Artikel ; Online: Identification of Tensin-3 as a MALT1 substrate that controls B cell adhesion and lymphoma dissemination.
Proceedings of the National Academy of Sciences of the United States of America
2023 Band 120, Heft 52, Seite(n) e2301155120
Abstract: The protease MALT1 promotes lymphocyte activation and lymphomagenesis by cleaving a limited set of cellular substrates, most of which control gene expression. Here, we identified the integrin-binding scaffold protein Tensin-3 as a MALT1 substrate in ... ...
Abstract | The protease MALT1 promotes lymphocyte activation and lymphomagenesis by cleaving a limited set of cellular substrates, most of which control gene expression. Here, we identified the integrin-binding scaffold protein Tensin-3 as a MALT1 substrate in activated human B cells. Activated B cells lacking Tensin-3 showed decreased integrin-dependent adhesion but exhibited comparable NF-κB1 and Jun N-terminal kinase transcriptional responses. Cells expressing a noncleavable form of Tensin-3, on the other hand, showed increased adhesion. To test the role of Tensin-3 cleavage in vivo, mice expressing a noncleavable version of Tensin-3 were generated, which showed a partial reduction in the T cell-dependent B cell response. Interestingly, human diffuse large B cell lymphomas and mantle cell lymphomas with constitutive MALT1 activity showed strong constitutive Tensin-3 cleavage and a decrease in uncleaved Tensin-3 levels. Moreover, silencing of Tensin-3 expression in MALT1-driven lymphoma promoted dissemination of xenografted lymphoma cells to the bone marrow and spleen. Thus, MALT1-dependent Tensin-3 cleavage reveals a unique aspect of the function of MALT1, which negatively regulates integrin-dependent B cell adhesion and facilitates metastatic spread of B cell lymphomas. |
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Mesh-Begriff(e) | Mice ; Humans ; Animals ; Adult ; Tensins/genetics ; Caspases/metabolism ; NF-kappa B/metabolism ; Cell Adhesion/genetics ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein/genetics ; Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein/metabolism ; Lymphoma, Large B-Cell, Diffuse/genetics ; Integrins |
Chemische Substanzen | Tensins ; Caspases (EC 3.4.22.-) ; NF-kappa B ; Neoplasm Proteins ; Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein (EC 3.4.22.-) ; Integrins ; MALT1 protein, human (EC 3.4.22.-) |
Sprache | Englisch |
Erscheinungsdatum | 2023-12-18 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article |
ZDB-ID | 209104-5 |
ISSN | 1091-6490 ; 0027-8424 |
ISSN (online) | 1091-6490 |
ISSN | 0027-8424 |
DOI | 10.1073/pnas.2301155120 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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