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  1. Artikel ; Online: Chondroid Syringoma of the Foot: A Rare Diagnosis.

    Madi, Khaled / Attanasio, Alicia / Cecunjanin, Fejzo / Garcia, Roberto A / Vidershayn, Alexander / Lucido, Jeffrey V

    The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons

    2016  Band 55, Heft 2, Seite(n) 373–378

    Abstract: Chondroid syringoma is a rare tumor with the potential for malignant transformation and distant metastasis. The site of predilection for benign chondroid syringoma is the head and neck region, and it is less likely to involve the foot. In contrast, ... ...

    Abstract Chondroid syringoma is a rare tumor with the potential for malignant transformation and distant metastasis. The site of predilection for benign chondroid syringoma is the head and neck region, and it is less likely to involve the foot. In contrast, malignant chondroid syringoma is more commonly encountered in the extremities and is characterized by rapid growth, local invasion, and distant metastasis. We report an unusual case of benign chondroid syringoma in a 47-year-old female who presented with a 20-year history of a mass in her left foot to bring such cases to the attention of foot and ankle specialists. We highlight the histologic diagnosis and surgical procedures with a 6-month postoperative follow-up period. It is unlikely that a treating physician would anticipate this histologic tumor type, considering the rarity of the condition, the long history of this patient's lesion, and the benign presentation in the extremities.
    Mesh-Begriff(e) Adenoma, Pleomorphic/diagnosis ; Adenoma, Pleomorphic/surgery ; Female ; Humans ; Middle Aged ; Sweat Gland Neoplasms/diagnosis ; Sweat Gland Neoplasms/surgery
    Sprache Englisch
    Erscheinungsdatum 2016-03
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 1146972-9
    ISSN 1542-2224 ; 1067-2516
    ISSN (online) 1542-2224
    ISSN 1067-2516
    DOI 10.1053/j.jfas.2014.12.032
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Marked changes in endogenous antioxidant expression precede vitamin A-, C-, and E-protectable, radiation-induced reductions in small intestinal nutrient transport

    Roche, Marjolaine / Kemp, Francis W / Agrawal, Amit / Attanasio, Alicia / Neti, Prasad V.S.V / Howell, Roger W / Ferraris, Ronaldo P

    Free radical biology & medicine. 2011 Jan. 1, v. 50, no. 1

    2011  

    Abstract: Rapidly proliferating epithelial crypt cells of the small intestine are susceptible to radiation-induced oxidative stress, yet there is a dearth of data linking this stress to expression of antioxidant enzymes and to alterations in intestinal nutrient ... ...

    Abstract Rapidly proliferating epithelial crypt cells of the small intestine are susceptible to radiation-induced oxidative stress, yet there is a dearth of data linking this stress to expression of antioxidant enzymes and to alterations in intestinal nutrient absorption. We previously showed that 5–14days after acute γ-irradiation, intestinal sugar absorption decreased without change in antioxidant enzyme expression. In the present study, we measured antioxidant mRNA and protein expression in mouse intestines taken at early times postirradiation. Observed changes in antioxidant expression are characterized by a rapid decrease within 1h postirradiation, followed by dramatic upregulation within 4h and then downregulation a few days later. The cell type and location expressing the greatest changes in levels of the oxidative stress marker 4HNE and of antioxidant enzymes are, respectively, epithelial cells responsible for nutrient absorption and the crypt region comprising mainly undifferentiated cells. Consumption of a cocktail of antioxidant vitamins A, C, and E, before irradiation, prevents reductions in transport of intestinal sugars, amino acids, bile acids, and peptides. Ingestion of antioxidants may blunt radiation-induced decreases in nutrient transport, perhaps by reducing acute oxidative stress in crypt cells, thereby allowing the small intestine to retain its absorptive function when those cells migrate to the villus days after the insult.
    Schlagwörter absorption ; amino acids ; antioxidants ; bile acids ; enzymes ; epithelial cells ; gamma radiation ; ingestion ; intestinal absorption ; irradiation ; messenger RNA ; mice ; nutrient transport ; oxidative stress ; peptides ; protein synthesis ; small intestine ; sugars ; villi ; vitamin A
    Sprache Englisch
    Erscheinungsverlauf 2011-0101
    Umfang p. 55-65.
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2010.10.689
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel ; Online: Marked changes in endogenous antioxidant expression precede vitamin A-, C-, and E-protectable, radiation-induced reductions in small intestinal nutrient transport.

    Roche, Marjolaine / Kemp, Francis W / Agrawal, Amit / Attanasio, Alicia / Neti, Prasad V S V / Howell, Roger W / Ferraris, Ronaldo P

    Free radical biology & medicine

    2010  Band 50, Heft 1, Seite(n) 55–65

    Abstract: Rapidly proliferating epithelial crypt cells of the small intestine are susceptible to radiation-induced oxidative stress, yet there is a dearth of data linking this stress to expression of antioxidant enzymes and to alterations in intestinal nutrient ... ...

    Abstract Rapidly proliferating epithelial crypt cells of the small intestine are susceptible to radiation-induced oxidative stress, yet there is a dearth of data linking this stress to expression of antioxidant enzymes and to alterations in intestinal nutrient absorption. We previously showed that 5-14 days after acute γ-irradiation, intestinal sugar absorption decreased without change in antioxidant enzyme expression. In the present study, we measured antioxidant mRNA and protein expression in mouse intestines taken at early times postirradiation. Observed changes in antioxidant expression are characterized by a rapid decrease within 1h postirradiation, followed by dramatic upregulation within 4h and then downregulation a few days later. The cell type and location expressing the greatest changes in levels of the oxidative stress marker 4HNE and of antioxidant enzymes are, respectively, epithelial cells responsible for nutrient absorption and the crypt region comprising mainly undifferentiated cells. Consumption of a cocktail of antioxidant vitamins A, C, and E, before irradiation, prevents reductions in transport of intestinal sugars, amino acids, bile acids, and peptides. Ingestion of antioxidants may blunt radiation-induced decreases in nutrient transport, perhaps by reducing acute oxidative stress in crypt cells, thereby allowing the small intestine to retain its absorptive function when those cells migrate to the villus days after the insult.
    Mesh-Begriff(e) Animals ; Antioxidants/metabolism ; Antioxidants/pharmacology ; Antioxidants/physiology ; Ascorbic Acid/pharmacology ; Biological Transport/drug effects ; Biological Transport/radiation effects ; Cytoprotection/drug effects ; Down-Regulation/radiation effects ; Eating/drug effects ; Eating/physiology ; Eating/radiation effects ; Food ; Intestinal Absorption/drug effects ; Intestinal Absorption/radiation effects ; Intestine, Small/drug effects ; Intestine, Small/metabolism ; Intestine, Small/pathology ; Intestine, Small/radiation effects ; Male ; Mice ; Models, Biological ; Radiation Injuries/metabolism ; Radiation Injuries/pathology ; Radiation Injuries/prevention & control ; Vitamin A/pharmacology ; Vitamin E/pharmacology
    Chemische Substanzen Antioxidants ; Vitamin A (11103-57-4) ; Vitamin E (1406-18-4) ; Ascorbic Acid (PQ6CK8PD0R)
    Sprache Englisch
    Erscheinungsdatum 2010-10-21
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2010.10.689
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Radiation-induced reductions in transporter mRNA levels parallel reductions in intestinal sugar transport.

    Roche, Marjolaine / Neti, Prasad V S V / Kemp, Francis W / Agrawal, Amit / Attanasio, Alicia / Douard, Véronique / Muduli, Anjali / Azzam, Edouard I / Norkus, Edward / Brimacombe, Michael / Howell, Roger W / Ferraris, Ronaldo P

    American journal of physiology. Regulatory, integrative and comparative physiology

    2009  Band 298, Heft 1, Seite(n) R173–82

    Abstract: More than a century ago, ionizing radiation was observed to damage the radiosensitive small intestine. Although a large number of studies has since shown that radiation reduces rates of intestinal digestion and absorption of nutrients, no study has ... ...

    Abstract More than a century ago, ionizing radiation was observed to damage the radiosensitive small intestine. Although a large number of studies has since shown that radiation reduces rates of intestinal digestion and absorption of nutrients, no study has determined whether radiation affects mRNA expression and dietary regulation of nutrient transporters. Since radiation generates free radicals and disrupts DNA replication, we tested the hypotheses that at doses known to reduce sugar absorption, radiation decreases the mRNA abundance of sugar transporters SGLT1 and GLUT5, prevents substrate regulation of sugar transporter expression, and causes reductions in sugar absorption that can be prevented by consumption of the antioxidant vitamin A, previously shown by us to radioprotect the testes. Mice were acutely irradiated with (137)Cs gamma rays at doses of 0, 7, 8.5, or 10 Gy over the whole body. Mice were fed with vitamin A-supplemented diet (100x the control diet) for 5 days prior to irradiation after which the diet was continued until death. Intestinal sugar transport was studied at days 2, 5, 8, and 14 postirradiation. By day 8, d-glucose uptake decreased by approximately 10-20% and d-fructose uptake by 25-85%. With increasing radiation dose, the quantity of heterogeneous nuclear RNA increased for both transporters, whereas mRNA levels decreased, paralleling reductions in transport. Enterocytes of mice fed the vitamin A supplement had > or = 6-fold retinol concentrations than those of mice fed control diets, confirming considerable intestinal vitamin A uptake. However, vitamin A supplementation had no effect on clinical or transport parameters and afforded no protection against radiation-induced changes in intestinal sugar transport. Radiation markedly reduced GLUT5 activity and mRNA abundance, but high-d-fructose diets enhanced GLUT5 activity and mRNA expression in both unirradiated and irradiated mice. In conclusion, the effect of radiation may be posttranscriptional, and radiation-damaged intestines can still respond to dietary stimuli.
    Mesh-Begriff(e) Animals ; Antioxidants/pharmacology ; Biological Transport/drug effects ; Biological Transport/physiology ; Biological Transport/radiation effects ; Body Weight/physiology ; Dietary Supplements ; Dose-Response Relationship, Radiation ; Fructose/metabolism ; Gamma Rays ; Glucose/metabolism ; Glucose Transport Proteins, Facilitative/metabolism ; Glucose Transport Proteins, Facilitative/radiation effects ; Glucose Transporter Type 5 ; Intestine, Small/metabolism ; Intestine, Small/pathology ; Intestine, Small/radiation effects ; Male ; Mice ; Models, Animal ; RNA, Messenger/metabolism ; Sodium-Glucose Transporter 1/metabolism ; Sodium-Glucose Transporter 1/radiation effects ; Vitamin A/pharmacology
    Chemische Substanzen Antioxidants ; Glucose Transport Proteins, Facilitative ; Glucose Transporter Type 5 ; RNA, Messenger ; Slc2a5 protein, mouse ; Slc5a1 protein, mouse ; Sodium-Glucose Transporter 1 ; Vitamin A (11103-57-4) ; Fructose (30237-26-4) ; Glucose (IY9XDZ35W2)
    Sprache Englisch
    Erscheinungsdatum 2009-11-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 603839-6
    ISSN 1522-1490 ; 0363-6119
    ISSN (online) 1522-1490
    ISSN 0363-6119
    DOI 10.1152/ajpregu.00612.2009
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Marked changes in endogenous antioxidant expression precede vitamin A-, C-, and E-protectable, radiation-induced reductions in small intestinal nutrient transport

    Roche, Marjolaine / Kemp, Francis W. / Agrawal, Amit / Attanasio, Alicia / Neti, Prasad V.S.V. / Howell, Roger W. / Ferraris, Ronaldo P.

    Free Radical Biology and Medicine

    Band v. 50,, Heft no. 1

    Abstract: Rapidly proliferating epithelial crypt cells of the small intestine are susceptible to radiation-induced oxidative stress, yet there is a dearth of data linking this stress to expression of antioxidant enzymes and to alterations in intestinal nutrient ... ...

    Abstract Rapidly proliferating epithelial crypt cells of the small intestine are susceptible to radiation-induced oxidative stress, yet there is a dearth of data linking this stress to expression of antioxidant enzymes and to alterations in intestinal nutrient absorption. We previously showed that 5–14days after acute γ-irradiation, intestinal sugar absorption decreased without change in antioxidant enzyme expression. In the present study, we measured antioxidant mRNA and protein expression in mouse intestines taken at early times postirradiation. Observed changes in antioxidant expression are characterized by a rapid decrease within 1h postirradiation, followed by dramatic upregulation within 4h and then downregulation a few days later. The cell type and location expressing the greatest changes in levels of the oxidative stress marker 4HNE and of antioxidant enzymes are, respectively, epithelial cells responsible for nutrient absorption and the crypt region comprising mainly undifferentiated cells. Consumption of a cocktail of antioxidant vitamins A, C, and E, before irradiation, prevents reductions in transport of intestinal sugars, amino acids, bile acids, and peptides. Ingestion of antioxidants may blunt radiation-induced decreases in nutrient transport, perhaps by reducing acute oxidative stress in crypt cells, thereby allowing the small intestine to retain its absorptive function when those cells migrate to the villus days after the insult.
    Schlagwörter small intestine ; irradiation ; nutrient transport ; messenger RNA ; villi ; enzymes ; gamma radiation ; oxidative stress ; sugars ; intestinal absorption ; mice ; protein synthesis ; absorption ; ingestion ; antioxidants ; amino acids ; vitamin A ; peptides ; epithelial cells ; bile acids
    Sprache Englisch
    Dokumenttyp Artikel
    ISSN 0891-5849
    Datenquelle AGRIS - International Information System for the Agricultural Sciences and Technology

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