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Artikel ; Online: Immunological differences between heart- and kidney-transplanted children: a cross-sectional study - CORRIGENDUM.

Ekman-Joelsson, Britt-Marie / Brandström, Per / Allén, Maria / Andersson, Bengt / Wåhlander, Håkan / Mellgren, Karin / Ekwall, Olov

Cardiology in the young

2022 Band 33, Heft 5, Seite(n) 842

Mesh-Begriff(e)	Humans ; Child ; Cross-Sectional Studies ; Kidney Transplantation ; Graft Rejection ; Heart ; Kidney
Sprache	Englisch
Erscheinungsdatum	2022-07-22
Erscheinungsland	England
Dokumenttyp	Journal Article ; Published Erratum
ZDB-ID	1078466-4
ISSN	1467-1107 ; 1047-9511
ISSN (online)	1467-1107
ISSN	1047-9511
DOI	10.1017/S1047951122002347
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Immunological differences between heart- and kidney-transplanted children: a cross-sectional study.

Ekman-Joelsson, Britt-Marie / Brandström, Per / Allén, Maria / Andersson, Bengt / Wåhlander, Håkan / Mellgren, Karin / Ekwall, Olov

Cardiology in the young

2022 Band 33, Heft 5, Seite(n) 787–792

Abstract: Post-transplantation lymphoproliferative disorder is a potentially mortal complication after heart transplantation in children. As the immune system plays a crucial role in the development of lymphoma, we explored the influence of thymus function in ... ...

Abstract	Post-transplantation lymphoproliferative disorder is a potentially mortal complication after heart transplantation in children. As the immune system plays a crucial role in the development of lymphoma, we explored the influence of thymus function in relation to immunosuppressive treatment in organ-transplanted children and healthy control subjects. A prospective case-control study was performed at a single centre, in which 36 children who had undergone heart transplantation were compared to two control groups: 34 kidney-transplanted children and 33 healthy age- and sex-matched children. T- and B-lymphocyte subtypes and monocytes were analysed by flow cytometry, and T-cell receptor excision circles were assessed using quantitative polymerase chain reaction. Heart-transplanted children had a lymphocyte profile characterised by reduced or absent thymic function with low numbers of T-cell receptor excision circles and total and naïve T cells, together with immune activation against the allograft. Despite similar immunosuppressive treatment, the kidney-transplanted group showed an activated T-lymphocyte compartment.
Mesh-Begriff(e)	Humans ; Child ; Cross-Sectional Studies ; Case-Control Studies ; T-Lymphocytes ; Immunosuppressive Agents ; Receptors, Antigen, T-Cell ; Kidney
Chemische Substanzen	Immunosuppressive Agents ; Receptors, Antigen, T-Cell
Sprache	Englisch
Erscheinungsdatum	2022-06-24
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	1078466-4
ISSN	1467-1107 ; 1047-9511
ISSN (online)	1467-1107
ISSN	1047-9511
DOI	10.1017/S1047951122001743
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Seizure control via pH manipulation: a phase II double-blind randomised controlled trial of inhaled carbogen as adjunctive treatment of paediatric convulsive status epilepticus (Carbogen for Status Epilepticus in Children Trial (CRESCENT)).

Forsyth, Rob / Allen, Maria / Bedson, Emma / Downes, Alice / Gough, Chris / Hartshorn, Stuart / Lawton, Kelly / Lyttle, Mark D / Messahel, Shrouk / Mullen, Niall / Raper, Joseph / Rosala-Harris, Anna / Taggart, Leigh / Urron, Jason / Walton, Emily / Gamble, Carrol

Trials

2024 Band 25, Heft 1, Seite(n) 349

Abstract: Background: Paediatric convulsive status epilepticus is the most common neurological emergency presenting to emergency departments. Risks of resultant neurological morbidity and mortality increase with seizure duration. If the seizure fails to stop ... ...

Abstract	Background: Paediatric convulsive status epilepticus is the most common neurological emergency presenting to emergency departments. Risks of resultant neurological morbidity and mortality increase with seizure duration. If the seizure fails to stop within defined time-windows, standard care follows an algorithm of stepwise escalation to more intensive treatments, ultimately resorting to induction of general anaesthesia and ventilation. Additionally, ventilatory support may also be required to treat respiratory depression, a common unwanted effect of treatment. There is strong pre-clinical evidence that pH (acid-base balance) is an important determinant of seizure commencement and cessation, with seizures tending to start under alkaline conditions and terminate under acidic conditions. These mechanisms may be particularly important in febrile status epilepticus: prolonged fever-related seizures which predominantly affect very young children. This trial will assess whether imposition of mild respiratory acidosis by manipulation of inhaled medical gas improves response rates to first-line medical treatment. Methods: A double-blind, placebo-controlled trial of pH manipulation as an adjunct to standard medical treatment of convulsive status epilepticus in children. The control arm receives standard medical management whilst inhaling 100% oxygen; the active arm receives standard medical management whilst inhaling a commercially available mixture of 95% oxygen, 5% carbon dioxide known as 'carbogen'. Due to the urgent need to treat the seizure, deferred consent is used. The primary outcome is success of first-line treatment in seizure cessation. Planned subgroup analyses will be undertaken for febrile and non-febrile seizures. Secondary outcomes include rates of induction of general anaesthesia, admission to intensive care, adverse events, and 30-day mortality. Discussion: If safe and effective 95% oxygen, 5% carbon dioxide may be an important adjunct in the management of convulsive status epilepticus with potential for pre-hospital use by paramedics, families, and school staff. Trial registration: EudraCT: 2021-005367-49. CTA: 17136/0300/001. Isrctn: 52731862. Registered on July 2022.
Mesh-Begriff(e)	Humans ; Status Epilepticus/drug therapy ; Double-Blind Method ; Hydrogen-Ion Concentration ; Randomized Controlled Trials as Topic ; Administration, Inhalation ; Child ; Carbon Dioxide/administration & dosage ; Carbon Dioxide/adverse effects ; Child, Preschool ; Treatment Outcome ; Clinical Trials, Phase II as Topic ; Acidosis, Respiratory/etiology ; Infant ; Seizures, Febrile/drug therapy ; Acid-Base Equilibrium/drug effects ; Female ; Male ; Oxygen
Chemische Substanzen	carbogen (8063-77-2) ; Carbon Dioxide (142M471B3J) ; Oxygen (S88TT14065)
Sprache	Englisch
Erscheinungsdatum	2024-05-29
Erscheinungsland	England
Dokumenttyp	Journal Article ; Clinical Trial Protocol
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-024-08188-5
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch ; Online: The Routledge Portuguese Bilingual Dictionary

Allen, Maria F

Portuguese-English and English-Portuguese

(Routledge Bilingual Dictionaries)

2011

Abstract: This comprehensive and up-to-date bilingual dictionary will be the ideal reference for translators and students ... ...

Serientitel	Routledge Bilingual Dictionaries
Abstract	This comprehensive and up-to-date bilingual dictionary will be the ideal reference for translators and students alike
Sprache	Englisch
Umfang	Online-Ressource (785 p)
Verlag	Taylor & Francis
Erscheinungsort	Hoboken
Dokumenttyp	Buch ; Online
Anmerkung	Description based upon print version of record
ISBN	9780415434348 ; 0415434343
Datenquelle	Katalog der Technische Informationsbibliothek Hannover

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Artikel: Institutions and investments by emerging-economy multinationals in developed economies

Allen, Matthew M. C / Allen, Maria L

The rise of multinationals from emerging economies : achieving a new balance , p. 83-98

solar PV firms and the role of political authorities in Germany

2015 , Seite(n) 83–98

Verfasserangabe	Matthew M. C. Allen and Maria L. Allen
Schlagwörter	Multinationales Unternehmen ; Subvention ; Erneuerbare Energie ; Internationaler Wettbewerb ; Photovoltaik ; Industrie ; Deutschland
Sprache	Englisch
Verlag	Palgrave Macmillan
Erscheinungsort	Houndmills, Basingstoke Hampshire [u.a.
Dokumenttyp	Artikel
ISBN	978-1-137-47310-3 ; 1-137-47310-X
Datenquelle	ECONomics Information System

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Artikel ; Online: Bone marrow mesenchymal stem cells from patients with SLE maintain an interferon signature during in vitro culture.

Gao, Lin / OConnell, Mary / Allen, Maria / Liesveld, Jane / McDavid, Andrew / Anolik, Jennifer H / Looney, Richard J

Cytokine

2019 Band 132, Seite(n) 154725

Abstract: Background: We have previously shown that SLE BMSC have decreased proliferation, increased ROS, increased DNA damage and repair (DDR), a senescence associated secretory phenotype, and increased senescence-associated β-galactosidase. We have also shown ... ...

Abstract	Background: We have previously shown that SLE BMSC have decreased proliferation, increased ROS, increased DNA damage and repair (DDR), a senescence associated secretory phenotype, and increased senescence-associated β-galactosidase. We have also shown SLE BMSC produce increased amounts of interferon beta (IFNβ), have increased mRNA for several genes induced by IFNβ, and have a pro-inflammatory feedback loop mediated by a MAVS. To better understand the phenotype of SLE BMSC we conducted mRNA sequencing. Methods: Patients fulfilling SLE classification criteria and age and sex matched healthy controls were recruited under an Institutional Review Board approved protocol. Bone marrow aspirates and peripheral blood samples were obtained. BMSC were isolated and grown in tissue culture. Early passage BMSC were harvested and mRNA samples were sent for RNAseq. Serum samples were assayed for IFNβ by ELISA. Results: On the basis of top differentially expressed genes between SLE and healthy controls, SLE patients with high levels of serum IFNβ clustered together while SLE patients with low levels of IFNβ clustered with healthy controls. Those genes differentially expressed in SLE patients generally belonged to known IFN pathways, and showed a strong overlap with the set of genes differentially expressed in IFNβ high subjects, per se. Moreover, gene expression changes induced by treating healthy BMSC with exogenous IFNβ were remarkably similar to gene expression differences in SLE IFNβ high vs low BMSC. Conclusions: BMSCs from SLE patients are heterogeneous. A subgroup of SLE BMSC is distinguished from other SLE BMSC and from controls by increased levels of mRNAs induced by type I interferons. This subgroup of SLE patients had increased levels of IFNβ in vivo.
Sprache	Englisch
Erscheinungsdatum	2019-05-29
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2019.05.012
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Dual bronchodilators in Bronchiectasis study (DIBS): protocol for a pragmatic, multicentre, placebo-controlled, three-arm, double-blinded, randomised controlled trial studying bronchodilators in preventing exacerbations of bronchiectasis.

BMJ open

2023 Band 13, Heft 8, Seite(n) e071906

Abstract: Introduction: Bronchiectasis is a long-term lung condition, with dilated bronchi, chronic inflammation, chronic infection and acute exacerbations. Recurrent exacerbations are associated with poorer clinical outcomes such as increased severity of lung ... ...

Abstract	Introduction: Bronchiectasis is a long-term lung condition, with dilated bronchi, chronic inflammation, chronic infection and acute exacerbations. Recurrent exacerbations are associated with poorer clinical outcomes such as increased severity of lung disease, further exacerbations, hospitalisations, reduced quality of life and increased risk of death. Despite an increasing prevalence of bronchiectasis, there is a critical lack of high-quality studies into the disease and no treatments specifically approved for its treatment. This trial aims to establish whether inhaled dual bronchodilators (long acting beta agonist (LABA) and long acting muscarinic antagonist (LAMA)) taken as either a stand-alone therapy or in combination with inhaled corticosteroid (ICS) reduce the number of exacerbations of bronchiectasis requiring treatment with antibiotics during a 12 month treatment period. Methods: This is a multicentre, pragmatic, double-blind, randomised controlled trial, incorporating an internal pilot and embedded economic evaluation. 600 adult patients (≥18 years) with CT confirmed bronchiectasis will be recruited and randomised to either inhaled dual therapy (LABA+LAMA), triple therapy (LABA+LAMA+ICS) or matched placebo, in a 2:2:1 ratio (respectively). The primary outcome is the number of protocol defined exacerbations requiring treatment with antibiotics during the 12 month treatment period. Ethics and dissemination: Favourable ethical opinion was received from the North East-Newcastle and North Tyneside 2 Research Ethics Committee (reference: 21/NE/0020). Results will be disseminated in peer-reviewed publications, at national and international conferences, in the NIHR Trial registration number: ISRCTN15988757.
Mesh-Begriff(e)	Adult ; Humans ; Bronchodilator Agents/therapeutic use ; Quality of Life ; Adrenergic beta-2 Receptor Agonists ; Muscarinic Antagonists ; Bronchiectasis/drug therapy ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Administration, Inhalation ; Drug Therapy, Combination ; Adrenal Cortex Hormones/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Randomized Controlled Trials as Topic ; Multicenter Studies as Topic
Chemische Substanzen	Bronchodilator Agents ; Adrenergic beta-2 Receptor Agonists ; Muscarinic Antagonists ; Adrenal Cortex Hormones ; Anti-Bacterial Agents
Sprache	Englisch
Erscheinungsdatum	2023-08-10
Erscheinungsland	England
Dokumenttyp	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-071906
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Prevalence of allergic disease in Old Order Mennonites in New York.

Martina, Camille / Looney, R John / Marcus, Carolina / Allen, Maria / Stahlhut, Richard

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

2016 Band 117, Heft 5, Seite(n) 562–563.e1

Sprache	Englisch
Erscheinungsdatum	2016-11
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	1228189-x
ISSN	1534-4436 ; 0003-4738 ; 1081-1206
ISSN (online)	1534-4436
ISSN	0003-4738 ; 1081-1206
DOI	10.1016/j.anai.2016.08.023
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Traditional Farming Lifestyle in Old Older Mennonites Modulates Human Milk Composition.

Seppo, Antti E / Choudhury, Rakin / Pizzarello, Catherine / Palli, Rohith / Fridy, Sade / Rajani, Puja Sood / Stern, Jessica / Martina, Camille / Yonemitsu, Chloe / Bode, Lars / Bu, Kevin / Tamburini, Sabrina / Piras, Enrica / Wallach, David S / Allen, Maria / Looney, R John / Clemente, Jose C / Thakar, Juilee / Järvinen, Kirsi M

Frontiers in immunology

2021 Band 12, Seite(n) 741513

Abstract: Background: In addition to farming exposures in childhood, maternal farming exposures provide strong protection against allergic disease in their children; however, the effect of farming lifestyle on human milk (HM) composition is unknown.: Objective!# ...

Abstract	Background: In addition to farming exposures in childhood, maternal farming exposures provide strong protection against allergic disease in their children; however, the effect of farming lifestyle on human milk (HM) composition is unknown. Objective: This study aims to characterize the maternal immune effects of Old Order Mennonite (OOM) traditional farming lifestyle when compared with Rochester (ROC) families at higher risk for asthma and allergic diseases using HM as a proxy. Methods: HM samples collected at median 2 months of lactation from 52 OOM and 29 ROC mothers were assayed for IgA Results: HM contains IgA Conclusion: Traditional, agrarian lifestyle, and antibiotic use are strong regulators of maternally derived immune and metabolic factors, which may have downstream implications for postnatal developmental programming of infant's gut microbiome and immune system.
Mesh-Begriff(e)	Agriculture ; Child, Preschool ; Female ; Gastrointestinal Microbiome/genetics ; Gastrointestinal Microbiome/immunology ; Humans ; Hypersensitivity, Immediate/epidemiology ; Hypersensitivity, Immediate/immunology ; Immunoglobulin A/metabolism ; Life Style ; Male ; Maternal Exposure/adverse effects ; Milk, Human/immunology ; Milk, Human/metabolism ; Religion ; Rural Population ; United States/epidemiology ; Up-Regulation
Chemische Substanzen	Immunoglobulin A
Sprache	Englisch
Erscheinungsdatum	2021-10-11
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.741513
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Infant gut microbiome is enriched with Bifidobacterium longum ssp. infantis in Old Order Mennonites with traditional farming lifestyle.

Seppo, Antti E / Bu, Kevin / Jumabaeva, Madina / Thakar, Juilee / Choudhury, Rakin A / Yonemitsu, Chloe / Bode, Lars / Martina, Camille A / Allen, Maria / Tamburini, Sabrina / Piras, Enrica / Wallach, David S / Looney, R John / Clemente, Jose C / Järvinen, Kirsi M

Allergy

2021 Band 76, Heft 11, Seite(n) 3489–3503

Abstract: Background: Growing up on traditional, single-family farms is associated with protection against asthma in school age, but the mechanisms against early manifestations of atopic disease are largely unknown. We sought determine the gut microbiome and ... ...

Abstract	Background: Growing up on traditional, single-family farms is associated with protection against asthma in school age, but the mechanisms against early manifestations of atopic disease are largely unknown. We sought determine the gut microbiome and metabolome composition in rural Old Order Mennonite (OOM) infants at low risk and Rochester, NY urban/suburban infants at high risk for atopic diseases. Methods: In a cohort of 65 OOM and 39 Rochester mother-infant pairs, 101 infant stool and 61 human milk samples were assessed by 16S rRNA gene sequencing for microbiome composition and qPCR to quantify Bifidobacterium spp. and B. longum ssp. infantis (B. infantis), a consumer of human milk oligosaccharides (HMOs). Fatty acids (FAs) were analyzed in 34 stool and human 24 milk samples. Diagnoses and symptoms of atopic diseases by 3 years of age were assessed by telephone. Results: At a median age of 2 months, stool was enriched with Bifidobacteriaceae, Clostridiaceae, and Aerococcaceae in the OOM compared with Rochester infants. B. infantis was more abundant (p < .001) and prevalent, detected in 70% of OOM compared with 21% of Rochester infants (p < .001). Stool colonized with B. infantis had higher levels of lactate and several medium- to long/odd-chain FAs. In contrast, paired human milk was enriched with a distinct set of FAs including butyrate. Atopic diseases were reported in 6.5% of OOM and 35% of Rochester children (p < .001). Conclusion: A high rate of B. infantis colonization, similar to that seen in developing countries, is found in the OOM at low risk for atopic diseases.
Mesh-Begriff(e)	Bifidobacterium longum subspecies infantis ; Child ; Farms ; Gastrointestinal Microbiome ; Humans ; Infant ; Life Style ; Milk, Human ; Oligosaccharides ; RNA, Ribosomal, 16S/genetics
Chemische Substanzen	Oligosaccharides ; RNA, Ribosomal, 16S
Sprache	Englisch
Erscheinungsdatum	2021-05-14
Erscheinungsland	Denmark
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.14877
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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