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  1. AU="Al-Hadlaq, Malak"
  2. AU="Fred H Gage"

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  1. Artikel ; Online: Acromegaly: Overview and associated temporomandibular joint disorders.

    Al-Hadlaq, Malak / Sroussi, Herve

    Oral diseases

    2024  

    Abstract: Objective: To provide a review on acromegaly and its orofacial manifestations, with a focus on associated arthropathies and temporomandibular joint disorders (TMD).: Methods: A review of current literature was performed through an electronic search ... ...

    Abstract Objective: To provide a review on acromegaly and its orofacial manifestations, with a focus on associated arthropathies and temporomandibular joint disorders (TMD).
    Methods: A review of current literature was performed through an electronic search of three databases: PubMed, ScienceDirect, and Google Scholar. The literature review was focused on the following topics of interest: etiology, diagnosis, and management of acromegaly, orofacial manifestations of acromegaly, acromegalic arthropathies, and acromegaly-associated TMD.
    Results: Acromegaly is a chronic multisystem condition in which excessive production of growth hormone in adults, most commonly caused by benign pituitary adenomas, leads to somatic overgrowth. Orofacial changes are considered hallmarks of the disease. It is important for dentists to recognize signs and symptoms of acromegaly, as this may help to achieve early diagnosis and improve overall disease prognosis. Acromegalic arthropathies typically involve large joints, however, the temporomandibular joints (TMJ) can be affected. TMD associated with acromegaly is under-recognized and poorly characterized in current literature.
    Conclusion: In the appropriate clinical context, acromegaly should be considered as part of the differential diagnosis for patients presenting with TMD. Further studies are needed to better characterize the nature of TMD associated with acromegaly and to define the role of TMJ involvement in early diagnosis.
    Sprache Englisch
    Erscheinungsdatum 2024-01-15
    Erscheinungsland Denmark
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14861
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4427: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Artikel ; Online: White plaques of the oral mucosa.

    Al-Hadlaq, Malak / Woo, Sook-Bin

    Journal of the American Dental Association (1939)

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-02-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 220622-5
    ISSN 1943-4723 ; 0002-8177 ; 1048-6364
    ISSN (online) 1943-4723
    ISSN 0002-8177 ; 1048-6364
    DOI 10.1016/j.adaj.2023.12.006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Hydroxychloroquine for the management of recalcitrant oral lichen planus.

    Chirravur, Prazwala / Sroussi, Herve / Treister, Nathaniel / Al Hadlaq, Malak / Whiting, Brent / Santoianni, James A / Woo, Sook Bin

    Oral surgery, oral medicine, oral pathology and oral radiology

    2023  Band 137, Heft 4, Seite(n) 355–361

    Abstract: Objective: The objective of this study is to describe the efficacy of hydroxychloroquine (HCQ) in patients with oral lichen planus (OLP) refractory to conventional therapy.: Study design: In this single-center retrospective study, patients were ... ...

    Abstract Objective: The objective of this study is to describe the efficacy of hydroxychloroquine (HCQ) in patients with oral lichen planus (OLP) refractory to conventional therapy.
    Study design: In this single-center retrospective study, patients were prescribed HCQ 200 mg twice daily. Pain, reticulation, erythema, and ulceration scores were recorded. Two-sample and paired t tests were used to evaluate mean and paired pain scores and paired t test to determine substantial differences in paired REU scores, at HCQ initiation visit and final follow-up at 12 to 24 months.
    Results: Thirty-six patients (69.4% female) with a median age of 70 ± 12.0 (range 48-99) were initiated on HCQ. Only 30 patients were evaluable because pruritus developed in 5 patients (13.9%) and gastrointestinal symptoms in 1 (2.8%). The mean follow-up was 23.2 months (range 1-74). In 19 patients, there was a significant decline in the worst pain score from a mean of 3.9 (SD± 2.8, n = 19) to 1.9 (SD ± 2.4, n = 19) (t = 2.837, P < .006). Paired reticulation, erythema, and ulceration (REU scores) decreased from a weighted mean score of 16.0 (SD ± 8.0, n = 12) to 12.0 (SD ± 6.3, n = 12) (t = 2.07, P < .032).
    Conclusion: Hydroxychloroquine was a suitable option and effective in reducing symptoms and disease severity in patients with recalcitrant OLP who do not adequately respond to standard therapy.
    Mesh-Begriff(e) Humans ; Female ; Male ; Lichen Planus, Oral/drug therapy ; Hydroxychloroquine/therapeutic use ; Retrospective Studies ; Pain ; Erythema
    Chemische Substanzen Hydroxychloroquine (4QWG6N8QKH)
    Sprache Englisch
    Erscheinungsdatum 2023-12-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2023.12.007
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Oral lichen planus: comparative efficacy and treatment costs-a systematic review.

    Sandhu, Shaiba / Klein, Brittany A / Al-Hadlaq, Malak / Chirravur, Prazwala / Bajonaid, Amal / Xu, Yuanming / Intini, Rossella / Hussein, Mai / Vacharotayangul, Piamkamon / Sroussi, Herve / Treister, Nathaniel / Sonis, Stephen

    BMC oral health

    2022  Band 22, Heft 1, Seite(n) 161

    Abstract: Objective: To compare the reported efficacy and costs of available interventions used for the management of oral lichen planus (OLP).: Materials and methods: A systematic literature search was performed from database inception until March 2021 in ... ...

    Abstract Objective: To compare the reported efficacy and costs of available interventions used for the management of oral lichen planus (OLP).
    Materials and methods: A systematic literature search was performed from database inception until March 2021 in MEDLINE via PubMed and the Cochrane library following PRISMA guidelines. Only randomized controlled trials (RCT) comparing an active intervention with placebo or different active interventions for OLP management were considered.
    Results: Seventy (70) RCTs were included. The majority of evidence suggested efficacy of topical steroids (dexamethasone, clobetasol, fluocinonide, triamcinolone), topical calcineurin inhibitors (tacrolimus, pimecrolimus, cyclosporine), topical retinoids, intra-lesional triamcinolone, aloe-vera gel, photodynamic therapy, and low-level laser therapies for OLP management. Based on the estimated cost per month and evidence for efficacy and side-effects, topical steroids (fluocinonide > dexamethasone > clobetasol > triamcinolone) appear to be more cost-effective than topical calcineurin inhibitors (tacrolimus > pimecrolimus > cyclosporine) followed by intra-lesional triamcinolone.
    Conclusion: Of common treatment regimens for OLP, topical steroids appear to be the most economical and efficacious option followed by topical calcineurin inhibitors. Large-scale multi-modality, prospective trials in which head-to-head comparisons interventions are compared are required to definitely assess the cost-effectiveness of OLP treatments.
    Mesh-Begriff(e) Administration, Topical ; Calcineurin Inhibitors/therapeutic use ; Clobetasol/therapeutic use ; Cyclosporins/therapeutic use ; Dexamethasone/therapeutic use ; Fluocinonide/therapeutic use ; Health Care Costs ; Humans ; Lichen Planus, Oral/drug therapy ; Steroids/therapeutic use ; Tacrolimus/therapeutic use ; Treatment Outcome ; Triamcinolone/therapeutic use
    Chemische Substanzen Calcineurin Inhibitors ; Cyclosporins ; Steroids ; Triamcinolone (1ZK20VI6TY) ; Fluocinonide (2W4A77YPAN) ; Dexamethasone (7S5I7G3JQL) ; Clobetasol (ADN79D536H) ; Tacrolimus (WM0HAQ4WNM)
    Sprache Englisch
    Erscheinungsdatum 2022-05-06
    Erscheinungsland England
    Dokumenttyp Journal Article ; Systematic Review
    ZDB-ID 2091511-1
    ISSN 1472-6831 ; 1472-6831
    ISSN (online) 1472-6831
    ISSN 1472-6831
    DOI 10.1186/s12903-022-02168-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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