Artikel: Evaluation of phytochemical, anti-oxidant and cardiac depressant effect of Rumex dentatus by using Langendorff's isolated heart apparatus.
Pakistan journal of pharmaceutical sciences
2021 Band 34, Heft 2(Supplementary), Seite(n) 671–677
Abstract: Rumex dentatus has been used traditionally for ailment of cardiovascular diseases. The aim of the present study was to assess cardiovascular effects in isolated perfused rabbit heart. Aqueous and n-butanolic fractions were assessed for their effect on ... ...
Abstract | Rumex dentatus has been used traditionally for ailment of cardiovascular diseases. The aim of the present study was to assess cardiovascular effects in isolated perfused rabbit heart. Aqueous and n-butanolic fractions were assessed for their effect on perfusion pressure (PP), force of contraction (FC) and heart rate (HR) of rabbit heart using Langendorff's method. The possible mechanisms of action of extracts/fraction were assessed with and without application of different agonist/antagonist. Phytochemical, toxicity and anti-oxidant activities were also determined. Both extracts at 1mg/mL dose produced a highly significant decrease in FC and HR but PP remained unchanged. Moreover, aqueous fraction of Rumex dentatus at 0.001mg/mL dose produced a highly significant decrease in FC and HR but no significant change in PP was observed. Atropine 10 |
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Mesh-Begriff(e) | Animals ; Antioxidants/pharmacology ; Atropine/pharmacology ; Calcium Chloride/pharmacology ; Cardiovascular Agents/adverse effects ; Cardiovascular Agents/pharmacology ; Epinephrine/pharmacology ; Female ; Heart/drug effects ; Heart Rate/drug effects ; Isolated Heart Preparation/methods ; Male ; Mice ; Myocardial Contraction/drug effects ; Plant Extracts/adverse effects ; Plant Extracts/pharmacology ; Rabbits ; Rats ; Rats, Sprague-Dawley ; Rumex/adverse effects ; Rumex/chemistry |
Chemische Substanzen | Antioxidants ; Cardiovascular Agents ; Plant Extracts ; Atropine (7C0697DR9I) ; Calcium Chloride (M4I0D6VV5M) ; Epinephrine (YKH834O4BH) |
Sprache | Englisch |
Erscheinungsdatum | 2021-06-30 |
Erscheinungsland | Pakistan |
Dokumenttyp | Journal Article |
ZDB-ID | 885131-1 |
ISSN | 1011-601X |
ISSN | 1011-601X |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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