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Artikel ; Online: Association of Use and Dose of Lipid-Lowering Therapy Post Acute Myocardial Infarction With 5-Year Survival in Older Adults.

Fayol, Antoine / Schiele, François / Ferrières, Jean / Puymirat, Etienne / Bataille, Vincent / Tea, Victoria / Chamandi, Chekrallah / Albert, Franck / Lemesle, Gilles / Cayla, Guillaume / Weizman, Orianne / Simon, Tabassome / Danchin, Nicolas

Circulation. Cardiovascular quality and outcomes

2024 Band 17, Heft 5, Seite(n) e010685

Abstract: Background: Older people are underrepresented in randomized trials. The association between lipid-lowering therapy (LLT) and its intensity after acute myocardial infarction and long-term mortality in this population deserves to be assessed.: Methods: ...

Abstract	Background: Older people are underrepresented in randomized trials. The association between lipid-lowering therapy (LLT) and its intensity after acute myocardial infarction and long-term mortality in this population deserves to be assessed. Methods: The FAST-MI (French Registry of Acute ST-Elevation or Non-ST-Elevation Myocardial Infarction) program consists of nationwide French surveys including all patients admitted for acute myocardial infarction ≤48 hours from onset over a 1- to 2-month period in 2005, 2010, and 2015, with long-term follow-up. Numerous data were collected and a centralized 10-year follow-up was organized. The present analysis focused on the association between prescription of LLT (atorvastatin ≥40 mg or equivalent, or any combination of statin and ezetimibe) and 5-year mortality in patients aged ≥80 years discharged alive. Cox multivariable analysis and propensity score matching were used to adjust for baseline differences. Results: Among the 2258 patients aged ≥80 years (mean age, 85±4 years; 51% women; 39% ST-segment elevation myocardial infarction; 58% with percutaneous coronary intervention), 415 were discharged without LLT (18%), 866 with conventional doses (38%), and 977 with high-dose LLT (43%). Five-year survival was 36%, 47.5%, and 58%, respectively. Compared with patients without LLT, high-dose LLT was significantly associated with lower 5-year mortality (adjusted hazard ratio, 0.78 [95% CI, 0.66-0.92]), whereas conventional-intensity LLT was not (adjusted hazard ratio, 0.93 [95% CI, 0.80-1.09]). In propensity score-matched cohorts (n=278 receiving high-intensity LLT and n=278 receiving no statins), 5-year survival was 52% with high-intensity LLT at discharge and 42% without statins (hazard ratio, 0.78 [95% CI, 0.62-0.98]). Conclusions: In these observational cohorts, high-intensity LLT at discharge after acute myocardial infarction was associated with reduced all-cause mortality at 5 years in an older adult population. These results suggest that high-intensity LLT should not be denied to patients on the basis of old age. Registration: URL: https://www.clinicaltrials.gov; Unique identifiers: NCT00673036, NCT01237418, and NCT02566200.
Mesh-Begriff(e)	Humans ; Female ; Male ; Time Factors ; France/epidemiology ; Aged, 80 and over ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Registries ; Treatment Outcome ; ST Elevation Myocardial Infarction/mortality ; ST Elevation Myocardial Infarction/therapy ; ST Elevation Myocardial Infarction/diagnosis ; Age Factors ; Risk Factors ; Non-ST Elevated Myocardial Infarction/mortality ; Non-ST Elevated Myocardial Infarction/diagnosis ; Non-ST Elevated Myocardial Infarction/therapy ; Ezetimibe/therapeutic use ; Ezetimibe/adverse effects ; Ezetimibe/administration & dosage ; Risk Assessment ; Dyslipidemias/drug therapy ; Dyslipidemias/mortality ; Dyslipidemias/diagnosis ; Dyslipidemias/blood ; Atorvastatin/administration & dosage ; Atorvastatin/adverse effects ; Drug Therapy, Combination ; Percutaneous Coronary Intervention/mortality ; Percutaneous Coronary Intervention/adverse effects ; Lipids/blood
Sprache	Englisch
Erscheinungsdatum	2024-04-29
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Observational Study ; Multicenter Study
ZDB-ID	2483197-9
ISSN	1941-7705 ; 1941-7713
ISSN (online)	1941-7705
ISSN	1941-7713
DOI	10.1161/CIRCOUTCOMES.123.010685
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Applicability of the REDUCE-IT trial to the FAST-MI registry. Are the results of randomized trials relevant in routine clinical practice?

Ferrières, Jean / Bataille, Vincent / Puymirat, Etienne / Schiele, François / Simon, Tabassome / Danchin, Nicolas

Clinical cardiology

2020 Band 43, Heft 11, Seite(n) 1260–1265

Abstract: Background: The reduction of cardiovascular events with icosapent ethyl-intervention trial (REDUCE-IT) trial revealed robust atherosclerotic cardiovascular risk reduction with a strategy comprising high-dose omega-3 icosapent ethyl vs placebo in statin- ... ...

Abstract	Background: The reduction of cardiovascular events with icosapent ethyl-intervention trial (REDUCE-IT) trial revealed robust atherosclerotic cardiovascular risk reduction with a strategy comprising high-dose omega-3 icosapent ethyl vs placebo in statin-treated patients with elevated triglycerides and controlled low-density lipoprotein cholesterol (LDL-C). Hypothesis: Are the results of the REDUCE-IT trial applicable to the French registry on acute ST-elevation and non-ST-elevation myocardial infarction (FAST-MI) population? Methods: Data were extracted from the FAST-MI 2010 and 2015 registries. We applied the REDUCE-IT enrolment criteria (triglycerides 150-500 mg/dL and LDL-C 40-100 mg/dL on statins) to the FAST-MI population in patients aged ≥45 years who had detailed lipid values postacute hospitalization, focusing on their clinical profile and cardiovascular prognosis. Results: Of the 3789 FAST-MI patients with a full lipid profile (median 11.1 [IQR 7.6-17.4] months after hospitalization for myocardial infarction), 472 (12.5%; 95% CI 11.4-13.5) met the eligibility criteria for REDUCE-IT (REDUCE-IT-like group). The cardiovascular event rate (all-cause death, nonfatal myocardial infarction, nonfatal stroke) was 36.7 (95% CI 27.8-48.6) per 1000 person-years for the REDUCE-IT-like group, which compares with the 36.9 (95% CI 26.1-51.5) per 1000 person-years (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke) reported in the REDUCE-IT trial. The residual cardiovascular risk related to elevated triglycerides in the REDUCE-IT-like group was similar to the risk in the REDUCE-IT trial. Conclusions: If the results of REDUCE-IT are applied to patients hospitalized for a myocardial infarction in France, 12.5% of these patients could benefit from a strategy of high-dose omega-3 icosapent ethyl on top of contemporary therapy including statins to improve their clinical outcomes.
Mesh-Begriff(e)	Aged ; Cholesterol, LDL/blood ; Female ; France/epidemiology ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Incidence ; Male ; Middle Aged ; Myocardial Infarction/blood ; Myocardial Infarction/drug therapy ; Myocardial Infarction/epidemiology ; Platelet Aggregation Inhibitors/therapeutic use ; Randomized Controlled Trials as Topic ; Registries ; Risk Factors ; Triglycerides/blood
Chemische Substanzen	Cholesterol, LDL ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Platelet Aggregation Inhibitors ; Triglycerides
Sprache	Englisch
Erscheinungsdatum	2020-07-28
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Multicenter Study
ZDB-ID	391935-3
ISSN	1932-8737 ; 0160-9289
ISSN (online)	1932-8737
ISSN	0160-9289
DOI	10.1002/clc.23437
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: TIcagrelor in Rotational Atherectomy to Reduce TROPonin Enhancement: The TIRATROP Study, A Randomized Controlled Trial.

Lhermusier, Thibault / Motreff, Pascal / Bataille, Vincent / Cayla, Guillaume / Farah, Bruno / Roncalli, Jerome / Elbaz, Meyer / Boudou, Nicolas / Campello-Parada, Fransisco / Bouisset, Frederic / Souteyrand, Geraud / Berard, Emilie / Bongard, Vanina / Carrie, Didier

Journal of clinical medicine

2023 Band 12, Heft 4

Abstract: Background: Because rotational atherectomy (RA) is associated with arterial trauma and platelet activation, patients treated with RA may benefit from more potent antiplatelet drugs. The aim of this trial was to assess the superiority of ticagrelor over ... ...

Abstract	Background: Because rotational atherectomy (RA) is associated with arterial trauma and platelet activation, patients treated with RA may benefit from more potent antiplatelet drugs. The aim of this trial was to assess the superiority of ticagrelor over clopidogrel in reducing post procedure troponin release. Methods: TIRATROP (TIcagrelor in Rotational Atherectomy to reduce TROPonin enhancement) is a multicenter double-blind randomized controlled trial that included 180 patients with severe calcified lesions requiring RA who received either clopidogrel (300 mg loading dose, then 75 mg/d) or ticagrelor (loading dose 180 mg then 90 mg twice daily). Blood samples were collected at the beginning (T0), and 6, 12, 18, 24 and 36 h after the procedure. Primary end point was troponin release within the first 24 h using area under the curve analysis (troponin level as a function of time). Results: The mean age of patients was 76 ± 10 years, 35% had diabetes. RA was used to treat 1, 2 or 3 calcified lesions in 72%, 23% and 5% of patients, respectively. Troponin release within the first 24 h was similar in both the ticagrelor (adjusted mean ±SD of ln AUC 8.85 ± 0.33) and the clopidogrel (8.77 ± 0.34, Conclusion: Troponin release did not differ among treatment arms. Our results suggest that greater platelet inhibition does not affect periprocedural myocardial necrosis in the setting of RA.
Sprache	Englisch
Erscheinungsdatum	2023-02-11
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12041445
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Health-Related Quality of Life and Its Association With Outcomes in Adults With Congenital Heart Disease and Heart Failure: Insight From FRESH-ACHD Registry.

Ly, Reaksmei / Karsenty, Clément / Amedro, Pascal / Cohen, Sarah / Domanski, Olivia / Godart, Francois / Radojevic, Jelena / Vaksmann, Guy / Naccache, Nicole / Boubrit, Anissa / Bataille, Vincent / Hascoet, Sébastien / Ladouceur, Magalie

Journal of the American Heart Association

2023 Band 12, Heft 8, Seite(n) e027819

Abstract: Background Quality of Life (QoL) is a prognostic factor in heart failure (HF) of patients with acquired cardiac disease. The aim of this study was to determine the predictive value of QoL on outcomes in adults with congenital heart disease (ACHD) and HF. ...

Abstract	Background Quality of Life (QoL) is a prognostic factor in heart failure (HF) of patients with acquired cardiac disease. The aim of this study was to determine the predictive value of QoL on outcomes in adults with congenital heart disease (ACHD) and HF. Methods and Results Quality of life of 196 adults with congenital heart disease with clinical heart failure (HF) (mean age: 44.3±13.8 years; 51% male; 56% with complex congenital heart disease; 47% New York Heart Association class III/IV) included in the prospective multicentric registry FRESH-ACHD (French Survey on Heart Failure-Adult with Congenital Heart Disease) was assessed using the 36-Item Short Form Survey (SF-36), a patient-reported survey. The primary end point was defined by all-cause death, HF-related hospitalization, heart transplantation, and mechanical circulatory support. At 12 months, 28 (14%) patients reached the combined end point. Patients with low quality of life experienced major adverse events more frequently (logrank
Mesh-Begriff(e)	Adult ; Humans ; Male ; Middle Aged ; Female ; Quality of Life ; Prospective Studies ; Heart Defects, Congenital/complications ; Heart Defects, Congenital/therapy ; Heart Failure/epidemiology ; Heart Failure/therapy ; Heart Failure/complications ; Registries
Sprache	Englisch
Erscheinungsdatum	2023-04-07
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.122.027819
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Outcomes of Provisional Stenting With Versus Without Side Branch Intervention in Patients With Bifurcation Lesion-Related ST-Segment Elevation Myocardial Infarction.

Servoz, Clément / Matta, Anthony / Bataille, Vincent / Philippe, John / Laszlo, Levai / Blanco, Stéphanie / Elbaz, Meyer / Bouisset, Frédéric / Campelo-Parada, Francisco / Carrié, Didier / Lhermusier, Thibault

The American journal of cardiology

2023 Band 208, Seite(n) 190–194

Abstract: To date, the best approach to coronary bifurcation lesion remains unsettled, and the parameters to guide side branch ballooning or stenting are not yet defined. This study aimed to compare the survival outcomes after provisional stenting with versus ... ...

Abstract	To date, the best approach to coronary bifurcation lesion remains unsettled, and the parameters to guide side branch ballooning or stenting are not yet defined. This study aimed to compare the survival outcomes after provisional stenting with versus without side branch intervention. A cohort was conducted on 132 patients who underwent coronary angiography at Toulouse University Hospital for ST-segment elevation myocardial infarction with large culprit nonleft main coronary bifurcation lesion. Study participants were divided into 2 groups depending on the performance or not of a side branch intervention. We observed the living status at 1-year after hospital discharge. Side branch intervention by balloon inflation or final balloon kissing technique was performed in 34.1% of study participants. At 1-year follow-up, the incidence of all-cause mortality was 7.8 per 100 person-years (95% confidence interval [CI] 4.1 to 15), and although it seemed higher in the side branch intervention group (10 per 100 person-years [95% CI 3.8 to 26.7] vs 6.6 per 100 persons-years [95% CI 2.8 to 15.9]), the survival analyses showed no differences in survival outcomes (hazard ratio
Mesh-Begriff(e)	Humans ; Angioplasty, Balloon, Coronary/methods ; Treatment Outcome ; Stents/adverse effects ; Coronary Angiography/adverse effects ; Myocardial Infarction/etiology ; Coronary Artery Disease/complications ; Coronary Artery Disease/surgery
Sprache	Englisch
Erscheinungsdatum	2023-10-21
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2023.09.049
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Very long-term outcomes after acute myocardial infarction in young men and women: Insights from the FAST-MI program.

Weizman, Orianne / Tea, Victoria / Marijon, Eloi / Eltchaninoff, Hélène / Manzo-Silberman, Stéphane / Leclercq, Florence / Albert, Franck / Bataille, Vincent / Drouet, Elodie / Naccache, Nicole / Puymirat, Etienne / Ferrières, Jean / Schiele, François / Simon, Tabassome / Danchin, Nicolas

Archives of cardiovascular diseases

2023 Band 116, Heft 6-7, Seite(n) 324–334

Abstract: Aims: Conflicting data exists about long-term outcomes in young women and men experiencing acute myocardial infarction (AMI).: Methods: The FAST-MI program consists of three nationwide French surveys carried out 5years apart from 2005 to 2015, ... ...

Abstract	Aims: Conflicting data exists about long-term outcomes in young women and men experiencing acute myocardial infarction (AMI). Methods: The FAST-MI program consists of three nationwide French surveys carried out 5years apart from 2005 to 2015, including consecutive patients with AMI over a 1-month period with up to 10-year follow-up. The present analysis focused on adults≤50 yo according to their gender. Results: Women accounted for 17.5% (335) of the 1912 patients under 50 yo and had a similar age as men (43.9±5.1 vs. 43.9±5.5years, P=0.92). They received less percutaneous coronary interventions (PCI) than men (85.9% vs. 91.3%, P=0.005), even in ST-elevation myocardial infarction (83.6% vs. 93.5%, P<0.001). Recommended secondary prevention medications were less frequently prescribed at discharge in women (40.6% vs. 52.8%, P<0.001), a trend that persisted in 2015 (59.1% vs. 72.8% in 2015, P<0.001). Still, ten-year survival was similar in men (90.5%) and women (92.3%) (crude HR: 0.86 [95% CI: 0.55-1.35], P=0.52, adjusted HR: 0.63 [95% CI: 0.38-1.07], P=0.09); similar results were found for ten-year survival among hospital survivors (91.2% in men vs. 93.7% in women, adjusted HR: 0.87 [95% CI: 0.45-1.66], P=0.66). Of the 1684 patients alive at hospital discharge with morbidity follow-up≥6months available, death, AMI or stroke at 8years occurred in 12.9% men and 11.2% in women (adjusted HR: 0.90 [95% CI: 0.60-1.33], P=0.59). Conclusions: Young women with AMI undergo less cardiac interventions and are less often prescribed secondary prevention treatment than men, even when significant coronary artery disease is present, but keep a similar long-term prognosis after AMI. Optimal management of these young patients, regardless of gender, is necessary to ensure best outcomes after this major cardiovascular event.
Mesh-Begriff(e)	Male ; Adult ; Humans ; Female ; Percutaneous Coronary Intervention/adverse effects ; Treatment Outcome ; Risk Factors ; Myocardial Infarction/diagnosis ; Myocardial Infarction/epidemiology ; Myocardial Infarction/therapy ; Coronary Artery Disease ; Sex Factors
Sprache	Englisch
Erscheinungsdatum	2023-06-17
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	2408778-6
ISSN	1875-2128 ; 1875-2136
ISSN (online)	1875-2128
ISSN	1875-2136
DOI	10.1016/j.acvd.2023.05.006
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Clinical Outcomes of Left Main Coronary Artery PCI With Rotational Atherectomy.

Bouisset, Frédéric / Ribichini, Flavio / Bataille, Vincent / Reczuch, Krzysztof / Lhermusier, Thibault / Dobrzycki, Slawomir / Meyer-Gessner, Markus / Bressollette, Erwan / Zajdel, Wojciech / Faurie, Benjamin / Mezilis, Nikolaos / Palazuelos, Jorge / Vaquerizo, Beatriz / Ferenc, Miroslaw / Cayla, Guillaume / Barbato, Emanuele / Carrié, Didier

The American journal of cardiology

2022 Band 186, Seite(n) 36–42

Abstract: Data regarding rotational atherectomy percutaneous coronary intervention (RA PCI) angioplasty in the left main (LM) coronary artery are scarce, and mostly outdated. We aimed to describe clinical outcomes of RA PCI in LM. Patients requiring RA in 8 ... ...

Abstract	Data regarding rotational atherectomy percutaneous coronary intervention (RA PCI) angioplasty in the left main (LM) coronary artery are scarce, and mostly outdated. We aimed to describe clinical outcomes of RA PCI in LM. Patients requiring RA in 8 European countries and 19 centers were prospectively and consecutively included in the European registry of Cardiac Care of Calcified and Complex patients registry. In-hospital data collection and 1-year follow-up were performed for each patient. Between October 2016 and July 2018, 966 patients with complete data were included. Among them, 241 presented with an LM lesion, and 171 required an LM lesion preparation by RA. The latter, allocated to the LM-RA group, were compared with the 725 patients in the non-LM-RA group. Clinical success of the RA procedure was comparable in both groups, but in-hospital major adverse cardiac events were higher in the RA-LM group (7.6% vs 3.2%, adjusted p = 0.04), mainly driven by a higher in-hospital mortality rate (5.3 vs 0.3%, adjusted p = 0.005). At 1-year follow-up, mortality and major adverse cardiac event rates were comparable in both groups (12.9% vs 8.0%, adjusted p value: 0.821, and 15.8% vs 10.9%, adjusted p value: 0.329, respectively), but the rate of target vessel revascularization remained higher in the RA-LM group (5.3% vs 3.2%, adjusted p = 0.021). In conclusion, RA PCI is an efficient option for calcified LM lesions, providing acceptable outcomes regarding this population with high risk at 1 year, and yields comparable outcomes with RA PCI performed on non-LM lesions.
Mesh-Begriff(e)	Humans ; Atherectomy, Coronary/methods ; Percutaneous Coronary Intervention/methods ; Coronary Artery Disease ; Treatment Outcome ; Coronary Angiography/methods ; Vascular Calcification/surgery
Sprache	Englisch
Erscheinungsdatum	2022-11-04
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2022.09.031
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Increased mortality risk in diabetic patients discharged from hospital with insulin therapy after an acute myocardial infarction: Data from the FAST-MI 2005 registry.

Bataille, Vincent / Ferrières, Jean / Danchin, Nicolas / Puymirat, Etienne / Zeller, Marianne / Simon, Tabassome / Carrié, Didier

European heart journal. Acute cardiovascular care

2017 Band 8, Heft 3, Seite(n) 218–230

Abstract: Background: Merits of insulin use for diabetes treatment in patients with advanced atherosclerosis are debated. This observational study conducted in diabetic patients after an acute myocardial infarction aimed to assess whether insulin prescription at ... ...

Abstract	Background: Merits of insulin use for diabetes treatment in patients with advanced atherosclerosis are debated. This observational study conducted in diabetic patients after an acute myocardial infarction aimed to assess whether insulin prescription at discharge (IPD) was related to all-cause mortality during follow-up. Methods: Subjects were diabetic patients admitted in intensive- or coronary-care units for acute myocardial infarction (consecutively recruited in 223 centres in France) and discharged alive from the hospital, with or without an IPD. Vital status after five years was obtained and the relationship between insulin prescription at discharge and survival was studied. Results: Overall, 1221 diabetic patients were discharged alive and 38% had an IPD. Factors independently related to IPD were female gender, hospitalization in a public hospital, duration of diabetes, HbA1c level, smoking, peripheral artery disease, history of coronary heart disease and Killip class. After adjustment, IPD was independently related to all-cause mortality after five years of follow-up (adjusted hazard ratio = 1.72 (1.42-2.09), p<0.001). This increased mortality in subjects with IPD was also observed in propensity matched analyses, when subjects actually treated or actually not treated with insulin at discharge were compared in two groups matched on their computed probability of having had insulin prescribed. Conclusions: Insulin was preferably prescribed in seriously affected patients, regarding diabetes and cardiovascular risk. However, insulin prescription at discharge was associated with increased all-cause mortality after extensive adjustments for confounders. These results suggest possible intrinsic harmful effects of insulin in high-risk diabetic patients after myocardial infarction.
Mesh-Begriff(e)	Aged ; Cause of Death/trends ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/mortality ; Drug Prescriptions ; Female ; Follow-Up Studies ; France/epidemiology ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin/therapeutic use ; Male ; Myocardial Infarction/complications ; Myocardial Infarction/mortality ; Patient Discharge/statistics & numerical data ; Registries ; Retrospective Studies ; Risk Factors ; Survival Rate/trends
Chemische Substanzen	Hypoglycemic Agents ; Insulin
Sprache	Englisch
Erscheinungsdatum	2017-07-10
Erscheinungsland	England
Dokumenttyp	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	2663340-1
ISSN	2048-8734 ; 2048-8726
ISSN (online)	2048-8734
ISSN	2048-8726
DOI	10.1177/2048872617719639
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Mottling as a prognosis marker in cardiogenic shock.

Merdji, Hamid / Bataille, Vincent / Curtiaud, Anais / Bonello, Laurent / Roubille, François / Levy, Bruno / Lim, Pascal / Schneider, Francis / Khachab, Hadi / Dib, Jean-Claude / Seronde, Marie-France / Schurtz, Guillaume / Harbaoui, Brahim / Vanzetto, Gerald / Marchand, Severine / Gebhard, Caroline Eva / Henry, Patrick / Combaret, Nicolas / Marchandot, Benjamin /

Lattuca, Benoit / Biendel, Caroline / Leurent, Guillaume / Gerbaud, Edouard / Puymirat, Etienne / Bonnefoy, Eric / Meziani, Ferhat / Delmas, Clément

Annals of intensive care

2023 Band 13, Heft 1, Seite(n) 80

Abstract: Aims: Impact of skin mottling has been poorly studied in patients admitted for cardiogenic shock. This study aimed to address this issue and identify determinants of 30-day and 1-year mortality in a large cardiogenic shock cohort of all etiologies.: ... ...

Abstract	Aims: Impact of skin mottling has been poorly studied in patients admitted for cardiogenic shock. This study aimed to address this issue and identify determinants of 30-day and 1-year mortality in a large cardiogenic shock cohort of all etiologies. Methods and results: FRENSHOCK is a prospective multicenter observational registry conducted in French critical care units between April and October, 2016. Among the 772 enrolled patients (mean age 65.7 ± 14.9 years; 71.5% male), 660 had skin mottling assessed at admission (85.5%) with almost 39% of patients in cardiogenic shock presenting mottling. The need for invasive respiratory support was significantly higher in patients with mottling (50.2% vs. 30.1%, p < 0.001) and likewise for the need for renal replacement therapy (19.9% vs. 12.4%, p = 0.09). However, the need for mechanical circulatory support was similar in both groups. Patients with mottling at admission presented a higher length of stay (19 vs. 16 days, p = 0.033), a higher 30-day mortality rate (31% vs. 23.3%, p = 0.031), and also showed significantly higher mortality at 1-year (54% vs. 42%, p = 0.003). The subgroup of patients in whom mottling appeared during the first 24 h after admission had the worst prognosis at 30 days. Conclusion: Skin mottling at admission in patients with cardiogenic shock was statistically associated with prolonged length of stay and poor outcomes. As a perfusion-targeted resuscitation parameter, mottling is a simple, clinical-based approach and may thus help to improve and guide immediate goal-directed therapy to improve cardiogenic shock patients' outcomes.
Sprache	Englisch
Erscheinungsdatum	2023-09-06
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	2617094-2
ISSN	2110-5820
ISSN	2110-5820
DOI	10.1186/s13613-023-01175-0
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Percutaneous Myocardial Revascularization in Late-Presenting Patients With STEMI.

Bouisset, Frédéric / Gerbaud, Edouard / Bataille, Vincent / Coste, Pierre / Puymirat, Etienne / Belle, Loic / Delmas, Clément / Cayla, Guillaume / Motreff, Pascal / Lemesle, Gilles / Aissaoui, Nadia / Blanchard, Didier / Schiele, François / Simon, Tabassome / Danchin, Nicolas / Ferrières, Jean

Journal of the American College of Cardiology

2021 Band 78, Heft 13, Seite(n) 1291–1305

Abstract: Background: The optimal management of patients with ST-segment elevation myocardial infarction (STEMI) presenting late->12 hours following symptom onset-is still under debate.: Objectives: The purpose of this study was to describe characteristics, ... ...

Abstract	Background: The optimal management of patients with ST-segment elevation myocardial infarction (STEMI) presenting late->12 hours following symptom onset-is still under debate. Objectives: The purpose of this study was to describe characteristics, temporal trends, and impact of revascularization in a large population of latecomer STEMI patients. Methods: The authors analyzed the data of 3 nationwide observational studies from the FAST-MI (French Registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction) program, conducted over a 1-month period in 2005, 2010, and 2015. Patients presenting between 12 and 48 hours after symptom onset were classified as latecomers. Results: A total of 6,273 STEMI patients were included in the 3 cohorts, 1,169 (18.6%) of whom were latecomers. After exclusion of patients treated with fibrinolysis and patients deceased within 2 days after admission, 1,077 patients were analyzed, of whom 729 (67.7%) were revascularized within 48 hours after hospital admission. At 30-day follow-up, all-cause death rate was significantly lower among revascularized latecomers (2.1% vs 7.2%; P < 0.001). After a median follow-up of 58 months, the rate of all-cause death was 30.4 (95% CI: 25.7-35.9) per 1,000 patient-years in the revascularized latecomers group vs 78.7 (95% CI: 67.2-92.3) per 1,000 patient-years in the nonrevascularized latecomers group (P < 0.001). In multivariate analysis, revascularization of latecomer STEMI patients was independently associated with a significant reduction of mortality occurrence during follow-up (HR: 0.65 [95% CI: 0.50-0.84]; P = 0.001). Conclusions: Coronary revascularization of latecomer STEMI patients is associated with better short and long-term clinical outcomes.
Mesh-Begriff(e)	Aged ; Female ; France/epidemiology ; Humans ; Male ; Middle Aged ; Percutaneous Coronary Intervention/mortality ; Registries ; ST Elevation Myocardial Infarction/surgery ; Time-to-Treatment
Sprache	Englisch
Erscheinungsdatum	2021-09-23
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2021.07.039
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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