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  1. Buch ; Dissertation / Habilitation: Einfluß von HIV-1 und CMV auf die In-vitro-Hämatopoese frischer und kultivierter Knochenmarkzellen sowie Analyse der LTBMC-Zellzusammensetzung mit Hilfe der Durchflußzytometrie

    Baumgarte, Sigrid

    1996  

    Verfasserangabe vorgelegt von Sigrid Baumgarte
    Sprache Deutsch
    Umfang 158 S. : Ill., graph. Darst.
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Hamburg, Univ., Diss., 1996
    HBZ-ID HT008951611
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    98 D 2415 bestellbar zur Ausleihe Magazin

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  2. Artikel: Investigation of a Limited but Explosive COVID-19 Outbreak in a German Secondary School

    Baumgarte, Sigrid / Hartkopf, Felix / Hölzer, Martin / von Kleist, Max / Neitz, Sabine / Kriegel, Martin / Bollongino, Kirsten

    Viruses. 2022 Jan. 04, v. 14, no. 1

    2022  

    Abstract: The role of schools as a source of infection and driver in the coronavirus-pandemic has been controversial and is still not completely clarified. To prevent harm and disadvantages for children and adolescents, but also adults, detailed data on school ... ...

    Abstract The role of schools as a source of infection and driver in the coronavirus-pandemic has been controversial and is still not completely clarified. To prevent harm and disadvantages for children and adolescents, but also adults, detailed data on school outbreaks is needed, especially when talking about open schools employing evidence-based safety concepts. Here, we investigated the first significant COVID-19 school outbreak in Hamburg, Germany, after the re-opening of schools in 2020. Using clinical, laboratory, and contact data and spatial measures for epidemiological and environmental studies combined with whole-genome sequencing (WGS) analysis, we examined the causes and the course of the secondary school outbreak. The potential index case was identified by epidemiological tracking and the lessons in classrooms with presumably high virus spreading rates and further infection chains in the setting. Sequence analysis of samples detected one sample of a different virus lineage and 25 virus genomes with almost identical sequences, of which 21 showed 100% similarity. Most infections occurred in connection with two lesson units of the primary case. Likely, 31 students (12–14 years old), two staff members, and three family members were infected in the school or the typical household. Sequence analysis revealed an outbreak cluster with a single source that was epidemiologically identified as a member of the educational staff. In lesson units, two superspreading events of varying degrees with airborne transmission took place. These were influenced by several parameters including the exposure times, the use of respiratory masks while speaking and spatial or structural conditions at that time.
    Schlagwörter COVID-19 infection ; airborne transmission ; genome ; secondary education ; sequence analysis ; viruses ; Germany
    Sprache Englisch
    Erscheinungsverlauf 2022-0104
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14010087
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel ; Online: SARS-CoV-2 Aerosol Transmission Indoors: A Closer Look at Viral Load, Infectivity, the Effectiveness of Preventive Measures and a Simple Approach for Practical Recommendations.

    Kriegel, Martin / Hartmann, Anne / Buchholz, Udo / Seifried, Janna / Baumgarte, Sigrid / Gastmeier, Petra

    International journal of environmental research and public health

    2021  Band 19, Heft 1

    Abstract: There is uncertainty about the viral loads of infectious individuals required to transmit COVID-19 via aerosol. In addition, there is a lack of both quantification of the influencing parameters on airborne transmission and simple-to-use models for ... ...

    Abstract There is uncertainty about the viral loads of infectious individuals required to transmit COVID-19 via aerosol. In addition, there is a lack of both quantification of the influencing parameters on airborne transmission and simple-to-use models for assessing the risk of infection in practice, which furthermore quantify the influence of non-medical preventive measures. In this study, a dose-response model was adopted to analyze 25 documented outbreaks at infection rates of 4-100%. We show that infection was only possible if the viral load was higher than 10
    Mesh-Begriff(e) Aerosols ; COVID-19 ; Humans ; Masks ; SARS-CoV-2 ; Viral Load
    Chemische Substanzen Aerosols
    Sprache Englisch
    Erscheinungsdatum 2021-12-25
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19010220
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Investigation of a Limited but Explosive COVID-19 Outbreak in a German Secondary School.

    Baumgarte, Sigrid / Hartkopf, Felix / Hölzer, Martin / von Kleist, Max / Neitz, Sabine / Kriegel, Martin / Bollongino, Kirsten

    Viruses

    2022  Band 14, Heft 1

    Abstract: The role of schools as a source of infection and driver in the coronavirus-pandemic has been controversial and is still not completely clarified. To prevent harm and disadvantages for children and adolescents, but also adults, detailed data on school ... ...

    Abstract The role of schools as a source of infection and driver in the coronavirus-pandemic has been controversial and is still not completely clarified. To prevent harm and disadvantages for children and adolescents, but also adults, detailed data on school outbreaks is needed, especially when talking about open schools employing evidence-based safety concepts. Here, we investigated the first significant COVID-19 school outbreak in Hamburg, Germany, after the re-opening of schools in 2020. Using clinical, laboratory, and contact data and spatial measures for epidemiological and environmental studies combined with whole-genome sequencing (WGS) analysis, we examined the causes and the course of the secondary school outbreak. The potential index case was identified by epidemiological tracking and the lessons in classrooms with presumably high virus spreading rates and further infection chains in the setting. Sequence analysis of samples detected one sample of a different virus lineage and 25 virus genomes with almost identical sequences, of which 21 showed 100% similarity. Most infections occurred in connection with two lesson units of the primary case. Likely, 31 students (12-14 years old), two staff members, and three family members were infected in the school or the typical household. Sequence analysis revealed an outbreak cluster with a single source that was epidemiologically identified as a member of the educational staff. In lesson units, two superspreading events of varying degrees with airborne transmission took place. These were influenced by several parameters including the exposure times, the use of respiratory masks while speaking and spatial or structural conditions at that time.
    Mesh-Begriff(e) COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/transmission ; Contact Tracing ; Disease Outbreaks/prevention & control ; Educational Personnel ; Family ; Female ; Genome, Viral/genetics ; Germany/epidemiology ; Humans ; Male ; Phylogeny ; Quarantine ; Risk Factors ; SARS-CoV-2/classification ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Schools ; Students
    Sprache Englisch
    Erscheinungsdatum 2022-01-04
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14010087
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: SARS-CoV-2 Aerosol Transmission Indoors: A Closer Look at Viral Load, Infectivity, the Effectiveness of Preventive Measures and a Simple Approach for Practical Recommendations

    Kriegel, Martin / Hartmann, Anne / Buchholz, Udo / Seifried, Janna / Baumgarte, Sigrid / Gastmeier, Petra

    medRxiv

    Abstract: Currently, airborne transmission is seen as the most important transmission path for SARS-CoV-2. In this investigation, a classic dose-response model is used on the one hand to find out retrospectively the probable viral load of the infectious source ... ...

    Abstract Currently, airborne transmission is seen as the most important transmission path for SARS-CoV-2. In this investigation, a classic dose-response model is used on the one hand to find out retrospectively the probable viral load of the infectious source patient at the time of transmission in 25 documented outbreaks. We showed that an infection due to airborne transmission at a distance from the infectious person was probably only possible in the 25 outbreaks examined, with attack rates of 4-100%, if the viral load had been higher than 1E+08 viral copies/ml. This demonstrates that the viral load estimated from the swab might overestimate a person9s infectivity via aerosol, because a person is generally considered infectious, independent of the transmission way, when the viral load from the swab is 1E+06 viral copies/ml. On the other hand, a possible approach is presented to predict the probable situational Attack Rate (PARs) of a group of persons in a room through aerosol particles emitted by an infectious source patient. Four main categories of influence on the risk of infection are formed: First the emitted viruses, depending on the viral load and the amount of respiratory particles, and necessary number of reproducible viruses for infection, second the room-specific data and duration of stay of the group of people, third the activity of the exposed persons, and fourth the effect of personal protection (e.g. wearing masks from infectious and/or susceptible person). Furthermore, a simplified method is presented to calculate either the maximum possible number of persons in a room, so that probably a maximum of one person becomes infected when an infectious person is in the room, or the PARs,simple for a given number of persons, ventilation rate and time of occupancy. We additionally show, taking into account organizational preventive measures, which person-related virus-free supply air flow rates are necessary to keep the number of newly infected persons to less than 1. The simple approach makes it easy to derive preventive organizational and ventilation measures. Our results show that the volume flow rate or a person-related flow rate is a much more effective parameter to evaluate ventilation for infection prevention than the air change rate. We suggest to monitor the CO2 concentration as an easy to implement and valid measurement system for indoor spaces. Finally, we show that of the three measures, besides of wearing masks and increasing ventilation, testing contributes the most to the joint protective effect. This corresponds to the classic approach to implement protection concepts: preventing the source from entering the room and emitting viruses at all. In summary, a layered approach of different measures is recommended to mutually compensate for possible failures of any one measure (e.g. incorrect execution of tests, incorrect fit of masks or irregular window opening), to increase the degree of protection and thus reduce the risk of transmission of SARS-CoV-2.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2021-11-04
    Verlag Cold Spring Harbor Laboratory Press
    Dokumenttyp Artikel ; Online
    DOI 10.1101/2021.11.04.21265910
    Datenquelle COVID19

    Volltext online

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  6. Artikel: Sepsisartige Erkrankungen durch humane Parechoviren Typ 3. Fall-Kontroll-Studie an jungen Säuglingen. Sepsis-like illness caused by human parechovirus type 3. Case-control study in young infants

    Kemen, C. / Baumgarte, S. / Höger, P. H.

    Monatsschrift Kinderheilkunde

    2013  Band 161, Heft 5, Seite(n) 425

    Sprache Deutsch
    Dokumenttyp Artikel
    ZDB-ID 137102-2
    ISSN 0026-9298
    Datenquelle Current Contents Medizin

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  7. Artikel: Field studies on the environmental fate of the Cry1Ab Bt-toxin produced by transgenic maize (MON810) and its effect on bacterial communities in the maize rhizosphere

    Baumgarte, S / Tebbe, C.C

    Molecular ecology. 2005 July, v. 14, no. 8

    2005  

    Schlagwörter Zea mays ; corn ; transgenic plants ; gene expression ; transgenes ; insecticidal proteins ; Bacillus thuringiensis subsp. kurstaki ; crystal proteins ; environmental impact ; soil bacteria ; rhizosphere ; polymerase chain reaction ; single-stranded conformational polymorphism ; community structure ; species diversity ; ribosomal RNA ; genes ; risk assessment
    Sprache Englisch
    Erscheinungsverlauf 2005-07
    Umfang p. 2539-2551.
    Dokumenttyp Artikel
    ZDB-ID 1126687-9
    ISSN 1365-294X ; 0962-1083
    ISSN (online) 1365-294X
    ISSN 0962-1083
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Bonn

    Z 2005/723: Hefte anzeigen
    Nees-Institut: Meckenheimer Allee: Hefte anzeigen

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  8. Artikel: Tiefkühlfrüchte als Risikofaktor für Gastroenteritis-Ausbrüche durch Noroviren: Ergebnisse einer Ausbruchsuntersuchung im Sommer 2005 in Hamburg.

    Fell, Gerhard / Boyens, M / Baumgarte, S

    Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz

    2007  Band 50, Heft 2, Seite(n) 230–236

    Abstract: An outbreak of acute gastroenteritis occurred in Hamburg among guests of a canteen in August 2005. A total of 241 persons were found ill. In stool samples of 16 of them Norovirus Genogroup I was identified. Neither bacterial nor viral pathogens could be ... ...

    Titelübersetzung Frozen berries as a risk factor for outbreaks of norovirus gastroenteritis. Results of an outbreak investigation in the summer of 2005 in Hamburg.
    Abstract An outbreak of acute gastroenteritis occurred in Hamburg among guests of a canteen in August 2005. A total of 241 persons were found ill. In stool samples of 16 of them Norovirus Genogroup I was identified. Neither bacterial nor viral pathogens could be detected in food samples. Among 162 guests enrolled in a cohort study, 69 (42.6 %) met the case definition. A desert dish made from blackberries and yoghurt showed a significant association with the disease (RR 6.9; 95% CI 3.36-14.16). In addition, a protective effect of the decision for the alternative desert dish ice cream was observed (RR 0.9; 95% CI 0.08-0.45). The desert, which was prepared in the canteen kitchen from yoghurt and frozen blackberries, was the most likely source of the outbreak. Frozen berries should be included in the HACCP concepts for canteen kitchens.
    Mesh-Begriff(e) Caliciviridae Infections/epidemiology ; Caliciviridae Infections/transmission ; Caliciviridae Infections/virology ; Cross-Sectional Studies ; Disease Outbreaks ; Food Microbiology ; Food Services ; Foodborne Diseases/epidemiology ; Foodborne Diseases/virology ; Frozen Foods/virology ; Fruit/virology ; Gastroenteritis/epidemiology ; Gastroenteritis/virology ; Genotype ; Germany ; Humans ; Norovirus/genetics ; Norovirus/pathogenicity ; Virulence/genetics
    Sprache Deutsch
    Erscheinungsdatum 2007-02
    Erscheinungsland Germany
    Dokumenttyp English Abstract ; Journal Article
    ZDB-ID 1461973-8
    ISSN 1437-1588 ; 1436-9990
    ISSN (online) 1437-1588
    ISSN 1436-9990
    DOI 10.1007/s00103-007-0142-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Buch ; Online ; Dissertation / Habilitation: Microbial diversity of soda lake habitats

    Baumgarte, Susanne

    2003  

    Verfasserangabe von Susanne Baumgarte
    Sprache Englisch
    Umfang Online-Ressource, Ill., graph. Darst., Kt
    Erscheinungsort Braunschweig: UB
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Dissertation / Habilitation Techn. Univ., Diss.--Braunschweig, 2003
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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  10. Artikel ; Online: Description of measles D4-Hamburg outbreak in Hamburg, Germany, December 2008 to June 2009, which disproportionally affected a local Roma community.

    Hegasy, G / Kätzner, K / Helle, M / Mankertz, A / Baumgarte, S / Wille, A / Fell, G

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

    2012  Band 17, Heft 24

    Abstract: From December 2008 to June 2009 a measles outbreak occurred in the Federal State of Hamburg, Germany. The outbreak affected 216 persons and was caused by a new measles strain termed D4-Hamburg which led to consecutive outbreaks between 2009 and 2011 in ... ...

    Abstract From December 2008 to June 2009 a measles outbreak occurred in the Federal State of Hamburg, Germany. The outbreak affected 216 persons and was caused by a new measles strain termed D4-Hamburg which led to consecutive outbreaks between 2009 and 2011 in at least 12 European countries. Here, we describe epidemiological characteristics of the outbreak and evaluate the control measures taken in Hamburg. In one of the seven boroughs of Hamburg a local Roma community comprised more than 50% of the notified cases.We compared in a stratified analysis the age distribution of these cases with cases of fellow citizens who did not belong to the Roma community. The age group of infants (0-11 months) comprised 33% among the non-Roma measles cases, while in the Roma community only 4% belonged to this stratum. In the stratum of 5-17 year-olds only 8% were affected among the non-Roma cases, whereas in the Roma community 50% belonged to this age group. We discuss the influencing factors that might have led to this difference in age distribution between the two groups.
    Mesh-Begriff(e) Adolescent ; Adult ; Age Distribution ; Catchment Area (Health) ; Chi-Square Distribution ; Child ; Child, Preschool ; Disease Notification ; Disease Outbreaks ; Female ; Germany/epidemiology ; Humans ; Immunization/statistics & numerical data ; Infant ; Male ; Measles/diagnosis ; Measles/epidemiology ; Measles/immunology ; Measles/prevention & control ; Measles Vaccine/administration & dosage ; Measles virus/immunology ; Medically Underserved Area ; Middle Aged ; Polymerase Chain Reaction ; Population Surveillance ; Travel ; Young Adult
    Chemische Substanzen Measles Vaccine
    Sprache Englisch
    Erscheinungsdatum 2012-06-14
    Erscheinungsland Sweden
    Dokumenttyp Journal Article
    ZDB-ID 1338803-4
    ISSN 1560-7917 ; 1025-496X
    ISSN (online) 1560-7917
    ISSN 1025-496X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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