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  1. Artikel: Chemokine expression profile of an innate granuloma.

    Amason, Megan E / Harvest, Carissa K / Beatty, Cole J / Saban, Daniel R / Miao, Edward A

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Granulomas are defined by the presence of organized layers of immune cells that include macrophages. Granulomas are often characterized as a way for the immune system to contain an infection and prevent its dissemination. We recently established a mouse ... ...

    Abstract Granulomas are defined by the presence of organized layers of immune cells that include macrophages. Granulomas are often characterized as a way for the immune system to contain an infection and prevent its dissemination. We recently established a mouse infection model where
    Sprache Englisch
    Erscheinungsdatum 2024-02-01
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.01.30.577927
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: The Yin and Yang of non-immune and immune responses in meibomian gland dysfunction.

    Beatty, Cole J / Ruiz-Lozano, Raul E / Quiroga-Garza, Manuel E / Perez, Victor L / Jester, James V / Saban, Daniel R

    The ocular surface

    2024  Band 32, Seite(n) 81–90

    Abstract: Meibomian gland dysfunction (MGD) is a leading cause of dry eye disease and one of the most common ophthalmic conditions encountered in eye clinics worldwide. These holocrine glands are situated in the eyelid, where they produce specialized lipids, or ... ...

    Abstract Meibomian gland dysfunction (MGD) is a leading cause of dry eye disease and one of the most common ophthalmic conditions encountered in eye clinics worldwide. These holocrine glands are situated in the eyelid, where they produce specialized lipids, or meibum, needed to lubricate the eye surface and slow tear film evaporation - functions which are critical to preserving high-resolution vision. MGD results in tear instability, rapid tear evaporation, changes in local microflora, and dry eye disease, amongst other pathological entities. While studies identifying the mechanisms of MGD have generally focused on gland obstruction, we now know that age is a major risk factor for MGD that is associated with abnormal cell differentiation and renewal. It is also now appreciated that immune-inflammatory disorders, such as certain autoimmune diseases and atopy, may trigger MGD, as demonstrated through a T cell-driven neutrophil response. Here, we independently discuss the underlying roles of gland and immune related factors in MGD, as well as the integration of these two distinct mechanisms into a unified perspective that may aid future studies. From this unique standpoint, we propose a revised model in which glandular dysfunction and immunopathogenic pathways are not primary versus secondary contributors in MGD, but are fluid, interactive, and dynamic, which we likened to the Yin and Yang of MGD.
    Mesh-Begriff(e) Humans ; Meibomian Gland Dysfunction/immunology ; Meibomian Glands/immunology ; Meibomian Glands/pathology ; Meibomian Glands/metabolism ; Tears/metabolism ; Dry Eye Syndromes/immunology ; Dry Eye Syndromes/physiopathology
    Sprache Englisch
    Erscheinungsdatum 2024-01-14
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2208578-6
    ISSN 1937-5913 ; 1542-0124
    ISSN (online) 1937-5913
    ISSN 1542-0124
    DOI 10.1016/j.jtos.2024.01.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: An innate granuloma eradicates an environmental pathogen using Gsdmd and Nos2.

    Harvest, Carissa K / Abele, Taylor J / Yu, Chen / Beatty, Cole J / Amason, Megan E / Billman, Zachary P / DePrizio, Morgan A / Souza, Fernando W / Lacey, Carolyn A / Maltez, Vivien I / Larson, Heather N / McGlaughon, Benjamin D / Saban, Daniel R / Montgomery, Stephanie A / Miao, Edward A

    Nature communications

    2023  Band 14, Heft 1, Seite(n) 6686

    Abstract: Granulomas often form around pathogens that cause chronic infections. Here, we discover an innate granuloma model in mice with an environmental bacterium called Chromobacterium violaceum. Granuloma formation not only successfully walls off, but also ... ...

    Abstract Granulomas often form around pathogens that cause chronic infections. Here, we discover an innate granuloma model in mice with an environmental bacterium called Chromobacterium violaceum. Granuloma formation not only successfully walls off, but also clears, the infection. The infected lesion can arise from a single bacterium that replicates despite the presence of a neutrophil swarm. Bacterial replication ceases when macrophages organize around the infection and form a granuloma. This granuloma response is accomplished independently of adaptive immunity that is typically required to organize granulomas. The C. violaceum-induced granuloma requires at least two separate defense pathways, gasdermin D and iNOS, to maintain the integrity of the granuloma architecture. This innate granuloma successfully eradicates C. violaceum infection. Therefore, this C. violaceum-induced granuloma model demonstrates that innate immune cells successfully organize a granuloma and thereby resolve infection by an environmental pathogen.
    Mesh-Begriff(e) Animals ; Mice ; Granuloma ; Macrophages/metabolism ; Neutrophils ; Nitric Oxide Synthase Type II/metabolism
    Chemische Substanzen Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Nos2 protein, mouse (EC 1.14.13.39) ; Gsdmd protein, mouse
    Sprache Englisch
    Erscheinungsdatum 2023-10-21
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-42218-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: An innate granuloma eradicates an environmental pathogen using

    Harvest, Carissa K / Abele, Taylor J / Yu, Chen / Beatty, Cole J / Amason, Megan E / Billman, Zachary P / DePrizio, Morgan A / Lacey, Carolyn A / Maltez, Vivien I / Larson, Heather N / McGlaughon, Benjamin D / Saban, Daniel R / Montgomery, Stephanie A / Miao, Edward A

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Granulomas often form around pathogens that cause chronic infections. Here, we discover a novel granuloma model in mice. ...

    Abstract Granulomas often form around pathogens that cause chronic infections. Here, we discover a novel granuloma model in mice.
    Sprache Englisch
    Erscheinungsdatum 2023-03-09
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.03.07.531568
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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