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  1. Artikel ; Online: Reduction of oocyte shedding and cecal inflammation by 5-aminolevulinic acid daily supplementation in laying hens infected with Eimeria tenella.

    Hatabu, Toshimitsu / Pham, Hung Hoang Son / Aota, Wataru / Fujino, Shota / Nishihara, Rio / Kawamura, Go / Sakogawa, Yuudai / Taniguchi, Shin / Matsubayashi, Makoto

    Animal science journal = Nihon chikusan Gakkaiho

    2023  Band 94, Heft 1, Seite(n) e13806

    Abstract: The present study aimed to evaluate the effects of 5-aminolevulinic acid (5-ALA) on Eimeria tenella infection in laying hens. Oocyst shedding and histopathology were evaluated. A reduced oocyst shedding was observed 5 and 7 days post-infection (dpi) in ... ...

    Abstract The present study aimed to evaluate the effects of 5-aminolevulinic acid (5-ALA) on Eimeria tenella infection in laying hens. Oocyst shedding and histopathology were evaluated. A reduced oocyst shedding was observed 5 and 7 days post-infection (dpi) in the 5-ALA-administered group, but the total number of oocysts during the first infection period was not different between control and 5-ALA-treated groups. After E. tenella attack infection, the period of oocyst shedding in the 5-ALA-administered group lasted less long than that in controls. During the attack infection period, the total number of fecal oocysts in the 5-ALA-treated group was significantly lower than that in the control group. However, the parasite burden score in hens receiving 5-ALA was higher than that in controls after E. tenella attack infection. The lesion scores at 5 and 30 dpi in the control group were significantly lower than those in the 5-ALA-administered group. Therefore, 5-ALA administration might be beneficial against E. tenella infection in laying hens.
    Mesh-Begriff(e) Animals ; Female ; Eimeria tenella ; Coccidiosis/veterinary ; Chickens ; Aminolevulinic Acid/pharmacology ; Poultry Diseases/drug therapy ; Oocytes ; Oocysts ; Dietary Supplements ; Inflammation/veterinary
    Chemische Substanzen Aminolevulinic Acid (88755TAZ87)
    Sprache Englisch
    Erscheinungsdatum 2023-01-11
    Erscheinungsland Australia
    Dokumenttyp Journal Article
    ZDB-ID 2095161-9
    ISSN 1740-0929 ; 1344-3941
    ISSN (online) 1740-0929
    ISSN 1344-3941
    DOI 10.1111/asj.13806
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Reduction of macrophages by carrageenan decreases oocyst output and modifies local immune reaction in chick cecum with Eimeria tenella.

    Ho, Dung Thi / Pham, Hung Hoang Son / Aota, Wataru / Matsubayashi, Makoto / Tsuji, Naotoshi / Hatabu, Toshimitsu

    Research in veterinary science

    2021  Band 139, Seite(n) 59–66

    Abstract: This study aimed to evaluate the disease severity and local immune responses in macrophage-depleted chicks with Eimeria tenella. Macrophages were reduced by intraperitoneal injection of a carrageenan solution at 12, 13, and 16 days old, whereas the ... ...

    Abstract This study aimed to evaluate the disease severity and local immune responses in macrophage-depleted chicks with Eimeria tenella. Macrophages were reduced by intraperitoneal injection of a carrageenan solution at 12, 13, and 16 days old, whereas the control group received intraperitoneal phosphate-buffered saline. Both chick groups were orally inoculated with E. tenella sporulated oocysts at 14 days old. Feces were collected daily, which were then quantified for oocysts. The chicks were sacrificed on day 5, and the ceca were collected for histopathological observation. The gene expression levels were measured using real-time quantitative reverse transcription-polymerase chain reaction. Macrophage-depleted chicks have been observed to shed a significantly reduced number of fecal oocysts compared to the infected control group. The parasite burden score in cecum specimens of macrophage-depleted chicks was significantly lower than those of infected control on day 5 after infection. Furthermore, macrophage reduction yielded significantly lower cecum histopathological scores and CD4 expression than those of the infected control group. The expression of interleukin (IL)-18, IL-22, interferon-γ, and inducible nitric oxide synthase was also noted to be significantly upregulated in both infected control and macrophage-depleted chicks compared to uninfected chicks. IL-4, IL-13, IL-17, and perforin expressions were also higher with macrophage depletion than in both control groups. These results suggest that macrophages serve as an invasive gate or a transporting vehicle to the site of first merogony. Furthermore, mononuclear phagocytes may play an important role in local immune responses, thus contributing to parasite development during early E. tenella infection.
    Mesh-Begriff(e) Animals ; Carrageenan ; Cecum ; Chickens ; Coccidiosis/veterinary ; Eimeria tenella ; Macrophages ; Oocysts ; Poultry Diseases/parasitology
    Chemische Substanzen Carrageenan (9000-07-1)
    Sprache Englisch
    Erscheinungsdatum 2021-07-06
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 840961-4
    ISSN 1532-2661 ; 0034-5288
    ISSN (online) 1532-2661
    ISSN 0034-5288
    DOI 10.1016/j.rvsc.2021.07.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Reduction of macrophages by carrageenan decreases oocyst output and modifies local immune reaction in chick cecum with Eimeria tenella

    Ho, Dung Thi / Pham, Hung Hoang Son / Aota, Wataru / Matsubayashi, Makoto / Tsuji, Naotoshi / Hatabu, Toshimitsu

    Research in veterinary science. 2021 Oct., v. 139

    2021  

    Abstract: This study aimed to evaluate the disease severity and local immune responses in macrophage-depleted chicks with Eimeria tenella. Macrophages were reduced by intraperitoneal injection of a carrageenan solution at 12, 13, and 16 days old, whereas the ... ...

    Abstract This study aimed to evaluate the disease severity and local immune responses in macrophage-depleted chicks with Eimeria tenella. Macrophages were reduced by intraperitoneal injection of a carrageenan solution at 12, 13, and 16 days old, whereas the control group received intraperitoneal phosphate-buffered saline. Both chick groups were orally inoculated with E. tenella sporulated oocysts at 14 days old. Feces were collected daily, which were then quantified for oocysts. The chicks were sacrificed on day 5, and the ceca were collected for histopathological observation. The gene expression levels were measured using real-time quantitative reverse transcription-polymerase chain reaction. Macrophage-depleted chicks have been observed to shed a significantly reduced number of fecal oocysts compared to the infected control group. The parasite burden score in cecum specimens of macrophage-depleted chicks was significantly lower than those of infected control on day 5 after infection. Furthermore, macrophage reduction yielded significantly lower cecum histopathological scores and CD4 expression than those of the infected control group. The expression of interleukin (IL)-18, IL-22, interferon-γ, and inducible nitric oxide synthase was also noted to be significantly upregulated in both infected control and macrophage-depleted chicks compared to uninfected chicks. IL-4, IL-13, IL-17, and perforin expressions were also higher with macrophage depletion than in both control groups. These results suggest that macrophages serve as an invasive gate or a transporting vehicle to the site of first merogony. Furthermore, mononuclear phagocytes may play an important role in local immune responses, thus contributing to parasite development during early E. tenella infection.
    Schlagwörter Eimeria tenella ; carrageenan ; cecum ; chicks ; disease severity ; feces ; gene expression ; histopathology ; immune response ; inducible nitric oxide synthase ; interleukin-13 ; interleukin-17 ; interleukin-4 ; intraperitoneal injection ; macrophages ; oocysts ; parasites ; research ; reverse transcriptase polymerase chain reaction ; veterinary medicine
    Sprache Englisch
    Erscheinungsverlauf 2021-10
    Umfang p. 59-66.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 840961-4
    ISSN 1532-2661 ; 0034-5288
    ISSN (online) 1532-2661
    ISSN 0034-5288
    DOI 10.1016/j.rvsc.2021.07.003
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Bonn

    Z 2292: Hefte anzeigen

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