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  1. Artikel ; Online: Frequency and Focus of in Vitro Studies of Microglia-Expressed Cytokines in Response to Viral Infection: A Systematic Review.

    Barrios-González, Diego A / Philibert-Rosas, Santiago / Martínez-Juárez, Iris E / Sotelo-Díaz, Fernando / Rivas-Alonso, Verónica / Sotelo, Julio / Sebastián-Díaz, Mario A

    Cellular and molecular neurobiology

    2024  Band 44, Heft 1, Seite(n) 21

    Abstract: It is well known that as part of their response to infectious agents such as viruses, microglia transition from a quiescent state to an activated state that includes proinflammatory and anti-inflammatory phases; this behavior has been described through ... ...

    Abstract It is well known that as part of their response to infectious agents such as viruses, microglia transition from a quiescent state to an activated state that includes proinflammatory and anti-inflammatory phases; this behavior has been described through in vitro studies. However, recent in vivo studies on the function of microglia have questioned the two-phase paradigm; therefore, a change in the frequency of in vitro studies is expected. A systematic review was carried out to identify the microglial cytokine profile against viral infection that has been further evaluated through in vitro studies (pro-inflammatory or anti-inflammatory), along with analysis of its publication frequency over the years. For this review, 531 articles published in the English language were collected from PubMed, Web of Science, EBSCO and ResearchGate. Only 27 papers met the inclusion criteria for this systematic review. In total, 19 cytokines were evaluated in these studies, most of which are proinflammatory; the most common are IL-6, followed by TNF-α and IL-1β. It should be pointed out that half of the studies were published between 2015 and 2022 (raw data available in https://github.com/dadriba05/SystematicReview.git ). In this review, we identified that evaluation of pro-inflammatory cytokines released by microglia against viral infections has been performed more frequently than that of anti-inflammatory cytokines; additionally, a higher frequency of evaluation of the response of microglia cells to viral infection through in vitro studies from 2015 and beyond was noted.
    Mesh-Begriff(e) Humans ; Cytokines ; Microglia ; Virus Diseases ; Tumor Necrosis Factor-alpha ; Anti-Inflammatory Agents
    Chemische Substanzen Cytokines ; Tumor Necrosis Factor-alpha ; Anti-Inflammatory Agents
    Sprache Englisch
    Erscheinungsdatum 2024-02-13
    Erscheinungsland United States
    Dokumenttyp Systematic Review ; Journal Article ; Review
    ZDB-ID 283404-2
    ISSN 1573-6830 ; 0272-4340
    ISSN (online) 1573-6830
    ISSN 0272-4340
    DOI 10.1007/s10571-024-01454-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Association of variants in the ABCB1, CYP2C19 and CYP2C9 genes for Juvenile Myoclonic Epilepsy.

    Jara-Prado, Aurelio / Guerrero-Camacho, Jorge Luis / Ángeles-López, Quetzalli Denisse / Ochoa-Morales, Adriana / Dávila-Ortiz de Montellano, David José / Ramírez-García, Miguel Ángel / Breda-Yepes, Michelle / Durón, Reyna M / Delgado-Escueta, Antonio V / Barrios-González, Diego A / Martínez-Juárez, Iris E

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2023  Band 45, Heft 4, Seite(n) 1635–1643

    Abstract: Juvenile myoclonic epilepsy (JME) is the most common of the generalized genetic epilepsies, with multiple causal and susceptibility genes; however, its etiopathogenesis is mainly unknown. The toxic effects caused by xenobiotics in cells occur during ... ...

    Abstract Juvenile myoclonic epilepsy (JME) is the most common of the generalized genetic epilepsies, with multiple causal and susceptibility genes; however, its etiopathogenesis is mainly unknown. The toxic effects caused by xenobiotics in cells occur during their metabolic transformation, mainly by enzymes belonging to cytochrome P450. The elimination of these compounds by transporters of the ABC type protects the central nervous system, but their accumulation causes neuronal damage, resulting in neurological diseases. The present study has sought the association between single nucleotide genetic variants of the CYP2C9, CYP2C19, and ABCB1 genes and the development of JME in patients compared to healthy controls. The CC1236 and GG2677 genotypes of ABCB1 in women; allele G 2677, genotypes GG 2677 and CC 3435 in men; the CYP2C19*2A allele, and the CYP2C19*3G/A genotype in both sexes were found to be risk factors for JME. Furthermore, carriers of the TTGGCC genotype combination of the ABCB1 gene (1236/2677/3435) have a 10.5 times higher risk of developing JME than non-carriers. Using the STRING database, we found an interaction between the proteins encoded by these genes and other possible proteins. These findings indicate that the CYP450 system and ABC transporters could interact with other genes in the JME.
    Mesh-Begriff(e) Male ; Humans ; Female ; Myoclonic Epilepsy, Juvenile/genetics ; Cytochrome P-450 CYP2C9/genetics ; Cytochrome P-450 CYP2C19/genetics ; Genotype ; Epilepsy, Generalized ; ATP Binding Cassette Transporter, Subfamily B/genetics
    Chemische Substanzen Cytochrome P-450 CYP2C9 (EC 1.14.13.-) ; Cytochrome P-450 CYP2C19 (EC 1.14.14.1) ; CYP2C9 protein, human (EC 1.14.13.-) ; CYP2C19 protein, human (EC 1.14.14.1) ; ABCB1 protein, human ; ATP Binding Cassette Transporter, Subfamily B
    Sprache Englisch
    Erscheinungsdatum 2023-10-25
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-023-07124-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1877: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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