Artikel: Reduced Mortality With Ondansetron Use in SARS-CoV-2-Infected Inpatients.
Open forum infectious diseases
2021 Band 8, Heft 7, Seite(n) ofab336
Abstract: Background: The coronavirus disease 2019 (COVID-19) pandemic has led to a surge in clinical trials evaluating investigational and approved drugs. Retrospective analysis of drugs taken by COVID-19 inpatients provides key information on drugs associated ... ...
Abstract | Background: The coronavirus disease 2019 (COVID-19) pandemic has led to a surge in clinical trials evaluating investigational and approved drugs. Retrospective analysis of drugs taken by COVID-19 inpatients provides key information on drugs associated with better or worse outcomes. Methods: We conducted a retrospective cohort study of 10 741 patients testing positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection within 3 days of admission to compare risk of 30-day all-cause mortality in patients receiving ondansetron using multivariate Cox proportional hazard models. All-cause mortality, length of hospital stay, adverse events such as ischemic cerebral infarction, and subsequent positive COVID-19 tests were measured. Results: Administration of ≥8 mg of ondansetron within 48 hours of admission was correlated with an adjusted hazard ratio for 30-day all-cause mortality of 0.55 (95% CI, 0.42-0.70; Conclusions: If confirmed by prospective clinical trials, our results suggest that ondansetron, a safe, widely available drug, could be used to decrease morbidity and mortality in at-risk populations. |
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Sprache | Englisch |
Erscheinungsdatum | 2021-07-14 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article |
ZDB-ID | 2757767-3 |
ISSN | 2328-8957 |
ISSN | 2328-8957 |
DOI | 10.1093/ofid/ofab336 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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