Article: Leveraging genome editing to functionally evaluate Plasmodium diversity
2022
Abstract: The ambitious goal of malaria elimination requires an in-depth understanding of the parasite’s biology to counter the growing threat of antimalarial resistance and immune evasion. Timely assessment of the functional impact of antigenic diversity in the ... ...
Abstract | The ambitious goal of malaria elimination requires an in-depth understanding of the parasite’s biology to counter the growing threat of antimalarial resistance and immune evasion. Timely assessment of the functional impact of antigenic diversity in the early stages of vaccine development will be critical for achieving the goal of malaria control, elimination, and, ultimately, eradication. Recent advances in targeted genome editing enabled the functional validation of resistance-associated markers in Plasmodium falciparum, the deadliest malaria causing pathogen and strain-specific immune neutralization. This review explores recent advances made in leveraging genome editing to aid the functional evaluation of Plasmodium diversity and highlights how these techniques can assist in prioritizing both therapeutic and vaccine candidates. |
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Keywords | Plasmodium falciparum ; antigenic variation ; antimalarials ; genome ; immune evasion ; malaria ; neutralization ; parasites ; parasitology ; pathogens ; therapeutics ; vaccine development ; vaccines |
Language | English |
Publishing place | Elsevier Ltd |
Document type | Article |
Note | Pre-press version |
ZDB-ID | 2036227-4 |
ISSN | 1471-5007 ; 1471-4922 |
ISSN (online) | 1471-5007 |
ISSN | 1471-4922 |
DOI | 10.1016/j.pt.2022.03.005 |
Database | NAL-Catalogue (AGRICOLA) |
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