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  1. Artikel ; Online: The management of osteoarthritis symptomatology through nanotechnology: a patent review.

    Santos, Mariana Mendonça / Santos, Anamaria Mendonça / Nascimento Júnior, José Adão Carvalho / Andrade, Tatianny De Araujo / Rajkumar, Gomathi / Frank, Luiza Abrahão / Serafini, Mairim Russo

    Journal of microencapsulation

    2023  Band 40, Heft 7, Seite(n) 475–490

    Abstract: Osteoarthritis is considered a degenerative joint disease that is characterised by inflammation, chronic pain, and functional limitation. The increasing development of nanotechnology in drug delivery systems has provided new ideas and methods for ... ...

    Abstract Osteoarthritis is considered a degenerative joint disease that is characterised by inflammation, chronic pain, and functional limitation. The increasing development of nanotechnology in drug delivery systems has provided new ideas and methods for osteoarthritis therapy. This review aimed to evaluate patents that have developed innovations, therapeutic strategies, and alternatives using nanotechnology in osteoarthritis treatment. The results show patents deposited from 2015 to November 2021 in the online databases European Patent Office and World Intellectual Property Organisation. A total of 651 patents were identified for preliminary assessment and 16 were selected for full reading and discussion. The evaluated patents are focused on the intraarticular route, oral route, and topical route for osteoarthritis treatment. The intraarticular route presented a higher patent number, followed by the oral and topical routes, respectively. The development of new technologies allows us to envision a promising and positive future in osteoarthritis treatment.
    Mesh-Begriff(e) Humans ; Drug Delivery Systems ; Nanotechnology ; Osteoarthritis/drug therapy
    Sprache Englisch
    Erscheinungsdatum 2023-09-12
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 843632-0
    ISSN 1464-5246 ; 0265-2048
    ISSN (online) 1464-5246
    ISSN 0265-2048
    DOI 10.1080/02652048.2023.2258955
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: A Patent Review on the Use of Cyclodextrin Inclusion Complexes to Enhance Physicochemical and Pharmacological Properties in Antidepressant Drugs.

    Nascimento Júnior, José Adão Carvalho / Frank, Luiza Abrahão / Santos, Alcimary Bispo / Santos, Anamaria Mendonça / Andrade, Tatianny de Araújo / Menezes, Paula Dos Passos / Contri, Renata Vidor / Serafini, Mairim Russo

    Critical reviews in therapeutic drug carrier systems

    2024  Band 41, Heft 6, Seite(n) 57–88

    Abstract: Major depressive disorder is considered one of the most common and prevalent diseases worldwide, affecting children, adults, and the elderly. Currently, several antidepressant drugs are available on the market, but the low adherence of patients due to ... ...

    Abstract Major depressive disorder is considered one of the most common and prevalent diseases worldwide, affecting children, adults, and the elderly. Currently, several antidepressant drugs are available on the market, but the low adherence of patients due to the slow therapeutic response is a problem to be solved. In this way, cyclodextrins become an alternative to circumvent the limitations and improve the physicochemical and pharmacological properties of this class of drugs. Thus, the objective of this work is to carry out a current review of patents associating antidepressant drugs and cyclodextrins. The patent search was performed in two patent databases, the World Intellectual Property Organization and the European Patent Office using terms in the title and abstract fields and the international patent classification code for antidepressant drugs. In the end, 27 patent documents were selected and divided into three classifications, physical-chemical characterization study, pre-clinical in vivo trials, and clinical trials. The scientific evidence found in the patents considers the use of cyclodextrins as an important alternative to improve the therapeutic and physicochemical properties of antidepressant drugs, among the main improved properties are, solubility, stability, masking taste and odor, bioavailability.
    Mesh-Begriff(e) Patents as Topic ; Antidepressive Agents/chemistry ; Antidepressive Agents/pharmacology ; Antidepressive Agents/administration & dosage ; Cyclodextrins/chemistry ; Humans ; Animals ; Solubility ; Depressive Disorder, Major/drug therapy ; Biological Availability ; Drug Stability
    Chemische Substanzen Antidepressive Agents ; Cyclodextrins
    Sprache Englisch
    Erscheinungsdatum 2024-05-28
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2012632-3
    ISSN 2162-660X ; 0743-4863
    ISSN (online) 2162-660X
    ISSN 0743-4863
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Antibacterial drugs and cyclodextrin inclusion complexes: a patent review.

    Santos, Anamaria Mendonça / Carvalho Santana Júnior, Cláudio / Nascimento Júnior, José Adão Carvalho / Andrade, Tatianny de Araujo / Shanmugam, Saravanan / Thangaraj, Parimelazhagan / Frank, Luiza Abrahão / Serafini, Mairim Russo

    Expert opinion on drug delivery

    2023  Band 20, Heft 3, Seite(n) 349–366

    Abstract: Introduction: Bacterial antibiotic resistance occurs when bacteria mutate and escape the effect of antibiotics, which makes the antibiotics no longer effective in treating infections. New solutions for bacterial infections are a persistent need ... ...

    Abstract Introduction: Bacterial antibiotic resistance occurs when bacteria mutate and escape the effect of antibiotics, which makes the antibiotics no longer effective in treating infections. New solutions for bacterial infections are a persistent need including the identification of drugs with better pharmacological profiles, more potent, and safer. Cyclodextrins inclusion complexes have been able to improve the physicochemical and pharmacological properties of the formulation molecules, resulting in new alternatives with better efficacy.
    Areas covered: The patents analyzed in the review used treatments based on antibiotics already on the market, natural products, and synthesized molecules composed of the formulation with cyclodextrins. The combination between cyclodextrin and nanostructures also were presented in the patents review process. Moreover, inclusion complexes have been an alternative in developing treatment mainly in China by the pharmaceutical industries in several countries such as Germany, Hungary, the United States of America, Japan and China.
    Expert opinion: This review is broad and complete since it considers the first patent involving cyclodextrins and antibacterial drugs. Therefore, the various inclusion complexes and antibacterial drugs alternatives presented in this review offer therapeutic options to fight bacterial infections. If shown to be effective, these drugs may be extremely important in the current clinical practice.
    Mesh-Begriff(e) Cyclodextrins/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Solubility
    Chemische Substanzen Cyclodextrins ; Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2023-02-15
    Erscheinungsland England
    Dokumenttyp Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2167286-6
    ISSN 1744-7593 ; 1742-5247
    ISSN (online) 1744-7593
    ISSN 1742-5247
    DOI 10.1080/17425247.2023.2175815
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Advances of nanosystems containing cyclodextrins and their applications in pharmaceuticals.

    Menezes, Paula Dos Passos / Andrade, Tatianny de Araújo / Frank, Luiza Abrahão / de Souza, Eloísa Portugal Barros Silva Soares / Trindade, Gabriela das Graças Gomes / Trindade, Igor Araújo Santos / Serafini, Mairim Russo / Guterres, Sílvia Stanisçuaski / Araújo, Adriano Antunes de Souza

    International journal of pharmaceutics

    2019  Band 559, Seite(n) 312–328

    Abstract: For many years, researchers have worked with supramolecular structures involving inclusion complexes with cyclodextrins. These studies have resulted in new commercially available drugs which have been of great benefit. More recently, studies using ... ...

    Abstract For many years, researchers have worked with supramolecular structures involving inclusion complexes with cyclodextrins. These studies have resulted in new commercially available drugs which have been of great benefit. More recently, studies using nanoparticles, including nanosystems containing cyclodextrins, have become a focus of academic research due to the versatility of the systems and their remarkable therapeutic potential. This review focuses on studies published between 2002 and 2018 involving nanosystems containing cyclodextrins. We consider the type of nanosystems, their importance in a health context, the physicochemical techniques used to show the quality of these systems and their potential for the development of novel pharmaceutical formulations. These have been developed in recent studies which have mainly been focusing on basic science with no clinical trials as yet being performed. This is important to note because it means that the studies do not include any toxicity tests. Despite this limitation, the characterization assays performed suggest that these new formulations may have therapeutic potential. However, more research is required to assess the efficacy and safety of these nanosystems.
    Mesh-Begriff(e) Animals ; Chemistry, Pharmaceutical/methods ; Cyclodextrins/chemistry ; Drug Compounding/methods ; Drug Delivery Systems/methods ; Humans ; Nanoparticles/chemistry ; Nanotechnology/methods
    Chemische Substanzen Cyclodextrins
    Sprache Englisch
    Erscheinungsdatum 2019-01-29
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2019.01.041
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Evaluation of the antibacterial and modulatory potential of α-bisabolol, β-cyclodextrin and α-bisabolol/β-cyclodextrin complex.

    Oliveira, Fernanda de Sousa / Freitas, Thiago Sampaio de / Cruz, Rafael Pereira da / Costa, Maria do Socorro / Pereira, Raimundo Luiz Silva / Quintans-Júnior, Lucindo José / Andrade, Tatianny de Araújo / Menezes, Paula Dos Passos / Sousa, Bruna Maria Hipólito de / Nunes, Paula Santos / Serafini, Mairim Russo / Menezes, Irwin Rose Alencar de / Araújo, Adriano Antunes de Souza / Coutinho, Henrique Douglas Melo

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2017  Band 92, Seite(n) 1111–1118

    Abstract: The present study aimed to evaluate the antibacterial and modulatory potential of α-bisabolol, β-cyclodextrin and α-bisabolol/β-cyclodextrin complex. The minimum inhibitory concentration was determined through the broth microdilution technique using the ... ...

    Abstract The present study aimed to evaluate the antibacterial and modulatory potential of α-bisabolol, β-cyclodextrin and α-bisabolol/β-cyclodextrin complex. The minimum inhibitory concentration was determined through the broth microdilution technique using the bacterial strains: Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The drugs norfloxacin, imipenem and gentamicin were used in the tests, and the compounds α-bisabolol and β-cyclodextrin; all the compounds were diluted in DMSO. To obtain the minimum inhibitory concentration (MIC) a serial microdilution of the substances in volumes corresponding to the sub-inhibitory concentration (MIC/8), and microdilution with the antibiotic until the penultimate well were performed. The results showed that β-cyclodextrin did not present synergistic effects when combined with the antibiotics. It was found that α-bisabolol presented a synergistic effect against S. aureus, when combined with the antibiotic norfloxacin. Moreover, α-bisabolol presented synergism against E. coli when combined with gentamicin. The results of this study show that α-bisabolol presents a modulatory synergistic effect for some antibiotics, as gentamicin, and this is an interesting result against multidrug resistant bacteria (MDR). By other side, the complexation of α-bisabolol with β-cyclodextrin apparently reduces the modulatory effect, maybe due the polarity enhancement of the polarity of α-bisabolol, affecting the interaction of this compound with the cell membrane bilayer. However, more studies are necessary to demonstrate or not these interactions.
    Sprache Englisch
    Erscheinungsdatum 2017-08
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2017.06.020
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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