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  1. Artikel: Anatomie mit klinischen Bezügen – Teil 1 Inneres und äußeres Genitale

    Anetsberger, Daniel / Beckmann, Matthias W. / Gaß, Paul / Heindl, Felix

    Frauenheilkunde up2date

    2023  Band 17, Heft 05, Seite(n) 437–454

    Schlagwörter Anatomie ; Gynäkologie ; Geburtshilfe ; Embryonalentwicklung
    Sprache Deutsch
    Erscheinungsdatum 2023-10-01
    Verlag Georg Thieme Verlag KG
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ZDB-ID 2272764-4
    ISSN 1611-650X ; 1439-3719
    ISSN (online) 1611-650X
    ISSN 1439-3719
    DOI 10.1055/a-1861-0460
    Datenquelle Thieme Verlag

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  2. Buch ; Online ; Dissertation / Habilitation: Morphological and Immunohistochemical Characterization of Human Intrinsic Gastric Neurons

    Anetsberger, Daniel [Verfasser] / Brehmer, Axel [Akademischer Betreuer] / Brehmer, Axel [Gutachter] / Fester, Lars [Gutachter]

    2023  

    Verfasserangabe Daniel Anetsberger ; Gutachter: Axel Brehmer, Lars Fester ; Betreuer: Axel Brehmer
    Schlagwörter Medizin, Gesundheit ; Medicine, Health
    Thema/Rubrik (Code) sg610
    Sprache Mehrere Sprachen
    Verlag Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Erscheinungsort Erlangen
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

    Volltext online

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  3. Artikel ; Online: Morphological and Immunohistochemical Characterization of Human Intrinsic Gastric Neurons.

    Anetsberger, Daniel / Kürten, Stefanie / Jabari, Samir / Brehmer, Axel

    Cells, tissues, organs

    2019  Band 206, Heft 4-5, Seite(n) 183–195

    Abstract: Our knowledge about human gastric enteric neuron types is even more limited than that of human intestinal types. Here, we immunohistochemically stained wholemounts and sections of gastric specimens obtained from 18 tumor-resected patients. Myenteric ... ...

    Abstract Our knowledge about human gastric enteric neuron types is even more limited than that of human intestinal types. Here, we immunohistochemically stained wholemounts and sections of gastric specimens obtained from 18 tumor-resected patients. Myenteric wholemounts were labeled for choline acetyl transferase (ChAT), neuronal nitric oxide synthase (NOS), and the human neuronal protein HuC/D (as pan-neuronal marker for quantitative analysis) or alternatively for neurofilament (for morphological evaluation). ChAT-positive neurons outnumbered NOS-positive neurons (56 vs. 27%), and neurons negative for both markers accounted for 17%. Two larger groups of neurons (each between 12 and 14%) costained for ChAT and vasoactive intestinal peptide (VIP) or for NOS and VIP, respectively. Clear morphochemical correlation was found for uniaxonal stubby type I neurons (ChAT+; putative excitatory inter- or motor neurons), for uniaxonal spiny type I neurons (NOS+/VIP+; putative inhibitory motor or interneurons), and for multiaxonal type II neurons (ChAT+; putative afferent neurons; immunostaining of additional wholemounts revealed their coreactivity for somatostatin). Whereas these latter neuron types were already known from the human intestine, the morphology of gastric myenteric neurons coreactive for ChAT and VIP was newly described: they had numerous short, extremely thin dendrites and resembled, together with their cell bodies, a "hairy" head. In our sections, nerve fibers coreactive for ChAT and VIP were commonly found only in the mucosa. We suggest these myenteric ChAT+/VIP+/hairy neurons to be mucosal effector neurons. In contrast to myenteric neurons, the much less common submucosal neurons were not embedded in a continuous plexus and did not display any clear morphochemical phenotypes.
    Sprache Englisch
    Erscheinungsdatum 2019-06-21
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1468141-9
    ISSN 1422-6421 ; 1422-6405
    ISSN (online) 1422-6421
    ISSN 1422-6405
    DOI 10.1159/000500566
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Morphological and Immunohistochemical Characterization of Human Intrinsic Gastric Neurons

    Anetsberger, Daniel / Kürten, Stefanie / Jabari, Samir / Brehmer, Axel

    Cells Tissues Organs

    2019  Band 206, Heft 4-5, Seite(n) 183–195

    Abstract: Our knowledge about human gastric enteric neuron types is even more limited than that of human intestinal types. Here, we immunohistochemically stained wholemounts and sections of gastric specimens obtained from 18 tumor-resected patients. Myenteric ... ...

    Körperschaft Institute of Anatomy and Cell Biology, Friedrich Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany
    Institute of Neuropathology, Friedrich Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany
    Abstract Our knowledge about human gastric enteric neuron types is even more limited than that of human intestinal types. Here, we immunohistochemically stained wholemounts and sections of gastric specimens obtained from 18 tumor-resected patients. Myenteric wholemounts were labeled for choline acetyl transferase (ChAT), neuronal nitric oxide synthase (NOS), and the human neuronal protein HuC/D (as pan­neuronal marker for quantitative analysis) or alternatively for neurofilament (for morphological evaluation). ChAT-positive neurons outnumbered NOS-positive neurons (56 vs. 27%), and neurons negative for both markers accounted for 17%. Two larger groups of neurons (each between 12 and 14%) costained for ChAT and vasoactive intestinal peptide (VIP) or for NOS and VIP, respectively. Clear morphochemical correlation was found for uniaxonal stubby type I neurons (ChAT+; putative excitatory inter- or motor neurons), for uniaxonal spiny type I neurons (NOS+/VIP+; putative inhibitory motor or interneurons), and for multiaxonal type II neurons (ChAT+; putative afferent neurons; immunostaining of additional wholemounts revealed their coreactivity for somatostatin). Whereas these latter neuron types were already known from the human intestine, the morphology of gastric myenteric neurons coreactive for ChAT and VIP was newly described: they had numerous short, extremely thin dendrites and resembled, together with their cell bodies, a “hairy” head. In our sections, nerve fibers coreactive for ChAT and VIP were commonly found only in the mucosa. We suggest these myenteric ChAT+/VIP+/hairy neurons to be mucosal effector neurons. In contrast to myenteric neurons, the much less common submucosal neurons were not embedded in a continuous plexus and did not display any clear morphochemical phenotypes.
    Schlagwörter Chemical coding ; Enteric nervous system ; Innervation ; Morphology ; Neurons ; Stomach
    Sprache Englisch
    Erscheinungsdatum 2019-06-21
    Verlag S. Karger AG
    Erscheinungsort Basel, Switzerland
    Dokumenttyp Artikel
    Anmerkung Developmental Biology / Research Article
    ZDB-ID 1468141-9
    ISSN 1422-6421 ; 1422-6405
    ISSN (online) 1422-6421
    ISSN 1422-6405
    DOI 10.1159/000500566
    Datenquelle Karger Verlag

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  5. Artikel: CDK4/6 Inhibition - Therapy Sequences and the Quest to Find the Best Biomarkers - an Overview of Current Programs.

    Schneeweiss, Andreas / Brucker, Sara Y / Huebner, Hanna / Volmer, Lea L / Hack, Carolin C / Seitz, Katharina / Ruebner, Matthias / Heublein, Sabine / Thewes, Verena / Lüftner, Diana / Lux, Michael P / Jurhasz-Böss, Ingolf / Taran, Florin-Andrei / Wimberger, Pauline / Anetsberger, Daniel / Beierlein, Milena / Schmidt, Marcus / Radosa, Julia / Müller, Volkmar /
    Janni, Wolfgang / Rack, Brigitte / Belleville, Erik / Untch, Michael / Thill, Marc / Ditsch, Nina / Aktas, Bahriye / Nel, Ivonne / Kolberg, Hans-Christian / Engerle, Tobias / Tesch, Hans / Roos, Christian / Budden, Christina / Neubauer, Hans / Hartkopf, Andreas D / Fehm, Tanja N / Fasching, Peter A

    Geburtshilfe und Frauenheilkunde

    2024  Band 84, Heft 5, Seite(n) 443–458

    Abstract: In recent years, new targeted therapies have been developed to treat patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer. Some of these therapies have not just become the new therapy ... ...

    Abstract In recent years, new targeted therapies have been developed to treat patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer. Some of these therapies have not just become the new therapy standard but also led to significantly longer overall survival rates. The cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) have become the therapeutic standard for first-line therapy. Around 70 - 80% of patients are treated with a CDK4/6i. In recent years, a number of biomarkers associated with progression, clonal selection or evolution have been reported for CDK4/6i and their endocrine combination partners. Understanding the mechanisms behind treatment efficacy and resistance is important. A better understanding could contribute to planning the most effective therapeutic sequences and utilizing basic molecular information to overcome endocrine resistance. One study with large numbers of patients which aims to elucidate these mechanisms is the Comprehensive Analysis of sPatial, TempORal and molecular patterns of ribociclib efficacy and resistance in advanced Breast Cancer patients (CAPTOR BC) trial. This overview summarizes the latest clinical research on resistance to endocrine therapies, focusing on CDK4/6 inhibitors and discussing current study concepts.
    Sprache Englisch
    Erscheinungsdatum 2024-05-29
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 80111-2
    ISSN 1438-8804 ; 0016-5751 ; 1615-3359
    ISSN (online) 1438-8804
    ISSN 0016-5751 ; 1615-3359
    DOI 10.1055/a-2286-6066
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 655: Hefte anzeigen

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