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  1. Artikel ; Online: The interplay between bile acids and mucosal adaptive immunity.

    Mohammed, Ahmed Dawood / Ball, Ryan A W / Kubinak, Jason L

    PLoS pathogens

    2023  Band 19, Heft 6, Seite(n) e1011356

    Mesh-Begriff(e) Bile Acids and Salts ; Mucous Membrane ; Adaptive Immunity ; Immunity, Mucosal
    Chemische Substanzen Bile Acids and Salts
    Sprache Englisch
    Erscheinungsdatum 2023-06-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1011356
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Studying the cellular basis of small bowel enteropathy using high-parameter flow cytometry in mouse models of primary antibody deficiency.

    Mohammed, Ahmed D / Ball, Ryan A W / Jolly, Amy / Nagarkatti, Prakash / Nagarkatti, Mitzi / Kubinak, Jason L

    Frontiers in immunology

    2024  Band 15, Seite(n) 1278197

    Abstract: Background: Primary immunodeficiencies are heritable defects in immune system function. Antibody deficiency is the most common form of primary immunodeficiency in humans, can be caused by abnormalities in both the development and activation of B cells, ... ...

    Abstract Background: Primary immunodeficiencies are heritable defects in immune system function. Antibody deficiency is the most common form of primary immunodeficiency in humans, can be caused by abnormalities in both the development and activation of B cells, and may result from B-cell-intrinsic defects or defective responses by other cells relevant to humoral immunity. Inflammatory gastrointestinal complications are commonly observed in antibody-deficient patients, but the underlying immune mechanisms driving this are largely undefined.
    Methods: In this study, several mouse strains reflecting a spectrum of primary antibody deficiency (IgA
    Results: Results from our experiments indicate that the severity of primary antibody deficiency positively correlates with the degree of immune dysregulation that can be expected to develop in an individual. In the SI of mice, immune dysregulation is primarily explained by defective homeostatic responses in T cell and invariant natural killer-like T (iNKT) cell subsets. These defects are strongly correlated with abnormalities in the balance between protein (MHCII-mediated) versus lipid (CD1d-mediated) antigen presentation by intestinal epithelial cells (IECs) and intestinal stem cells (ISCs), respectively.
    Conclusions: Multivariate statistical approaches can be used to obtain quantifiable estimates of immune dysregulation based on high-parameter flow cytometry readouts of immune function. Using one such estimate, we reveal a previously unrecognized tradeoff between iNKT cell activation and type 1 immunity that underlies disease in the small bowel. The balance between protein/lipid antigen presentation by ISCs may play a crucial role in regulating this balance and thereby suppressing inflammatory disease in the small bowel.
    Mesh-Begriff(e) Animals ; Mice ; Disease Models, Animal ; Flow Cytometry/methods ; Intestine, Small/immunology ; Intestine, Small/pathology ; Mice, Knockout ; Primary Immunodeficiency Diseases/immunology ; Primary Immunodeficiency Diseases/genetics ; Mice, Inbred C57BL ; B-Lymphocytes/immunology ; Intestinal Diseases/immunology ; Intestinal Diseases/pathology
    Sprache Englisch
    Erscheinungsdatum 2024-05-13
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1278197
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel: Studying the cellular basis of small bowel enteropathy using high-parameter flow cytometry in mouse models of primary antibody deficiency.

    Mohammed, Ahmed D / Ball, Ryan A W / Jolly, Amy / Nagarkatti, Prakash / Nagarkatti, Mitzi / Kubinak, Jason L

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Background: Primary immunodeficiencies are heritable defects in immune system function. Antibody deficiency is the most common form of primary immunodeficiency in humans, can be caused by abnormalities in both the development and activation of B cells, ... ...

    Abstract Background: Primary immunodeficiencies are heritable defects in immune system function. Antibody deficiency is the most common form of primary immunodeficiency in humans, can be caused by abnormalities in both the development and activation of B cells, and may result from B-cell-intrinsic defects or defective responses by other cells relevant to humoral immunity. Inflammatory gastrointestinal complications are commonly observed in antibody-deficient patients, but the underlying immune mechanisms driving this are largely undefined.
    Methods: In this study, several mouse strains reflecting a spectrum of primary antibody deficiency (IgA
    Results: Results from our experiments indicate that the severity of primary antibody deficiency positively correlates with the degree of immune dysregulation that can be expected to develop in an individual. In the SI of mice, immune dysregulation is primarily explained by defective homeostatic responses in T cell and invariant natural killer-like T (iNKT) cell subsets. These defects are strongly correlated with abnormalities in the balance between protein (MHCII-mediated) versus lipid (CD1d-mediated) antigen presentation by intestinal epithelial cells (IECs) and intestinal stem cells (ISCs), respectively.
    Conclusions: Multivariate statistical approaches can be used to obtain quantifiable estimates of immune dysregulation based on high-parameter flow cytometry readouts of immune function. Using one such estimate, we reveal a previously unrecognized tradeoff between iNKT cell activation and type 1 immunity that underlies disease in the small bowel. The balance between protein/lipid antigen presentation by ISCs may play a crucial role in regulating this balance and thereby suppressing inflammatory disease in the small bowel.
    Sprache Englisch
    Erscheinungsdatum 2024-01-29
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.01.25.577009
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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