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  1. Book ; Online ; E-Book: Medicinal Plants Used in Traditional Persian Medicine

    Schulz, Hartwig / Emami, Seyed Ahmad / Nadjafi, Farsad / Abadi, Mamak Hashemi Habib / Akabery, Maryam / Askari, Seyyed Ahmad / Askari, Sayyedeh Fatemeh / Ayati, Zahra / Azad, Sajad / Badr, Parmis

    2023  

    Abstract: Traditional Persian Medicine (TPM) is one of the most ancient medical doctrines, and is well-documented in terms of information about diseases, diagnoses and treatments, especially by the application of medicinal plants. This book presents the key ... ...

    Abstract Traditional Persian Medicine (TPM) is one of the most ancient medical doctrines, and is well-documented in terms of information about diseases, diagnoses and treatments, especially by the application of medicinal plants. This book presents the key medicinal plants used in TPM.
    Subject code 615.3/210955
    Language English
    Size 1 online resource (636 pages)
    Edition 1st ed.
    Publisher CAB International
    Publishing place Oxford
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-80062-167-1 ; 1-80062-166-3 ; 9781800621657 ; 978-1-80062-167-1 ; 978-1-80062-166-4 ; 1800621655
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: A Review on the Efficacy and Safety of Intrathecal Administration of Novel Medications for Leptomeningeal Metastases in Solid Cancers.

    Jafari, Fatemeh / Nodeh, Mohammad Moeini / Hosseinjani, Hesamoddin / Baharara, Hamed / Azad, Sajad / Arasteh, Omid / Johnston, Thomas P / Sahebkar, Amirhossein

    Current medicinal chemistry

    2023  Volume 31, Issue 19, Page(s) 2732–2750

    Abstract: Leptomeningeal disease (LMD) is a rare and lethal manifestation that may occur in the advanced stages of solid tumors and hematological malignancies. With advances in diagnostic techniques, the detection and confirmation of the presence of LMD have ... ...

    Abstract Leptomeningeal disease (LMD) is a rare and lethal manifestation that may occur in the advanced stages of solid tumors and hematological malignancies. With advances in diagnostic techniques, the detection and confirmation of the presence of LMD have increased. Although its optimal treatment remains a challenge, the use of the intrathecal route for the delivery of novel therapeutics is now considered a promising drug delivery strategy to complement radiation and systemic-based therapies. Although methotrexate, cytarabine, and thiotepa have a long history in the treatment of LMD, other medications have also been shown to be beneficial. In this article, we have reviewed the effects of novel medications administered via the intrathecal route for the treatment of solid tumors. We have searched PubMed, Scopus, and Google Scholar databases till the end of September 2021 using the following keywords: "leptomeningeal disease", "leptomeningeal carcinomatosis", "leptomeningeal metastases", "solid tumors", "solid cancers", and "intrathecal". Our literature findings have uncovered that most studies on LMD, which occurs secondary to solid cancers, are available as 'case reports', and few clinical trials have been conducted to date. Single-drug (monotherapy) or combination drug therapy, administered via the intrathecal route, especially in metastatic breast and lung cancer, has been shown to improve patients' symptoms and overall lifespan, while exhibiting a low and acceptable prevalence of side effects. However, judgments/conclusions about the effectiveness and safety of these drugs still require further clinical evaluation.
    MeSH term(s) Humans ; Injections, Spinal ; Neoplasms/drug therapy ; Neoplasms/pathology ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/administration & dosage ; Meningeal Neoplasms/drug therapy ; Meningeal Neoplasms/secondary ; Meningeal Neoplasms/pathology ; Meningeal Carcinomatosis/drug therapy ; Meningeal Carcinomatosis/secondary
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2023-05-04
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867330666230508142657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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