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  1. Artikel ; Online: Bespoke nanostars: synthetic strategies, tactics, and uses of tailored branched gold nanoparticles.

    Siegel, Asher L / Baker, Gary A

    Nanoscale advances

    2021  Band 3, Heft 14, Seite(n) 3980–4004

    Abstract: Interest in branched colloidal gold nanosystems has gained increased traction due to the structures' outstanding optical and plasmonic properties, resulting in utilization in techniques such as surface-enhanced spectroscopy and bioimaging, as well as ... ...

    Abstract Interest in branched colloidal gold nanosystems has gained increased traction due to the structures' outstanding optical and plasmonic properties, resulting in utilization in techniques such as surface-enhanced spectroscopy and bioimaging, as well as plasmon photocatalysis and photothermal therapy. The unique morphologies of nanostars, multipods, urchins, and other highly branched nanomaterials exhibit selective optical and crystallographic features accessible by alterations in the respective wet-chemical syntheses, opening a vast array of useful applications. Examination of discriminatory reaction conditions, such as seeded growth (
    Sprache Englisch
    Erscheinungsdatum 2021-04-21
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ISSN 2516-0230
    ISSN (online) 2516-0230
    DOI 10.1039/d0na01057j
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Plasmon-controlled shaping of gold nanostar photothermal therapy agents.

    Siegel, Asher L / Polo-Parada, Luis / Baker, Gary A

    Chemical communications (Cambridge, England)

    2022  Band 58, Heft 94, Seite(n) 13119–13122

    Abstract: Tunable gold nanostars were synthesized through the reduction of gold salt by an aminosugar, ...

    Abstract Tunable gold nanostars were synthesized through the reduction of gold salt by an aminosugar,
    Mesh-Begriff(e) Metal Nanoparticles/therapeutic use ; Photothermal Therapy ; Gold/pharmacology ; Phototherapy
    Chemische Substanzen Gold (7440-57-5)
    Sprache Englisch
    Erscheinungsdatum 2022-11-24
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc04812d
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Platelet Electron Microscopy: Utilizing LEAN Methodology to Optimize Laboratory Workflow.

    Asher, Lucas / Hata, Jessica

    Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society

    2020  Band 23, Heft 5, Seite(n) 356–361

    Abstract: Background: Platelet electron microscopy (PEM) is the gold standard methodology for diagnosing storage pool disorder, defined as a paucity of delta granules, alpha granules, or both. PEM literature is limited with few published resources and without ... ...

    Abstract Background: Platelet electron microscopy (PEM) is the gold standard methodology for diagnosing storage pool disorder, defined as a paucity of delta granules, alpha granules, or both. PEM literature is limited with few published resources and without well-developed interlaboratory standardization for the preparation and examination of platelet samples.
    Methods: Whole mount (WM) dense body (DB) counts for 300 pediatric cases were reviewed to determine whether counting fewer platelets could yield the same results. For 6 cases, DB average was determined on the day of WM preparation and on 2 consecutive days. Both WM and thin section (TS) preparations were examined for all cases.
    Results: Employing LEAN methodology, an algorithm was developed to markedly decrease the number of platelets counted and still ensure accurate results. WMs decay with time; a statistically significant difference in DB counts was noted between day 0 and day 1 (
    Conclusion: It is possible to maintain accuracy and decrease 100 platelet DB counts by >75%. WMs must be counted on the day they are prepared to avoid false paucity of DB secondary to sample decay. An accurate evaluation of platelet morphology requires both the WM and TS techniques.
    Mesh-Begriff(e) Adolescent ; Algorithms ; Blood Platelets/pathology ; Child ; Child, Preschool ; Clinical Laboratory Services ; Efficiency ; Humans ; Infant ; Microscopy, Electron/methods ; Platelet Count/methods ; Platelet Storage Pool Deficiency/diagnostic imaging ; Platelet Storage Pool Deficiency/pathology ; Specimen Handling/methods ; Workflow ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2020-05-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1463498-3
    ISSN 1615-5742 ; 1093-5266
    ISSN (online) 1615-5742
    ISSN 1093-5266
    DOI 10.1177/1093526620915361
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: The effect of piling behavior on the production and mortality of free-range laying hens.

    Armstrong, David / Asher, Lucy / Rayner, Ann / Ngidda, Halima / Sharma, Bryony / Gray, Helen

    Poultry science

    2023  Band 102, Heft 10, Seite(n) 102989

    Abstract: Piling, a dense cluster of hens, is a behavior of major concern to the cage-free egg industry. It can cause large numbers of mortalities at which point it is considered smothering. The aim of this study was to quantify whether piling can also have ... ...

    Abstract Piling, a dense cluster of hens, is a behavior of major concern to the cage-free egg industry. It can cause large numbers of mortalities at which point it is considered smothering. The aim of this study was to quantify whether piling can also have consequences on production and non-smothering mortalities, which have not previously been described. Additionally, we aimed to describe characteristics of piling behavior relevant to for management. Video footage from 12 flocks of laying hens was analyzed for piling behavior across 3 wks. Production and mortality data were accessed using an integrated online management system. Bayesian linear mixed-effect models were used for formal statistical testing of the relationships between piling and production. Accounting for some missing data, a total of 252 d amounting to approximately 15,624 h were analyzed for the presence or absence of piling behavior, which we believe constitutes the largest analysis of piling behavior in the scientific literature to date. All flocks observed exhibited piling behavior even if they had no history of smothering. On average, flocks piled more than 4 times per day for around 44 min per event and the peak piling time occurred between 1300 and 1359. We found that the number of piling events was associated with a reduction in the number of eggs produced the next day; based on the average of 4 piles per day this amounted to 7.35 fewer eggs per 1,000 birds per day. Contrary to our hypothesis, we found total piling duration per day was positively associated with fewer Grade B eggs, with a decrease of 0.74 Grade B eggs for every hour of piling per day. No relationship was observed between piling and mortality not attributed to smothering. We discuss possible causes and explanations for these results including birds' response to stress, crowd dynamics, and daily rhythms. Here we show the potential for piling behavior to have sublethal consequences on production even in the absence of smothering-related deaths.
    Mesh-Begriff(e) Animals ; Female ; Chickens/physiology ; Bayes Theorem ; Housing, Animal ; Ovum ; Crowding ; Animal Husbandry/methods
    Sprache Englisch
    Erscheinungsdatum 2023-08-05
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 242586-5
    ISSN 1525-3171 ; 0032-5791
    ISSN (online) 1525-3171
    ISSN 0032-5791
    DOI 10.1016/j.psj.2023.102989
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Community-based rehabilitation intervention for people with schizophrenia in Ethiopia (RISE): results of a 12-month cluster-randomised controlled trial.

    Asher, Laura / Birhane, Rahel / Weiss, Helen A / Medhin, Girmay / Selamu, Medhin / Patel, Vikram / De Silva, Mary / Hanlon, Charlotte / Fekadu, Abebaw

    The Lancet. Global health

    2024  Band 10, Heft 4, Seite(n) e530–e542

    Abstract: Background: Community-based rehabilitation (CBR) is recommended to address the social and clinical needs of people with schizophrenia in resource-poor settings. We evaluated the effectiveness of CBR at reducing disability at 12 months in people with ... ...

    Abstract Background: Community-based rehabilitation (CBR) is recommended to address the social and clinical needs of people with schizophrenia in resource-poor settings. We evaluated the effectiveness of CBR at reducing disability at 12 months in people with schizophrenia who had disabling illness after having had the opportunity to access facility-based care for 6 months METHODS: This cluster-randomised controlled trial was conducted in a rural district of Ethiopia. Eligible clusters were subdistricts in Sodo district that had not participated in the pilot study. Available subdistricts were randomised (in a 1:1 ratio) to either the intervention group (CBR plus facility-based care) or to the control group (facility-based care alone). An optimisation procedure (accounting for the subdistrict mean WHO Disability Assessment Schedule (WHODAS) score and the potential number of participants per subdistrict) was applied for each of the eight health facilities in the district. An independent statistician, masked to the intervention or control label, used a computer programme to randomly choose the allocation sequence from the set of optimal ones. We recruited adults with disabling illness as a result of schizophrenia. The subdistricts were eligible for inclusion if they included participants that met the eligibility criteria. Researchers recruiting and assessing participants were masked to allocation status. Facility-based care was a task-shared model of mental health care integrated within primary care. CBR was delivered by lay workers over a 12-month period, comprising of home visits (psychoeducation, adherence support, family intervention, and crisis management) and community mobilisation. The primary outcome was disability, measured with the proxy-rated 36-item WHODAS score at 12 months. The subdistricts that had primary outcome data available were included in the primary analysis. This study is registered with ClinicalTrials.gov, NCT02160249.
    Findings: Enrolment took place between Sept 16, 2015 and Mar 11, 2016. 54 subdistricts were randomised (27 to the CBR plus facility-based care group and 27 to the facility-based care group). After exclusion of subdistricts without eligible participants, we enrolled 79 participants (66% men and 34% women) from 24 subdistricts assigned to CBR plus facility-based care and 87 participants (59% men and 41% women) from 24 subdistricts assigned to facility-based care only. The primary analysis included 149 (90%) participants in 46 subdistricts (73 participants in 22 subdistricts in the CBR plus facility-based care group and 76 participants in 24 subdistricts in the facility-based care group). At 12 months, the mean WHODAS scores were 46·1 (SD 23·3) in the facility-based care group and 40·6 (22·5) in the CBR plus facility-based care group, indicating a favourable intervention effect (adjusted mean difference -8·13 [95% CI -15·85 to -0·40]; p=0·039; effect size 0·35). Four (5%) CBR plus facility-based care group participants and nine (10%) facility-based care group participants had one or more serious adverse events (death, suicide attempt, and hospitalisation).
    Interpretation: CBR delivered by lay workers combined with task-shared facility-based care, was effective in reducing disability among people with schizophrenia. The RISE study CBR model is particularly relevant to low-income countries with few mental health specialists.
    Funding: Wellcome Trust.
    Mesh-Begriff(e) Adult ; Disabled Persons ; Ethiopia ; Female ; Humans ; Male ; Mental Health ; Pilot Projects ; Schizophrenia/rehabilitation
    Sprache Englisch
    Erscheinungsdatum 2024-02-06
    Erscheinungsland England
    Dokumenttyp Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(22)00027-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: "Medical treatments are also part of God's gift": Holy water attendants' perspectives on a collaboration between spiritual and psychiatric treatment for mental illness in Ethiopia.

    Asher, Laura / Birhanu, Ribka / Baheretibeb, Yonas / Fekadu, Abebaw

    Transcultural psychiatry

    2021  Band 58, Heft 4, Seite(n) 585–599

    Abstract: In Ethiopia, traditional and spiritual treatments, such as holy water, are used by people with mental disorders instead of, or alongside, psychiatric services. Collaborations between traditional and psychiatric providers may increase access to evidence- ... ...

    Abstract In Ethiopia, traditional and spiritual treatments, such as holy water, are used by people with mental disorders instead of, or alongside, psychiatric services. Collaborations between traditional and psychiatric providers may increase access to evidence-based treatments and address human rights abuses. This study aimed to explore the perspectives of holy water attendants on a novel collaboration between holy water and psychiatric care, at St Mary's Clinic, Entoto, Ethiopia, and to characterize the users of this service. Semi-structured interviews were conducted with 14 holy water attendants, who run group houses for holy water residents and are paid by family members. A thematic analysis was conducted. Socio-demographic and clinical data were extracted from the records of all service users who had attended the clinic. A total of 174 individuals have attended the clinic in the three years since it opened. The majority were diagnosed with schizophrenia. Holy water attendants provide a partial gatekeeping role to psychiatric care, selecting which of their clients they think will benefit and, for these individuals, facilitating attendance to the clinic and antipsychotic medication adherence. Psychiatric care was felt to be compatible with holy water by some, but not all, attendants. However, family members often had the "final say" in individuals attending the clinic, in some cases putting up strong resistance to using psychiatric care. A novel collaboration is acceptable to some holy water attendants and may increase access to psychiatric care amongst people with mental illness living at a holy water site in Ethiopia.
    Mesh-Begriff(e) Ethiopia ; Humans ; Mental Disorders/therapy ; Psychotherapy ; Schizophrenia ; Water
    Chemische Substanzen Water (059QF0KO0R)
    Sprache Englisch
    Erscheinungsdatum 2021-05-25
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1378978-8
    ISSN 1461-7471 ; 1363-4615
    ISSN (online) 1461-7471
    ISSN 1363-4615
    DOI 10.1177/13634615211015082
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: COVID-19 experience of people with severe mental health conditions and families in South Africa.

    Brooke-Sumner, Carrie / Rapiya, Bongwekazi / Myers, Bronwyn / Petersen, Inge / Hanlon, Charlotte / Repper, Julie / Asher, Laura

    The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa

    2024  Band 30, Seite(n) 2207

    Abstract: Background: People with severe mental health conditions, such as schizophrenia, and their family caregivers are underserved in low- and middle-income countries where structured psychosocial support in the community is often lacking. This can present ... ...

    Abstract Background: People with severe mental health conditions, such as schizophrenia, and their family caregivers are underserved in low- and middle-income countries where structured psychosocial support in the community is often lacking. This can present challenges to recovery and for coping with additional strains, such as a pandemic.
    Aim: This study explored the experiences and coping strategies of people with lived experience of a severe mental health condition, and family caregivers, in South Africa during the initial stages of the coronavirus disease 2019 (COVID-19) pandemic.
    Setting: This qualitative study was conducted in the Nelson Mandela Bay District, Eastern Cape, South Africa, in the most restrictive period of the COVID-19 lockdown.
    Methods: Telephonic qualitative interviews were conducted with people with lived experience (
    Results: Participants described negative impacts including increased material hardship, intensified social isolation and heightened anxiety, particularly among caregivers who had multiple caregiving responsibilities. Coping strategies included finding ways to not only get support from others but also give support, engaging in productive activities and taking care of physical health. The main limitation was inclusion only of people with access to a telephone.
    Conclusion: Support needs for people with severe mental health conditions and their families should include opportunities for social interaction and sharing coping strategies as well as bolstering financial security.
    Contribution: These findings indicate that current support for this vulnerable group is inadequate, and resource allocation for implementation of additional community-based, recovery-focused services for families must be prioritised.
    Sprache Englisch
    Erscheinungsdatum 2024-04-09
    Erscheinungsland South Africa
    Dokumenttyp Journal Article
    ISSN 1608-9685
    ISSN 1608-9685
    DOI 10.4102/sajpsychiatry.v30i0.2207
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Racial Disparities in Diagnosis and Treatment of Depression Associated with Androgen Deprivation Therapy for Prostate Cancer.

    Mandel, Asher L / Simhal, Rishabh K / Shah, Yash B / Wang, Kerith R / Lallas, Costas D / Shah, Mihir S

    Urology

    2024  Band 186, Seite(n) 75–80

    Abstract: Objective: To analyze potential racial disparities in the diagnosis and management of depression associated with androgen deprivation therapy.: Methods: TriNetX health record network was queried for prostate cancer patients treated with androgen ... ...

    Abstract Objective: To analyze potential racial disparities in the diagnosis and management of depression associated with androgen deprivation therapy.
    Methods: TriNetX health record network was queried for prostate cancer patients treated with androgen deprivation therapy from 2003-2023. Differences in rates of depression diagnosis and treatment were compared between White and Black patients. Means, odds ratios, and t tests were calculated in univariate analysis with 95% confidence intervals (CI).
    Results: Data were queried from 93 health care organizations to yield 78,313 prostate cancer patients treated with androgen deprivation therapy. Patients on androgen deprivation therapy had 60% greater odds of developing depression vs other patients [9% vs 6%; odds ratio (OR) 1.6; 95% CI (1.5-1.7); P <.0001]. Of those with depression secondary to androgen deprivation therapy, only 35% were treated with antidepressants. After starting androgen deprivation therapy, White patients had 30% greater odds of being diagnosed with depression, compared to Black patients [10% vs 8%; OR 1.3; 95% CI (1.2-1.4); P <.001]. White patients also had higher odds of being treated with a first line antidepressant than Black patients [56% vs 48%; OR 1.4, 95% CI (1.2-1.6), P <.001].
    Conclusion: This analysis confirms a significant association between androgen deprivation therapy and the development of clinical depression, and highlights its medical undertreatment. Importantly, our findings also indicate significant racial disparities in the identification and treatment of depression. Routine screening initiatives that account for social determinants of health may alleviate this disparity. Limitations of this study include retrospective design and lack of data describing severity of depression, which might correlate with need for medication.
    Mesh-Begriff(e) Male ; Humans ; Prostatic Neoplasms/drug therapy ; Retrospective Studies ; Androgen Antagonists/adverse effects ; Androgens/therapeutic use ; Depression/diagnosis
    Chemische Substanzen Androgen Antagonists ; Androgens
    Sprache Englisch
    Erscheinungsdatum 2024-02-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2024.01.021
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: A little could go a long way: financing for mental healthcare in low- and middle-income countries.

    Asher, L / De Silva, M J

    Epidemiology and psychiatric sciences

    2017  Band 26, Heft 3, Seite(n) 248–251

    Mesh-Begriff(e) Developing Countries ; Health Policy ; Health Services Accessibility/economics ; Health Services Research ; Humans ; Insurance Coverage/organization & administration ; Insurance, Health ; Mental Health ; Mental Health Services/economics
    Sprache Englisch
    Erscheinungsdatum 2017-01-09
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2607964-1
    ISSN 2045-7979 ; 2045-7960
    ISSN (online) 2045-7979
    ISSN 2045-7960
    DOI 10.1017/S2045796016001116
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  10. Artikel ; Online: A step in the right direction: an open-design pedometer algorithm for dogs.

    Ladha, C / Belshaw, Z / O'Sullivan, J / Asher, L

    BMC veterinary research

    2018  Band 14, Heft 1, Seite(n) 107

    Abstract: Background: Accelerometer-based technologies could be useful in providing objective measures of canine ambulation, but most are either not tailored to the idiosyncrasies of canine gait, or, use un-validated or closed source approaches. The aim of this ... ...

    Abstract Background: Accelerometer-based technologies could be useful in providing objective measures of canine ambulation, but most are either not tailored to the idiosyncrasies of canine gait, or, use un-validated or closed source approaches. The aim of this paper was to validate algorithms which could be applied to accelerometer data for i) counting the number of steps and ii) distance travelled by a dog. To count steps, an approach based on partitioning acceleration was used. This was applied to accelerometer data from 13 dogs which were walked a set distance and filmed. Each footfall captured on video was annotated. In a second experiment, an approach based on signal features was used to estimate distance travelled. This was applied to accelerometer data from 10 dogs with osteoarthritis during normal walks with their owners where GPS (Global Positioning System) was also captured. Pearson's correlations and Bland Altman statistics were used to compare i) the number of steps measured on video footage and predicted by the algorithm and ii) the distance travelled estimated by GPS and predicted by the algorithm.
    Results: Both step count and distance travelled could be estimated accurately by the algorithms presented in this paper: 4695 steps were annotated from the video and the pedometer was able to detect 91%. GPS logged a total of 20,184 m meters across all dogs; the mean difference between the predicted and GPS estimated walk length was 211 m and the mean similarity was 79%.
    Conclusions: The algorithms described show promise in detecting number of steps and distance travelled from an accelerometer. The approach for detecting steps might be advantageous to methods which estimate gross activity because these include energy output from stationary activities. The approach for estimating distance might be suited to replacing GPS in indoor environments or others with limited satellite signal. The algorithms also allow for temporal and spatial components of ambulation to be calculated. Temporal and spatial aspects of dog ambulation are clinical indicators which could be used for diagnosis or monitoring of certain diseases, or used to provide information in support of canine weight-loss programmes.
    Mesh-Begriff(e) Accelerometry/instrumentation ; Accelerometry/methods ; Accelerometry/veterinary ; Algorithms ; Animals ; Dogs/physiology ; Female ; Male ; Walking/physiology ; Walking/statistics & numerical data
    Sprache Englisch
    Erscheinungsdatum 2018-03-20
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2191675-5
    ISSN 1746-6148 ; 1746-6148
    ISSN (online) 1746-6148
    ISSN 1746-6148
    DOI 10.1186/s12917-018-1422-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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