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  1. Artikel: Effects of Phone-Based Psychological Intervention on Caregivers of Patients with Early-Onset Alzheimer's Disease: A Six-Months Study during the COVID-19 Emergency in Italy.

    De Stefano, Manuela / Esposito, Sabrina / Iavarone, Alessandro / Carpinelli Mazzi, Michele / Siciliano, Mattia / Buonanno, Daniela / Atripaldi, Danilo / Trojsi, Francesca / Tedeschi, Gioacchino

    Brain sciences

    2022  Band 12, Heft 3

    Abstract: Caregivers of patients with early-onset Alzheimer's disease (EOAD) experience higher level of burden, stress, and depression, due to premature role changes and social isolation. Moreover, the SARS-CoV-2 pandemic compelled restrictions regarding social ... ...

    Abstract Caregivers of patients with early-onset Alzheimer's disease (EOAD) experience higher level of burden, stress, and depression, due to premature role changes and social isolation. Moreover, the SARS-CoV-2 pandemic compelled restrictions regarding social interactions and mobility in Italy from March 2020, prompting telemedicine approaches for supporting patients and their families confined at home. We reported our experience regarding the effects of psychological phone-intervention (phone-I) on EOAD caregivers during pandemic. Twenty caregivers of EOAD patients were randomly assigned to treatment (TG) or control (CG) group. TG weekly underwent a phone-I for one month. All participants were assessed for caregiver burden and needs, anxiety and depression levels, and subjective impact of traumatic events at baseline (T0), at the fifth week (T1) and after 6 months (T2) from phone-I. We observed higher vulnerability to post-traumatic stress in TG compared to CG in all timepoints (
    Sprache Englisch
    Erscheinungsdatum 2022-02-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci12030310
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Non-invasive brain stimulation in generalized anxiety disorder: A systematic review.

    Sagliano, Laura / Atripaldi, Danilo / De Vita, Dalila / D'Olimpio, Francesca / Trojano, Luigi

    Progress in neuro-psychopharmacology & biological psychiatry

    2019  Band 93, Seite(n) 31–38

    Abstract: In the last years, several studies using non-invasive brain stimulation (NIBS) techniques demonstrated that the dorsolateral prefrontal cortex (DLPFC) plays a key role in the neurobiological bases of anxiety disorders. Both transcranial magnetic ... ...

    Abstract In the last years, several studies using non-invasive brain stimulation (NIBS) techniques demonstrated that the dorsolateral prefrontal cortex (DLPFC) plays a key role in the neurobiological bases of anxiety disorders. Both transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) applied primarily over the prefrontal cortex have been shown to modulate anxiety symptomatology and attention allocation in the generalized anxiety disorder. A literature search on PubMed and PsycINFO databases following PRISMA guidelines identified 4 TMS studies (one open-label study and three randomized trials with active/sham conditions) and one tDCS case report study that have applied NIBS in patients with GAD. All the studies targeted the DLPFC except one in which the parietal cortex has been stimulated. Overall, the findings would suggest that NIBS could ameliorate anxiety symptoms and that improvements remained stable in the follow-up. Although a limited number of NIBS studies has been conducted on patients with anxiety disorders, these techniques could represent promising tools for the study of neurofunctional basis of anxiety disorders. Further sham-controlled studies are needed to clarify the mechanisms of action of NIBS in order to optimize stimulation protocols and to verify their effectiveness for treating anxiety symptoms.
    Mesh-Begriff(e) Anxiety Disorders/physiopathology ; Anxiety Disorders/therapy ; Brain/physiopathology ; Humans ; Transcranial Direct Current Stimulation/methods ; Transcranial Magnetic Stimulation/methods ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2019-03-12
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 781181-0
    ISSN 1878-4216 ; 0278-5846
    ISSN (online) 1878-4216
    ISSN 0278-5846
    DOI 10.1016/j.pnpbp.2019.03.002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Long-Term Neuromodulatory Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Plasmatic Matrix Metalloproteinases (MMPs) Levels and Visuospatial Abilities in Mild Cognitive Impairment (MCI).

    Cirillo, Giovanni / Pepe, Roberta / Siciliano, Mattia / Ippolito, Domenico / Ricciardi, Dario / de Stefano, Manuela / Buonanno, Daniela / Atripaldi, Danilo / Abbadessa, Salvatore / Perfetto, Brunella / Sharbafshaaer, Minoo / Sepe, Giovanna / Bonavita, Simona / Iavarone, Alessandro / Todisco, Vincenzo / Papa, Michele / Tedeschi, Gioacchino / Esposito, Sabrina / Trojsi, Francesca

    International journal of molecular sciences

    2023  Band 24, Heft 4

    Abstract: Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique that is used against cognitive impairment in mild cognitive impairment (MCI) and Alzheimer's disease (AD). However, the neurobiological mechanisms underlying ... ...

    Abstract Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique that is used against cognitive impairment in mild cognitive impairment (MCI) and Alzheimer's disease (AD). However, the neurobiological mechanisms underlying the rTMS therapeutic effects are still only partially investigated. Maladaptive plasticity, glial activation, and neuroinflammation, including metalloproteases (MMPs) activation, might represent new potential targets of the neurodegenerative process and progression from MCI to AD. In this study, we aimed to evaluate the effects of bilateral rTMS over the dorsolateral prefrontal cortex (DLPFC) on plasmatic levels of MMP1, -2, -9, and -10; MMPs-related tissue inhibitors TIMP1 and TIMP2; and cognitive performances in MCI patients. Patients received high-frequency (10 Hz) rTMS (MCI-TMS,
    Mesh-Begriff(e) Humans ; Transcranial Magnetic Stimulation/methods ; Matrix Metalloproteinase 1 ; Cognitive Dysfunction/psychology ; Alzheimer Disease/therapy ; Matrix Metalloproteinases ; Prefrontal Cortex
    Chemische Substanzen Matrix Metalloproteinase 1 (EC 3.4.24.7) ; Matrix Metalloproteinases (EC 3.4.24.-)
    Sprache Englisch
    Erscheinungsdatum 2023-02-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24043231
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Repetitive Transcranial Magnetic Stimulation (rTMS) of Dorsolateral Prefrontal Cortex May Influence Semantic Fluency and Functional Connectivity in Fronto-Parietal Network in Mild Cognitive Impairment (MCI).

    Esposito, Sabrina / Trojsi, Francesca / Cirillo, Giovanni / de Stefano, Manuela / Di Nardo, Federica / Siciliano, Mattia / Caiazzo, Giuseppina / Ippolito, Domenico / Ricciardi, Dario / Buonanno, Daniela / Atripaldi, Danilo / Pepe, Roberta / D'Alvano, Giulia / Mangione, Antonella / Bonavita, Simona / Santangelo, Gabriella / Iavarone, Alessandro / Cirillo, Mario / Esposito, Fabrizio /
    Sorbi, Sandro / Tedeschi, Gioacchino

    Biomedicines

    2022  Band 10, Heft 5

    Abstract: Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neuromodulation technique that is increasingly used as a nonpharmacological intervention against cognitive impairment in Alzheimer's disease (AD) and other dementias. Although rTMS has ... ...

    Abstract Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neuromodulation technique that is increasingly used as a nonpharmacological intervention against cognitive impairment in Alzheimer's disease (AD) and other dementias. Although rTMS has been shown to modify cognitive performances and brain functional connectivity (FC) in many neurological and psychiatric diseases, there is still no evidence about the possible relationship between executive performances and resting-state brain FC following rTMS in patients with mild cognitive impairment (MCI). In this preliminary study, we aimed to evaluate the possible effects of rTMS of the bilateral dorsolateral prefrontal cortex (DLPFC) in 27 MCI patients randomly assigned to two groups: one group received high-frequency (10 Hz) rTMS (HF-rTMS) for four weeks (
    Sprache Englisch
    Erscheinungsdatum 2022-04-25
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10050994
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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