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  1. Artikel ; Online: CD5 blockade, a novel immune checkpoint inhibitor, enhances T cell anti-tumour immunity and delays tumour growth in mice harbouring poorly immunogenic 4T1 breast tumour homografts.

    Alotaibi, Faizah M / Min, Wei-Ping / Koropatnick, James

    Frontiers in immunology

    2024  Band 15, Seite(n) 1256766

    Abstract: CD5 is a member of the scavenger receptor cysteine-rich superfamily that is expressed on T cells and a subset of B cells (B1a) cell and can regulate the T cell receptor signaling pathway. Blocking CD5 function may have therapeutic potential in treatment ... ...

    Abstract CD5 is a member of the scavenger receptor cysteine-rich superfamily that is expressed on T cells and a subset of B cells (B1a) cell and can regulate the T cell receptor signaling pathway. Blocking CD5 function may have therapeutic potential in treatment of cancer by enhancing cytotoxic T lymphocyte recognition and ablation of tumour cells. The effect of administering an anti-CD5 antibody to block or reduce CD5 function as an immune checkpoint blockade to enhance T cell anti-tumour activation and function
    Mesh-Begriff(e) Mice ; Animals ; Humans ; Female ; CD8-Positive T-Lymphocytes ; Immune Checkpoint Inhibitors/pharmacology ; T-Lymphocytes, Cytotoxic ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/therapeutic use ; Breast Neoplasms/drug therapy ; Allografts ; Tumor Microenvironment
    Chemische Substanzen Immune Checkpoint Inhibitors ; Antibodies, Monoclonal
    Sprache Englisch
    Erscheinungsdatum 2024-02-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1256766
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Antibiotic Exposure Concurrently with Anti-PD1 Blockade Therapy Reduces Overall Survival in Patients with Child-Pugh Class A Advanced Hepatocellular Carcinoma.

    Alshammari, Kanan / Alotaibi, Faizah M / Alsugheir, Futoon / Aldawoud, Mohammad / Alolayan, Ashwaq / Algarni, Mohammed Ahmad / Sabatin, Fouad / Mohammad, Mohammad F / Alosaimi, Abdulaziz / Sanai, Faisal M / Odah, Hassan / Alshehri, Ahmed Saleh / Aldibasi, Omar S / Alrehaily, Samah / Al Saleh, Abdullah S

    Cancers

    2023  Band 16, Heft 1

    Abstract: Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide with a poor prognosis. Treatment with immune checkpoint inhibitors (ICIs) has improved overall survival in patients with HCC. However, not all patients benefit from the ... ...

    Abstract Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide with a poor prognosis. Treatment with immune checkpoint inhibitors (ICIs) has improved overall survival in patients with HCC. However, not all patients benefit from the treatment. In this study, 59 patients with HCC were enrolled from two medical centers in Saudi Arabia, with 34% using antibiotics concurrently with their Nivolumab (anti-PD1 blockade). The impact of antibiotic use on the clinical outcomes of patients with HCC undergoing treatment with anti-PD1 blockade was examined. The patients' overall survival (OS) was 5 months (95% CI: 3.2, 6.7) compared to 10 months (95% CI: 0, 22.2) (
    Sprache Englisch
    Erscheinungsdatum 2023-12-27
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16010133
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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