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  1. Artikel ; Online: Muscle blood flow and vasodilation are blunted at the onset of exercise following an acute bout of ischemia-reperfusion.

    Hanson, Brady E / Feider, Andrew J / Hanada, Satoshi / Aldrich, Aric W / Casey, Darren P

    Journal of applied physiology (Bethesda, Md. : 1985)

    2023  Band 135, Heft 5, Seite(n) 1053–1061

    Abstract: Ischemia-reperfusion (I/R) injury can attenuate endothelial function and impair nitric oxide bioavailability. We tested the hypothesis that I/R also blunts the rapid and steady-state hyperemic and vasodilatory responses to handgrip exercise. Ten subjects ...

    Abstract Ischemia-reperfusion (I/R) injury can attenuate endothelial function and impair nitric oxide bioavailability. We tested the hypothesis that I/R also blunts the rapid and steady-state hyperemic and vasodilatory responses to handgrip exercise. Ten subjects (8M/2F; 24 ± 4 yr) performed handgrip exercises before and after I/R (20 min of ischemia/20 min of reperfusion) and time control (40-min supine rest) trials. Forearm blood flow (FBF) and forearm vascular conductance (FVC) were assessed with Doppler ultrasound during single forearm contractions and 3 min of rhythmic handgrip exercise. Venous blood samples were drawn at rest and during exercise to assess plasma [nitrite]. Peak ΔFBF (from baseline) and ΔFVC following single contractions were attenuated following I/R (134 ± 48 vs. 103 ± 42 mL·min
    Mesh-Begriff(e) Humans ; Vasodilation/physiology ; Hyperemia ; Hand Strength/physiology ; Nitrites ; Regional Blood Flow/physiology ; Ischemia ; Muscle, Skeletal ; Nitric Oxide ; Muscle Contraction ; Reperfusion ; Forearm/blood supply
    Chemische Substanzen Nitrites ; Nitric Oxide (31C4KY9ESH)
    Sprache Englisch
    Erscheinungsdatum 2023-09-28
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00314.2023
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Acute inorganic nitrate supplementation and the hypoxic ventilatory response in patients with obstructive sleep apnea.

    Bock, Joshua M / Hanson, Brady E / Asama, Thomas F / Feider, Andrew J / Hanada, Satoshi / Aldrich, Aric W / Dyken, Mark Eric / Casey, Darren P

    Journal of applied physiology (Bethesda, Md. : 1985)

    2020  Band 130, Heft 1, Seite(n) 87–95

    Abstract: Patients with obstructive sleep apnea (OSA) have increased cardiovascular disease risk largely attributable to hypertension. Heightened peripheral chemoreflex sensitivity (i.e., exaggerated responsiveness to hypoxia) facilitates hypertension in these ... ...

    Abstract Patients with obstructive sleep apnea (OSA) have increased cardiovascular disease risk largely attributable to hypertension. Heightened peripheral chemoreflex sensitivity (i.e., exaggerated responsiveness to hypoxia) facilitates hypertension in these patients. Nitric oxide blunts the peripheral chemoreflex, and patients with OSA have reduced nitric oxide bioavailability. We therefore investigated the dose-dependent effects of acute inorganic nitrate supplementation (beetroot juice), an exogenous nitric oxide source, on blood pressure and cardiopulmonary responses to hypoxia in patients with OSA using a randomized, double-blind, placebo-controlled crossover design. Fourteen patients with OSA (53 ± 10 yr, 29.2 ± 5.8 kg/m
    Mesh-Begriff(e) Beta vulgaris ; Blood Pressure ; Dietary Supplements ; Double-Blind Method ; Humans ; Hypoxia ; Nitrates ; Nitrogen Oxides ; Sleep Apnea, Obstructive
    Chemische Substanzen Nitrates ; Nitrogen Oxides
    Sprache Englisch
    Erscheinungsdatum 2020-11-19
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00696.2020
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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