Artikel ; Online: Blood Biomarkers in Neurodegenerative Diseases: Implications for the Clinical Neurologist.
2023 Band 101, Heft 4, Seite(n) 172–180
Abstract: Blood-based biomarkers offer a major advance in the clinical evaluation of neurodegenerative diseases. Currently, research studies have reported robust assays of blood markers for the detection of amyloid and tau pathologies specific to Alzheimer disease ...
Abstract | Blood-based biomarkers offer a major advance in the clinical evaluation of neurodegenerative diseases. Currently, research studies have reported robust assays of blood markers for the detection of amyloid and tau pathologies specific to Alzheimer disease (amyloid-β peptides, and p-tau) and nonspecific blood markers of neuronal (neurofilament light, β-synuclein, and ubiquitin-C-terminal-hydrolase-L1) and glial degeneration (glial fibrillary acidic protein) that can measure key pathophysiologic processes in several neurodegenerative diseases. In the near future, these markers may be used for screening, diagnosis, or disease and treatment response monitoring. Blood-based biomarkers for neurodegenerative diseases have been rapidly implemented in research, and they have the potential to enter clinical use soon in different clinical settings. In this review, we will describe the main developments and their potential implications for the general neurologist. |
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Mesh-Begriff(e) | Humans ; Alzheimer Disease/diagnosis ; Neurodegenerative Diseases/diagnosis ; Neurologists ; Amyloid beta-Peptides ; Biomarkers/blood |
Chemische Substanzen | Amyloid beta-Peptides ; Biomarkers |
Sprache | Englisch |
Erscheinungsdatum | 2023-03-06 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article ; Review ; Comment |
ZDB-ID | 207147-2 |
ISSN | 1526-632X ; 0028-3878 |
ISSN (online) | 1526-632X |
ISSN | 0028-3878 |
DOI | 10.1212/WNL.0000000000207193 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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