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  1. Artikel: Pyrroloquinolone A, a new alkaloid and other phytochemicals from Atractylis cancellata L. with antioxidant and anticholinesterase activities

    Badaoui, Mohamed Ibrahim / Alabdul Magid, Abdulmagid / Benkhaled, Mohammed / Bensouici, Chawki / Harakat, Dominique / Voutquenne-Nazabadioko, Laurence / Haba, Hamada

    Natural product research. 2021 Sept. 17, v. 35, no. 18

    2021  

    Abstract: A new alkaloid pyrroloquinolone A (1), along with fifteen known compounds 2–16 were isolated from the petroleum ether, EtOAc and n-BuOH extracts of the whole plant Atractylis cancellata L. Their structures were elucidated on the basis of extensive ... ...

    Abstract A new alkaloid pyrroloquinolone A (1), along with fifteen known compounds 2–16 were isolated from the petroleum ether, EtOAc and n-BuOH extracts of the whole plant Atractylis cancellata L. Their structures were elucidated on the basis of extensive spectroscopic analysis including 1D- and 2D-NMR and HR-ESI-MS techniques. This is the first report of alkaloids in the genus Atractylis. Some of the isolated compounds and extracts were evaluated for their antioxidant potential (scavenging activity of DPPH and ABTS radicals, and reducing Fe⁺³ and Cu⁺² power assays) and acetylcholinesterase and butyrylcholinesterase inhibitory activities. Compounds 8 and 11 showed good antioxidant capacity compared to ascorbic acid, BHA, and BHT used as standards, whereas compounds 1 and 2 exhibited good anticholinesterase activities compared to galantamine used as standard.
    Schlagwörter acetylcholinesterase ; alkaloids ; antioxidant activity ; antioxidants ; ascorbic acid ; cholinesterase ; ethyl acetate ; petroleum ; phytochemicals ; research ; spectral analysis
    Sprache Englisch
    Erscheinungsverlauf 2021-0917
    Umfang p. 2997-3003.
    Erscheinungsort Taylor & Francis
    Dokumenttyp Artikel
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2019.1682575
    Datenquelle NAL Katalog (AGRICOLA)

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  2. Artikel: Antioxidant activity-guided isolation of constituents from Euphorbia gaditana Coss. and their antioxidant and tyrosinase inhibitory activities

    Badaoui, Mohamed Ibrahim / Magid, Abdulmagid Alabdul / Voutquenne-Nazabadioko, Laurence / Benkhaled, Mohammed / Harakat, Dominique / Robert, Anthony / Haba, Hamada

    Phytochemical Society of Europe Phytochemistry letters. 2020 Oct., v. 39

    2020  

    Abstract: Two previously unreported compounds, 4-O-(2′′-O-galloyl-β-d-glucopyranosyl)-3,5-dihydroxyacetophenone (1) and 5-isopropyl-2-oxo-3,6-dihydropyran-4-carboxylic acid (2), along with twenty-nine known compounds (3−31) were isolated from the aerial parts of ... ...

    Abstract Two previously unreported compounds, 4-O-(2′′-O-galloyl-β-d-glucopyranosyl)-3,5-dihydroxyacetophenone (1) and 5-isopropyl-2-oxo-3,6-dihydropyran-4-carboxylic acid (2), along with twenty-nine known compounds (3−31) were isolated from the aerial parts of Euphorbia gaditana Coss. Their structures were elucidated based on extensive spectroscopic analysis 1D and 2D-NMR, mass spectrometry HR-ESI-MS, optical rotation [α]D, acid hydrolysis and the comparison of NMR data with those described in literature. The antioxidant activity-guided study was conducted using DPPH and CUPRAC methods started from the extracts to bioactive isolated molecules. Most of the isolates (1-31) showed a good to excellent antioxidant activity compared to the standards BHT and ascorbic acid. Furthermore, 1 and 2 exhibited a moderate tyrosinase inhibitory activity (IC₅₀ 89.78 ± 0.93 and 52.39 ± 0.69 μg/mL, respectively) compared to the standard kojic acid (IC₅₀ 25.23 ± 0.78 μg/mL).
    Schlagwörter 2,2-diphenyl-1-picrylhydrazyl ; Euphorbia ; acetophenones ; acid hydrolysis ; aerial parts ; antioxidant activity ; bioactive compounds ; carboxylic acids ; chemical structure ; copper ; electrospray ionization mass spectrometry ; enzyme inhibition ; isolation techniques ; monophenol monooxygenase ; nuclear magnetic resonance spectroscopy
    Sprache Englisch
    Erscheinungsverlauf 2020-10
    Umfang p. 99-104.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    Anmerkung golden set
    ISSN 1874-3900
    DOI 10.1016/j.phytol.2020.07.012
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel ; Online: Pyrroloquinolone A, a new alkaloid and other phytochemicals from

    Badaoui, Mohamed Ibrahim / Alabdul Magid, Abdulmagid / Benkhaled, Mohammed / Bensouici, Chawki / Harakat, Dominique / Voutquenne-Nazabadioko, Laurence / Haba, Hamada

    Natural product research

    2019  Band 35, Heft 18, Seite(n) 2997–3003

    Abstract: A new alkaloid pyrroloquinolone A ( ...

    Abstract A new alkaloid pyrroloquinolone A (
    Mesh-Begriff(e) Alkaloids/isolation & purification ; Alkaloids/pharmacology ; Antioxidants/isolation & purification ; Antioxidants/pharmacology ; Atractylis/chemistry ; Cholinesterase Inhibitors/isolation & purification ; Cholinesterase Inhibitors/pharmacology ; Molecular Structure ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Plant Extracts/pharmacology ; Quinolones/isolation & purification ; Quinolones/pharmacology
    Chemische Substanzen Alkaloids ; Antioxidants ; Cholinesterase Inhibitors ; Phytochemicals ; Plant Extracts ; Quinolones
    Sprache Englisch
    Erscheinungsdatum 2019-11-07
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2019.1682575
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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