Article ; Online: Vitamin D as a Principal Factor in Mediating Rheumatoid Arthritis-Derived Immune Response.
2019 Volume 2019, Page(s) 3494937
Abstract: Rheumatoid arthritis (RA) is a systemic multifactorial autoimmune disorder. The interactions between diverse environmental and genetic factors lead to the onset of this complex autoimmune disorder. Serum levels of vitamin D (VD) are involved in the ... ...
| Abstract | Rheumatoid arthritis (RA) is a systemic multifactorial autoimmune disorder. The interactions between diverse environmental and genetic factors lead to the onset of this complex autoimmune disorder. Serum levels of vitamin D (VD) are involved in the regulation of various immune responses. Vitamin D is a key signaling molecule in the human body that maintains calcium as well as phosphate homeostasis. It also regulates the functions of the immune system and, thus, can play a substantial role in the etiology of various autoimmune disorders, including RA. Low serum VD levels have been found to be associated with a higher risk of RA, although this finding has not been replicated consistently. The molecular mechanisms by which VD influences autoimmunity need to be further explored to understand how variation in plasma VD levels could affect the pathogenesis of RA. This mini-review focuses on the influence of VD and its serum levels on RA susceptibility, RA-associated complexities, treatment, and transcriptome products of key proinflammatory cytokines, along with other cytokines that are key regulators of inflammation in rheumatoid joints. |
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| MeSH term(s) | Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/metabolism ; Arthritis, Rheumatoid/pathology ; Calcium/immunology ; Calcium/metabolism ; Cytokines/immunology ; Cytokines/metabolism ; Humans ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/pathology ; Signal Transduction/immunology ; Vitamin D/immunology ; Vitamin D/metabolism |
| Chemical Substances | Cytokines ; Vitamin D (1406-16-2) ; Calcium (SY7Q814VUP) |
| Language | English |
| Publishing date | 2019-05-07 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ZDB-ID | 2698540-8 |
| ISSN | 2314-6141 ; 2314-6133 |
| ISSN (online) | 2314-6141 |
| ISSN | 2314-6133 |
| DOI | 10.1155/2019/3494937 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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