ursodeoxycholic Acid (724L30Y2QR) ; Ribosomal Protein S6 Kinases, 70-kDa (EC 2.7.11.1) ; Troponin I
    Sprache Englisch
    Erscheinungsdatum 2023-05-27
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1138990-4
    ISSN 0717-6287 ; 0716-9760
    ISSN (online) 0717-6287
    ISSN 0716-9760
    DOI 10.1186/s40659-023-00431-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Analysis of the Psychosocial Sphere of Older Adults in Extreme Poverty in the Peruvian Amazon.

    Murillo-Llorente, María Teresa / Caballero Coloma, Nerea / Tomás-Aguirre, Francisco / Tejeda-Adell, Manuel / Ventura, Ignacio / Perez-Bermejo, Marcelino

    Healthcare (Basel, Switzerland)

    2023  Band 11, Heft 23

    Abstract: The situation of social exclusion in which older adults live in extreme poverty is a problem that leads to psychological alterations such as depression or cognitive deterioration. Our objective was to analyze the living conditions and the psychosocial ... ...

    Abstract The situation of social exclusion in which older adults live in extreme poverty is a problem that leads to psychological alterations such as depression or cognitive deterioration. Our objective was to analyze the living conditions and the psychosocial sphere of older adult people living in extreme poverty in Requena del Tapiche in Peru. This was an observational, descriptive, cross-sectional study. Sixty participants between 60 and 100 years of age of both sexes were included who gave their informed consent. Sociodemographic variables were analyzed, and the Gijón, family Apgar, Yesavage, and Pfeiffer scales were used. The sample was composed of 55% women and 45% men, with a mean age of 79.2 years (SD 6.67). More than half live alone or with their spouse. Fifty-seven percent sleep on the floor or on wood, and about 82% do not have safe water. Family dysfunction is found in 40%, and 98% are at social risk or with an established social problem and a precarious economic situation. More than 60% suffer from depressive symptoms, which are more frequent in women. We conclude that older adults perceive deficient family support, observing a deteriorated social situation. Most of them are at risk of social exclusion and loneliness, making them more vulnerable. They show sadness, with a high rate of depression. People with more cognitive impairment live alone, and those in social exclusion suffer a higher degree of depression. More cooperative projects and health promotion interventions developed in the peripheral neighborhoods of Requena del Tapiche are needed to improve the impact on the health of older adult people in extreme poverty.
    Sprache Englisch
    Erscheinungsdatum 2023-11-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare11233022
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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