Article ; Online: Primary paraganglioma of the spine
Journal of Craniovertebral Junction and Spine, Vol 5, Iss 1, Pp 20-
A clinicopathological study of eight cases
2014 Volume 24
Abstract: Context: Spinal paragangliomas are rare neuroendocrine tumors of the extra-adrenal paraganglionic system. Aims: This study describes the clinicopathological features of eight cases of spinal paraganglioma and highlights the significance of important ... ...
Abstract | Context: Spinal paragangliomas are rare neuroendocrine tumors of the extra-adrenal paraganglionic system. Aims: This study describes the clinicopathological features of eight cases of spinal paraganglioma and highlights the significance of important morphological features and immunohistochemistry in the diagnosis of paraganglioma at this unusual site. Material and Methods: All the cases of primary spinal paragangliomas diagnosed during the last six years (2008-2013) in the Department of Pathology at our hospital were reviewed. Results: There were six males and two females. The mean age at diagnosis was 50.4 years. All patients presented with low back pain. All tumors were located in the cauda equina or conus medullaris region. Magnetic Resonance Imaging and intraoperative appearance were that of a vascular, well-circumscribed intradural, extramedullary tumor suggestive of either schwannoma or ependymoma. All the patients underwent gross total resection of the tumor. Histopathology in five of the cases showed ′ependymoma-like histology′ while only three cases had a predominant classic ′zellballen′ pattern. Two cases had prominent ′gangliocytic differentiation′. In the five cases with ′ependymoma-like histology′, the diagnosis was confirmed on Immunohistochemistry (IHC). Conclusions: Even though relatively rare, paraganglioma should be considered in the differential diagnosis of spinal tumors and due to their clinical, radiological and histopathological similarity to schwannoma and ependymoma, the diagnosis should be based on close examination of the clinical, radiological and pathological findings. |
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Keywords | Cauda equina ; ependymoma-like histology ; paraganglioma ; spinal ; Orthopedic surgery ; RD701-811 ; Surgery ; RD1-811 ; Medicine ; R |
Subject code | 616 |
Language | English |
Publishing date | 2014-01-01T00:00:00Z |
Publisher | Medknow Publications |
Document type | Article ; Online |
Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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