Article: Longitudinal Trends in HIV-1 Subtypes and Drug Resistance in Children from Argentina over a 15-Year Period (2006-2021).
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion
2024 Volume 76, Issue 1, Page(s) 29–36
Abstract: Background: Human immunodeficiency virus (HIV) drug resistance is a major cause of treatment failure in children and adolescents infected with the virus.: Objectives: The objectives of the study are to investigate HIV drug resistance (HIVDR) in ... ...
Abstract | Background: Human immunodeficiency virus (HIV) drug resistance is a major cause of treatment failure in children and adolescents infected with the virus. Objectives: The objectives of the study are to investigate HIV drug resistance (HIVDR) in patients who attended a referral care center in Argentina over a 15-year period and to compare mutational patterns between HIV-1 polsequences characterized as B or BF recombinants. Methods: Individual resistance-associated mutations (RAMs) (to protease and reverse transcriptase inhibitors) were identified according to IAS-USA guidelines in 374 HIV-1-infected children and adolescents. HIV-1 subtype was characterized by phylogenetic and recombination analysis using MEGA5.1 and Simplot. Poisson linear regression was used to model the dynamics of the RAMs over time. Results: The prevalence of RAMs to protease inhibitors (R2 = 0.52, p = 0.0012) and nucleoside reverse transcriptase inhibitors (R2 = 0.30, p = 0.0225) decreased over time. HIVDR to non-nucleoside reverse transcriptase inhibitors remained moderate to high, ranging between 33% and 76%. BF recombinants showed a higher frequency of thymidine analog mutation 1 RAMs profile and I54V mutation. Conclusion: In Argentina, HIVDR observed in children and adolescents has decreased over the past 15 years, regardless of the viral subtype. (REV INVEST CLIN. 2024;76(1):29-36). |
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MeSH term(s) | Adolescent ; Child ; Humans ; Argentina/epidemiology ; HIV-1/genetics ; Phylogeny ; Reverse Transcriptase Inhibitors/pharmacology ; Reverse Transcriptase Inhibitors/therapeutic use ; HIV Infections/drug therapy ; HIV Infections/epidemiology |
Chemical Substances | Reverse Transcriptase Inhibitors |
Language | English |
Publishing date | 2024-03-04 |
Publishing country | Mexico |
Document type | Journal Article |
ZDB-ID | 138348-6 |
ISSN | 0034-8376 |
ISSN | 0034-8376 |
DOI | 10.24875/RIC.23000210 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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