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  1. AU="Batista, Craig"
  2. TI=Deja vu: Stimulating open drug discovery for SARS CoV 2

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  1. Buch ; Online ; E-Book: Pocket prescriber pulmonary medicine

    Batista, Craig / Singer, Donald Rj / Barnes, Peter J.

    (Pocket Prescriber Series)

    2024  

    Abstract: Pocket Prescriber Pulmonary Medicine is a concise, up-to-date prescribing guide containing all the 'must-have' information that clinical professionals treating patients with respiratory conditions need to know. ...

    Verfasserangabe Craig Batista, Donald Rj Singer, and Peter J. Barnes
    Serientitel Pocket Prescriber Series
    Abstract Pocket Prescriber Pulmonary Medicine is a concise, up-to-date prescribing guide containing all the 'must-have' information that clinical professionals treating patients with respiratory conditions need to know.
    Schlagwörter Drug abuse
    Thema/Rubrik (Code) 613.8
    Sprache Englisch
    Umfang 1 online resource (329 pages)
    Verlag CRC Press
    Erscheinungsort Boca Raton, FL
    Dokumenttyp Buch ; Online ; E-Book
    Bemerkung Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-315-15181-2 ; 1-4987-4441-9 ; 9781498744409 ; 978-1-315-15181-6 ; 978-1-4987-4441-6 ; 1498744400
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Artikel ; Online: Metastatic cancer masquerading as miliary tuberculosis in an immunocompetent young adult.

    Ng, Peng Yun / Kadam, Mustafa / Batista, Craig

    BMJ case reports

    2022  Band 15, Heft 5

    Abstract: A healthy, immunocompetent South Asian man in his mid-20s, with a medical history of gastric ulcer, presented to Accident & Emergency with pleuritic chest pain, shortness of breath, fever, night sweats, weight loss, dry cough and asymptomatic iron ... ...

    Abstract A healthy, immunocompetent South Asian man in his mid-20s, with a medical history of gastric ulcer, presented to Accident & Emergency with pleuritic chest pain, shortness of breath, fever, night sweats, weight loss, dry cough and asymptomatic iron deficiency anaemia. Following his initial assessment and investigations (chest X-ray, CT and blood tests), a diagnosis of miliary tuberculosis (TB) was made and empirical antimicrobial treatment started. However, subsequent microbiological testing, including urine, blood, induced sputum and lymph node sampling, was negative. Being interpreted as non-diagnostic, the antimicrobial therapy was continued. Following a clinical deterioration while on treatment, the patient's case was re-evaluated and further investigations, including a repeat CT and a liver biopsy, confirmed a diagnosis of stage IV (T1aN3bM1) gastric carcinoma. Our case highlights the diagnostic challenges in differentiating metastatic cancer from miliary TB. We also focus on possible cognitive biases that may have influenced the initial management decisions.
    Mesh-Begriff(e) Cough ; Fever ; Humans ; Male ; Neoplasms ; Sputum ; Tuberculosis, Miliary/diagnosis ; Tuberculosis, Miliary/drug therapy ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2022-05-24
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-249880
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Development and implementation of the lung volume reduction pulmonary rehabilitation tool to identify eligibility for lung volume reduction in people with chronic obstructive pulmonary disease during pulmonary rehabilitation.

    Buttery, Sara C / Williams, Parris J / Brighton, Lisa J / Batista, Craig / Dewar, Amy / Hogg, Lauren / Ingram, Karen / Korff, Gemma / Koulopoulou, Maria / Lammin, Helen / Maddocks, Matthew / McDonnell, Lynn / Mehta, Bhavin / Meyrick, Victoria / Pritchard, Lisa / Smith, Oliver / Trivedi, Puja / Lawson, Rod A / Hopkinson, Nicholas S

    Chronic respiratory disease

    2023  Band 20, Seite(n) 14799731231198863

    Abstract: Background: Completion of pulmonary rehabilitation is recognised in chronic obstructive pulmonary disease (COPD) guidelines as a key opportunity to consider systematically whether a respiratory review to assess potential suitability for a lung volume ... ...

    Abstract Background: Completion of pulmonary rehabilitation is recognised in chronic obstructive pulmonary disease (COPD) guidelines as a key opportunity to consider systematically whether a respiratory review to assess potential suitability for a lung volume reduction (LVR) procedure might be appropriate. We describe the development of a simple decision-support tool (the LVR-PR tool) to aid clinicians working in pulmonary rehabilitation, to operationalise this process.
    Methods: We took an iterative mixed methods approach, which was partnership-based and involved an initial consensus survey, focus groups and an observational study cohort at multiple pulmonary rehabilitation centres.
    Results: Diagnosis (97%), exercise capacity (84%), breathlessness (78%) and co-morbidities (76%) were acknowledged to be essential items for assessing basic LVR eligibility. Collating prior investigations and assessing patient understanding were considered useful but not essential. Clinician concerns included; streamlining the tool; access to clinical information and investigations; and care needed around introducing LVR therapies to patients in a PR setting. Access to clearer information about LVR procedures, the clinician's role in considering eligibility and how educational resources should be delivered were identified as important themes from patient group discussions. The LVR-PR tool was considered to be feasible and valid for implementation in a variety of PR services across the UK subject to the provision of appropriate health professional training. Clinicians working in specialist LVR centres across the UK who were not otherwise involved in the development process confirmed the tool's validity using the content validity index (CVI).
    Interpretation: The LVR-PR tool appears to be an acceptable tool that can be feasibly implemented in PR services subject to good quality educational resources for both patients and healthcare professionals.
    Mesh-Begriff(e) Humans ; Pneumonectomy ; Pulmonary Disease, Chronic Obstructive ; Surveys and Questionnaires ; Focus Groups ; Quality of Life
    Sprache Englisch
    Erscheinungsdatum 2023-09-01
    Erscheinungsland England
    Dokumenttyp Observational Study ; Journal Article
    ZDB-ID 2211488-9
    ISSN 1479-9731 ; 1479-9723
    ISSN (online) 1479-9731
    ISSN 1479-9723
    DOI 10.1177/14799731231198863
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages.

    Belchamber, Kylie B R / Singh, Richa / Batista, Craig M / Whyte, Moira K / Dockrell, David H / Kilty, Iain / Robinson, Matthew J / Wedzicha, Jadwiga A / Barnes, Peter J / Donnelly, Louise E

    The European respiratory journal

    2019  Band 54, Heft 4

    Abstract: Increased reactive oxygen species (ROS) have been implicated in the pathophysiology of chronic obstructive pulmonary disease (COPD). This study examined the effect of exogenous and endogenous oxidative stress on macrophage phagocytosis in patients with ... ...

    Abstract Increased reactive oxygen species (ROS) have been implicated in the pathophysiology of chronic obstructive pulmonary disease (COPD). This study examined the effect of exogenous and endogenous oxidative stress on macrophage phagocytosis in patients with COPD.Monocyte-derived macrophages (MDMs) were generated from non-smoker, smoker and COPD subjects, differentiated in either granulocyte macrophage-colony stimulating factor (G-Mφ) or macrophage-colony stimulating factor (M-Mφ). Alveolar macrophages were isolated from lung tissue or bronchoalveolar lavage fluid. Macrophages were incubated in ±200 µM H
    Mesh-Begriff(e) Aged ; Bacteria ; Cell Survival ; Female ; Haemophilus influenzae ; Humans ; In Vitro Techniques ; Macrophages/immunology ; Macrophages/metabolism ; Macrophages/pathology ; Macrophages, Alveolar/immunology ; Macrophages, Alveolar/metabolism ; Macrophages, Alveolar/pathology ; Male ; Membrane Potential, Mitochondrial ; Microscopy, Confocal ; Middle Aged ; Mitochondria/metabolism ; Phagocytosis/immunology ; Pulmonary Disease, Chronic Obstructive/immunology ; Pulmonary Disease, Chronic Obstructive/metabolism ; Reactive Oxygen Species/metabolism ; Streptococcus pneumoniae
    Chemische Substanzen Reactive Oxygen Species
    Sprache Englisch
    Erscheinungsdatum 2019-10-10
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02244-2018
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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