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  1. Artikel ; Online: Efficacy of dupilumab in patients with aspirin-exacerbated respiratory disease and previous inadequate response to anti-IL-5 or anti-IL-5Rα in a real-world setting.

    Bavaro, Nicole / Gakpo, Deborah / Mittal, Anisha / Bensko, Jillian C / Laidlaw, Tanya M / Buchheit, Kathleen M

    The journal of allergy and clinical immunology. In practice

    2021  Band 9, Heft 7, Seite(n) 2910–2912.e1

    Mesh-Begriff(e) Antibodies, Monoclonal, Humanized ; Aspirin ; Humans ; Sinusitis
    Chemische Substanzen Antibodies, Monoclonal, Humanized ; dupilumab (420K487FSG) ; Aspirin (R16CO5Y76E)
    Sprache Englisch
    Erscheinungsdatum 2021-02-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.02.020
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Prominent Longitudinal Strain Reduction of Basal Left Ventricular Segments in Patients With Coronavirus Disease-19.

    Goerlich, Erin / Gilotra, Nisha A / Minhas, Anum S / Bavaro, Nicole / Hays, Allison G / Cingolani, Oscar H

    Journal of cardiac failure

    2020  Band 27, Heft 1, Seite(n) 100–104

    Abstract: Background: Coronavirus disease-19 (COVID-19) has been associated with overt and subclinical myocardial dysfunction. We observed a recurring pattern of reduced basal left ventricular (LV) longitudinal strain on speckle-tracking echocardiography in ... ...

    Abstract Background: Coronavirus disease-19 (COVID-19) has been associated with overt and subclinical myocardial dysfunction. We observed a recurring pattern of reduced basal left ventricular (LV) longitudinal strain on speckle-tracking echocardiography in hospitalized patients with COVID-19 and subsequently aimed to identify characteristics of affected patients. We hypothesized that patients with COVID-19 with reduced basal LV strain would demonstrate elevated cardiac biomarkers.
    Methods and result: Eighty-one consecutive patients with COVID-19 underwent speckle-tracking echocardiography. Those with poor quality speckle-tracking echocardiography (n = 2) or a known LV ejection fraction of <50% (n = 4) were excluded. Patients with an absolute value basal longitudinal strain of <13.9% (2 standard deviations below normal) were designated as cases (n = 39); those with a basal longitudinal strain of ≥13.9% were designated as controls (n = 36). Demographics and clinical variables were compared. Of 75 included patients (mean age 62 ± 14 years, 41% women), 52% had reduced basal strain. Cases had higher body mass index (median 34.1; interquartile range 26.5-37.9 kg/m
    Conclusions: Reduced basal LV strain is common in patients with COVID-19. Patients with hypertension, diabetes, obesity, and Black race were more likely to have reduced basal strain. Further investigation into the significance of this strain pattern is warranted.
    Mesh-Begriff(e) Aged ; COVID-19/diagnostic imaging ; COVID-19/epidemiology ; Echocardiography/methods ; Echocardiography/trends ; Female ; Heart Failure/diagnostic imaging ; Heart Failure/epidemiology ; Hospitalization/trends ; Humans ; Male ; Middle Aged ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/epidemiology
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-09-28
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2020.09.469
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Prevalence and prognostic implications of hypertensive response to exercise in patients with hypertrophic cardiomyopathy.

    Lu, Dai-Yin / Ventoulis, Ioannis / Liu, Hongyun / Haileselassie, Bereketeab / Pozios, Iraklis / Liang, Hsin-Yueh / Sorensen, Lars L / Canepa, Marco / Bavaro, Nicole / Phillip, Susan / Abraham, M Roselle / Abraham, Theodore P

    International journal of cardiology. Cardiovascular risk and prevention

    2023  Band 16, Seite(n) 200166

    Abstract: Objective: Hypertensive response to exercise (HRE) is observed in patients with hypertrophic cardiomyopathy (HCM) with normal resting blood pressure (BP). However, the prevalence or prognostic implications of HRE in HCM remain unclear.: Methods: In ... ...

    Abstract Objective: Hypertensive response to exercise (HRE) is observed in patients with hypertrophic cardiomyopathy (HCM) with normal resting blood pressure (BP). However, the prevalence or prognostic implications of HRE in HCM remain unclear.
    Methods: In this study, normotensive HCM subjects were enrolled. HRE was defined as systolic BP > 210 mmHg in men or >190 mmHg in women, or diastolic BP > 90 mmHg, or an increase in diastolic BP > 10 mmHg during treadmill exercise. All participants were followed for subsequent development of hypertension, atrial fibrillation (AF), heart failure (HF), sustained ventricular tachycardia/fibrillation (VT/VF), and all-cause death. Six hundred and eighty HCM patients were screened.
    Results: 347 patients had baseline hypertension, and 333 patients were baseline normotensive. 132 (40%) of the 333 patients had HRE. HRE was associated with female sex, lower body mass index and milder left ventricular outflow tract obstruction. Exercise duration and metabolic equivalents were similar between patients with or without HRE, but the HRE group had higher peak heart rate (HR), better chronotropic response and more rapid HR recovery. Conversely, non-HRE patients were more likely to exhibit chronotropic incompetence and hypotensive response to exercise. After a mean follow-up of 3.4 years, patients with and without HRE had similar risks of progression to hypertension, AF, HF, sustained VT/VF or death.
    Conclusion: HRE is common in normotensive HCM patients during exercise. HRE did not carry higher risks of future hypertension or cardiovascular adverse outcomes. Conversely, the absence of HRE was associated with chronotropic incompetence and hypotensive response to exercise.
    Sprache Englisch
    Erscheinungsdatum 2023-01-13
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ISSN 2772-4875
    ISSN (online) 2772-4875
    DOI 10.1016/j.ijcrp.2022.200166
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Unsupervised machine learning demonstrates the prognostic value of TAPSE/PASP ratio among hospitalized patients with COVID-19.

    Jani, Vivek / Kapoor, Karan / Meyer, Joseph / Lu, Jim / Goerlich, Erin / Metkus, Thomas S / Madrazo, Jose A / Michos, Erin / Wu, Katherine / Bavaro, Nicole / Kutty, Shelby / Hays, Allison G / Mukherjee, Monica

    Echocardiography (Mount Kisco, N.Y.)

    2022  Band 39, Heft 9, Seite(n) 1198–1208

    Abstract: Background: The ratio of tricuspid annular plane systolic excursion (TAPSE) to pulmonary artery systolic pressure (PASP) is a validated index of right ventricular-pulmonary arterial (RV-PA) coupling with prognostic value. We determined the predictive ... ...

    Abstract Background: The ratio of tricuspid annular plane systolic excursion (TAPSE) to pulmonary artery systolic pressure (PASP) is a validated index of right ventricular-pulmonary arterial (RV-PA) coupling with prognostic value. We determined the predictive value of TAPSE/PASP ratio and adverse clinical outcomes in hospitalized patients with COVID-19.
    Methods: Two hundred and twenty-nine consecutive hospitalized racially/ethnically diverse adults (≥18 years of age) admitted with COVID-19 between March and June 2020 with clinically indicated transthoracic echocardiograms (TTE) that included adequate tricuspid regurgitation (TR) velocities for calculation of PASP were studied. The exposure of interest was impaired RV-PA coupling as assessed by TAPSE/PASP ratio. The primary outcome was in-hospital mortality. Secondary endpoints comprised of ICU admission, incident acute respiratory distress syndrome (ARDS), and systolic heart failure.
    Results: One hundred and seventy-six patients had both technically adequate TAPSE measurements and measurable TR velocities for analysis. After adjustment for age, sex, BMI, race/ethnicity, diabetes mellitus, and smoking status, log(TAPSE/PASP) had a significantly inverse association with ICU admission (p = 0.015) and death (p = 0.038). ROC analysis showed the optimal cutoff for TAPSE/PASP for death was 0.51 mm mmHg
    Conclusion: Impaired RV-PA coupling, assessed noninvasively via the TAPSE/PASP ratio, was predictive of need for ICU level care and in-hospital mortality in hospitalized patients with COVID-19 suggesting utility of TAPSE/PASP in identification of poor clinical outcomes in this population both by traditional statistical and unsupervised machine learning based methods.
    Mesh-Begriff(e) Adult ; Humans ; COVID-19 ; Echocardiography, Doppler ; Prognosis ; Prospective Studies ; Unsupervised Machine Learning ; Ventricular Dysfunction, Right ; Ventricular Function, Right
    Sprache Englisch
    Erscheinungsdatum 2022-07-30
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 843645-9
    ISSN 1540-8175 ; 0742-2822
    ISSN (online) 1540-8175
    ISSN 0742-2822
    DOI 10.1111/echo.15432
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Prominent Longitudinal Strain Reduction of Basal Left Ventricular Segments in Patients with COVID-19

    Goerlich, Erin / Gilotra, Nisha A / Minhas, Anum S / Bavaro, Nicole / Hays, Allison G / Cingolani, Oscar H

    J. card. fail

    Abstract: BACKGROUND: COVID-19 has been associated with overt and subclinical myocardial dysfunction. We observed a recurring pattern of reduced basal left ventricular (LV) longitudinal strain (LS) on speckle-tracking echocardiography (STE) in hospitalized COVID- ... ...

    Abstract BACKGROUND: COVID-19 has been associated with overt and subclinical myocardial dysfunction. We observed a recurring pattern of reduced basal left ventricular (LV) longitudinal strain (LS) on speckle-tracking echocardiography (STE) in hospitalized COVID-19 patients and subsequently aimed to identify characteristics of affected patients. We hypothesized that COVID-19 patients with reduced basal LV strain would demonstrate elevated cardiac biomarkers. METHODS: 81 consecutive COVID-19 patients underwent STE. Those with poor quality STE (n=2) or known LV ejection fraction<50% (n=4) were excluded. Patients with absolute value basal LS<13.9% (2SD below normal) were designated as cases (n=39); those with basal LS≥13.9% as controls (n=36). Demographics and clinical variables were compared. RESULTS: Of 75 included patients (mean age 62±14 years, 41% women), 52% had reduced basal strain. Cases had higher BMI (median[IQR]) (34.1[26.5-37.9]kg/m2 vs. 26.9[24.8-30.0]kg/m2, p=0.009), and greater proportions of Black (74% vs. 36%, p=0.0009), hypertensive (79% vs. 56%, p=0.026) and diabetic patients (44% vs. 19%, p=0.025) compared to controls. Troponin and NT-proBNP levels trended higher in cases but were not significantly different. CONCLUSIONS AND RELEVANCE: Reduced basal LV strain is common in COVID-19 patients. Patients with hypertension, diabetes, obesity, and Black race were more likely to have reduced basal strain. Further investigation into the significance of this strain pattern is warranted.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #799270
    Datenquelle COVID19

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  6. Artikel ; Online: Prominent Longitudinal Strain Reduction of Basal Left Ventricular Segments in Patients with COVID-19

    Goerlich, Erin / Gilotra, Nisha A. / Minhas, Anum S. / Bavaro, Nicole / Hays, Allison G. / Cingolani, Oscar H.

    Journal of Cardiac Failure ; ISSN 1071-9164

    2020  

    Schlagwörter Cardiology and Cardiovascular Medicine ; covid19
    Sprache Englisch
    Verlag Elsevier BV
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    DOI 10.1016/j.cardfail.2020.09.469
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel: Myocardial Work Efficiency, A Novel Measure of Myocardial Dysfunction, Is Reduced in COVID-19 Patients and Associated With In-Hospital Mortality.

    Minhas, Anum S / Gilotra, Nisha A / Goerlich, Erin / Metkus, Thomas / Garibaldi, Brian T / Sharma, Garima / Bavaro, Nicole / Phillip, Susan / Michos, Erin D / Hays, Allison G

    Frontiers in cardiovascular medicine

    2021  Band 8, Seite(n) 667721

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2021-06-14
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.667721
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