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Frontiers in Cell and Developmental Biology, Vol
Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes
2021 Band 9
Abstract: In the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (IP3R)- ...
| Abstract | In the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (IP3R)-mediated calcium (Ca2+) release plays a central role. Recent evidence suggests that IP3R isoforms participate in synthesis and degradation pathways. This minireview will summarize the current findings in this area, emphasizing the critical role of Ca2+ communication on organelle function as well as catabolism and anabolism, particularly in cancer. |
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| Schlagwörter | IP3Rs ; calcium ; endoplasmic reticulum ; mitochondria ; lysosome ; metabolism ; Biology (General) ; QH301-705.5 |
| Sprache | Englisch |
| Erscheinungsdatum | 2021-03-01T00:00:00Z |
| Verlag | Frontiers Media S.A. |
| Dokumenttyp | Artikel ; Online |
| Datenquelle | BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl) |
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