LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 4 von insgesamt 4

Suchoptionen

  1. Artikel ; Online: Distress in the care of people with chronic low back pain: insights from an ethnographic study.

    Dillon, Miriam / Olson, Rebecca E / Plage, Stefanie / Miciak, Maxi / Window, Peter / Stewart, Matthew / Christoffersen, Anja / Kilner, Simon / Barthel, Natalie / Setchell, Jenny

    Frontiers in sociology

    2023  Band 8, Seite(n) 1281912

    Abstract: Introduction: Distress is part of the experiences and care for people with chronic low back pain. However, distress is often pathologised and individualised; it is seen as a problem within the individual in pain and something to be downplayed, avoided, ... ...

    Abstract Introduction: Distress is part of the experiences and care for people with chronic low back pain. However, distress is often pathologised and individualised; it is seen as a problem within the individual in pain and something to be downplayed, avoided, or fixed. To that end, we situate distress as a normal everyday relational experience circulating, affecting, moving in, through, and across bodies. Challenging practices that may amplify distress, we draw on the theorisation of affect as a relational assemblage to analyse physiotherapy clinical encounters in the care of people with chronic low back pain.
    Methods: Adopting a critical reflexive ethnographic approach, we analyse data from a qualitative project involving 15 ethnographic observations of patient-physiotherapist interactions and 6 collaborative dialogues between researchers and physiotherapists. We foreground conceptualisations of distress- and what they make (im)possible-to trace embodied assemblage formations and relationality when caring for people with chronic low back pain.
    Results: Our findings indicate that conceptualisation matters to the clinical entanglement, particularly how distress is recognised and navigated. Our study highlights how distress is both a lived experience and an affective relation-that both the physiotherapist and people with chronic low back pain experience distress and can be affected by and affect each other within clinical encounters.
    Discussion: Situated at the intersection of health sociology, sociology of emotions, and physiotherapy, our study offers a worked example of applying an affective assemblage theoretical framework to understanding emotionally imbued clinical interactions. Viewing physiotherapy care through an affective assemblage lens allows for recognising that life, pain, and distress are emerging, always in flux. Such an approach recognises that clinicians and patients experience distress; they are affected by and affect each other. It demands a more humanistic approach to care and helps move towards reconnecting the inseparable in clinical practice-emotion and reason, body and mind, carer and cared for.
    Sprache Englisch
    Erscheinungsdatum 2023-11-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ISSN 2297-7775
    ISSN (online) 2297-7775
    DOI 10.3389/fsoc.2023.1281912
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  2. Artikel ; Online: Natural proteome diversity links aneuploidy tolerance to protein turnover.

    Muenzner, Julia / Trébulle, Pauline / Agostini, Federica / Zauber, Henrik / Messner, Christoph B / Steger, Martin / Kilian, Christiane / Lau, Kate / Barthel, Natalie / Lehmann, Andrea / Textoris-Taube, Kathrin / Caudal, Elodie / Egger, Anna-Sophia / Amari, Fatma / De Chiara, Matteo / Demichev, Vadim / Gossmann, Toni I / Mülleder, Michael / Liti, Gianni /
    Schacherer, Joseph / Selbach, Matthias / Berman, Judith / Ralser, Markus

    Nature

    2024  

    Abstract: Accessing the natural genetic diversity of species unveils hidden genetic traits, clarifies gene functions and allows the generalizability of laboratory findings to be assessed. One notable discovery made in natural isolates of Saccharomyces cerevisiae ... ...

    Abstract Accessing the natural genetic diversity of species unveils hidden genetic traits, clarifies gene functions and allows the generalizability of laboratory findings to be assessed. One notable discovery made in natural isolates of Saccharomyces cerevisiae is that aneuploidy-an imbalance in chromosome copy numbers-is frequent
    Sprache Englisch
    Erscheinungsdatum 2024-05-22
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-024-07442-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  3. Artikel ; Online: The proteomic landscape of genome-wide genetic perturbations.

    Messner, Christoph B / Demichev, Vadim / Muenzner, Julia / Aulakh, Simran K / Barthel, Natalie / Röhl, Annika / Herrera-Domínguez, Lucía / Egger, Anna-Sophia / Kamrad, Stephan / Hou, Jing / Tan, Guihong / Lemke, Oliver / Calvani, Enrica / Szyrwiel, Lukasz / Mülleder, Michael / Lilley, Kathryn S / Boone, Charles / Kustatscher, Georg / Ralser, Markus

    Cell

    2023  Band 186, Heft 9, Seite(n) 2018–2034.e21

    Abstract: Functional genomic strategies have become fundamental for annotating gene function and regulatory networks. Here, we combined functional genomics with proteomics by quantifying protein abundances in a genome-scale knockout library in Saccharomyces ... ...

    Abstract Functional genomic strategies have become fundamental for annotating gene function and regulatory networks. Here, we combined functional genomics with proteomics by quantifying protein abundances in a genome-scale knockout library in Saccharomyces cerevisiae, using data-independent acquisition mass spectrometry. We find that global protein expression is driven by a complex interplay of (1) general biological properties, including translation rate, protein turnover, the formation of protein complexes, growth rate, and genome architecture, followed by (2) functional properties, such as the connectivity of a protein in genetic, metabolic, and physical interaction networks. Moreover, we show that functional proteomics complements current gene annotation strategies through the assessment of proteome profile similarity, protein covariation, and reverse proteome profiling. Thus, our study reveals principles that govern protein expression and provides a genome-spanning resource for functional annotation.
    Mesh-Begriff(e) Proteomics/methods ; Proteome/metabolism ; Genomics/methods ; Genome ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism
    Chemische Substanzen Proteome
    Sprache Englisch
    Erscheinungsdatum 2023-04-19
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2023.03.026
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  4. Artikel ; Online: The proteomic landscape of genome-wide genetic perturbations

    Messner, Christoph B. / Demichev, Vadim / Muenzner, Julia / Aulakh, Simran K. / Barthel, Natalie / Röhl, Annika / Herrera-Domínguez, Lucía / Egger, Anna-Sophia / Kamrad, Stephan / Hou, Jing / Tan, Guihong / Lemke, Oliver / Calvani, Enrica / Szyrwiel, Lukasz / Mülleder, Michael / Lilley, Kathryn S. / Boone, Charles / Kustatscher, Georg / Ralser, Markus

    Cell. 2023 Apr. 19,

    2023  

    Abstract: Functional genomic strategies have become fundamental for annotating gene function and regulatory networks. Here, we combined functional genomics with proteomics by quantifying protein abundances in a genome-scale knockout library in Saccharomyces ... ...

    Abstract Functional genomic strategies have become fundamental for annotating gene function and regulatory networks. Here, we combined functional genomics with proteomics by quantifying protein abundances in a genome-scale knockout library in Saccharomyces cerevisiae, using data-independent acquisition mass spectrometry. We find that global protein expression is driven by a complex interplay of (1) general biological properties, including translation rate, protein turnover, the formation of protein complexes, growth rate, and genome architecture, followed by (2) functional properties, such as the connectivity of a protein in genetic, metabolic, and physical interaction networks. Moreover, we show that functional proteomics complements current gene annotation strategies through the assessment of proteome profile similarity, protein covariation, and reverse proteome profiling. Thus, our study reveals principles that govern protein expression and provides a genome-spanning resource for functional annotation.
    Schlagwörter Saccharomyces cerevisiae ; genes ; genomics ; mass spectrometry ; protein synthesis ; proteome ; proteomics ; quantitative proteomics ; data-independent acquisition ; knockout ; deletion ; systems biology ; functional proteomics ; high throughput ; functional genomics ; gene annotation
    Sprache Englisch
    Erscheinungsverlauf 2023-0419
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel ; Online
    Anmerkung Pre-press version ; Use and reproduction
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2023.03.026
    Datenquelle NAL Katalog (AGRICOLA)

    Zusatzmaterialien

    Kategorien

Zum Seitenanfang