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  1. Artikel ; Online: Adjuvant Alpelisib Therapy for Congenital Hyperinsulinism.

    Dauleh, Hajar / Amin, Rasha / Pasha, Maheen / Hussain, Khalid

    The New England journal of medicine

    2024  Band 390, Heft 4, Seite(n) 379–380

    Mesh-Begriff(e) Humans ; Congenital Hyperinsulinism/drug therapy ; Thiazoles/therapeutic use ; Class I Phosphatidylinositol 3-Kinases/therapeutic use
    Chemische Substanzen Alpelisib (08W5N2C97Q) ; Thiazoles ; Class I Phosphatidylinositol 3-Kinases (EC 2.7.1.137)
    Sprache Englisch
    Erscheinungsdatum 2024-01-23
    Erscheinungsland United States
    Dokumenttyp Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2312807
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Ua VI Zs.34: Hefte anzeigen Standort:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  2. Artikel ; Online: Increased serum interleukin-6 and lactate dehydrogenase levels among nonsurvival severe COVID-19 patients when compared to survival ones.

    Haroun, Riham Abdel-Hamid / Osman, Waleed H / Amin, Rasha E / Eessa, Asmaa M / Saad, Soha

    International immunopharmacology

    2023  Band 122, Seite(n) 110626

    Abstract: Background: Accurate and rapid laboratory diagnosis of COVID-19 infection and its deterioration is one of the milestones of pandemic control. Therefore, this study aimed to compare the diagnostic and prognostic accuracy of the mainly used laboratory ... ...

    Abstract Background: Accurate and rapid laboratory diagnosis of COVID-19 infection and its deterioration is one of the milestones of pandemic control. Therefore, this study aimed to compare the diagnostic and prognostic accuracy of the mainly used laboratory biomarkers (WBCS, neutrophil and lymphocyte percentages, CRP, ferritin, IL-6, D-dimer, procalcitonin, and LDH) in the sera of severe COVID-19 Egyptian patients to assess the most appropriate biomarker used in severe COVID-19 patients.
    Methods: A total of 180 unvaccinated severe COVID-19 patients were enrolled in our study. Demographic data, hospitalization time, medical history, oxygen saturation, respiratory rate, oxygen supply, laboratory findings, and thorax tomography of the patients were obtained retrospectively from the hospital's electronic information system.
    Results: Our results revealed that the levels of neutrophil percentage, CRP, IL-6, PCT, and LDH were significantly increased while lymphocyte percentage was significantly decreased among nonsurvival severe COVID-19 patients when compared with survival ones. By using ROC curve analysis, IL-6, and LDH are the most sensitive and specific markers for the prediction of bad prognosis and mortality among severe COVID-19 patients with 100% and 93% sensitivity and 93.7% specificity; respectively. IL-6 and LDH showed significant correlations with the other parameters, which suggested their association with the severity of COVID-19.
    Conclusion: By using survival severe COVID-19 patients as a control group, our results showed that blood neutrophil percentage, serum CRP, IL-6, PCT, and LDH were significantly increased in non-survivors as compared to survivors. As biomarkers, our results revealed that IL-6 and LDH are good predictors of mortality among severe COVID-19 patients.
    Mesh-Begriff(e) Humans ; COVID-19 ; Interleukin-6 ; Retrospective Studies ; Biomarkers ; Lactate Dehydrogenases ; C-Reactive Protein/analysis ; L-Lactate Dehydrogenase
    Chemische Substanzen Interleukin-6 ; Biomarkers ; Lactate Dehydrogenases (EC 1.1.-) ; C-Reactive Protein (9007-41-4) ; L-Lactate Dehydrogenase (EC 1.1.1.27)
    Sprache Englisch
    Erscheinungsdatum 2023-07-15
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2023.110626
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5408: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Artikel ; Online: Circulating plasma miR-155 is a potential biomarker for the detection of SARS-CoV-2 infection.

    Haroun, Riham Abdel-Hamid / Osman, Waleed H / Amin, Rasha E / Hassan, Ahmad K / Abo-Shanab, Waleed S / Eessa, Asmaa M

    Pathology

    2021  Band 54, Heft 1, Seite(n) 104–110

    Abstract: Identification of human miRNAs involved in coronavirus-host interplay is important due to the current COVID-19 pandemic. Therefore, this study aimed to measure the circulating plasma miR-155 expression level in COVID-19 patients and healthy controls to ... ...

    Abstract Identification of human miRNAs involved in coronavirus-host interplay is important due to the current COVID-19 pandemic. Therefore, this study aimed to measure the circulating plasma miR-155 expression level in COVID-19 patients and healthy controls to investigate its roles in the pathogenesis and severity of COVID-19 disease and to assess its usefulness as a clinical biomarker for the detection of COVID-19 disease and the severity of infection. A total of 150 COVID-19 patients and 50 controls were enrolled into our study. Beside the routine laboratory work and chest computed tomography (CT) scans of COVID-19 patients, plasma miR-155 expression level was measured using reverse transcription quantitative real-time PCR (RT-qPCR) technique. Our results demonstrated increased miR-155 expression level in COVID-19 patients compared to controls, in severe compared to moderate COVID-19 patients, and in non-survival compared to survival COVID-19 patients. miR-155 expression level also had significant correlation with clinicopathological characteristics of COVID-19 patients such as chest CT findings, CRP, ferritin, mortality, D-dimer, WBC count, and lymphocytes and neutrophils percentages. Also, our results showed that the area under the curve (AUC) for miR-155 was 0.986 with 90% sensitivity and 100% specificity when used as a biomarker for the detection of COVID-19 disease; while in detection of severity of COVID-19 disease, AUC for miR-155 was 0.75 with 76% sensitivity and specificity. From these results we can conclude that miR-155 has a crucial role in the pathogenesis and severity of COVID-19; also, it could be a good diagnostic clinical biomarker for the detection of COVID-19 disease and the severity of infection.
    Mesh-Begriff(e) Adult ; Biomarkers/blood ; COVID-19/blood ; COVID-19/diagnosis ; Female ; Humans ; Male ; MicroRNAs/blood ; Middle Aged ; SARS-CoV-2 ; Sensitivity and Specificity
    Chemische Substanzen Biomarkers ; MIRN155 microRNA, human ; MicroRNAs
    Sprache Englisch
    Erscheinungsdatum 2021-11-06
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1016/j.pathol.2021.09.006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 723: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Artikel: Vitamin D deficiency is associated with urinary tract infection in children.

    Shalaby, Sherein Abdelhamid / Handoka, Nesrein Mosad / Amin, Rasha Emad

    Archives of medical science : AMS

    2016  Band 14, Heft 1, Seite(n) 115–121

    Abstract: Introduction: In humans, vitamin D has been shown to play a role in infectious diseases, but its association with acquisition and a complicated course of febrile urinary tract infections (UTIs) has not been investigated. We aimed to investigate the ... ...

    Abstract Introduction: In humans, vitamin D has been shown to play a role in infectious diseases, but its association with acquisition and a complicated course of febrile urinary tract infections (UTIs) has not been investigated. We aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D
    Material and methods: This prospective case-control study included 50 children with first febrile UTI, with no risk factors for UTI, and 50 age- and sex-matched healthy siblings as controls. White blood cell count, serum C-reactive protein, calcium, phosphorus, alkaline phosphatase and parathormone were measured in all studied children. Vitamin D status was determined by measuring plasma 25(OH)D
    Results: Children with UTI had significantly lower mean serum levels of 25(OH)D
    Conclusions: Vitamin D deficiency (≤ 25 nmol/l) was an independent risk factor for UTI in children.
    Sprache Englisch
    Erscheinungsdatum 2016-10-26
    Erscheinungsland Poland
    Dokumenttyp Journal Article
    ZDB-ID 2203781-0
    ISSN 1734-1922
    ISSN 1734-1922
    DOI 10.5114/aoms.2016.63262
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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